OriGene

Pan-CDH Monoclonal Antibody (OTI1A7), TrueMAB™

View all (16) Pan-cadherin antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

TA190310

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI1A7

Immunogen

Synthetic peptide corresponding to the conserved region of human cadherin family.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 1% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cadherin 1, E-cadherin (epithelial); cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-Cadherin; E-cadherin 1; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; Retinal cadherin; Uvomorulin

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Gene Aliases: Arc-1; CAD4; CD324; CD325; CDH1; CDH2; CDH3; CDH4; CDHE; CDHN; CDHP; CDw325; ECAD; HJMD; LCAM; NCAD; PCAD; R-CAD; RCAD; UVO

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UniProt ID: (Human) P12830, (Human) P19022, (Human) P22223, (Human) P55283

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Entrez Gene ID: (Human) 999, (Human) 1000, (Human) 1001, (Human) 1002

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Function(s)
glycoprotein binding calcium ion binding protein binding beta-catenin binding ankyrin binding GTPase activating protein binding gamma-catenin binding cell adhesion molecule binding cadherin binding involved in cell-cell adhesion protein kinase binding protein phosphatase binding protein complex binding alpha-catenin binding nitric-oxide synthase binding molecular_function cadherin
Process(es)
homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly response to toxic substance single organismal cell-cell adhesion pituitary gland development negative regulation of cell-cell adhesion extracellular matrix disassembly extracellular matrix organization neuron projection development adherens junction organization response to drug positive regulation of transcription factor import into nucleus positive regulation of transcription, DNA-templated cellular response to lithium ion cellular response to indole-3-methanol protein localization to plasma membrane establishment of protein localization to plasma membrane cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glial cell differentiation calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration cerebral cortex development regulation of myelination regulation of Rho protein signal transduction positive regulation of MAPK cascade cell-cell adhesion mediated by cadherin blood vessel morphogenesis brain morphogenesis homeostasis of number of cells regulation of axonogenesis striated muscle cell differentiation positive regulation of muscle cell differentiation protein heterooligomerization radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation negative regulation of canonical Wnt signaling pathway neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering retina homeostasis visual perception positive regulation of gene expression positive regulation of keratinocyte proliferation hair cycle process keratinization positive regulation of monophenol monooxygenase activity negative regulation of transforming growth factor beta2 production wound healing positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen canonical Wnt signaling pathway regulation of hair cycle by canonical Wnt signaling pathway positive regulation of melanosome transport axon guidance positive regulation of axon extension
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