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Immunogen sequence: ANNHYDKIL AHSRIRGRDQ GPNVCALQQI LGTKKKYFST CKNWYKKSIC GQKTTVLYEC CPGYMRMEGM KGCPAVLPID HVYGTLGIVG ATTTQRYSDA SKLREEIEGK GSFTYFAPSN EAWDNLDSDI RRGLESNVNV ELLNALHSHM INKRMLTKDL KNGMIIPSMY NNLGLFINHY PNGVVTVNCA RIIHGNQIAT NGVVHVIDRV LTQIGTSIQD FIEAEDDLSS FRAAAITSDI LEALGRDGHF TLFAPTNEAF EKLPRGVLER IMGDKVASEA LMKYHILNTL QCSESIMGGA VFETLEGNTI EIGCDGDSIT VNGIKMVNKK DIVTNNGVIH LIDQVLIPD (21-368 aa encoded by BC106710)
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; periostin-like factor; PN; RP11 412K4.1; RP11-412K4.1
Gene Aliases: A630052E07Rik; AI747096; OSF-2; OSF2; PDLPOSTN; peri; PLF; PN; POSTN
UniProt ID: (Human) Q15063, (Mouse) Q62009
Entrez Gene ID: (Human) 10631, (Rat) 361945, (Mouse) 50706
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