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Pannexin 1 Antibody (ACC-234-200UL) in IHC (F)
Expression of Pannexin 1 in rat cortex - Immunohistochemical staining of immersion-fixed, free floating rat brain frozen sections using Anti-Pannexin 1 Antibody (#ACC-234), (1:300). PANX1 staining (green) is apparent in cells with neuronal outline (vertical arrows) and apical dendrites (horizontal arrows) in the parietal cingulated cortex region. Cell nuclei are stained with DAPI (blue).
Product Details
ACC-234-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)KEPTEPKFKGLRLE, corresponding to amino acid residues 18- 31 of human PANX1, Intracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: innexin; Pannexin-1; PANX1
Gene Aliases: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7, (Rat) P60570, (Mouse) Q9JIP4
Entrez Gene ID: (Human) 24145, (Rat) 315435, (Mouse) 55991
protease binding
receptor binding
calcium channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
actin binding
gap junction channel activity
protein binding
channel activity
wide pore channel activity
response to ischemia
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
transmembrane transport
calcium ion transmembrane transport
transport
ion transport
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