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Perilipin 5 Polyclonal Antibody

Perilipin 5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Perilipin 5 Antibody (26951-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 26951-1-AP ( Perilipin 5 antibody at dilution of 1:200 (under 40x lens).

Perilipin 5 Antibody in Western Blot (WB)

Product Image Gallery

Product Details

26951-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Pig

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Perilipin 5 Fusion Protein Ag25272 (381-463 aa encoded by BC131524)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ILVERPEPL PDLADLVDEV IGGPDPRWAH LDWPAQQRAW EAEHRDGSGN GDGDRMGVAG DICEQEPETP SCPVKHTLMP ELDF (381-463 aa encoded by B C131524)

Target Information

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.

Developmental cell

Ouyang Q,Chen Q,Ke S,Ding L,Yang X,Rong P,Feng W,Cao Y,Wang Q,Li M,Su S,Wei W,Liu M,Liu J,Zhang X,Li JZ,Wang HY,Chen S

Mon Feb 27 00:00:00 EST 2023

Perilipin5 protects against non-alcoholic steatohepatitis by increasing 11-Dodecenoic acid and inhibiting the occurrence of ferroptosis.

Nutrition & metabolism

Xu X,Qiu J,Li X,Chen J,Li Y,Huang X,Zang S,Ma X,Liu J

Thu Jun 22 00:00:00 EDT 2023

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.

Life science alliance

Cinato M,Mardani I,Miljanovic A,Drevinge C,Laudette M,Bollano E,Henricsson M,Tolö J,Bauza Thorbrügge M,Levin M,Lindbom M,Arif M,Pacher P,Andersson L,Olofsson CS,Borén J,Levin MC

Sat Apr 01 00:00:00 EDT 2023

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.

Life science alliance

Cinato M,Mardani I,Miljanovic A,Drevinge C,Laudette M,Bollano E,Henricsson M,Tolö J,Bauza Thorbrügge M,Levin M,Lindbom M,Arif M,Pacher P,Andersson L,Olofsson CS,Borén J,Levin MC

Sat Apr 01 00:00:00 EDT 2023

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.

Life science alliance

Cinato M,Mardani I,Miljanovic A,Drevinge C,Laudette M,Bollano E,Henricsson M,Tolö J,Bauza Thorbrügge M,Levin M,Lindbom M,Arif M,Pacher P,Andersson L,Olofsson CS,Borén J,Levin MC

Sat Apr 01 00:00:00 EDT 2023

Cardiac Plin5 interacts with SERCA2 and promotes calcium handling and cardiomyocyte contractility.

Life science alliance

Cinato M,Mardani I,Miljanovic A,Drevinge C,Laudette M,Bollano E,Henricsson M,Tolö J,Bauza Thorbrügge M,Levin M,Lindbom M,Arif M,Pacher P,Andersson L,Olofsson CS,Borén J,Levin MC

Sat Apr 01 00:00:00 EDT 2023

Daytime-restricted feeding enhances running endurance without prior exercise in mice.

Nature metabolism

Xin H,Huang R,Zhou M,Chen J,Zhang J,Zhou T,Ji S,Liu X,Tian H,Lam SM,Bao X,Li L,Tong S,Deng F,Shui G,Zhang Z,Wong CCL,Li MD

Sat Jul 01 00:00:00 EDT 2023

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice.

Drug design, development and therapy

Zuo Q,Zhang G,He L,Ma S,Ma H,Zhai J,Wang Z,Zhang T,Wang Y,Guo Y

Wed Dec 14 00:00:00 EST 2022

Knockdown of hepatocyte Perilipin-3 mitigates hepatic steatosis and steatohepatitis caused by hepatocyte CGI-58 deletion in mice.

Journal of molecular cell biology

Bao X,Ma X,Huang R,Chen J,Xin H,Zhou M,Li L,Tong S,Zhang Q,Shui G,Deng F,Yu L,Li MD,Zhang Z

Mon Dec 26 00:00:00 EST 2022

Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.

International immunopharmacology

Huo K,Ma KG,Guo QY,Duan P,Xu J

Fri Jul 01 00:00:00 EDT 2022

Effects of Simvastatin on Lipid Metabolism in Wild-Type Mice and Mice with Muscle PGC-1α Overexpression.

International journal of molecular sciences

Panajatovic MV,Singh F,Krähenbühl S,Bouitbir J

Fri May 07 00:00:00 EDT 2021

Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.

Biochemical and biophysical research communications

Feng J,Xie L,Yu X,Liu C,Dong H,Lu W,Kong R

Fri Mar 12 00:00:00 EST 2021

miR-183 and miR-96 orchestrate both glucose and fat utilization in skeletal muscle.

EMBO reports

Wang H,Ma M,Li Y,Liu J,Sun C,Liu S,Ma Y,Yan Y,Tang Z,Shen S,Yu J,Wu Y,Jiang J,Wang L,Jin ZB,Ying H,Li Y

Mon Sep 06 00:00:00 EDT 2021

Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.

Human cell

Wang HC,Liu KY,Wang LT,Hsu SH,Wang SC,Huang SK

Sat May 01 00:00:00 EDT 2021

Aryl hydrocarbon receptor promotes lipid droplet biogenesis and metabolic shift in respiratory Club cells.

Human cell

Wang HC,Liu KY,Wang LT,Hsu SH,Wang SC,Huang SK

Sat May 01 00:00:00 EDT 2021

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells.

Cells

Tan Y,Jin Y,Wang Q,Huang J,Wu X,Ren Z

Fri Oct 11 00:00:00 EDT 2019

ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells.

Biochemical and biophysical research communications

Wang X,Wang QC,Sun Z,Li T,Yang K,An C,Guo C,Tang TS

Tue May 14 00:00:00 EDT 2019

Bioinformatics

Protein Aliases: lipid droplet associated protein; Lipid droplet-associated protein PAT-1; Lipid storage droplet protein 5; Myocardial LD protein; Perilipin-5

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Gene Aliases: 2310076L09Rik; AI415325; AW109675; LSDA5; LSDP5; MLDP; OXPAT; PAT-1; Pat1; PLIN5

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UniProt ID: (Human) Q00G26, (Mouse) Q8BVZ1

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Entrez Gene ID: (Human) 440503, (Pig) 100142670, (Mouse) 66968

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Function(s)

lipase binding identical protein binding protein binding scaffold/adaptor protein

Process(es)

positive regulation of triglyceride biosynthetic process positive regulation of lipid storage positive regulation of sequestering of triglyceride negative regulation of triglyceride catabolic process lipid storage negative regulation of fatty acid beta-oxidation positive regulation of fatty acid beta-oxidation lipid particle organization negative regulation of peroxisome proliferator activated receptor signaling pathway mitochondrion localization negative regulation of lipase activity positive regulation of lipase activity negative regulation of reactive oxygen species metabolic process lipid metabolic process negative regulation of lipid catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Perilipin 5 Polyclonal Antibody

Perilipin 5 Antibody (26951-1-AP) in IHC (P)

Product Details

26951-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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