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Pancreatic polypeptide (PP) is a 36 amino-acid residue peptide with sequence and 3-D structural homology with NPY and PYY. PP is the least conserved of the three peptides and was the first to be identified. It is almost exclusively expressed in the endocrine pancreas and released in response to cholinergic stimulation and food intake. PP has inhibitory effects on gall bladder secretion, intestinal motility and pancreatic secretion. PP may serve as a marker for certain gut endocrine tumors including carcinoid tumors.
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Protein Aliases: HGNC:9327; IOPPP; Pancreatic polypeptide prohormone; Pancreatic polypeptide Y; PH; PPA1; prepro-PP (prepropancreatic polypeptide); SID6-8061
Gene Aliases: PNP; PP; PPY
UniProt ID: (Human) P01298
Entrez Gene ID: (Human) 5539
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