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Product Details
BS-5011R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PYGL, amino acids 451-550.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glycogen liver; Glycogen phosphorylase, liver form; GPLL; liver glycogen phosphorylase
Gene Aliases: GSD6; Lgp; PYGL
UniProt ID: (Human) P06737, (Mouse) Q9ET01, (Rat) P09811
Entrez Gene ID: (Human) 5836, (Mouse) 110095, (Rat) 64035
purine nucleobase binding
protein binding
ATP binding
glucose binding
drug binding
glycogen phosphorylase activity
AMP binding
vitamin binding
pyridoxal phosphate binding
bile acid binding
protein homodimerization activity
nucleotide binding
catalytic activity
phosphorylase activity
transferase activity
transferase activity, transferring glycosyl groups
carbohydrate binding
glycosyltransferase
transferase
metabolite interconversion enzyme
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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