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Immunogen sequence: DSNRVVLRSG KDDYINASCV EGLSPYCPPL VATQAPLPGT AADFWLMVHE QKVSVIVMLV SEAEMEKQKV ARYFPTERGQ PMVHGALSLA LSSVRSTETH VERVLSLQFR DQSLKRSLVH LHFPTWPELG LPDSPSNLLR FIQEVHAHYL HQRPLHTPII VHCSSGVGRT GAFALLYAAV QEVEAGNGIP ELPQLVRRMR QQRKHMLQEK LHLRFCYEAV V; Positive Samples: Mouse eye, Rat kidney; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Early endosome, Endosome, Nucleus, cilium basal body, cytoskeleton
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: his domain-containing protein tyrosine phosphatase; protein tyrosine phosphatase TD14; Tyrosine-protein phosphatase non-receptor type 23
Gene Aliases: AI462446; HD-PTP; Kiaa1471; PTP-TD14; Ptpn23
UniProt ID: (Mouse) Q6PB44
Entrez Gene ID: (Mouse) 104831, (Rat) 117552
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