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Invitrogen
Pannexin 1 Recombinant Rabbit Monoclonal Antibody (ARC1207)
FIGURE: 1 / 2
Pannexin 1 Antibody (MA5-35664) in IHC (P)
Immunohistochemistry analysis of Pannexin 1 in paraffin-embedded human esophageal cancer. Samples were incubated with Pannexin 1 Monoclonal antibody (Product # MA5-35664) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35664
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ARC1207
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 327-426 of human Pannexin 1 (Q96RD7)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2849564
Product Specific Information
Immunogen sequence: DLSLYNLFLE ENISEVKSYK CLKVLENIKS SGQGIDPMLL LTNLGMIKMD VVDGKTPMSA EMREEQGNQT AELQGMNIDS ETKANNGEKN ARQRLLDSSC
Target Information
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: innexin; Pannexin-1; PANX1
Gene Aliases: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7, (Rat) P60570, (Mouse) Q9JIP4
Entrez Gene ID: (Human) 24145, (Rat) 315435, (Mouse) 55991
protease binding
receptor binding
calcium channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
actin binding
gap junction channel activity
protein binding
channel activity
wide pore channel activity
response to ischemia
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
transmembrane transport
calcium ion transmembrane transport
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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