Invitrogen

Pannexin 1 Polyclonal Antibody

Pannexin 1 Antibody in Immunohistochemistry (IHC)

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Pannexin 1 Antibody (487900) in IHC

American journal of physiology. Cell physiology 2017 - Published figure using Pannexin 1 polyclonal antibody (Product # 487900) in Immunohistochemistry

Pannexin 1 Antibody in Western Blot (WB)

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Product Details

487900

Applications

Tested Dilution

Publications

Western Blot (WB)

1-3 µg/mL

View 6 publications 6 publications

Immunohistochemistry (IHC)

2-4 µg/mL

View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

View 1 publication 1 publication

Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the N-terminal region of the mouse Pannexin 1 protein (Accession# NP_062355), which is identical to rat and human sequences.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2532253

Target Information

The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein.

Molecular biology of the cell

Nouri-Nejad D,O'Donnell BL,Patil CS,Sanchez-Pupo RE,Johnston D,Sayedyahossein S,Jurcic K,Lau R,Gyenis L,Litchfield DW,Jackson MF,Gloor GB,Penuela S

Published figure using Pannexin 1 polyclonal antibody (Product # 487900) in Western Blot

Mon Mar 01 00:00:00 EST 2021

Pannexin-1 and CaV1.1 show reciprocal interaction during excitation-contraction and excitation-transcription coupling in skeletal muscle.

The Journal of general physiology

Jaque-Fernández F,Jorquera G,Troc-Gajardo J,Pietri-Rouxel F,Gentil C,Buvinic S,Allard B,Jaimovich E,Jacquemond V,Casas M

487900 was used in Western Blotting to reveal intimate functional interactions between the process of excitation-induced contraction and the process of excitation-induced transcriptional activity in skeletal muscle.

Mon Dec 06 00:00:00 EST 2021

Pannexin-1 channel opening is critical for COVID-19 pathogenesis.

iScience

Luu R,Valdebenito S,Scemes E,Cibelli A,Spray DC,Rovegno M,Tichauer J,Cottignies-Calamarte A,Rosenberg A,Capron C,Belouzard S,Dubuisson J,Annane D,de la Grandmaison GL,Cramer-Bordé E,Bomsel M,Eugenin E

487900 was used in Immunohistochemistry-immunofluorescence to demonstrated that Panx-1 channel is a critical contributor to SARS-CoV-2 infection and should be considered as an alternative therapy.

Fri Dec 17 00:00:00 EST 2021

Role of pannexin 1 channels in load-induced skeletal response.

Annals of the New York Academy of Sciences

Seref-Ferlengez Z,Urban-Maldonado M,Sun HB,Schaffler MB,Suadicani SO,Thi MM

487900 was used in Western Blotting to demonstrate the existence of a Panx1-dependent mechanosensitive mechanism that not only modulates ATP signaling but also coordinates Wnt/β-catenin signaling that is essential for proper skeletal response to mechanical loading.

Mon Apr 01 00:00:00 EDT 2019

Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function.

Frontiers in molecular neuroscience

Zorzi V,Paciello F,Ziraldo G,Peres C,Mazzarda F,Nardin C,Pasquini M,Chiani F,Raspa M,Scavizzi F,Carrer A,Crispino G,Ciubotaru CD,Monyer H,Fetoni AR,M Salvatore A,Mammano F

Published figure using Pannexin 1 polyclonal antibody (Product # 487900) in Western Blot

Thu Oct 01 00:00:00 EDT 2020

Possible roles for ATP release from RBCs exclude the cAMP-mediated Panx1 pathway.

American journal of physiology. Cell physiology

Keller AS,Diederich L,Panknin C,DeLalio LJ,Drake JC,Sherman R,Jackson EK,Yan Z,Kelm M,Cortese-Krott MM,Isakson BE

Published figure using Pannexin 1 polyclonal antibody (Product # 487900) in Immunohistochemistry

Fri Dec 01 00:00:00 EST 2017

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes.

PloS one

Seref-Ferlengez Z,Maung S,Schaffler MB,Spray DC,Suadicani SO,Thi MM

487900 was used in western blot to study impairment of bone mechanosignaling under high glucose levels linked to type-1 diabetes through a P2X7R-Panx1 complex

Wed Jul 26 00:00:00 EDT 2017

CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.

The Journal of biological chemistry

Melhorn MI,Brodsky AS,Estanislau J,Khoory JA,Illigens B,Hamachi I,Kurishita Y,Fraser AD,Nicholson-Weller A,Dolmatova E,Duffy HS,Ghiran IC

Published figure using Pannexin 1 polyclonal antibody (Product # 487900) in Western Blot

Fri Oct 25 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: Pannexin-1

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Gene Aliases: AI847747; Panx1

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UniProt ID: (Mouse) Q9JIP4

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Entrez Gene ID: (Mouse) 55991

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Function(s)

protease binding actin binding receptor binding gap junction channel activity calcium channel activity protein binding channel activity wide pore channel activity leak channel activity ion channel binding protein heterodimerization activity actin filament binding gap junction hemi-channel activity scaffold protein binding

Process(es)

response to ischemia transport ion transport cation transport calcium ion transport cell-cell signaling response to ATP protein hexamerization positive regulation of cytokine secretion positive regulation of interleukin-1 alpha secretion positive regulation of interleukin-1 beta secretion transmembrane transport calcium ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Pannexin 1 Polyclonal Antibody

Pannexin 1 Antibody (487900) in IHC

Product Details

487900

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Frozen) (IHC (F))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

Bioinformatics

Performance Guarantee

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