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Product Details
H00009232-M65
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4E5
Immunogen
PTTG1 (NP_004210, 177 a.a. approximately 197 a.a) synthetic peptide.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SSILSTLDVE C
Target Information
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Esp1-associated protein; ESP1-associated protein 1; MGC126883; MGC138276; Pituitary tumor-transforming gene 1 protein; Securin; Tumor-transforming protein 1
Gene Aliases: EAP1; HPTTG; PTTG; PTTG1; TUTR1
UniProt ID: (Human) O95997
Entrez Gene ID: (Human) 9232
DNA repair
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
mitotic nuclear division
spermatogenesis
negative regulation of endopeptidase activity
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
homologous chromosome segregation
chromosome organization
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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