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Product Details
MA5-31567
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
GT1132
Immunogen
Recombinant protein encompassing a sequence within the center region of human PYK2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2787194
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (92%), Rat (93%), Bovine (94%).
Positive Control: A431.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CADTK; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; cellular adhesion kinase beta; FADK; FADK 2; FAK; FAK1; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK2B protein tyrosine kinase 2 beta; RAFTK; Related adhesion focal tyrosine kinase
Gene Aliases: CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK
UniProt ID: (Human) Q14289, (Mouse) Q9QVP9
Entrez Gene ID: (Human) 2185, (Mouse) 19229
calmodulin-dependent protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
signal transducer activity
NMDA glutamate receptor activity
receptor binding
protein binding
ATP binding
protein complex binding
3-phosphoinositide-dependent protein kinase binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
angiogenesis
oocyte maturation
response to hypoxia
positive regulation of cell-matrix adhesion
sprouting angiogenesis
adaptive immune response
marginal zone B cell differentiation
protein complex assembly
protein phosphorylation
apoptotic process
response to stress
cellular defense response
response to osmotic stress
signal transduction
cell surface receptor signaling pathway
signal complex assembly
epidermal growth factor receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
integrin-mediated signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell shape
response to mechanical stimulus
response to hormone
response to glucose
response to lithium ion
positive regulation of endothelial cell migration
negative regulation of muscle cell apoptotic process
regulation of cGMP-mediated signaling
regulation of macrophage chemotaxis
positive regulation of neuron projection development
glial cell proliferation
peptidyl-tyrosine phosphorylation
regulation of cell adhesion
positive regulation of cell growth
positive regulation of cell migration
negative regulation of bone mineralization
regulation of cGMP biosynthetic process
positive regulation of actin filament polymerization
neuron projection development
regulation of inositol trisphosphate biosynthetic process
tumor necrosis factor-mediated signaling pathway
ionotropic glutamate receptor signaling pathway
response to immobilization stress
peptidyl-tyrosine autophosphorylation
response to cocaine
response to drug
response to hydrogen peroxide
activation of Janus kinase activity
negative regulation of apoptotic process
stress fiber assembly
negative regulation of potassium ion transport
positive regulation of JUN kinase activity
negative regulation of neuron apoptotic process
blood vessel endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
positive regulation of nitric oxide biosynthetic process
bone resorption
response to ethanol
negative regulation of myeloid cell differentiation
positive regulation of translation
positive regulation of angiogenesis
positive regulation of protein kinase activity
positive regulation of JNK cascade
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
focal adhesion assembly
positive regulation of peptidyl-tyrosine phosphorylation
regulation of calcium-mediated signaling
positive regulation of nitric-oxide synthase activity
regulation of release of sequestered calcium ion into cytosol
response to cAMP
response to calcium ion
positive regulation of synaptic transmission, glutamatergic
long-term synaptic potentiation
long term synaptic depression
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
cellular response to fluid shear stress
activation of GTPase activity
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
regulation of establishment of cell polarity
regulation of actin cytoskeleton reorganization
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of excitatory postsynaptic potential
positive regulation of B cell chemotaxis
positive regulation of DNA biosynthetic process
immune system process
cytoskeleton organization
actin filament organization
cell adhesion
phosphorylation
cell migration
negative regulation of ossification
regulation of nitric oxide biosynthetic process
positive regulation of reactive oxygen species metabolic process
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