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Invitrogen
Phospho-4EBP1/2/3 (Thr46, Thr32) Recombinant Rabbit Monoclonal Antibody (23GB3850)
Advanced Verification
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
Phospho-4EBP1/2/3 (Thr46, Thr32) Antibody (MA5-53650) in ICC/IF
Immunocytochemistry analysis of 4EBP1/2/3 in C2C12 cells. Nuclei were stained blue with DAPI; 4EBP1/2/3 recombinant monoclonal antibody (Product # MA5-53650) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: High. Scale bar: 20 μm.
Product Details
MA5-53650
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
23GB3850
Immunogen
A synthetic peptide of human Phospho-eIF4EBP1/2/3 (Thr46+Thr46+Thr32) (39-53AA).
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
4EBP1, 4EBP2, and 4EBP3 are members of the eukaryotic translation initiation factor 4E-binding protein (4EBP) family. These proteins play a crucial role in the regulation of protein synthesis, specifically by controlling the availability of the eukaryotic translation initiation factor 4E (eIF4E).| 4EBP1, 4EBP2, and 4EBP3 are structurally similar but exhibit some differences in their tissue distribution and expression levels. They are widely expressed in various tissues and cell types and have been implicated in the regulation of different biological processes, including cell growth, proliferation, and survival. Dysregulation of 4EBP proteins has also been associated with various diseases, including cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4E-BP1; 4E-BP1/2/3; 4EBP1/2/3; BP-1/2/3; eIF4E-binding protein 1; EIF4E-Binding Protein 1/2/3; EIF4EBP1/2/3; Eukaryotic Translation Initiation Factor 4E Binding Protein 1/2/3; Eukaryotic translation initiation factor 4E-binding protein 1; Eukaryotic Translation Initiation Factor 4E-Binding Protein 1/2/3; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1; Phosphorylated Heat- And Acid-Stable Protein Regulated By Insulin 1/2/3
Gene Aliases: 4E-BP1; 4EBP1; AA959816; BP-1; EIF4EBP1; PHAS-I
UniProt ID: (Human) Q13541, (Mouse) Q60876, (Rat) Q62622
Entrez Gene ID: (Human) 1978, (Mouse) 13685, (Rat) 116636
G1/S transition of mitotic cell cycle
IRES-dependent translational initiation
response to ischemia
insulin receptor signaling pathway
lung development
negative regulation of protein complex assembly
TOR signaling
response to ethanol
positive regulation of mitotic cell cycle
negative regulation of translational initiation
cellular response to hypoxia
regulation of translation
regulation of translational initiation
negative regulation of translation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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