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Periostin Polyclonal Antibody

Periostin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Periostin Antibody (19899-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 19899-1-AP (Periostin antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

19899-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 11 publications 11 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Periostin Fusion Protein Ag13791 (21-368 aa encoded by BC106710)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ANNHYDKIL AHSRIRGRDQ GPNVCALQQI LGTKKKYFST CKNWYKKSIC GQKTTVLYEC CPGYMRMEGM KGCPAVLPID HVYGTLGIVG ATTTQRYSDA SKLREEIEGK GSFTYFAPSN EAWDNLDSDI RRGLESNVNV ELLNALHSHM INKRMLTKDL KNGMIIPSMY NNLGLFINHY PNGVVTVNCA RIIHGNQIAT NGVVHVIDRV LTQIGTSIQD FIEAEDDLSS FRAAAITSDI LEALGRDGHF TLFAPTNEAF EKLPRGVLER IMGDKVASEA LMKYHILNTL QCSESIMGGA VFETLEGNTI EIGCDGDSIT VNGIKMVNKK DIVTNNGVIH LIDQVLIPD (21-368 aa encoded by BC106710)

Target Information

Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Journal of periodontal research

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Tue Aug 01 00:00:00 EDT 2023

Oncostatin M-Enriched Small Extracellular Vesicles Derived from Mesenchymal Stem Cells Prevent Isoproterenol-Induced Fibrosis and Enhance Angiogenesis.

International journal of molecular sciences

Tejedor S,Buigues M,González-King H,Silva AM,García NA,Dekker N,Sepúlveda P

Thu Mar 30 00:00:00 EDT 2023

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway.

Clinical and experimental hypertension (New York, N.Y. : 1993)

Peng K,Wang M,Wang J,Wang Q,Li D,Sun X,Yang Y,Yang D

Sun Dec 31 00:00:00 EST 2023

Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling.

Journal of periodontology

Yuan X,Amin V,Zhu T,Kittaka M,Ueki Y,Bellido TM,Turkkahraman H

Wed Feb 01 00:00:00 EST 2023

Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival.

Cancer immunology research

Sawada J,Hiraoka N,Qi R,Jiang L,Fournier-Goss AE,Yoshida M,Kawashima H,Komatsu M

Fri Apr 01 00:00:00 EDT 2022

Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival.

Cancer immunology research

Sawada J,Hiraoka N,Qi R,Jiang L,Fournier-Goss AE,Yoshida M,Kawashima H,Komatsu M

Fri Apr 01 00:00:00 EDT 2022

Prognostic Impact of the Angiogenic Gene POSTN and Its Related Genes on Lung Adenocarcinoma.

Frontiers in oncology

Sun D,Gai Z,Wu J,Chen Q

Sat Jul 16 00:00:00 EDT 2022

3D Polycaprolactone/Gelatin-Oriented Electrospun Scaffolds Promote Periodontal Regeneration.

ACS applied materials & interfaces

Xu X,Zhou Y,Zheng K,Li X,Li L,Xu Y

Wed Oct 19 00:00:00 EDT 2022

Upregulation of Periostin Through CREB Participates in Myocardial Infarction-induced Myocardial Fibrosis.

Journal of cardiovascular pharmacology

Xue K,Chen S,Chai J,Yan W,Zhu X,Dai H,Wang W

Sun May 01 00:00:00 EDT 2022

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Journal of nanobiotechnology

Zhao N,Gui X,Fang Q,Zhang R,Zhu W,Zhang H,Li Q,Zhou Y,Zhao J,Cui X,Gao G,Tang H,Shen N,Chen T,Song H,Shen W

Sat Apr 02 00:00:00 EDT 2022

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Journal of nanobiotechnology

Zhao N,Gui X,Fang Q,Zhang R,Zhu W,Zhang H,Li Q,Zhou Y,Zhao J,Cui X,Gao G,Tang H,Shen N,Chen T,Song H,Shen W

Sat Apr 02 00:00:00 EDT 2022

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Journal of nanobiotechnology

Zhao N,Gui X,Fang Q,Zhang R,Zhu W,Zhang H,Li Q,Zhou Y,Zhao J,Cui X,Gao G,Tang H,Shen N,Chen T,Song H,Shen W

Sat Apr 02 00:00:00 EDT 2022

Graphene quantum dots rescue angiogenic retinopathy via blocking STAT3/Periostin/ERK signaling.

Journal of nanobiotechnology

Zhao N,Gui X,Fang Q,Zhang R,Zhu W,Zhang H,Li Q,Zhou Y,Zhao J,Cui X,Gao G,Tang H,Shen N,Chen T,Song H,Shen W

Sat Apr 02 00:00:00 EDT 2022

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Stem cell research & therapy

Yuan Y,Zhang X,Zhan Y,Tang S,Deng P,Wang Z,Li J

Fri Jun 03 00:00:00 EDT 2022

Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhanced Proangiogenic Potential of Cardiac Fibroblasts via Angiopoietin-Like 4.

Stem cells international

Li J,Xu X,Fei S,Wang R,Wang H,Zhu W,Zhao Y

Sun May 01 00:00:00 EDT 2022

Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhanced Proangiogenic Potential of Cardiac Fibroblasts via Angiopoietin-Like 4.

Stem cells international

Li J,Xu X,Fei S,Wang R,Wang H,Zhu W,Zhao Y

Sun May 01 00:00:00 EDT 2022

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Galectin-3 Derived from HucMSC Exosomes Promoted Myocardial Fibroblast-to-Myofibroblast Differentiation Associated with β-catenin Upregulation.

International journal of stem cells

Guo Q,Zhao Y,Li J,Huang C,Wang H,Zhao X,Wang M,Zhu W

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Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells.

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Fibroblast-to-Myofibroblast Differentiation in Inflammatory Environments and Benefit Cardioprotective Effects.

Stem cells and development

Shi Y,Yang Y,Guo Q,Gao Q,Ding Y,Wang H,Xu W,Yu B,Wang M,Zhao Y,Zhu W

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Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines.

International journal of molecular sciences

Sterzyńska K,Kaźmierczak D,Klejewski A,Świerczewska M,Wojtowicz K,Nowacka M,Brązert J,Nowicki M,Januchowski R

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Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7.

Cell death & disease

Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

Mon Oct 22 00:00:00 EDT 2018

Periostin secreted by cancer-associated fibroblasts promotes cancer stemness in head and neck cancer by activating protein tyrosine kinase 7.

Cell death & disease

Yu B,Wu K,Wang X,Zhang J,Wang L,Jiang Y,Zhu X,Chen W,Yan M

Mon Oct 22 00:00:00 EDT 2018

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Identification of colonic fibroblast secretomes reveals secretory factors regulating colon cancer cell proliferation.

Journal of proteomics

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Tue Oct 14 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; periostin-like factor; PN; RP11 412K4.1; RP11-412K4.1

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Gene Aliases: A630052E07Rik; AI747096; OSF-2; OSF2; PDLPOSTN; peri; PLF; PN; POSTN

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UniProt ID: (Human) Q15063, (Mouse) Q62009

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Entrez Gene ID: (Human) 10631, (Rat) 361945, (Mouse) 50706

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Function(s)

protein binding heparin binding metal ion binding cell adhesion molecule binding cell adhesion molecule

Process(es)

skeletal system development response to hypoxia negative regulation of cell-matrix adhesion regulation of systemic arterial blood pressure cell adhesion regulation of Notch signaling pathway response to mechanical stimulus response to muscle activity positive regulation of smooth muscle cell migration extracellular matrix organization response to estradiol cellular response to fibroblast growth factor stimulus cellular response to vitamin K cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus negative regulation of substrate adhesion-dependent cell spreading positive regulation of chemokine (C-C motif) ligand 2 secretion neuron projection extension bone regeneration tissue development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Periostin Polyclonal Antibody

Periostin Antibody (19899-1-AP) in IHC (P)

Product Details

19899-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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