Proteintech

PYGB Polyclonal Antibody

PYGB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PYGB Antibody (12075-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse heart tissue slide using 12075-1-AP (PYGB antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

PYGB Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12075-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PYGB Fusion Protein Ag2732 (544-843 aa encoded by BC017045)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LKFSAFLEK EYKVKINPSS MFDVHVKRIH EYKRQLLNCL HVVTLYNRIK RDPAKAFVPR TVMIGGKAAP GYHMAKLIIK LVTSIGDVVN HDPVVGDRLK VIFLENYRVS LAEKVIPAAD LSQQISTAGT EASGTGNMKF MLNGALTIGT MDGANVEMAE EAGAENLFIF GLRVEDVEAL DRKGYNAREY YDHLPELKQA VDQISSGFFS PKEPDCFKDI VNMLMHHDRF KVFADYEAYM QCQAQVDQLY RNPKEWTKKV IRNIACSGKF SSDRTITEYA REIWGVEPSD LQIPPPNIPR D (544-843 aa encoded by BC017045)

Target Information

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This enzyme catalyzes the rate-determining step in glycogen degradation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.

iScience

Hsu YH,Pintacuda G,Liu R,Nacu E,Kim A,Tsafou K,Petrossian N,Crotty W,Suh JM,Riseman J,Martin JM,Biagini JC,Mena D,Ching JKT,Malolepsza E,Li T,Singh T,Ge T,Egri SB,Tanenbaum B,Stanclift CR,Apffel AM,Carr SA,Schenone M,Jaffe J,Fornelos N,Huang H,Eggan KC,Lage K

Fri May 19 00:00:00 EDT 2023

PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer.

International journal of biological sciences

Ji Q,Li H,Cai Z,Yuan X,Pu X,Huang Y,Fu S,Chu L,Jiang C,Xue J,Zhang X,Li R

Wed Apr 19 00:00:00 EDT 2023

Amyotrophic lateral sclerosis alters the metabolic aging profile in patient derived fibroblasts.

Neurobiology of aging

Gerou M,Hall B,Woof R,Allsop J,Kolb SJ,Meyer K,Shaw PJ,Allen SP

Wed Sep 01 00:00:00 EDT 2021

Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma.

Nature metabolism

Xie H,Song J,Godfrey J,Riscal R,Skuli N,Nissim I,Simon MC

Mon Mar 01 00:00:00 EST 2021

Glycogen Phosphorylase B Is Regulated by miR101-3p and Promotes Hepatocellular Carcinoma Tumorigenesis.

Frontiers in cell and developmental biology

Cui G,Wang H,Liu W,Xing J,Song W,Zeng Z,Liu L,Wang H,Wang X,Luo H,Leng X,Shen S

Thu Dec 17 00:00:00 EST 2020

The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma.

Clinical proteomics

Lu Y,Luo G,Zhu S,Wang X,Chen Y,Dong Z,Wang S,Ma J,Deng H,Wu D,Dong J

Wed Apr 13 00:00:00 EDT 2022

The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma.

Clinical proteomics

Lu Y,Luo G,Zhu S,Wang X,Chen Y,Dong Z,Wang S,Ma J,Deng H,Wu D,Dong J

Wed Apr 13 00:00:00 EDT 2022

Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhou Y,Jin Z,Wang C

Sun Dec 01 00:00:00 EST 2019

Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Zhou Y,Jin Z,Wang C

Sun Dec 01 00:00:00 EST 2019

Decreased Glycogenolysis by miR-338-3p Promotes Regional Glycogen Accumulation Within the Spinal Cord of Amyotrophic Lateral Sclerosis Mice.

Frontiers in molecular neuroscience

Li C,Wei Q,Gu X,Chen Y,Chen X,Cao B,Ou R,Shang H

Thu Oct 01 00:00:00 EDT 2020

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis.

Brain : a journal of neurology

Allen SP,Hall B,Woof R,Francis L,Gatto N,Shaw AC,Myszczynska M,Hemingway J,Coldicott I,Willcock A,Job L,Hughes RM,Boschian C,Bayatti N,Heath PR,Bandmann O,Mortiboys H,Ferraiuolo L,Shaw PJ

Sun Dec 01 00:00:00 EST 2019

Multiomics Integration Reveals the Landscape of Prometastasis Metabolism in Hepatocellular Carcinoma.

Molecular & cellular proteomics : MCP

Li Y,Zhuang H,Zhang X,Li Y,Liu Y,Yi X,Qin G,Wei W,Chen R

Sun Apr 01 00:00:00 EDT 2018

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

JCI insight

Rahman SMJ,Ji X,Zimmerman LJ,Li M,Harris BK,Hoeksema MD,Trenary IA,Zou Y,Qian J,Slebos RJ,Beane J,Spira A,Shyr Y,Eisenberg R,Liebler DC,Young JD,Massion PP

Thu Nov 17 00:00:00 EST 2016

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

JCI insight

Rahman SMJ,Ji X,Zimmerman LJ,Li M,Harris BK,Hoeksema MD,Trenary IA,Zou Y,Qian J,Slebos RJ,Beane J,Spira A,Shyr Y,Eisenberg R,Liebler DC,Young JD,Massion PP

Thu Nov 17 00:00:00 EST 2016

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.

PloS one

Tadi M,Allaman I,Lengacher S,Grenningloh G,Magistretti PJ

Fri Jun 17 00:00:00 EDT 2016

Learning-Induced Gene Expression in the Hippocampus Reveals a Role of Neuron -Astrocyte Metabolic Coupling in Long Term Memory.

PloS one

Tadi M,Allaman I,Lengacher S,Grenningloh G,Magistretti PJ

Fri Jun 17 00:00:00 EDT 2016

Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons.

Brain research

Takezawa Y,Kohsaka S,Nakajima K

Fri Oct 24 00:00:00 EDT 2014

Transient down-regulation and restoration of glycogen synthase levels in axotomized rat facial motoneurons.

Brain research

Takezawa Y,Kohsaka S,Nakajima K

Fri Oct 24 00:00:00 EDT 2014

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Journal of cellular and molecular medicine

Xi L,Zhu SG,Hobbs DC,Kukreja RC

Tue Nov 01 00:00:00 EDT 2011

Identification of protein targets underlying dietary nitrate-induced protection against doxorubicin cardiotoxicity.

Journal of cellular and molecular medicine

Xi L,Zhu SG,Hobbs DC,Kukreja RC

Tue Nov 01 00:00:00 EDT 2011

Bioinformatics

Protein Aliases: brain glycogen phosphorylase; glycogen phosphorylase B; Glycogen phosphorylase, brain form; MGC9213

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Gene Aliases: GLYPHOA; GPBB; PYGB

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UniProt ID: (Human) P11216, (Mouse) Q8CI94, (Rat) P53534

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Entrez Gene ID: (Human) 5834, (Mouse) 110078, (Rat) 25739

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Function(s)

protein binding glycogen phosphorylase activity pyridoxal phosphate binding catalytic activity phosphorylase activity drug binding transferase activity transferase activity, transferring glycosyl groups carbohydrate binding protein homodimerization activity glycosyltransferase transferase metabolite interconversion enzyme

Process(es)

glycogen catabolic process carbohydrate metabolic process glycogen metabolic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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PYGB Polyclonal Antibody

PYGB Antibody (12075-1-AP) in IHC (P)

Product Details

12075-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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