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Antibody detectsAntibody detects endogenous levels of ABL1 when phosphorylated at Tyr70 or ABL2 when phosphorylated at Tyr116.
The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase.
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Protein Aliases: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abelson murine leukemia viral (v-abl) oncogene homolog 2; Abelson murine leukemia viral oncogene homolog 1; Abelson murine leukemia viral oncogene homolog 2; Abelson tyrosine-protein kinase 1; Abelson tyrosine-protein kinase 2; Abelson-related gene protein; Abl1-related gene product; abl2; arg tyrosine kinase; bcr/c-abl oncogene protein; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl oncogene 2, non-receptor tyrosine kinase; p150; Proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; tyrosine kinase ARG; Tyrosine-protein kinase ABL1; Tyrosine-protein kinase ABL2; Tyrosine-protein kinase ARG; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene 2; v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 2; v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
Gene Aliases: AA536808; ABL; ABL1; ABL2; ABLL; AI325092; ARG; bcr/abl; c-ABL; c-ABL1; E430008G22Rik; JTK7; p150; v-abl
UniProt ID: (Human) P00519, (Human) P42684, (Mouse) P00520
Entrez Gene ID: (Human) 25, (Human) 27, (Rat) 311860, (Mouse) 11350, (Mouse) 11352, (Rat) 304883
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