Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: GTPSPIPDPS VATVATGENG ITQISSTAES FHKQNGTGTP QVETNTSEDG ESSGANDSLR TPEQGSNGTD GASQKTPSST GPSPVFDIKA VSISPTNVIL
CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD148; CD148 antigen; Density-enhanced phosphatase 1; DEP-1; HPTP eta; human density enhanced phosphatase-1; protein tyrosine phosphatase, receptor type, J polypeptide; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; susceptibility to colon cancer 1, mouse, homolog of
Gene Aliases: CD148; DEP1; HPTPeta; PTPRJ; R-PTP-ETA; SCC1
UniProt ID: (Human) Q12913
Entrez Gene ID: (Human) 5795
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support