Product References
Monotropein attenuates doxorubicin-induced oxidative stress, inflammation, and arrhythmia via the AKT signal pathway.
Biochemical and biophysical research communications
Fang Z,Wei W,Jiang X
Sun Jan 01 00:00:00 EST 2023
Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
Behavioural brain research
Fu A,Qiao F,Feng H,Luo Q
Sun Jul 09 00:00:00 EDT 2023
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
International ophthalmology
Liu W,Chen Y,Song X,Xue Y,Zhang Y
Mon May 01 00:00:00 EDT 2023
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Drug design, development and therapy
Huang Y,Zhang Y,Wu Y,Xiang Q,Yu R
Fri Feb 03 00:00:00 EST 2023
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Oncology reports
Shen C,Chen Z,Zhang Y,Xu W,Peng R,Jiang J,Zuo W,Fan Y,Zheng B
Sun Jan 01 00:00:00 EST 2023
Single-cell transcriptome analysis identifies Versican(+) myofibroblast as a hallmark for thoracic aortic aneurysm marked by activation of PI3K-AKT signaling pathway.
Biochemical and biophysical research communications
Song W,Qin L,Chen Y,Chen J,Wei L
Sun Feb 05 00:00:00 EST 2023
Single-cell transcriptome analysis identifies Versican(+) myofibroblast as a hallmark for thoracic aortic aneurysm marked by activation of PI3K-AKT signaling pathway.
Biochemical and biophysical research communications
Song W,Qin L,Chen Y,Chen J,Wei L
Sun Feb 05 00:00:00 EST 2023
Single-cell transcriptome analysis identifies Versican(+) myofibroblast as a hallmark for thoracic aortic aneurysm marked by activation of PI3K-AKT signaling pathway.
Biochemical and biophysical research communications
Song W,Qin L,Chen Y,Chen J,Wei L
Sun Feb 05 00:00:00 EST 2023
Radiation induces IRAK1 expression to promote radioresistance by suppressing autophagic cell death via decreasing the ubiquitination of PRDX1 in glioma cells.
Cell death & disease
Li J,Sun Y,Zhao X,Ma Y,Xie Y,Liu S,Hui B,Shi X,Sun X,Zhang X
Sat Apr 08 00:00:00 EDT 2023
Acteoside Derived from Cistanche Improves Glucocorticoid-Induced Osteoporosis by Activating PI3K/AKT/mTOR Pathway.
Journal of investigative surgery : the official journal of the Academy of Surgical Research
Li S,Cui Y,Li M,Zhang W,Sun X,Xin Z,Li J
Fri Dec 01 00:00:00 EST 2023
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Cell death discovery
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Sat Jan 21 00:00:00 EST 2023
Toxicity mechanism of peri-implantation pesticide beta-cypermethrin exposure on endometrial remodeling in early pregnant mice.
Toxicology
Zhou YJ,Qiao QF,Wang LQ,Sheng TY,Cui MX,Chen QD,Wang CY,Zhang YX
Mon May 01 00:00:00 EDT 2023
LncRNA NR2F1-AS1 was involved in azacitidine resistance of THP-1 cells by targeting IGF1 with miR-483-3p.
Cytokine
Hu C,Li S,Fu X,Zhao X,Peng J
Wed Feb 01 00:00:00 EST 2023
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Cell & bioscience
Li D,Xia L,Huang P,Wang Z,Guo Q,Huang C,Leng W,Qin S
Mon Jul 03 00:00:00 EDT 2023
The effect of PINK1/Parkin pathway on glucose homeostasis imbalance induced by tacrolimus in mouse livers.
Heliyon
Li Z,Xiang J,Mei S,Wu Y,Xu Y
Sat Apr 01 00:00:00 EDT 2023
Liraglutide Attenuates Myocardial Ischemia/Reperfusion Injury Through the Inhibition of Necroptosis by Activating GLP-1R/PI3K/Akt Pathway.
Cardiovascular toxicology
Zhou G,Wu H,Yang J,Ye M,Liu D,Li Y,Zhang D,Zhang J,Yang Q,Liu Y
Sat Apr 01 00:00:00 EDT 2023
Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.
Journal of ethnopharmacology
Liu L,Liang D,Zheng Q,Zhao M,Lv R,Tang J,Chen N
Wed Mar 01 00:00:00 EST 2023
Empagliflozin-Pretreated Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Attenuated Heart Injury.
Oxidative medicine and cellular longevity
Chi B,Zou A,Mao L,Cai D,Xiao T,Wang Y,Wang Q,Ji Y,Sun L
Wed Mar 01 00:00:00 EST 2023
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
International journal of molecular sciences
Li TY,Du Y,Wang MC,Liu K,Liu Y,Cao Y,Wang YY,Chen WW,Qian XY,Qiu PC,Tang HF,Lu YY
Wed Apr 12 00:00:00 EDT 2023
Tumor Necrosis Factor-α Promotes the Tumorigenesis, Lymphangiogenesis, and Lymphatic Metastasis in Cervical Cancer via Activating VEGFC-Mediated AKT and ERK Pathways.
Mediators of inflammation
Chen X,Lin L,Wu Q,Li S,Wang H,Sun Y
Sat Oct 28 00:00:00 EDT 2023
Acinetobacter baumannii outer membrane protein A induces autophagy in bone marrow-derived dendritic cells involving the PI3K/mTOR pathway.
Immunity, inflammation and disease
Tan H,Cao L
Sat Apr 01 00:00:00 EDT 2023
FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.
International journal of molecular sciences
Wang T,Yu M,Li H,Qin S,Ren W,Ma Y,Bo W,Xi Y,Cai M,Tian Z
Sun Feb 19 00:00:00 EST 2023
P53 Deficiency Accelerate Esophageal Epithelium Intestinal Metaplasia Malignancy.
Biomedicines
Qiu Q,Guo G,Guo X,Hu X,Yu T,Liu G,Zhang H,Chen Y,She J
Mon Mar 13 00:00:00 EDT 2023
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Cancers
Jin L,Mi T,Wu X,Wang Z,Zhang Z,Liu J,Wang Z,Wang J,Li M,Ren C,Guo P,He D
Tue Mar 28 00:00:00 EDT 2023
Budding uninhibited by benzimidazoles 1 overexpression is associated with poor prognosis and malignant phenotype: A promising therapeutic target for lung adenocarcinoma.
Thoracic cancer
Chen R,Wang Z,Lu T,Liu Y,Ji Y,Yu Y,Tou F,Guo S
Sat Apr 01 00:00:00 EDT 2023
Effect of isorhamnetin on carbonic anhydrase IX expression and tumorigenesis of bladder cancer by activating PPARγ/PTEN/AKT pathway.
Tissue & cell
Zhang P,Sun Y,Shi L,Sun D,Wang L,Feng D,Ding C
Thu Jun 01 00:00:00 EDT 2023
Gypenosides suppress fibrosis of the renal NRK-49F cells by targeting miR-378a-5p through the PI3K/AKT signaling pathway.
Journal of ethnopharmacology
Zhang L,Wang X,He S,Zhang F,Li Y
Sat Jul 15 00:00:00 EDT 2023
Chinese herbal medicine alleviates the pathogenesis of polycystic ovary syndrome by improving oxidative stress and glucose metabolism via mitochondrial Sirtuin 3 signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Zhang Q,Ren J,Wang F,Li M,Pan M,Zhang H,Qu F
Sun Jan 01 00:00:00 EST 2023
Identification of PIK3CG as a hub in septic myocardial injury using network pharmacology and weighted gene co-expression network analysis.
Bioengineering & translational medicine
Liu Q,Dong Y,Escames G,Wu X,Ren J,Yang W,Zhang S,Zhu Y,Tian Y,Acuña-Castroviejo D,Yang Y
Sun Jan 01 00:00:00 EST 2023
MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension.
Cardiovascular therapeutics
Tang Y,Huo X,Liu J,Tang Y,Zhang M,Xie W,Zheng Z,He J,Lian J
Thu Feb 10 00:00:00 EST 2022
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Oxidative medicine and cellular longevity
Wei B,Hao Z,Zheng H,Qin Y,Zhao F,Shi L
Tue Jan 10 00:00:00 EST 2023
Downregulating MFN2 Promotes the Differentiation of Induced Pluripotent Stem Cells into Mesenchymal Stem Cells through the PI3K/Akt/GSK-3β/Wnt Signaling Pathway.
Stem cells and development
Deng L,Yi S,Yin X,Li Y,Luan Q
Fri Apr 01 00:00:00 EDT 2022
Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Journal of ethnopharmacology
Dong S,Liu Q,Jiang M,Ma Q,Huang Q,Liu T,Li Y,Ni L,Shi Y
Tue May 10 00:00:00 EDT 2022
Protective effect of 3-n-butylphthalide against intrastriatal injection of malonic acid-induced neurotoxicity and biochemical alteration in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Yuan C,Zheng L,Zhao Y
Tue Nov 01 00:00:00 EDT 2022
FAM83A has a pro-tumor function in ovarian cancer by affecting the Akt/Wnt/β-catenin pathway.
Environmental toxicology
Zhao J,Zhao F,Yang T,Tian S,Zhao M,Wang S,Yang X
Fri Apr 01 00:00:00 EDT 2022
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
European journal of medicinal chemistry
Liang JJ,Yu WL,Yang L,Qin KM,Yin YP,Li D,Ni YH,Yan JJ,Zhong YX,Deng ZX,Hong K
Sun Jun 05 00:00:00 EDT 2022
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Cell biology and toxicology
Wang H,Ai J,Shopit A,Niu M,Ahmed N,Tesfaldet T,Tang Z,Li X,Jamalat Y,Chu P,Peng J,Ma X,Qaed E,Han G,Zhang W,Wang J,Tang Z
Wed Jun 01 00:00:00 EDT 2022
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Cell biology and toxicology
Wang H,Ai J,Shopit A,Niu M,Ahmed N,Tesfaldet T,Tang Z,Li X,Jamalat Y,Chu P,Peng J,Ma X,Qaed E,Han G,Zhang W,Wang J,Tang Z
Wed Jun 01 00:00:00 EDT 2022
Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3.
Free radical biology & medicine
Zhang Q,Ren J,Wang F,Pan M,Cui L,Li M,Qu F
Fri Jul 01 00:00:00 EDT 2022
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
International immunopharmacology
Qu Y,Shen Y,Teng L,Huang Y,Yang Y,Jian X,Fan S,Wu P,Fu Q
Sat Oct 01 00:00:00 EDT 2022
Berberine attenuates sepsis-induced cardiac dysfunction by upregulating the Akt/eNOS pathway in mice.
Experimental and therapeutic medicine
Zhang H,Wu X,Tao Y,Lu G
Wed Jun 01 00:00:00 EDT 2022
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Cell death & disease
Hu L,Wei J,Zhang Y,Wang Z,Tang J,Tang J,Gao Y,Zhang X,Li Y,Liu Y,Ma S,Guo X,Zhang Q
Mon Jul 18 00:00:00 EDT 2022
TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice.
Journal of neuroinflammation
Yan J,Zhang Y,Wang L,Li Z,Tang S,Wang Y,Gu N,Sun X,Li L
Sat Dec 03 00:00:00 EST 2022
Protective Effects of Herba Houttuyniae Aqueous Extract against OVA-Induced Airway Hyperresponsiveness and Inflammation in Asthmatic Mice.
Evidence-based complementary and alternative medicine : eCAM
Yang Y,Lai Q,Wang C,Zhou G
Tue Nov 22 00:00:00 EST 2022
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Microvascular research
Zhou YH,Tang YZ,Guo LY,Zheng LL,Zhang D,Yang CY,Wang W
Sat Jan 01 00:00:00 EST 2022
RNA-seq and ATAC-seq analyses of multilineage differentiating stress enduring cells: Comparison with dermal fibroblasts.
Cell biology international
Mao XQ,Cheng Y,Zhang RZ,Liu YB,Li Y,Ge K,Jin HL
Thu Sep 01 00:00:00 EDT 2022
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
The Journal of international medical research
Guo W,Long X,Lv M,Deng S,Liu D,Yang Q
Thu Sep 01 00:00:00 EDT 2022
MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
Iranian journal of basic medical sciences
Zhao C,Liu J,Xu Y,Guo J,Wang L,Chen L,Xu L,Dong G,Zheng W,Li Z,Cai H,Li S
Sat Oct 01 00:00:00 EDT 2022
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
International journal of molecular sciences
Zhang W,Ho CT,Lu M
Tue May 17 00:00:00 EDT 2022
Farrerol prevents Angiotensin II-induced cardiac remodeling in vivo and in vitro.
Frontiers in pharmacology
He J,Xu D,Wang L,Yu X
Thu Feb 02 00:00:00 EST 2023
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Disease markers
Lei Y,Chan M,Liu H,Lyu W,Chen L,Zhong Y,Gan H,Wang M,Qi M,Guo Y,Liu J,Zhang E
Fri Jul 29 00:00:00 EDT 2022
Astragaloside IV - mediated endothelial progenitor cell exosomes promote autophagy and inhibit apoptosis in hyperglycemic damaged endothelial cells via miR-21/PTEN axis.
Folia histochemica et cytobiologica
Xiong W,Huang XL,Li CY,Wang XL,Lan HW,Wang TT,Chen ZL,Yang QP,Hu AL,Xia YF,Zhu FR,Zhou ZZ
Mon Jan 02 00:00:00 EST 2023
NUF2 overexpression contributes to epithelial ovarian cancer progression via ERBB3-mediated PI3K-AKT and MAPK signaling axes.
Frontiers in oncology
Leng R,Meng Y,Sun X,Zhao Y
Wed Jan 11 00:00:00 EST 2023
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Cells
He D,Liu Y,Li J,Wang H,Ye B,He Y,Li Z,Gao X,Fu S,Liu D
Mon Sep 19 00:00:00 EDT 2022
Evaluating the Therapeutic Mechanisms of Selected Active Compounds in Houttuynia cordata Thunb. in Pulmonary Fibrosis via Network Pharmacology Analysis.
Frontiers in pharmacology
Zhu DW,Yu Q,Sun JJ,Shen YH
Fri Oct 22 00:00:00 EDT 2021
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Journal of materials chemistry. B
Zhang Z,Li Z,Wang Y,Wang Q,Yao M,Zhao L,Shi J,Guan F,Ma S
Sat Aug 21 00:00:00 EDT 2021
A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization.
Journal of nanobiotechnology
Liu W,Yu M,Chen F,Wang L,Ye C,Chen Q,Zhu Q,Xie D,Shao M,Yang L
Tue Sep 07 00:00:00 EDT 2021
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Scientific reports
Zhao Y,Liu X,Zheng Y,Liu W,Ding C
Mon Oct 18 00:00:00 EDT 2021
Senescence marker protein 30 (SMP30) protects against high glucose-induced apoptosis, oxidative stress and inflammatory response in retinal ganglion cells by enhancing Nrf2 activation via regulation of Akt/GSK-3β pathway.
International immunopharmacology
Zhang L,Zhu T,He F,Li X
Wed Dec 01 00:00:00 EST 2021
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Food & function
Liu XL,Zhao YC,Zhu HY,Wu M,Zheng YN,Yang M,Cheng ZQ,Ding CB,Liu WC
Mon Nov 29 00:00:00 EST 2021
LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.
Archives of gerontology and geriatrics
Li L,Zheng B,Zhang F,Luo X,Li F,Xu T,Zhao H,Shi G,Guo Y,Shi J,Sun J
Mon Oct 25 00:00:00 EDT 2021
New targets of morphine postconditioning protection of the myocardium in ischemia/reperfusion injury: Involvement of HSP90/Akt and C5a/NF-κB.
Open medicine (Warsaw, Poland)
Tu RH,Wang DX,Zhong GQ,Meng JJ,Wen H,Bi Q,He Y
Wed Apr 27 00:00:00 EDT 2022
Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
BioMed research international
Che X,Zhan J,Zhao F,Zhong Z,Chen M,Han R,Wang Y
Thu Sep 23 00:00:00 EDT 2021
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Planta medica
Zeng Q,Zeng Y,Nie X,Guo Y,Zhan Y
Tue Dec 01 00:00:00 EST 2020