Product References
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Neoplasma
Li GH,Liu X,Feng LJ,Zhang L
Sun Aug 20 00:00:00 EDT 2023
Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats.
Biotechnology & genetic engineering reviews
Wang N,Guo W,Liu T,Chen X,Lin M
Mon Mar 06 00:00:00 EST 2023
Effect of STK3 on proliferation and apoptosis of pancreatic cancer cells via PI3K/AKT/mTOR pathway.
Cellular signalling
Chen J,Liu F,Wu J,Yang Y,He J,Wu F,Yang K,Li J,Jiang Z,Jiang Z
Thu Jun 01 00:00:00 EDT 2023
Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sun C,Zhang J,Hou J,Hui M,Qi H,Lei T,Zhang X,Zhao L,Du H
Sun Jan 01 00:00:00 EST 2023
Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sun C,Zhang J,Hou J,Hui M,Qi H,Lei T,Zhang X,Zhao L,Du H
Sun Jan 01 00:00:00 EST 2023
Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.
International journal of biological macromolecules
Zuo R,Shi J,Jiang S,Chu M,Wang Q,Kong L,Kang Q,Guo Y,Guan J
Tue Jan 31 00:00:00 EST 2023
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Cellular signalling
Wu Y,Jiang Y,Guo JQ,Yang ZW,Carvalho A,Qian LL,Ji JJ,Ji ZJ,Ma GS,Yao YY
Thu Jun 01 00:00:00 EDT 2023
Insulin ameliorates dim blue light at night-induced apoptosis in hippocampal neurons via the IR/IRS1/AKT/GSK3β/β-catenin signaling pathway.
Ecotoxicology and environmental safety
Liu Q,Wang Z,Cao J,Dong Y,Chen Y
Sun Jan 15 00:00:00 EST 2023
Enhanced De Novo Lipid Synthesis Mediated by FASN Induces Chemoresistance in Colorectal Cancer.
Cancers
Han L,Dai W,Luo W,Ye L,Fang H,Mo S,Li Q,Xu Y,Wang R,Cai G
Tue Jan 17 00:00:00 EST 2023
A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF/trkB/PI3K signal axis in CUMS rats.
BMC complementary medicine and therapies
Meng P,Zhang X,Liu TT,Liu J,Luo Y,Xie MX,Yang H,Fang R,Guo DW,Zhong ZY,Wang YH,Ge JW
Thu Jun 15 00:00:00 EDT 2023
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
Biochemical genetics
He Y,Zhang B,Han D,Du Y,Zhang X,Wang H,Yue Z,Shang P
Tue Aug 01 00:00:00 EDT 2023
GSK3β-driven SOX2 overexpression is a targetable vulnerability in esophageal squamous cell carcinoma.
Oncogene
Kang L,Liu Y,He J,Wang Y,Xue M,Wu X,Wang Z,Zhang Y,Chu M,Li J,Wei W,Li J,Li E,Liao L,Xiao J,Zhang R,Xu L,Wong J
Sat Jul 01 00:00:00 EDT 2023
Geranylgeranylacetone-induced heat shock protein70 expression reduces retinal ischemia-reperfusion injury through PI3K/AKT/mTOR signaling.
Experimental eye research
Zhang L,Xue K,Fan P,Chen C,Hu J,Huang J,Lu W,Xu J,Xu S,Ran J,Zhu S,Gan S
Sat Apr 01 00:00:00 EDT 2023
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Journal of Zhejiang University. Science. B
Li Y,She W,Xu X,Liu Y,Wang X,Tian S,Li S,Wang M,Yu C,Liu P,Huang T,Wei Y
Wed Mar 15 00:00:00 EDT 2023
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Journal of translational medicine
Liu Y,She W,Li Y,Wang M,Liu Y,Ning B,Xu T,Huang T,Wei Y
Sat Jan 07 00:00:00 EST 2023
SNORD60 promotes the tumorigenesis and progression of endometrial cancer through binding PIK3CA and regulating PI3K/AKT/mTOR signaling pathway.
Molecular carcinogenesis
Wu W,Chen X,Liu X,Bao HJ,Li QH,Xian JY,Lu BF,Zhao Y,Chen S
Sat Apr 01 00:00:00 EDT 2023
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
Molecules (Basel, Switzerland)
He Y,Luo M,Lei S,Zeng Z,Chen T,Wu Y,Wang D,Wang L,Wang L
Sun Feb 12 00:00:00 EST 2023
Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
The American journal of pathology
Chen X,Song QL,Wang JY,Ji R,Li ZH,Cao ML,Mu XF,Guo DY,Zhang Y,Yang J
Tue Aug 01 00:00:00 EDT 2023
Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion.
BMC neuroscience
Yang L,Du H,Zhang X,Gao B,Zhang D,Qiao Z,Su X,Bao T,Han S
Fri Jan 27 00:00:00 EST 2023
MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway.
Cancer medicine
Ren J,Zheng S,Zhang L,Liu J,Cao H,Wu S,Xu Y,Sun J
Mon May 01 00:00:00 EDT 2023
MAPK4 predicts poor prognosis and facilitates the proliferation and migration of glioma through the AKT/mTOR pathway.
Cancer medicine
Ren J,Zheng S,Zhang L,Liu J,Cao H,Wu S,Xu Y,Sun J
Mon May 01 00:00:00 EDT 2023
Harmine suppresses the malignant phenotypes and PI3K activity in breast cancer.
Anti-cancer drugs
Yao P,Yao P,Ku X,Yang J
Wed Mar 01 00:00:00 EST 2023
TWEAK Signaling-Induced ID1 Expression Drives Malignant Transformation of Hepatic Progenitor Cells During Hepatocarcinogenesis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu W,Gao L,Hou X,Feng S,Yan H,Pan H,Zhang S,Yang X,Jiang J,Ye F,Zhao Q,Wei L,Han Z
Thu Jun 01 00:00:00 EDT 2023
Baicalin and baicalein attenuate hyperuricemic nephropathy via inhibiting PI3K/AKT/NF-κB signalling pathway.
Nephrology (Carlton, Vic.)
Liu Z,Xiang H,Deng Q,Fu W,Li Y,Yu Z,Qiu Y,Mei Z,Xu L
Thu Jun 01 00:00:00 EDT 2023
The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Wang Y,Wei Z,Xu K,Wang X,Gao X,Han Q,Wang S,Chen M
Wed Mar 01 00:00:00 EST 2023
Radial Sponges Facilitate Wound Healing by Promoting Cell Migration and Angiogenesis.
Advanced healthcare materials
Li J,Xiao L,Gao S,Huang H,Lei Q,Chen Y,Chen Z,Xue L,Yan F,Cai L
Sat Apr 01 00:00:00 EDT 2023
Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1.
Nature communications
Bagka M,Choi H,Héritier M,Schwaemmle H,Pasquer QTL,Braun SMG,Scapozza L,Wu Y,Hoogendoorn S
Sat Jul 01 00:00:00 EDT 2023
Emetine, a small molecule natural product, displays potent anti-gastric cancer activity via regulation of multiple signaling pathways.
Cancer chemotherapy and pharmacology
Peng X,Shi J,Zhao Z,Tong R,Zhang X,Zhong L
Sat Apr 01 00:00:00 EDT 2023
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Journal of orthopaedic translation
Lu R,Xu H,Deng X,Wang Y,He Z,Xu S,Liang S,Huang X,You H,Guo F,Cheng P,Chen AM
Wed Mar 01 00:00:00 EST 2023
Prefoldin 6 promotes glioma progression via the AKT signalling pathway.
Cell biology international
Jiang L,Liu J
Sun Jan 01 00:00:00 EST 2023
Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway.
Journal of ethnopharmacology
Chen F,Cui JJ,Jiang DC,Wang HZ,Zhuang W,Feng YN,Lin XL,Xi SY
Wed May 10 00:00:00 EDT 2023
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Epigenomics
Zhao J,Liu J,Liu S,Tian S,Yuan H,Li S
Wed Mar 01 00:00:00 EST 2023
IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation.
Neurochemical research
Zhou J,Xiang W,Zhang K,Zhao Q,Xu Z,Li Z
Mon May 01 00:00:00 EDT 2023
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Transplantation and cellular therapy
Wang X,Zhou Y,Sun Q,Zhang Q,Zhou H,Zhang J,Du Y,Wang Y,Yuan K,Xu L,Zhang M,Yan D,Zeng L,Xu K,Sang W
Tue Aug 01 00:00:00 EDT 2023
Compound Kushen injection attenuates angiotensin II‑mediated heart failure by inhibiting the PI3K/Akt pathway.
International journal of molecular medicine
Wang W,Liu D,Yang L,Chen L,Miao M,Liu Y,Yin Y,Wei M,Liu G,An Y,Zheng M
Wed Mar 01 00:00:00 EST 2023
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhao Y,Zhang J,Cheng X,Huang W,Shen S,Wu S,Huang Y,Nie G,Wang H,Qiu W
Sat Jul 01 00:00:00 EDT 2023
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Experimental biology and medicine (Maywood, N.J.)
Wang W,Gu Y,Ni H,Quan Q,Guo L
Thu Jun 01 00:00:00 EDT 2023
Extracellular Calcium-Induced Calcium Transient Regulating the Proliferation of Osteoblasts through Glycolysis Metabolism Pathways.
International journal of molecular sciences
Gao X,Di X,Li J,Kang Y,Xie W,Sun L,Zhang J
Sun Mar 05 00:00:00 EST 2023
S-allylmercaptocysteine promotes anti-tumor immunity by suppressing PD-L1 expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Zhao J,Sun Y,Gao P,Zhao Z,Wei G
Mon May 01 00:00:00 EDT 2023
Geraniol prevents Helicobacterium pylori-induced human gastric cancer signalling by enhancing peroxiredoxin-1 expression in GES-1 cells.
Microbial pathogenesis
Zhuang K,Tang H,Guo H,Yuan S
Sun Jan 01 00:00:00 EST 2023
Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut microbiota.
International journal of biological macromolecules
Liu Y,Li H,Ren P,Che Y,Zhou J,Wang W,Yang Y,Guan L
Wed Mar 01 00:00:00 EST 2023
TREM2 as an independent predictor of poor prognosis promotes the migration via the PI3K/AKT axis in prostate cancer.
American journal of translational research
Gao HT,Yang Z,Sun H,Zhang Y,Wang Z,Liu WY,Wen HZ,Qu CB,Wang XL
Wed Mar 15 00:00:00 EDT 2023
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Xian Z,Tian J,Zhao Y,Yi Y,Li C,Han J,Zhang Y,Wang Y,Wang L,Liu S,Pan C,Liu C,Wang D,Meng J,Tang X,Wang F,Liang A
Thu Jun 01 00:00:00 EDT 2023
Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC.
Journal of medicinal chemistry
Dong H,Ye X,Zhu Y,Shen H,Shen H,Chen W,Ji M,Zheng M,Wang K,Cai Z,Sun H,Xiao Y,Yang P
Thu May 25 00:00:00 EDT 2023
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Leukemia research
Deng X,Zeng Y,Qiu X,Zhong M,Xiong X,Luo M,Zhang J,Chen X
Sat Jul 01 00:00:00 EDT 2023
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Life sciences
Lin JP,Huang MH,Sun ZT,Chen L,Lei YH,Huang YQ,Qi M,Fan SR,Chen SG,Chung CW,Chan MC,Liu JS,Hu M,Chen MF,Ye WC,Chen YY,Deng LJ
Sat Jul 01 00:00:00 EDT 2023
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Life sciences
Lin JP,Huang MH,Sun ZT,Chen L,Lei YH,Huang YQ,Qi M,Fan SR,Chen SG,Chung CW,Chan MC,Liu JS,Hu M,Chen MF,Ye WC,Chen YY,Deng LJ
Sat Jul 01 00:00:00 EDT 2023
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Journal of ethnopharmacology
Tian X,Ou G,Hu S,Wang C,Han F,Gao L
Thu Apr 06 00:00:00 EDT 2023
Network pharmacology reveals that Berberine may function against Alzheimer's disease via the AKT signaling pathway.
Frontiers in neuroscience
Wei W,Yao JX,Zhang TT,Wen JY,Zhang Z,Luo YM,Cao Y,Li H
Tue May 23 00:00:00 EDT 2023
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Experimental cell research
Dong J,Ru Y,Zhai L,Gao Y,Guo X,Chen B,Lv X
Mon May 15 00:00:00 EDT 2023
Targeting ABCB6 with nitidine chloride inhibits PI3K/AKT signaling pathway to promote ferroptosis in multiple myeloma.
Free radical biology & medicine
Yin Z,Lv Y,Deng L,Li G,Ou R,Chen L,Zhu Y,Zhong Q,Liu Z,Huang J,Wu H,Zhang Q,Fei J,Liu S
Sat Jul 01 00:00:00 EDT 2023
Chemical Constituents and Hypoglycemic Mechanisms of Dendrobium nobile in Treatment of Type 2 Diabetic Rats by UPLC-ESI-Q-Orbitrap, Network Pharmacology and In Vivo Experimental Verification.
Molecules (Basel, Switzerland)
Li Z,Zeng M,Geng K,Lai D,Xu Z,Zhou W
Thu Mar 16 00:00:00 EDT 2023
Betulinaldehyde exhibits effective anti-tumor effects in A549 cells by regulating intracellular autophagy.
Scientific reports
Huang PH,Duan XB,Tang ZZ,Zou ZX,Song WM,Gao G,Li D,Nie FQ,Yan X,Fu YX,Guo R,Xu YY
Fri Jan 13 00:00:00 EST 2023
Extracellular vesicles contribute to EMT in adenomyosis by inducing macrophage polarization†.
Biology of reproduction
Hu Y,Yuan M,Cheng L,Wang G
Tue Apr 11 00:00:00 EDT 2023
eIF4A1 Is a Prognostic Marker and Actionable Target in Human Hepatocellular Carcinoma.
International journal of molecular sciences
Steinmann SM,Sánchez-Martín A,Tanzer E,Cigliano A,Pes GM,Simile MM,Desaubry L,Marin JJG,Evert M,Calvisi DF
Fri Jan 20 00:00:00 EST 2023
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
World journal of gastrointestinal surgery
Zheng Z,Cao F,Ding YX,Lu JD,Fu YQ,Liu L,Guo YL,Liu S,Sun HC,Cui YQ,Li F
Thu Apr 27 00:00:00 EDT 2023
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
Journal of neuroinflammation
He D,Fu S,Ye B,Wang H,He Y,Li Z,Li J,Gao X,Liu D
Wed Mar 29 00:00:00 EDT 2023
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Liu W,Lin T,Gong L
Wed Mar 01 00:00:00 EST 2023
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Journal of ethnopharmacology
Li J,Zhang M,Pei Y,Yang Q,Zheng L,Wang G,Sun Y,Yang W,Liu L
Wed Nov 15 00:00:00 EST 2023
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Journal of cellular and molecular medicine
Xie Y,Mei X,Shi W
Sat Apr 01 00:00:00 EDT 2023
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Journal of Cancer
Zhang T,Liu MQ,Xie GS,Wu DM,Luo PW,Liu T,Deng SH,Wang YY,He S,Zhou Y,Zhou J,Xu Y
Thu Jun 08 00:00:00 EDT 2023
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Journal of Cancer
Zhang T,Liu MQ,Xie GS,Wu DM,Luo PW,Liu T,Deng SH,Wang YY,He S,Zhou Y,Zhou J,Xu Y
Thu Jun 08 00:00:00 EDT 2023
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Journal of Cancer
Zhang T,Liu MQ,Xie GS,Wu DM,Luo PW,Liu T,Deng SH,Wang YY,He S,Zhou Y,Zhou J,Xu Y
Thu Jun 08 00:00:00 EDT 2023
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Journal of Cancer
Zhang T,Liu MQ,Xie GS,Wu DM,Luo PW,Liu T,Deng SH,Wang YY,He S,Zhou Y,Zhou J,Xu Y
Thu Jun 08 00:00:00 EDT 2023
Comprehensive transcriptomic profiling and mutational landscape of primary gastric linitis plastica.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Liu Z,Hong LL,Zheng JS,Ling ZN,Zhang ZL,Qi YN,Zhang XY,Zhu TY,Wang JL,Han J,Chen XL,Yu QM,Wang S,Li P,Ling ZQ
Wed Mar 01 00:00:00 EST 2023
Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation.
Cell communication and signaling : CCS
Hu B,Zhao C,Pan X,Wei H,Mo G,Xian M,Luo W,Nie Q,Li H,Zhang X
Mon Jun 19 00:00:00 EDT 2023
The protective mechanism of a novel polysaccharide from Lactobacillus-fermented Nostoc commune Vauch. on attenuating cadmium-induced kidney injury in mice.
International journal of biological macromolecules
Li H,Liu Y,Zhou J,Liu S,Liu Y,Yang Y,Wang W,Che Y,Inam M,Guan L
Tue Jan 31 00:00:00 EST 2023
Exosome miR-3184-5p inhibits gastric cancer growth by targeting XBP1 to regulate the AKT, STAT3, and IRE1 signalling pathways.
Asia-Pacific journal of clinical oncology
Lin S,Que Y,Que C,Li F,Deng M,Xu D
Sat Apr 01 00:00:00 EDT 2023
RBM15 suppresses hepatic insulin sensitivity of offspring of gestational diabetes mellitus mice via m6A-mediated regulation of CLDN4.
Molecular medicine (Cambridge, Mass.)
Fang J,Wu X,He J,Zhang H,Chen X,Zhang H,Novakovic B,Qi H,Yu X
Mon Feb 20 00:00:00 EST 2023
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Journal of translational medicine
Zhang L,Liu J,Deng M,Chen X,Jiang L,Zhang J,Tao L,Yu W,Qiu Y
Thu Feb 02 00:00:00 EST 2023
FAM83A promotes the progression and metastasis of human pancreatic neuroendocrine tumors by inducing the epithelial-mesenchymal transition via the PI3K/AKT and ERK pathways.
Journal of endocrinological investigation
Zhou B,Zhou X,Zhan C,Jin M,Yan S
Thu Jun 01 00:00:00 EDT 2023
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Redox biology
Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S
Mon May 01 00:00:00 EDT 2023
Lycopene inhibits endothelial-to-mesenchymal transition of choroidal vascular endothelial cells in laser-induced mouse choroidal neovascularization.
Journal of cellular and molecular medicine
Li L,Cao X,Huang L,Huang X,Gu J,Yu X,Zhu Y,Zhou Y,Song Y,Zhu M
Mon May 01 00:00:00 EDT 2023
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Journal of ethnopharmacology
Shi Y,Zhang ZW,Du MM,Wu J,Li JX
Thu Aug 10 00:00:00 EDT 2023
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer.
Journal of traditional and complementary medicine
Huang W,Wen F,Ruan S,Gu P,Gu S,Song S,Zhou J,Li Y,Liu J,Shu P
Mon May 01 00:00:00 EDT 2023
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
Combinatorial chemistry & high throughput screening
Lu Y,Zi C,Zhang L,Cui B,Li L,Ma J
Mon Mar 27 00:00:00 EDT 2023
Six first-line tyrosine kinase inhibitors reveal novel inhibition potential for the EGFR S768I mutation.
Toxicology and applied pharmacology
Wang Y,Liu Q,Chu C,Li L,Wang Z,Liu Q,Wu G,Wei X,An L,Ma J
Wed Feb 15 00:00:00 EST 2023
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Journal of controlled release : official journal of the Controlled Release Society
Liang X,Yang Y,Huang C,Ye Z,Lai W,Luo J,Li X,Yi X,Fan JB,Wang Y,Wang Y
Sat Apr 01 00:00:00 EDT 2023
Synergistic effects of L-theanine and epigallocatechin gallate in alleviating ovalbumin allergy by regulating intestinal immunity through inhibition of mast cell degranulation.
Food & function
Xu W,Song X,Qu Q,Gong Z,Xiao W
Tue Feb 21 00:00:00 EST 2023
Decreasing REDD1 expression protects against high glucose-induced apoptosis, oxidative stress and inflammatory injury in podocytes through regulation of the AKT/GSK-3β/Nrf2 pathway.
Immunopharmacology and immunotoxicology
Wang X,Yang J,Wang W,Li Y,Yang Y
Sun Oct 01 00:00:00 EDT 2023
Embryonic 6:2 FTOH exposure causes reproductive toxicity by disrupting the formation of the blood-testis barrier in offspring mice.
Ecotoxicology and environmental safety
Xia Y,Hao L,Li Y,Li Y,Chen J,Li L,Han X,Liu Y,Wang X,Li D
Sun Jan 15 00:00:00 EST 2023
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
The Prostate
Chang T,Lian Z,Ma S,Liang Z,Ma X,Wen X,Wang Y,Liu R
Sat Apr 01 00:00:00 EDT 2023
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
The Prostate
Chang T,Lian Z,Ma S,Liang Z,Ma X,Wen X,Wang Y,Liu R
Sat Apr 01 00:00:00 EDT 2023
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Journal of ethnopharmacology
Jie XL,Luo ZR,Yu J,Tong ZR,Li QQ,Wu JH,Tao Y,Feng PS,Lan JP,Wang P
Tue Dec 05 00:00:00 EST 2023
TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.
Biochemical pharmacology
Man J,Zhou W,Zuo S,Zhao X,Wang Q,Ma H,Li HY
Sat Jul 01 00:00:00 EDT 2023
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Neuroscience letters
Lin H,Li W,Shen Z,Bei Y,Wei T,Yu Z,Dai Y,Dai H
Sun Jan 01 00:00:00 EST 2023
Dihydrotanshinone I inhibits hepatocellular carcinoma cells proliferation through DNA damage and EGFR pathway.
PeerJ
Wang L,Xu X,Chen D,Li C
Tue Mar 21 00:00:00 EDT 2023
α2,6-Sialylation promotes hepatocellular carcinoma cells migration and invasion via enhancement of nSmase2-mediated exosomal miRNA sorting.
Journal of physiology and biochemistry
Wang L,Chen X,Meng F,Huang T,Wang S,Zheng Z,Zheng G,Li W,Zhang J,Liu Y
Wed Feb 01 00:00:00 EST 2023
Onvansertib inhibits the proliferation and improves the cisplatin-resistance of lung adenocarcinoma via β-catenin/c-Myc signaling pathway.
American journal of cancer research
Wang R,Hou Y,Geng G,Zhu X,Wang Z,Cai W,Ye J,Zhao S,Mi Y,Jiang J
Sat Mar 11 00:00:00 EST 2023
PD-1+ mast cell enhanced by PD-1 blocking therapy associated with resistance to immunotherapy.
Cancer immunology, immunotherapy : CII
Li J,Peng G,Zhu K,Jie X,Xu Y,Rao X,Xu Y,Chen Y,Xing B,Wu G,Shi L
Wed Mar 01 00:00:00 EST 2023
Protective Roles of Xijiao Dihuang Tang on Coronary Artery Injury in Kawasaki Disease.
Cardiovascular drugs and therapy
Zhang J,Zhuge Y,Rong X,Ni C,Niu C,Wen Z,Lin H,Chu M,Jia C
Sat Apr 01 00:00:00 EDT 2023
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
Acta pharmacologica Sinica
He XY,Zhu MM,Zheng J,Wang CY,Zhao XK,Zhang BT,Zhou DC,Zhang S,Yang XX,Duan YJ,Han JH,Chen YL
Wed Mar 01 00:00:00 EST 2023
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Journal of cancer research and clinical oncology
Chen G,She W,Yu C,Rouzi T,Li X,Ma L,Zhang N,Jiang H,Liu X,Wu J,Wang Q,Shen H,Zhou F
Sat Jul 01 00:00:00 EDT 2023
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Journal of physiology and biochemistry
Li P,Dai S,Gao X,Li W
Tue Aug 01 00:00:00 EDT 2023
Metformin alleviates ethanol-induced cardiomyocyte injury by activating AKT/Nrf2 signaling in an ErbB2-dependent manner.
Molecular biology reports
Chen Y,Zhu S,Lin Z,Zhang Y,Jin C,He S,Chen X,Zhou X
Sat Apr 01 00:00:00 EDT 2023
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Environmental science and pollution research international
Feng H,Zhou P,Liu F,Zhang W,Yang H,Li X,Dong J
Sat Apr 01 00:00:00 EDT 2023
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Journal of ethnopharmacology
Zhang PP,Zhuo BY,Duan ZW,Li X,Huang SL,Cao Q,Zhao T,Wei SL,Hu XH,Zhang Y
Thu Aug 10 00:00:00 EDT 2023
Low Pi stress enhances the sensitivity of hepatocellular carcinoma to sorafenib.
Biochemical pharmacology
Bi QC,Deng ZQ,Lv YF,Liu Y,Xie CS,He YQ,Tang Q
Sat Jul 01 00:00:00 EDT 2023
Qingyihuaji Formula promotes apoptosis and autophagy through inhibition of MAPK/ERK and PI3K/Akt/mTOR signaling pathway on pancreatic cancer in vivo and in vitro.
Journal of ethnopharmacology
Qian X,Bi QY,Wang ZN,Han F,Liu LM,Song LB,Li CY,Zhang AQ,Ji XM
Wed May 10 00:00:00 EDT 2023
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Translational cancer research
Chang N,Feng J,Liao P,Hu Y,Li M,He Y,Li Y
Tue Feb 28 00:00:00 EST 2023
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Translational cancer research
Chang N,Feng J,Liao P,Hu Y,Li M,He Y,Li Y
Tue Feb 28 00:00:00 EST 2023
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Translational cancer research
Chang N,Feng J,Liao P,Hu Y,Li M,He Y,Li Y
Tue Feb 28 00:00:00 EST 2023
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Translational cancer research
Chang N,Feng J,Liao P,Hu Y,Li M,He Y,Li Y
Tue Feb 28 00:00:00 EST 2023
MSC-EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF-1α.
Pediatric pulmonology
Wang J,Zhang A,Huang F,Xu J,Zhao M
Mon May 01 00:00:00 EDT 2023
A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Liu X,Yu Y,Wu Y,Luo A,Yang M,Li T,Li T,Mao B,Chen X,Fu J,Jiang H,Liu W
Thu Jun 01 00:00:00 EDT 2023
Activation of long-non-coding RNA NEAT1 sponging microRNA-147 inhibits radiation damage by targeting PDPK1 in troxerutin radioprotection.
iScience
Hu YJ,Song GY,Zhang F,Zhang N,Wang F,Wang JL,Wang X,Wang TY,Li YF,Yan YD,Dou WT,Cheng CY,Xu P
Fri Feb 17 00:00:00 EST 2023
Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.
Molecular medicine (Cambridge, Mass.)
Cao X,Wu S,Wang X,Huang J,Zhang W,Liang C
Thu Mar 23 00:00:00 EDT 2023
Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis.
Journal of periodontal research
He L,Liu C,Liu Y,Cheng G,Zhang P,Guo S,Ding Y
Tue Aug 01 00:00:00 EDT 2023
Cysteamine and N-Acetyl-cysteine Alleviate Placental Oxidative Stress and Barrier Function Damage Induced by Deoxynivalenol.
Journal of agricultural and food chemistry
Huang S,Zhang L,Luo J,Wu D,Ma K,Chen Y,Ma S,Feng L,Li F,Liu D,Deng J,Tan C
Wed May 10 00:00:00 EDT 2023
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Journal of medicinal chemistry
Wang Z,Tan M,Su W,Huang W,Zhang J,Jia F,Cao G,Liu X,Song H,Ran H,Nie G,Wang H
Thu May 11 00:00:00 EDT 2023
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Oncology letters
Zhou H,Yun X,Shu Y,Xu K
Wed Mar 01 00:00:00 EST 2023
microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1.
Oral diseases
Wangzhou K,Fu W,Li M,Lu Z,Lai Z,Liu C,Tan Y,Hao C
Wed Mar 01 00:00:00 EST 2023
Jia-Wei-Si-Miao-Yong-An Fang stimulates the healing of acute radiation-induced cutaneous wounds through MAPK/ERK pathway.
Journal of ethnopharmacology
Wang Y,Gao J,Sun L,Li Q,Kang N,Gao C,Li T
Mon Apr 24 00:00:00 EDT 2023
Progranulin promotes proliferation, migration and invasion via the PI3K/Akt signalling pathway in a model of endometriosis.
Reproductive biomedicine online
Qin R,Zheng F,Qin W,Wang J,Ma N,Tian W,Li J,Liao M,Qin A
Wed Mar 01 00:00:00 EST 2023
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Cancer gene therapy
Huang B,Lu Y,Ni Z,Liu J,He Y,An H,Ye F,Shen J,Lin M,Chen Y,Lin J
Fri Sep 01 00:00:00 EDT 2023
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
iScience
Lu R,Wei Z,Wang Z,Xu S,Sun K,Cheng P,Huang X,You H,Guo F,Liang S,Chen AM
Fri Feb 17 00:00:00 EST 2023
Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.
Gene
Tu W,Qin M,Li Y,Wu W,Tong X
Wed Feb 15 00:00:00 EST 2023
hsa-mir-133a-2 promotes the proliferation and invasion of cervical cancer cells by targeting the LAMB3-mediated PI3K/ATK pathway.
Cancer medicine
Sui X,Sun Y,Zhang G,Chi N,Guan Y,Wang D,Li X
Wed Mar 01 00:00:00 EST 2023
Nobiletin attenuates monocrotaline-induced pulmonary arterial hypertension through PI3K/Akt/STAT3 pathway.
The Journal of pharmacy and pharmacology
Yin Q,Wang S,Yang J,Fan C,Yu Y,Li J,Mei F,Zhang S,Xi R,Zhang X
Tue Aug 01 00:00:00 EDT 2023
Bone marrow mesenchymal stem cell-derived exosomes reduce insulin resistance and obesity in mice via the PI3K/AKT signaling pathway.
FEBS open bio
Shi H,Hao X,Sun Y,Zhang H,Zhao Y,Wang B,Lu J,Hou W,Yan Y,Yu X,Xue L,Luo X,Wang H
Thu Jun 01 00:00:00 EDT 2023
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Biological trace element research
Fang Z,Li Y,Wang J,Wang X,Huang L,Sun L,Deng Q
Fri Sep 01 00:00:00 EDT 2023
Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression.
Experimental cell research
Sun Y,Xiao W,Yu Y,Jiang Y,Xiao Z,Huang D,Zhong T,Li J,Xiang X,He Y,Li Z
Mon May 15 00:00:00 EDT 2023
β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.
Experimental gerontology
Xia G,Wen Z,Zhang L,Huang J,Wang X,Liang C,Cui X,Cao X,Wu S
Mon May 01 00:00:00 EDT 2023
Progesterone Enhances the Invasion of Trophoblast Cells by Activating PI3K/AKT Signaling Pathway to Prevent Preeclampsia.
Cell transplantation
Liu H,Yu L,Ding Y,Peng M,Deng Y
Wed Jan 04 00:00:00 EST 2023
OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer.
Cell death discovery
Ouyang S,Zeng Z,Liu Z,Zhang Z,Sun J,Wang X,Ma M,Ye X,Yu J,Kang W
Wed Feb 02 00:00:00 EST 2022
Estrogen receptor-α36 is involved in diallyl sulfide-induced inhibition of malignant growth of HepG2 and Huh7 hepatocellular carcinoma cells.
Environmental toxicology
Wu W,Chen H,Wang R,Chen J,Yu H,Wei Z,Liu X,Xue M,Chen Q,Zhou H,Fu Z
Tue Feb 01 00:00:00 EST 2022
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma.
International journal of biological sciences
Li J,Yang T,Wang Q,Li Y,Wu H,Zhang M,Qi H,Zhang H,Li J
Tue Jul 12 00:00:00 EDT 2022
Chronic vitamin D3 supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Neuroscience letters
Lin J,Niu Z,Xue Y,Gao J,Zhang M,Li M,Peng Y,Zhang S,Li W,Zhang Q,Li X
Wed Jul 13 00:00:00 EDT 2022
The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Qiao D,Xing J,Duan Y,Wang S,Yao G,Zhang S,Jin J,Lin Z,Chen L,Piao Y
Wed Jun 01 00:00:00 EDT 2022
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Journal of orthopaedic translation
Cao Y,Li Y,Fu SC,Shen J,Zhang H,Jiang C,Shu-Hang Yung P
Sun May 01 00:00:00 EDT 2022
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Cell death & disease
Wang R,Wen P,Yang G,Feng Y,Mi Y,Wang X,Zhu S,Chen YQ
Tue Jul 19 00:00:00 EDT 2022
The Intracellular Interaction of Porcine β-Defensin 2 with VASH1 Alleviates Inflammation via Akt Signaling Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Huang C,Sun Y,Qiu X,Huang J,Wang A,Zhang Q,Pang S,Huang Q,Zhou R,Li L
Wed Jun 15 00:00:00 EDT 2022
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Phytotherapy research : PTR
Cheng L,Shi L,He C,Wang C,Lv Y,Li H,An Y,Dai H,Duan Y,Zhang H,Huang Y,Fu W,Meng Y,Zhao B
Wed Jun 01 00:00:00 EDT 2022
Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice.
Journal of genetics and genomics = Yi chuan xue bao
Wu J,Chen Y,Li X,Ran L,Liu X,Wang X,Zhen M,Shao S,Zeng L,Wang C,Liang B,Zhao J,Wu Y
Fri Apr 01 00:00:00 EDT 2022
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma.
FEBS open bio
Liu J,Mi J,Liu S,Chen H,Jiang L
Tue Nov 01 00:00:00 EDT 2022
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Experimental eye research
Tang Q,Xu F,Lin J,Zhang C,Liu X,Dong L,Zhao J,Zhu L,Lin T
Tue Nov 01 00:00:00 EDT 2022
Banxia-Houpu decoction diminishes iron toxicity damage in heart induced by chronic intermittent hypoxia.
Pharmaceutical biology
Song JX,Zhao YS,Zhen YQ,Yang XY,Chen Q,An JR,Ji ES
Thu Dec 01 00:00:00 EST 2022
In addition to its endosomal escape effect, platycodin D also synergizes with ribosomal inactivation protein to induce apoptosis in hepatoma cells through AKT and MAPK signaling pathways.
Chemico-biological interactions
Lei J,Zhao J,Long MY,Cao XW,Wang FJ
Thu Sep 01 00:00:00 EDT 2022
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.
Journal of Cancer
Zhou FJ,Meng S,Wu XF,Hou PF,Li ML,Chu SF,Bai J,Zheng JN
Tue Aug 02 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Life (Basel, Switzerland)
Li H,Li K,Shu D,Shen M,Tan Z,Zhang W,Pu D,Tan W,Tang Z,Jin A,Liu S
Tue Sep 20 00:00:00 EDT 2022
Analysis of the absorbed constituents and mechanism of liquidambaris fructus extract on hepatocellular carcinoma.
Frontiers in pharmacology
Wang S,Yang XX,Li TJ,Zhao L,Bao YR,Meng XS
Sat Sep 17 00:00:00 EDT 2022
L-arginine stimulates the proliferation of mouse mammary epithelial cells and the development of mammary gland in pubertal mice by activating the GPRC6A/PI3K/AKT/mTOR signalling pathway.
Journal of animal physiology and animal nutrition
Ge Y,Li F,He Y,Cao Y,Guo W,Hu G,Liu J,Fu S
Tue Nov 01 00:00:00 EDT 2022
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
BMC medical genomics
Li B,Ge N,Pan Z,Hou C,Xie K,Wang D,Liu J,Wan J,Deng F,Li M,Luo S
Tue Sep 13 00:00:00 EDT 2022
Angiotensin-(1-7) improves diabetes mellitus-induced erectile dysfunction in rats by regulating nitric oxide synthase levels.
Peptides
Xu Y,Zhang F,Li C,Hao H,Hao Y
Sun May 01 00:00:00 EDT 2022
Postoperative Ileus with the Topical Application of Tongfu Decoction Based on Network Pharmacology and Experimental Validation.
Evidence-based complementary and alternative medicine : eCAM
Zuo X,Shi X,Zhang X,Chen Z,Yang Z,Pan X,Lai R,Zhao Z
Fri Apr 08 00:00:00 EDT 2022
Tocotrienol-Rich Fractions Offer Potential to Suppress Pulmonary Fibrosis Progression.
International journal of molecular sciences
Lu Y,Zhang Y,Xu D,Wang Y,Pan D,Wang P,Xia J,Yin S,Liao W,Wang S,Sun G
Fri Nov 18 00:00:00 EST 2022
Upregulation of MHC-I and downregulation of PD-L1 expression by doxorubicin and deferasirox codelivered liposomal nanoparticles for chemoimmunotherapy of melanoma.
International journal of pharmaceutics
Song P,Han X,Zheng R,Yan J,Wu X,Wang Y,Zhang H
Thu Aug 25 00:00:00 EDT 2022
Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.
Experimental cell research
Liu Y,Li Q,Geng L,Zhou X,Zhou X,Dong Y,Zhang Y
Sat Oct 01 00:00:00 EDT 2022
Mesenchymal stem cells derived from adipose accelerate the progression of colon cancer by inducing a MT-CAFs phenotype via TRPC3/NF-KB axis.
Stem cell research & therapy
Xue C,Gao Y,Li X,Zhang M,Yang Y,Han Q,Sun Z,Bai C,Zhao RC
Sat Jul 23 00:00:00 EDT 2022
Integrated Network Pharmacology and Experimental Verification to Explore the Molecular Mechanism of Hedysarum Multijugum Maxim-Curcumae Rhizoma Herb Pair for Treating Non-Small Cell Lung Cancer.
Frontiers in oncology
Hu S,Ge M,Zhang S,Jiang M,Hu K,Gao L
Sat May 07 00:00:00 EDT 2022
Antidepressant-Like Effect and Mechanism of Ginsenoside Rd on Rodent Models of Depression.
Drug design, development and therapy
Li Y,Wang ML,Zhang B,Fan XX,Tang Q,Yu X,Li LN,Fan AR,Chang HS,Zhang LZ
Tue Apr 05 00:00:00 EDT 2022
Long course of low-dose dexamethasone following or after bleomycin administration ameliorates pulmonary fibrosis.
International immunopharmacology
Lu Y,Zhang Y,Xu D,Wang Y,Pan D,Xia H,Sun G
Thu Dec 01 00:00:00 EST 2022
Combination of Colchicine and Ticagrelor Inhibits Carrageenan-Induced Thrombi in Mice.
Oxidative medicine and cellular longevity
Zhang B,Huang R,Yang D,Chen G,Chen Y,Han J,Zhang S,Ma L,Yang X
Tue Mar 08 00:00:00 EST 2022
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Journal of cardiovascular translational research
Wang K,Li Z,Sun Y,Liu X,Ma W,Ding Y,Hong J,Qian L,Xu D
Mon Aug 01 00:00:00 EDT 2022
Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer.
Journal of experimental & clinical cancer research : CR
Lin F,Li X,Wang X,Sun H,Wang Z,Wang X
Thu Apr 07 00:00:00 EDT 2022
Preliminary Discovery of Small Molecule Inhibitors of Epidermal Growth Factor Receptor (EGFR) That Bind to the Extracellular Domain.
Cancers
Di Liddo R,Verona M,Vaccarin C,Acquasaliente L,Schrenk S,Piccione M,Cenzi C,De Franco M,Dal Prà M,Ribaudo G,Ferlin MG,Conconi MT,Chilin A,Gandin V,Marzaro G
Wed Jul 27 00:00:00 EDT 2022
ID2 inhibits lung adenocarcinoma cell malignant behaviors by inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Tissue & cell
Peng W,Chen J,He R,Tang Y,Jiang J,Li Y
Thu Dec 01 00:00:00 EST 2022
Comparison of Three Species of Rhubarb in Inhibiting Vascular Endothelial Injury via Regulation of PI3K/AKT/NF-κB Signaling Pathway.
Oxidative medicine and cellular longevity
Li X,Huang S,Zhuo B,Hu J,Shi Y,Zhao J,Tang J,Hu X,Wei S
Fri Apr 08 00:00:00 EDT 2022
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Molecular carcinogenesis
Fang J,Ma Y,Li Y,Li J,Zhang X,Han X,Ma S,Guan F
Tue Nov 01 00:00:00 EDT 2022
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Cancers
Adediran S,Wang L,Khan MA,Guang W,Fan X,Dan H,Qi J,Jay SM,Carrier F,Hussain A
Fri Sep 23 00:00:00 EDT 2022
Renoprotective effect of Tanshinone IIA against kidney injury induced by ischemia-reperfusion in obese rats.
Aging
Tai H,Cui XZ,He J,Lan ZM,Li SM,Li LB,Yao SC,Jiang XL,Meng XS,Kuang JS
Thu Oct 20 00:00:00 EDT 2022
Synthesis and biological evaluation of 4-(4-aminophenyl)-6-methylisoxazolo[3,4-b] pyridin-3-amine covalent inhibitors as potential agents for the treatment of acute myeloid leukemia.
Bioorganic & medicinal chemistry
Kang JB,Chen L,Leng XJ,Wang JJ,Cheng Y,Wu SH,Ma YY,Yang LJ,Cao YH,Yang X,Tong ZJ,Wu JZ,Wang YB,Zhou H,Liu JC,Ding N,Dai WC,Yu YC,Xue X,Sun SL,Dai XB,Chang L,Wang XL,Li NG,Shi ZH
Thu Sep 15 00:00:00 EDT 2022
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Toxicology and applied pharmacology
Fu NJ,Xi RY,Shi XK,Li RZ,Zhang ZH,Li LY,Zhang GL,Wang F
Fri Apr 15 00:00:00 EDT 2022
Multi-material basis and multi-mechanisms of the Dahuang Zhechong pill for regulating Treg/Th1 balance in hepatocellular carcinoma.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Wu L,Yang FR,Xing ML,Lu SF,Chen HL,Yang QW,Zhang YT,Lu Y,Huang Y
Wed Jun 01 00:00:00 EDT 2022
Therapeutic effect of adipose stromal vascular fraction spheroids for partial bladder outlet obstruction induced underactive bladder.
Stem cell research & therapy
Liu J,Zhou L,Zhao F,Zhou C,Yang T,Xu Z,Wang X,Xu L,Xu Z,Ge Y,Wu R,Jia R
Wed Feb 09 00:00:00 EST 2022
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
Frontiers in immunology
Huang J,Wang B,Tao S,Hu Y,Wang N,Zhang Q,Wang C,Chen C,Gao B,Cheng X,Li Y
Tue Oct 04 00:00:00 EDT 2022
RASSF1A independence and early galectin-1 upregulation in PIK3CA-induced hepatocarcinogenesis: new therapeutic venues.
Molecular oncology
Scheiter A,Evert K,Reibenspies L,Cigliano A,Annweiler K,Müller K,Pöhmerer LM,Xu H,Cui G,Itzel T,Materna-Reichelt S,Coluccio A,Honarnejad K,Teufel A,Brochhausen C,Dombrowski F,Chen X,Evert M,Calvisi DF,Utpatel K
Tue Mar 01 00:00:00 EST 2022
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Journal of periodontology
Yu Y,Jiang L,Li J,Lei L,Li H
Fri Jul 01 00:00:00 EDT 2022
TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.
International immunopharmacology
Wu J,Wang Y,Yang Y,Liu F,Jiang Z,Jiang Z
Sat Jan 01 00:00:00 EST 2022
Potential "Therapeutic" Effects of Tocotrienol-Rich Fraction (TRF) and Carotene "Against" Bleomycin-Induced Pulmonary Fibrosis in Rats via TGF-β/Smad, PI3K/Akt/mTOR and NF-κB Signaling Pathways.
Nutrients
Lu Y,Zhang Y,Pan Z,Yang C,Chen L,Wang Y,Xu D,Xia H,Wang S,Chen S,Hao YJ,Sun G
Sat Mar 05 00:00:00 EST 2022
Transcriptional Patterns of Lower-Grade Glioma Patients with Distinct Ferroptosis Levels, Immunotherapy Response, and Temozolomide Sensitivity.
Oxidative medicine and cellular longevity
Tu Z,Li J,Long X,Wu L,Zhu X,Huang K
Mon May 23 00:00:00 EDT 2022
Mesenchymal stem cells derived from adipose tissue accelerate the progression of colon cancer by inducing a MTCAF phenotype via ICAM1/STAT3/AKT axis.
Frontiers in oncology
Xue C,Gao Y,Sun Z,Li X,Zhang M,Yang Y,Han Q,Bai C,Zhao RC
Sat Aug 27 00:00:00 EDT 2022
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Drug design, development and therapy
Shu W,Wang Z,Zhao R,Shi R,Zhang J,Zhang W,Wang H
Fri Jun 24 00:00:00 EDT 2022
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Pathology, research and practice
Chen L,Kang Y,Jiang Y,You J,Huang C,Xu X,Chen F
Thu Sep 01 00:00:00 EDT 2022
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
The Journal of investigative dermatology
Zhou Q,Gong J,Bi J,Yang X,Zhang L,Lu C,Li L,Chen M,Cai J,Yang R,Li X,Li Z,Wang X
Fri Jul 01 00:00:00 EDT 2022
GALNT8 suppresses breast cancer cell metastasis potential by regulating EGFR O-GalNAcylation.
Biochemical and biophysical research communications
Huang T,Meng F,Huang H,Wang L,Wang L,Liu Y,Liu Y,Wang J,Li W,Zhang J,Liu Y
Sat Apr 23 00:00:00 EDT 2022
Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Kan Y,Song M,Cui X,Yang Q,Zang Y,Li Q,Li Y,Cai W,Chen Y,Weng X,Wang Y,Zhu X
Tue Feb 01 00:00:00 EST 2022
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.
Cell cycle (Georgetown, Tex.)
Lai T,Qiu H,Si L,Zhen Y,Chu D,Guo R
Mon Aug 01 00:00:00 EDT 2022
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Cancers
Liu X,Huang Y,Qi Y,Wu S,Hu F,Wang J,Shu K,Zhang H,Bartsch JW,Nimsky C,Dong F,Lei T
Fri Oct 07 00:00:00 EDT 2022
Qingda granule prevents obesity-induced hypertension and cardiac dysfunction by inhibiting adverse Akt signaling activation.
Heliyon
Gao Q,Ma E,Chen J,Zhao Q,He J,Peng J,Zhu W,Ren DN,Wo D
Thu Dec 01 00:00:00 EST 2022
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
PeerJ
Sun F,Zhou JL,Wei SX,Jiang ZW,Peng H
Fri Jan 13 00:00:00 EST 2023
The miRNA-144-5p/IRS1/AKT axis regulates the migration, proliferation, and mineralization of osteoblasts: A mechanism of bone repair in diabetic osteoporosis.
Cell biology international
Miao M,Zhang Y,Wang X,Lei S,Huang X,Qin L,Shou D
Thu Dec 01 00:00:00 EST 2022
HIF-1α induced NID1 expression promotes pulmonary metastases via the PI3K-AKT pathway in salivary gland adenoid cystic carcinoma.
Oral oncology
Han N,Li X,Wang Y,Li H,Zhang C,Zhao X,Zhang Z,Ruan M,Zhang C
Mon Aug 01 00:00:00 EDT 2022
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Frontiers in pharmacology
Liu M,Hu T,Gou W,Chang H,Li Y,Li Y,Zuo D,Hou W,Jiao S
Fri Feb 17 00:00:00 EST 2023
Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.
Frontiers in molecular biosciences
Lyu L,Cai Y,Zhang G,Jing Z,Liang J,Zhang R,Dang X,Zhang C
Sat Oct 29 00:00:00 EDT 2022
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
Aging
Zhao R,Ge Y,Gong Y,Li B,Xiao B,Zuo S
Fri Nov 11 00:00:00 EST 2022
The prognostic value and mechanisms of centromere protein M in patients with lung adenocarcinoma.
Translational cancer research
Qi N,Niu Y,Li Z,Xiao L,Tang D,Gao W
Sat Oct 01 00:00:00 EDT 2022
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Experimental cell research
Wang J,Luo X,Lu J,Wang X,Miao Y,Li Q,Wang L
Fri Jul 15 00:00:00 EDT 2022
Picropodophyllin Inhibits the Proliferation of Human Prostate Cancer DU145 and LNCaP Cells via ROS Production and PI3K/AKT Pathway Inhibition.
Biological & pharmaceutical bulletin
Zhu X,Chen X,Wang G,Lei D,Chen X,Lin K,Li M,Lin H,Li D,Zheng Q
Tue Aug 02 00:00:00 EDT 2022
Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis.
Frontiers in pharmacology
Qin LY,Guan P,Wang JX,Chen Y,Zhao YS,Yang SC,Guo YJ,Wang N,Ji ES
Tue Apr 05 00:00:00 EDT 2022
H2S Protects Against Immobilization-Induced Muscle Atrophy via Reducing Oxidative Stress and Inflammation.
Frontiers in physiology
Xu M,Liu X,Bao P,Wang YJ,Lu J,Liu YJ
Sat Jul 16 00:00:00 EDT 2022
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Frontiers in oncology
Sun X,Chen Y,Tao X,Zhang W,Wang X,Wang X,Ruan Z,Chen Z
Sat Sep 24 00:00:00 EDT 2022
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Frontiers in oncology
Sun X,Chen Y,Tao X,Zhang W,Wang X,Wang X,Ruan Z,Chen Z
Sat Sep 24 00:00:00 EDT 2022
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Frontiers in oncology
Sun X,Chen Y,Tao X,Zhang W,Wang X,Wang X,Ruan Z,Chen Z
Sat Sep 24 00:00:00 EDT 2022
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Frontiers in oncology
Sun X,Chen Y,Tao X,Zhang W,Wang X,Wang X,Ruan Z,Chen Z
Sat Sep 24 00:00:00 EDT 2022
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
International journal of biological sciences
Zhang Z,Xu P,Hu Z,Fu Z,Deng T,Deng X,Peng L,Xie Y,Long L,Zheng D,Shen P,Zhang M,Gong B,Zhu Z,Lin J,Chen R,Liu Z,Yang H,Li R,Fang W
Wed Jan 04 00:00:00 EST 2023
Network Pharmacology and Molecular Docking Analysis on Molecular Mechanism of Qingzi Zhitong Decoction in the Treatment of Ulcerative Colitis.
Frontiers in pharmacology
Shou X,Wang Y,Zhang X,Zhang Y,Yang Y,Duan C,Yang Y,Jia Q,Yuan G,Shi J,Shi S,Cui H,Hu Y
Fri Mar 04 00:00:00 EST 2022
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Genetics research
Lin L,Wang X,Zhao W,Chen Y
Mon Nov 07 00:00:00 EST 2022
Effects of apolipoprotein E on regulating insulin sensitivity via regulating insulin receptor signalosome in caveolae.
Life sciences
Liu M,Chen MY,An L,Ma SQ,Mei J,Huang WH,Zhang W
Tue Nov 01 00:00:00 EDT 2022
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Chinese medicine
Xu H,Xu S,Li L,Wu Y,Mai S,Xie Y,Tan Y,Li A,Xue F,He X,Li Y
Thu Nov 24 00:00:00 EST 2022
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Chinese medicine
Xu H,Xu S,Li L,Wu Y,Mai S,Xie Y,Tan Y,Li A,Xue F,He X,Li Y
Thu Nov 24 00:00:00 EST 2022
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).
Journal of translational medicine
He Z,Cheng M,Hu J,Liu L,Liu P,Chen L,Cao D,Tang J
Sat Oct 01 00:00:00 EDT 2022
Inhibiting Hv1 channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects.
Cell research
Zhang Q,Ren Y,Mo Y,Guo P,Liao P,Luo Y,Mu J,Chen Z,Zhang Y,Li Y,Yang L,Liao D,Fu J,Shen J,Huang W,Xu X,Guo Y,Mei L,Zuo Y,Liu J,Yang H,Jiang R
Sun May 01 00:00:00 EDT 2022
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Cancer communications (London, England)
Dai W,Xiang W,Han L,Yuan Z,Wang R,Ma Y,Yang Y,Cai S,Xu Y,Mo S,Li Q,Cai G
Thu Sep 01 00:00:00 EDT 2022
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Journal of ethnopharmacology
Jin D,Liu F,Yu M,Zhao Y,Yan G,Xue J,Sun Y,Zhao D,Li X,Qi W,Wang X
Fri Jul 15 00:00:00 EDT 2022
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Frontiers in endocrinology
Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W
Tue Dec 20 00:00:00 EST 2022
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Frontiers in pharmacology
Xin M,Gao Q,Xiang X,Xu J,Jiao Y,Li X,Zhang X,Jia X
Wed Nov 01 00:00:00 EDT 2023
Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway.
Environmental toxicology
Wang J,Quan Y,Lv J,Gong S,Ren P
Wed Jun 01 00:00:00 EDT 2022
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Chemico-biological interactions
Yu R,Zhong J,Zhou Q,Ren W,Liu Z,Bian Y
Sat Oct 01 00:00:00 EDT 2022
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Journal of the science of food and agriculture
Feng Z,Wei Y,Xu Y,Zhang R,Li M,Qin H,Gu R,Cai M
Wed Jun 01 00:00:00 EDT 2022
Construction and a preliminary study of paracrine effect of bone marrow-derived endothelial progenitor cell sheet.
Cell and tissue banking
Xue F,Bai Y,Jiang Y,Liu J,Jian K
Tue Mar 01 00:00:00 EST 2022
Digital Image Analysis-Based Evaluation of Claudin-1 and Claudin-7 Delocalization in Cutaneous Squamous Cell Carcinoma and in Its Precancerous State.
Journal of oncology
Xu L,Pan Y,Tang S,Bai J,Wu Y,Qiao J,Fang H
Tue Apr 19 00:00:00 EDT 2022
ALG-bFGF Hydrogel Inhibiting Autophagy Contributes to Protection of Blood-Spinal Cord Barrier Integrity via PI3K/Akt/FOXO1/KLF4 Pathway After SCI.
Frontiers in pharmacology
Zhang R,Xie L,Wu F,Xu J,Lu L,Cao L,Li L,Meng W,Zhang H,Shao C,Li X,Chen D
Tue Mar 29 00:00:00 EDT 2022
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Frontiers in pharmacology
Lu L,Peng J,Wan P,Peng H,Lu J,Xiong G
Fri Nov 18 00:00:00 EST 2022
Knockdown of USP8 inhibits prostate cancer cell growth, proliferation, and metastasis and promotes docetaxel's activity by suppressing the NF-kB signaling pathway.
Frontiers in oncology
Islam MT,Chen FZ,Chen HC,Wahid A
Tue Nov 08 00:00:00 EST 2022
Daidzein Activates Akt Pathway to Promote the Proliferation of Female Germline Stem Cells through Upregulating Clec11a.
Stem cell reviews and reports
Li F,Hu X,Wu J
Thu Dec 01 00:00:00 EST 2022
Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway.
International journal of biological macromolecules
Liu Y,Li H,Zheng Z,Niu A,Liu S,Li W,Ren P,Liu Y,Inam M,Guan L,Ma H
Fri Jul 01 00:00:00 EDT 2022
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Journal of gastrointestinal oncology
Yin L,Feng S,Sun Y,Jiang Y,Tang C,Sun D
Sat Oct 01 00:00:00 EDT 2022
IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Shi XY,Zhang XL,Shi QY,Qiu X,Wu XB,Zheng BL,Jiang HX,Qin SY
Wed Jun 01 00:00:00 EDT 2022
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Oncology reports
Wang T,Liu J,Huang X,Zhang C,Shangguan M,Chen J,Wu S,Chen M,Yang Z,Zhao S
Tue Nov 01 00:00:00 EDT 2022
Gomisin A enhances the antitumor effect of paclitaxel by suppressing oxidative stress in ovarian cancer.
Oncology reports
Wang T,Liu J,Huang X,Zhang C,Shangguan M,Chen J,Wu S,Chen M,Yang Z,Zhao S
Tue Nov 01 00:00:00 EDT 2022
Transcriptional landscape of human neuroblastoma cells in response to SARS-CoV-2.
BMC neuroscience
Yang RC,Huang K,Zhang HP,Li L,Tan C,Chen HC,Jin ML,Wang XR
Wed Jul 06 00:00:00 EDT 2022
Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
Proceedings of the National Academy of Sciences of the United States of America
An W,Lin H,Ma L,Zhang C,Zheng Y,Cheng Q,Ma C,Wu X,Zhang Z,Zhong Y,Wang M,He D,Yang Z,Du L,Feng S,Wang C,Yang F,Xiao P,Zhang P,Yu X,Sun JP
Tue Apr 12 00:00:00 EDT 2022
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Stem cell research & therapy
Yin BF,Li ZL,Yan ZQ,Guo Z,Liang JW,Wang Q,Zhao ZD,Li PL,Hao RC,Han MY,Li XT,Mao N,Ding L,Chen DF,Gao Y,Zhu H
Tue Jun 07 00:00:00 EDT 2022
SIRT3 Promotes the Development of Esophageal Squamous Cell Carcinoma by Regulating Hexokinase 2 through the AKT Signaling Pathway.
Bulletin of experimental biology and medicine
Yuan ML,Ren LH,Yu XC,Dong JW,Shi RH
Tue Nov 01 00:00:00 EDT 2022
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Journal of orthopaedic surgery (Hong Kong)
Zhang C,Li Z,Li L,Li S,Yang L,Chen L,Zhang X,Yang S,Guo Y
Tue Nov 01 00:00:00 EDT 2022
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Frontiers in pharmacology
Chen R,Zeng J,Li C,Xiao H,Li S,Lin Z,Huang K,Shen J,Huang H
Wed Apr 13 00:00:00 EDT 2022
Grass Carp Reovirus triggers autophagy enhancing virus replication via the Akt/mTOR pathway.
Fish & shellfish immunology
Zhu M,Zhang Y,Pan J,Tong X,Zhang X,Hu X,Gong C
Thu Sep 01 00:00:00 EDT 2022
Continuous wave irradiation at 0.1 terahertz facilitates transmembrane transport of small molecules.
iScience
Hu E,Zhang Q,Shang S,Jiang Y,Lu X
Fri Mar 18 00:00:00 EDT 2022
Extracellular Hsp90α, which participates in vascular inflammation, is a novel serum predictor of atherosclerosis in type 2 diabetes.
BMJ open diabetes research & care
Ding X,Meng C,Dong H,Zhang S,Zhou H,Tan W,Huang L,He A,Li J,Huang J,Li W,Zou F,Zou M
Sat Jan 01 00:00:00 EST 2022
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Cell death & disease
Jia X,Xin M,Xu J,Xiang X,Li X,Jiao Y,Wang L,Jiang J,Pang F,Zhang X,Zhang J
Tue Aug 30 00:00:00 EDT 2022
Discovery of Novel Phosphoinositide-3-Kinase α Inhibitors with High Selectivity, Excellent Bioavailability, and Long-Acting Efficacy for Gastric Cancer.
Journal of medicinal chemistry
Hou Y,Zhang F,Min W,Yuan K,Kuang W,Wang X,Zhu Y,Sun C,Xia F,Wang Y,Zhang H,Wang L,Yang P
Thu Jul 28 00:00:00 EDT 2022
Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.
Oxidative medicine and cellular longevity
Chen J,Cui Z,Wang Y,Lyu L,Feng C,Feng D,Cheng Y,Li Z,Sun S
Thu Mar 24 00:00:00 EDT 2022
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway.
Frontiers in cardiovascular medicine
Zha Y,Li Y,Ge Z,Wang J,Jiao Y,Zhang J,Zhang S
Tue Mar 01 00:00:00 EST 2022
SLC4A4 promotes prostate cancer progression in vivo and in vitro via AKT-mediated signalling pathway.
Cancer cell international
Liu Z,Wang Q,Zhai G,Ke S,Yu X,Guo J
Sat Mar 19 00:00:00 EDT 2022
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jiang T,He X,Zhao Z,Zhang X,Wang T,Jia L
Tue Nov 01 00:00:00 EDT 2022
Combining plasma extracellular vesicle Let-7b-5p, miR-184 and circulating miR-22-3p levels for NSCLC diagnosis and drug resistance prediction.
Scientific reports
Vadla GP,Daghat B,Patterson N,Ahmad V,Perez G,Garcia A,Manjunath Y,Kaifi JT,Li G,Chabu CY
Sat Apr 23 00:00:00 EDT 2022
FGF-2 signaling in nasopharyngeal carcinoma modulates pericyte-macrophage crosstalk and metastasis.
JCI insight
Wang Y,Sun Q,Ye Y,Sun X,Xie S,Zhan Y,Song J,Fan X,Zhang B,Yang M,Lv L,Hosaka K,Yang Y,Nie G
Mon May 23 00:00:00 EDT 2022
Trimetazidine and exercise offer analogous improvements to the skeletal muscle insulin resistance of mice through Nrf2 signaling.
BMJ open diabetes research & care
Zhang W,Dun Y,You B,Qiu L,Ripley-Gonzalez JW,Cheng J,Fu S,Li C,Liu S
Tue Mar 01 00:00:00 EST 2022
MDK induces temozolomide resistance in glioblastoma by promoting cancer stem-like properties.
American journal of cancer research
Yu X,Zhou Z,Tang S,Zhang K,Peng X,Zhou P,Zhang M,Shen L,Yang L
Thu Nov 17 00:00:00 EST 2022
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Evidence-based complementary and alternative medicine : eCAM
Cai W,Wu LR,Zhang SL
Wed Aug 10 00:00:00 EDT 2022
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Cancer medicine
Ying J,Pan R,Tang Z,Zhu J,Ren P,Lou Y,Zhang E,Huang D,Hu P,Li D,Bao Q,Li P
Tue Mar 01 00:00:00 EST 2022
Tollip Orchestrates Macrophage Polarization to Alleviate Intestinal Mucosal Inflammation.
Journal of Crohn's & colitis
Liu X,Ren X,Zhou L,Liu K,Deng L,Qing Q,Li J,Zhi F,Li M
Thu Aug 04 00:00:00 EDT 2022
Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells.
Evidence-based complementary and alternative medicine : eCAM
Liu X,Yang Y,Tang X,Guo L,Tang X,Zhu T,Zhao T,Zhang W,Zhang P
Wed Oct 19 00:00:00 EDT 2022
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Drug development research
Yuan D,Guo T,Qian H,Ge H,Zhao Y,Huang A,Wang X,Cao X,Zhu D,He C,Yu H
Thu Sep 01 00:00:00 EDT 2022
A peptide translated from circPPP1R12A promotes the malignancy of non-small cell lung cancer cells through AKT signaling pathway.
Journal of clinical laboratory analysis
Zhao W,Xue Y,Zhang Y,Zhu Y,Chen Z,Zhao X
Sat Oct 01 00:00:00 EDT 2022
Hypoglycemia-Exacerbated Mitochondrial Connexin 43 Accumulation Aggravates Cardiac Dysfunction in Diabetic Cardiomyopathy.
Frontiers in cardiovascular medicine
Wei X,Chang ACH,Chang H,Xu S,Xue Y,Zhang Y,Lei M,Chang ACY,Zhang Q
Tue Apr 05 00:00:00 EDT 2022
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Frontiers in genetics
Zhou Z,Wei B,Liu Y,Liu T,Zeng S,Gan J,Qi G
Wed Nov 02 00:00:00 EDT 2022
Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135.
Marine drugs
Wang W,Shi Y,Liu Y,Zhang Y,Wu J,Zhang G,Che Q,Zhu T,Li M,Li D
Mon May 23 00:00:00 EDT 2022
Identification of TLN1 as a prognostic biomarker to effect cell proliferation and differentiation in acute myeloid leukemia.
BMC cancer
Cui D,Cui X,Xu X,Zhang W,Yu Y,Gao Y,Mei C,Zheng W
Thu Sep 29 00:00:00 EDT 2022
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Archives of biochemistry and biophysics
Ji R,Jia FY,Chen X,Wang ZH,Jin WY,Yang J
Sat Jan 15 00:00:00 EST 2022
Comprehensive analysis of the prognostic implications and functional exploration of PAK gene family in human cancer.
Cancer cell international
Lei K,Luo M,Tu Z,Lv S,Liu J,Gong C,Ye M,Wu M,Sheng Y,Long X,Li J,Zhu X,Huang K
Mon Sep 05 00:00:00 EDT 2022
Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p.
Drug design, development and therapy
Wu P,Guo J,Yang H,Yuan D,Wang C,Wang Z
Tue Oct 18 00:00:00 EDT 2022
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Shen Y,Fan X,Qu Y,Tang M,Huang Y,Peng Y,Fu Q
Thu Sep 01 00:00:00 EDT 2022
DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism.
Cell death & disease
Li Z,Tan Y,Li X,Quan J,Bode AM,Cao Y,Luo X
Mon Oct 03 00:00:00 EDT 2022
MMP-9 secreted by M2-type macrophages promotes Wilms' tumour metastasis through the PI3K/AKT pathway.
Molecular biology reports
Tian K,Du G,Wang X,Wu X,Li L,Liu W,Wu R
Sun May 01 00:00:00 EDT 2022
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Biochimica et biophysica acta. Molecular basis of disease
Shen T,Li Y,Wang D,Su Y,Li G,Shang Z,Niu Y,Tan X
Thu Dec 01 00:00:00 EST 2022
Forkhead Box q1 promotes invasion and metastasis in colorectal cancer by activating the epidermal growth factor receptor pathway.
World journal of gastroenterology
Zhang JJ,Cao CX,Wan LL,Zhang W,Liu ZJ,Wang JL,Guo Q,Tang H
Sat May 07 00:00:00 EDT 2022
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
Stem cell research & therapy
Yi Y,Wu M,Zhou X,Xiong M,Tan Y,Yu H,Liu Z,Wu Y,Zhang Q
Mon Mar 21 00:00:00 EDT 2022
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Frontiers in pharmacology
Fan XX,Sun WY,Li Y,Tang Q,Li LN,Yu X,Wang SY,Fan AR,Xu XQ,Chang HS
Tue Sep 13 00:00:00 EDT 2022
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Cell biology international
Zhou Z,Dong Y,Li N,Niu M,Wang S,Zhou Y,Sun Z,Chu P,Tang Z
Tue Nov 01 00:00:00 EDT 2022
Exercise activates autophagy and regulates endoplasmic reticulum stress in muscle of high-fat diet mice to alleviate insulin resistance.
Biochemical and biophysical research communications
Cheng F,Dun Y,Cheng J,Ripley-Gonzalez JW,Jiang W,You B,Liu S
Sat Apr 23 00:00:00 EDT 2022
PI3K inhibitor impairs tumor progression and enhances sensitivity to anlotinib in anlotinib-resistant osteosarcoma.
Cancer letters
Chen C,Guo Y,Huang Q,Wang B,Wang W,Niu J,Lou J,Xu J,Ren T,Huang Y,Guo W
Tue Jun 28 00:00:00 EDT 2022
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway.
Cell biology international
Zhu L,Liu S,Liao YF,Sheng YM,He JC,Cai ZX,Man Q,Wu YY
Thu Sep 01 00:00:00 EDT 2022
Autophagy protects against high uric acid-induced hepatic insulin resistance.
Molecular and cellular endocrinology
He F,Wang M,Zhao H,Xie D,Lv J,Liu W,Yu W,Wang Q,Chen B,Xu C,Yamamoto T,Koyama H,Cheng J
Sun May 01 00:00:00 EDT 2022
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Cancer cell international
Li W,Huang BS,Xiong YY,Yang LJ,Wu LX
Tue Jan 18 00:00:00 EST 2022
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Molecular nutrition & food research
Huang L,He C,Zheng S,Wu C,Ren M,Shan Y
Tue Feb 01 00:00:00 EST 2022
Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
Proceedings of the National Academy of Sciences of the United States of America
Yan W,Zheng L,Xu X,Hao Z,Zhang Y,Lu J,Sun Z,Dai J,Shi D,Guo B,Jiang Q
Tue Sep 13 00:00:00 EDT 2022
A Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer.
Evidence-based complementary and alternative medicine : eCAM
Ding P,Guo Y,Wang C,Chen J,Guo C,Liu H,Shi Q
Sat Jul 16 00:00:00 EDT 2022
Effects of Lycium barbarum polysaccharide on the photoinduced autophagy of retinal pigment epithelium cells.
International journal of ophthalmology
Gao YY,Li J,Huang J,Li WJ,Yu Y
Tue Sep 19 00:00:00 EDT 2023
Dietary Nε-(carboxymethyl) lysine affects cardiac glucose metabolism and myocardial remodeling in mice.
World journal of diabetes
Wang ZQ,Sun Z
Tue Nov 15 00:00:00 EST 2022
HSPA6 is Correlated With the Malignant Progression and Immune Microenvironment of Gliomas.
Frontiers in cell and developmental biology
Zhou X,Ji Q,Li Q,Wang P,Hu G,Xiao F,Ye M,Lin L,Luo M,Guo Y,Wu W,Huang K,Guo H
Wed Mar 16 00:00:00 EDT 2022
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Journal of ethnopharmacology
Shen Y,Yang F,Peng H,Zhang G,Zhu F,Xu H,Shi L
Mon Jan 10 00:00:00 EST 2022
Human umbilical vein endothelial cells-derived exosomes enhance cardiac function after acute myocardial infarction by activating the PI3K/AKT signaling pathway.
Bioengineered
Liu W,Feng Y,Wang X,Ding J,Li H,Guan H,Chen Z
Fri Apr 01 00:00:00 EDT 2022
miR-141-3p regulates saturated fatty acid-induced cardiomyocyte apoptosis through Notch1/PTEN/AKT pathway via targeting PSEN1.
Environmental toxicology
Xin X,Duan L,Yang H,Yu H,Bao Y,Jia D,Wu N,Qiao Y
Fri Apr 01 00:00:00 EDT 2022
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Evidence-based complementary and alternative medicine : eCAM
Wu YY,Huang YL,Dai B,Liu JW,Han X
Sat Jul 16 00:00:00 EDT 2022
Suppression of SMOC2 alleviates myocardial fibrosis via the ILK/p38 pathway.
Frontiers in cardiovascular medicine
Rui H,Zhao F,Yuhua L,Hong J
Tue Mar 21 00:00:00 EDT 2023
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology
Pan C,Qin H,Jin H,Chen W,Guo H,Han X
Sat Oct 01 00:00:00 EDT 2022
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology
Pan C,Qin H,Jin H,Chen W,Guo H,Han X
Sat Oct 01 00:00:00 EDT 2022
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology
Pan C,Qin H,Jin H,Chen W,Guo H,Han X
Sat Oct 01 00:00:00 EDT 2022
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Toxicology
Pan C,Qin H,Jin H,Chen W,Guo H,Han X
Sat Oct 01 00:00:00 EDT 2022
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Stem cell research & therapy
Zhao X,Sun W,Guo B,Cui L
Sat Aug 13 00:00:00 EDT 2022
Irradiation-induced exosomal HMGB1 to confer radioresistance via the PI3K/AKT/FOXO3A signaling pathway in ESCC.
Journal of translational medicine
Du X,Zhang X,Dong J,Zou N,Guo D,Yao W,Wang X,Li S,Song C,Yan K,Shen W,Zhu S
Sat Nov 05 00:00:00 EDT 2022
A possible new activator of PI3K-Huayu Qutan Recipe alleviates mitochondrial apoptosis in obesity rats with acute myocardial infarction.
Journal of cellular and molecular medicine
Tai H,Tong YJ,Yu R,Yu Y,Yao SC,Li LB,Liu Y,Cui XZ,Kuang JS,Meng XS,Jiang XL
Wed Jun 01 00:00:00 EDT 2022
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Frontiers in cell and developmental biology
Shen G,Wang H,Zhu N,Lu Q,Liu J,Xu Q,Huang D
Sat Jul 16 00:00:00 EDT 2022
Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration via the miR-205-5p/PTEN/AKT pathway.
Acta biomaterialia
Shen K,Duan A,Cheng J,Yuan T,Zhou J,Song H,Chen Z,Wan B,Liu J,Zhang X,Zhang Y,Xie R,Liu F,Fan W,Zuo Q
Fri Apr 15 00:00:00 EDT 2022
Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats.
Advances in experimental medicine and biology
Li S,Wang D,Zhang M,Zhang C,Piao F
Thu Jul 28 00:00:00 EDT 2022
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
Journal of ethnopharmacology
Du X,Li C,Zhang S,Sun C,Zhang X,Chen C,Wang X,Cheng F,Wang Q
Thu Feb 10 00:00:00 EST 2022
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Bioengineered
Zhang J,Shang L,Jiang W,Wu W
Tue Mar 01 00:00:00 EST 2022
The mechanism of dioscin preventing lung cancer based on network pharmacology and experimental validation.
Journal of ethnopharmacology
Xi P,Niu Y,Zhang Y,Li W,Gao F,Gu W,Kui F,Liu Z,Lu L,Du G
Tue Jun 28 00:00:00 EDT 2022
Injectable cartilage matrix hydrogel loaded with cartilage endplate stem cells engineered to release exosomes for non-invasive treatment of intervertebral disc degeneration.
Bioactive materials
Luo L,Gong J,Wang Z,Liu Y,Cao J,Qin J,Zuo R,Zhang H,Wang S,Zhao P,Yang D,Zhang M,Wang Y,Zhang J,Zhou Y,Li C,Ni B,Tian Z,Liu M
Thu Sep 01 00:00:00 EDT 2022
Lysine stimulates the development of the murine mammary gland at puberty via PI3K/AKT/mTOR signalling axis.
Journal of animal physiology and animal nutrition
Li W,Long X,Li F,Cao Y,Liu J,Fu S,Guo W,Hu G
Tue Nov 01 00:00:00 EDT 2022
Astragalus-Scorpion Drug Pair Inhibits the Development of Prostate Cancer by Regulating GDPD4-2/PI3K/AKT/mTOR Pathway and Autophagy.
Frontiers in pharmacology
You X,Wu Y,Li Q,Sheng W,Zhou Q,Fu W
Tue Jul 19 00:00:00 EDT 2022
TRIM32 Inhibition Attenuates Apoptosis, Oxidative Stress, and Inflammatory Injury in Podocytes Induced by High Glucose by Modulating the Akt/GSK-3β/Nrf2 Pathway.
Inflammation
Chen Z,Tian L,Wang L,Ma X,Lei F,Chen X,Fu R
Wed Jun 01 00:00:00 EDT 2022
The Janus-faced role of TRPM2-S in retroperitoneal liposarcoma via increasing ROS levels.
Cell communication and signaling : CCS
Li X,Bu F,Ma S,Cananzi F,Zhao Y,Xiao M,Min L,Luo C
Thu Aug 25 00:00:00 EDT 2022
MicroRNA-221-5p Promotes Ricin Toxin-induced Inflammation via PI3K/Akt signaling pathway by targeting COL4a5.
Toxicon : official journal of the International Society on Toxinology
Zhao N,Yu H,Xi Y,Dong M,Wang Y,Sun C,Zhang J,Xu N,Liu W
Wed Jun 01 00:00:00 EDT 2022
Mesenchymal stem cell-derived exosome mediated long non-coding RNA KLF3-AS1 represses autophagy and apoptosis of chondrocytes in osteoarthritis.
Cell cycle (Georgetown, Tex.)
Wen C,Lin L,Zou R,Lin F,Liu Y
Tue Feb 01 00:00:00 EST 2022
METTL3-Mediated m6A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling.
Cell transplantation
Mao Y,Li W,Weng Y,Hua B,Gu X,Lu C,Xu B,Xu H,Wang Z
Fri Sep 09 00:00:00 EDT 2022
Structure-based discovery of a specific SHP2 inhibitor with enhanced blood-brain barrier penetration from PubChem database.
Bioorganic chemistry
Ma Y,Li WY,Sun T,Zhang L,Lu XH,Yang B,Wang RL
Fri Apr 01 00:00:00 EDT 2022
Xiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism.
Evidence-based complementary and alternative medicine : eCAM
Chen F,Qu F,Jia Y,Wang C,Yu Y,Liao J,Lin M,Chen F,Sun Z
Sat Jul 23 00:00:00 EDT 2022
LYPD3, a New Biomarker and Therapeutic Target for Acute Myelogenous Leukemia.
Frontiers in genetics
Hu T,Zhang Y,Yang T,He Q,Zhao M
Sat Apr 02 00:00:00 EDT 2022
Long non-coding RNA NEAT1 promotes angiogenesis in hepatoma carcinoma via the miR-125a-5p/VEGF pathway.
Open life sciences
Guo J,Yuan Q,Fang Y,Liao J,Zhang Z
Tue Oct 11 00:00:00 EDT 2022
LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.
Cell death & disease
Wang J,He Z,Liu X,Xu J,Jiang X,Quan G,Jiang J
Thu Aug 18 00:00:00 EDT 2022
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.
Journal of pineal research
Shin YY,Seo Y,Oh SJ,Ahn JS,Song MH,Kang MJ,Oh JM,Lee D,Kim YH,Sung ES,Kim HS
Sat Jan 01 00:00:00 EST 2022
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.
International journal of biological sciences
Zhang Y,Ji S,Zhang X,Lu M,Hu Y,Han Y,Shui G,Lam SM,Zou X
Mon Aug 22 00:00:00 EDT 2022
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Open medicine (Warsaw, Poland)
Zhang C,Pan R,Ma S,Xu S,Wang B
Tue Jan 03 00:00:00 EST 2023
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress.
Human & experimental toxicology
Zhang P,Zhang J,Quan H,Chen P,Wang J,Liang Y
Wed Mar 02 00:00:00 EST 2022
Network Pharmacology-Based Analysis on the Effects and Mechanism of the Wang-Bi Capsule for Rheumatoid Arthritis and Osteoarthritis.
ACS omega
Wu SS,Hao LJ,Shi YY,Lu ZJ,Yu JL,Jiang SQ,Liu QL,Wang T,Guo SY,Li P,Li F
Tue Mar 08 00:00:00 EST 2022
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice.
Neural plasticity
Peng Y,Chi R,Liu G,Tian W,Zhang J,Zhang R
Thu Sep 22 00:00:00 EDT 2022
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice.
Neural plasticity
Peng Y,Chi R,Liu G,Tian W,Zhang J,Zhang R
Thu Sep 22 00:00:00 EDT 2022
Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer.
Bioengineered
Wang X,Liu X,Yang Y,Yang D
Tue Mar 01 00:00:00 EST 2022
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Journal of oncology
Wang S,Tan J,Chen L,Wang J
Sat Jul 16 00:00:00 EDT 2022
Hydrogen Repairs LPS-Induced Endothelial Progenitor Cells Injury via PI3K/AKT/eNOS Pathway.
Frontiers in pharmacology
Mu Q,Lv K,Yu J,Chu S,Zhang L,Kong L,Zhang L,Tian Y,Jia X,Liu B,Wei Y,Yang N
Wed Nov 01 00:00:00 EDT 2023
α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Gan X,Huang H,Wen J,Liu K,Yang Y,Li X,Fang G,Liu Y,Wang X
Mon Aug 01 00:00:00 EDT 2022
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Journal of reproductive immunology
Wu S,Liu H,Zhou M,Shang Y,Luo L,Chen J,Yang J
Mon Aug 01 00:00:00 EDT 2022
Astragaloside IV drug-loaded exosomes (AS-IV EXOs) derived from endothelial progenitor cells improve the viability and tube formation in high-glucose impaired human endothelial cells by promoting miR-214 expression.
Endokrynologia Polska
Zou X,Xiao H,Bai X,Zou Y,Hu W,Lin X,Zhu C,Liang Y,Xiong W
Tue May 24 00:00:00 EDT 2022
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
International journal of biological macromolecules
Liu Y,Xu Z,Huang H,Xue Y,Zhang D,Zhang Y,Li W,Li X
Tue Mar 15 00:00:00 EDT 2022
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Food & function
Liu Y,Huang H,Xu Z,Xue Y,Zhang D,Zhang Y,Li W,Li X
Mon Mar 07 00:00:00 EST 2022
Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Journal of ethnopharmacology
He H,Deng J,Yang M,An L,Ye X,Li X
Tue Nov 15 00:00:00 EST 2022
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Evidence-based complementary and alternative medicine : eCAM
Xu G,Ma T,Zhou C,Zhao F,Peng K,Li B
Sat Jul 16 00:00:00 EDT 2022
High-mobility Group Box 1 Contributes to Hypoxic-Ischemic Brain Damage by Facilitating Imbalance of Microglial Polarization through RAGE-PI3K/Akt Pathway in Neonatal Rats.
International journal of medical sciences
Sun Y,Zhu X,Zhu K,Yu J,Cheng L,Hei M
Thu Dec 15 00:00:00 EST 2022
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.
Drug development research
Huang Z,Chen H,Tan P,Huang M,Shi H,Sun B,Cheng Y,Li T,Mou Z,Li Q,Fu W
Sun May 01 00:00:00 EDT 2022
Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway.
Drug development research
Huang Z,Chen H,Tan P,Huang M,Shi H,Sun B,Cheng Y,Li T,Mou Z,Li Q,Fu W
Sun May 01 00:00:00 EDT 2022
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Tang D,He WJ,Zhang ZT,Shi JJ,Wang X,Gu WT,Chen ZQ,Xu YH,Chen YB,Wang SM
Sat Jan 01 00:00:00 EST 2022
Artesunate Suppresses the Growth of Lung Cancer Cells by Downregulating the AKT/Survivin Signaling Pathway.
BioMed research international
Zhang W,Ning N,Huang J
Fri Apr 08 00:00:00 EDT 2022
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
The FEBS journal
Xu Z,Li X,Ding Z,Zhang Y,Peng Z,Yang X,Cao W,Du R
Thu Dec 01 00:00:00 EST 2022
Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation.
Cell reports
Li Y,Li YC,Liu XT,Zhang L,Chen YH,Zhao Q,Gao W,Liu B,Yang H,Li P
Tue Feb 15 00:00:00 EST 2022
Knockdown of EphB3 inhibits cell proliferation partly through the AKT signaling pathway and represses epithelial-mesenchymal transition in esophageal squamous cell carcinoma.
Translational cancer research
Tang L,Wang L,Yu T,Xu T,Zhang L,Shu Y
Sat Jan 01 00:00:00 EST 2022
PINK1 overexpression prevents forskolin-induced tau hyperphosphorylation and oxidative stress in a rat model of Alzheimer's disease.
Acta pharmacologica Sinica
Wang XJ,Qi L,Cheng YF,Ji XF,Chi TY,Liu P,Zou LB
Mon Aug 01 00:00:00 EDT 2022
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Cell research
Fu Z,Zhang X,Zhou X,Ur-Rehman U,Yu M,Liang H,Guo H,Guo X,Kong Y,Su Y,Ye Y,Hu X,Cheng W,Wu J,Wang Y,Gu Y,Lu SF,Wu D,Zen K,Li J,Yan C,Zhang CY,Chen X
Tue Jun 01 00:00:00 EDT 2021
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics.
Cell research
Fu Z,Zhang X,Zhou X,Ur-Rehman U,Yu M,Liang H,Guo H,Guo X,Kong Y,Su Y,Ye Y,Hu X,Cheng W,Wu J,Wang Y,Gu Y,Lu SF,Wu D,Zen K,Li J,Yan C,Zhang CY,Chen X
Tue Jun 01 00:00:00 EDT 2021
TPL Inhibits the Invasion and Migration of Drug-Resistant Ovarian Cancer by Targeting the PI3K/AKT/NF-κB-Signaling Pathway to Inhibit the Polarization of M2 TAMs.
Frontiers in oncology
Le F,Yang L,Han Y,Zhong Y,Zhan F,Feng Y,Hu H,Chen T,Tan B
Fri Aug 13 00:00:00 EDT 2021
The Effect of miR-520b on Macrophage Polarization and T Cell Immunity by Targeting PTEN in Breast Cancer.
Journal of oncology
Zhu Q,Yuan J,He Y,Hu Y
Wed Apr 27 00:00:00 EDT 2022
Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis.
Analytical cellular pathology (Amsterdam)
Tang Y,Weng X,Liu C,Li X,Chen C
Mon Mar 07 00:00:00 EST 2022
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Genetics and molecular biology
Yang X,Jin J,Yang J,Zhou L,Mi S,Qi G
Sat Dec 04 00:00:00 EST 2021
Downregulated MicroRNA-327 Attenuates Oxidative Stress-Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway.
Frontiers in pharmacology
Zheng T,Yang J,Zhang J,Yang C,Fan Z,Li Q,Zhai Y,Liu H,Yang J
Wed May 26 00:00:00 EDT 2021
LF-rTMS ameliorates social dysfunction of FMR1-/- mice via modulating Akt/GSK-3β signaling.
Biochemical and biophysical research communications
Hou Y,Zhao J,Yang D,Xuan R,Xie R,Wang M,Mo H,Liang L,Wang W,Wu S,Wang Y,Liu X
Fri Apr 23 00:00:00 EDT 2021
Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model.
Life sciences
He G,Gu J,Wang H,Cheng S,Xiong Q,Ke M,Hu Y,Feng J,Song L,Liu Z,Xu Y
Sun Aug 01 00:00:00 EDT 2021
Low-dose repeated exposure to chemical surfactant impairs corneal epithelium: When personal cleaning products entering the eye.
Experimental eye research
Wu J,Wu T,Zheng S,Huang Y,Wang L
Wed Sep 01 00:00:00 EDT 2021
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Environmental toxicology
Wang D,Liu J,Jiang H
Wed Sep 01 00:00:00 EDT 2021
mTOR pathway regulates the differentiation of peripheral blood Th2/Treg cell subsets in patients with pemphigus vulgaris.
Acta biochimica et biophysica Sinica
Lai K,Zhang W,Li S,Zhang Z,Xie S,Xu M,Li C,Zeng K
Fri Mar 26 00:00:00 EDT 2021
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Journal of cellular and molecular medicine
Ma L,Li C,Lian S,Xu B,Lv H,Liu Y,Lu J,Ji H,Li S,Guo J,Yang H
Sun Aug 01 00:00:00 EDT 2021
Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR.
Scientific reports
Gudi R,Palanisamy V,Vasu C
Wed Jun 16 00:00:00 EDT 2021
LncRNA MIR31HG is induced by tocilizumab and ameliorates rheumatoid arthritis fibroblast-like synoviocyte-mediated inflammation via miR-214-PTEN-AKT signaling pathway.
Aging
Cao L,Jiang H,Yang J,Mao J,Wei G,Meng X,Zang H
Tue Nov 09 00:00:00 EST 2021
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Pharmaceutical biology
Feng Z,Wang C,Meng Q,Wu J,Sun H
Wed Dec 01 00:00:00 EST 2021
CLIC1 Inhibition Protects Against Cellular Senescence and Endothelial Dysfunction Via the Nrf2/HO-1 Pathway.
Cell biochemistry and biophysics
Lu D,Le Y,Ding J,Dou X,Mao W,Zhu J
Tue Jun 01 00:00:00 EDT 2021
Tanshinone IIA combined with CsA inhibit myocardial cell apoptosis induced by renal ischemia-reperfusion injury in obese rats.
BMC complementary medicine and therapies
Tai H,Jiang XL,Lan ZM,Li Y,Kong L,Yao SC,Song N,Lv MJ,Wu J,Yang P,Xiao XS,Yang GL,Kuang JS,Jia LQ
Mon Mar 22 00:00:00 EDT 2021
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Huang B,Lu Y,Gui M,Guan J,Lin M,Zhao J,Mao Q,Lin J
Sat May 01 00:00:00 EDT 2021
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Frontiers in pharmacology
Pei W,Huang X,Ni B,Zhang R,Niu G,You H
Sat Oct 16 00:00:00 EDT 2021
Virtual screening based identification of miltefosine and octenidine as inhibitors of heat shock protein 90.
Naunyn-Schmiedeberg's archives of pharmacology
Li L,Yang M,Li C,Liu Y
Mon Nov 01 00:00:00 EDT 2021
Antagonistic effect of nano-selenium on hepatocyte apoptosis induced by DEHP via PI3K/AKT pathway in chicken liver.
Ecotoxicology and environmental safety
Li H,Zhang J,Xia Y,Pan W,Zhou D
Thu Apr 29 00:00:00 EDT 2021
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Journal of ethnopharmacology
Xiao Y,Liu Y,Lai Z,Huang J,Li C,Zhang Y,Gong X,Deng J,Ye X,Li X
Sat Apr 24 00:00:00 EDT 2021
Advanced oxidation protein products impair autophagic flux in macrophage by inducing lysosomal dysfunction via activation of PI3K-Akt-mTOR pathway in Crohn's disease.
Free radical biology & medicine
Liao Y,Xu J,Qin B,Shi J,Qin C,Xie F,Ou S,Tang J,Wang W,Wu F,Bai L
Fri Aug 20 00:00:00 EDT 2021
A Novel Small Molecular Antibody, HER2-Nanobody, Inhibits Tumor Proliferation in HER2-Positive Breast Cancer Cells In Vitro and In Vivo.
Frontiers in oncology
Yan Y,Cheng X,Li L,Zhang R,Zhu Y,Wu Z,Ding K
Tue Jun 01 00:00:00 EDT 2021
Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD.
Life sciences
Li H,Dun Y,Zhang W,You B,Liu Y,Fu S,Qiu L,Cheng J,Ripley-Gonzalez JW,Liu S
Sat May 15 00:00:00 EDT 2021
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Canadian journal of physiology and pharmacology
Ding F,Yang S
Wed Sep 01 00:00:00 EDT 2021
Methyl eugenol attenuates liver ischemia reperfusion injury via activating PI3K/Akt signaling.
International immunopharmacology
Wang M,Zhang J,Zhang J,Sun K,Li Q,Kuang B,Wang MMZ,Hou S,Gong N
Fri Oct 01 00:00:00 EDT 2021
Transcriptomic Analyses Reveal B-Cell Translocation Gene 2 as a Potential Therapeutic Target in Ovarian Cancer.
Frontiers in oncology
Wang J,Li H,Wang L,Zhang J,Li M,Qiao L,Zhang J,Liu L,Zhang C,Gao J,Li W
Tue Sep 07 00:00:00 EDT 2021
Downregulation of HOXA11 enhances endometrial cancer malignancy and cisplatin resistance via activating PTEN/AKT signaling pathway.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Kong C,Zhu Z,Li Y,Xue P,Chen L
Thu Jul 01 00:00:00 EDT 2021
PARP Inhibitor Upregulates PD-L1 Expression and Provides a New Combination Therapy in Pancreatic Cancer.
Frontiers in immunology
Wang Y,Zheng K,Xiong H,Huang Y,Chen X,Zhou Y,Qin W,Su J,Chen R,Qiu H,Yuan X,Wang Y,Zou Y
Thu Feb 10 00:00:00 EST 2022
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Stem cells (Dayton, Ohio)
Luo L,Jian X,Sun H,Qin J,Wang Y,Zhang J,Shen Z,Yang D,Li C,Zhao P,Liu M,Tian Z,Zhou Y
Thu Apr 01 00:00:00 EDT 2021
Typical phthalic acid esters induce apoptosis by regulating the PI3K/Akt/Bcl-2 signaling pathway in rat insulinoma cells.
Ecotoxicology and environmental safety
Li L,Wang F,Zhang J,Wang K,De X,Li L,Zhang Y
Fri Jan 15 00:00:00 EST 2021
ABCC5 facilitates the acquired resistance of sorafenib through the inhibition of SLC7A11-induced ferroptosis in hepatocellular carcinoma.
Neoplasia (New York, N.Y.)
Huang W,Chen K,Lu Y,Zhang D,Cheng Y,Li L,Huang W,He G,Liao H,Cai L,Tang Y,Zhao L,Pan M
Wed Dec 01 00:00:00 EST 2021
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Liu Y,Deng J,Fan D
Mon Feb 01 00:00:00 EST 2021
Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway.
Disease markers
Guo C,Zhang L,Gao Y,Sun J,Fan L,Bai Y,Zhang J,Naren G,Yang J,Li L
Mon Mar 14 00:00:00 EDT 2022
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination.
Cell & bioscience
Zhu M,Wu M,Bian S,Song Q,Xiao M,Huang H,You L,Zhang J,Zhang J,Cheng C,Ni W,Zheng W
Tue Feb 23 00:00:00 EST 2021
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination.
Cell & bioscience
Zhu M,Wu M,Bian S,Song Q,Xiao M,Huang H,You L,Zhang J,Zhang J,Cheng C,Ni W,Zheng W
Tue Feb 23 00:00:00 EST 2021
Clozapine Induced Disturbances in Hepatic Glucose Metabolism: The Potential Role of PGRMC1 Signaling.
Frontiers in endocrinology
Cao T,Chen Q,Zhang B,Wu X,Zeng C,Zhang S,Cai H
Mon Feb 14 00:00:00 EST 2022
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Journal of cellular physiology
Ma D,Liu P,Wang P,Zhou Z,Fang Q,Wang J
Wed Sep 01 00:00:00 EDT 2021
FoxP3-miR-150-5p/3p suppresses ovarian tumorigenesis via an IGF1R/IRS1 pathway feedback loop.
Cell death & disease
Zhang Q,Zhou X,Wan M,Zeng X,Luo J,Xu Y,Ji L,Zhang JA,Fan P,Zhong J,Wu J
Mon Mar 15 00:00:00 EDT 2021
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
ACS chemical neuroscience
Liu L,Liu M,Zhao W,Zhao YL,Wang Y
Wed Sep 15 00:00:00 EDT 2021
Human Mesenchymal Stem Cell-Derived Exosomal microRNA-143 Promotes Apoptosis and Suppresses Cell Growth in Pancreatic Cancer via Target Gene Regulation.
Frontiers in genetics
Wang B,Xu Y,Wei Y,Lv L,Liu N,Lin R,Wang X,Shi B
Wed Apr 20 00:00:00 EDT 2022
ADORA2A-AS1 Restricts Hepatocellular Carcinoma Progression via Binding HuR and Repressing FSCN1/AKT Axis.
Frontiers in oncology
Pu J,Zhang Y,Wang A,Qin Z,Zhuo C,Li W,Xu Z,Tang Q,Wang J,Wei H
Thu Apr 28 00:00:00 EDT 2022
Lipoxin A4 protects primary spinal cord neurons from Erastin-induced ferroptosis by activating the Akt/Nrf2/HO-1 signaling pathway.
FEBS open bio
Wei N,Lu T,Yang L,Dong Y,Liu X
Sun Aug 01 00:00:00 EDT 2021
MRPS17 promotes invasion and metastasis through PI3K/AKT signal pathway and could be potential prognostic marker for gastric cancer.
Journal of Cancer
Zhou W,Ouyang J,Li J,Liu F,An T,Cheng L,Kuo ZC,Zhang C,He Y
Fri Jul 09 00:00:00 EDT 2021
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Cancer cell international
Liu X,Yang J,Yang C,Huang X,Han M,Kang F,Li J
Thu Nov 25 00:00:00 EST 2021
Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibition.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Jia X,Zhu H,Li G,Lan M,Li X,Huang M,Xu W,Wu S
Sat May 01 00:00:00 EDT 2021
PHLDA3 exerts an antitumor function in prostate cancer by down-regulating Wnt/β-catenin pathway via inhibition of Akt.
Biochemical and biophysical research communications
Ma S,Quan P,Yu C,Fan X,Yang S,Jia W,Zhang L,Wang F,Liu F,Yang L,Qin W,Yang X
Fri Sep 24 00:00:00 EDT 2021
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Experimental and molecular pathology
Fan H,Xin T,Dong X,Yang F,Zhang R,Feng S,He D,Guo H,Pang Q
Mon Feb 01 00:00:00 EST 2021
FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer.
Acta biochimica et biophysica Sinica
Zhang Z,Qin Y,Ji S,Xu W,Liu M,Hu Q,Ye Z,Fan G,Yu X,Liu W,Xu X
Wed Jul 28 00:00:00 EDT 2021
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Scientific reports
Qi R,Sun J,Qiu X,Zhang Y,Wang J,Wang Q,Huang J,Ge L,Liu Z
Thu May 27 00:00:00 EDT 2021
Downregulated ADARB1 Facilitates Cell Proliferation, Invasion and has Effect on the Immune Regulation in Ovarian Cancer.
Frontiers in bioengineering and biotechnology
Zhu W,Xu Z,Huang M,Wang X,Ren X,Cai Y,Peng B,Liang Q,Chen X,Yan Y
Tue Jan 11 00:00:00 EST 2022
Downregulated ADARB1 Facilitates Cell Proliferation, Invasion and has Effect on the Immune Regulation in Ovarian Cancer.
Frontiers in bioengineering and biotechnology
Zhu W,Xu Z,Huang M,Wang X,Ren X,Cai Y,Peng B,Liang Q,Chen X,Yan Y
Tue Jan 11 00:00:00 EST 2022
BNIP3L/Nix-induced mitochondrial fission, mitophagy, and impaired myocyte glucose uptake are abrogated by PRKA/PKA phosphorylation.
Autophagy
da Silva Rosa SC,Martens MD,Field JT,Nguyen L,Kereliuk SM,Hai Y,Chapman D,Diehl-Jones W,Aliani M,West AR,Thliveris J,Ghavami S,Rampitsch C,Dolinsky VW,Gordon JW
Wed Sep 01 00:00:00 EDT 2021
Radiotherapy programs neutrophils to an antitumor phenotype by inducing mesenchymal-epithelial transition.
Translational lung cancer research
Liu Q,Hao Y,Du R,Hu D,Xie J,Zhang J,Deng G,Liang N,Tian T,Käsmann L,Rades D,Rim CH,Hu P,Zhang J
Mon Mar 01 00:00:00 EST 2021
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Journal of cellular and molecular medicine
Chen W,Zhao S,Yu W,Rao T,Ruan Y,Zhu S,Xia Y,Song H,Cheng F
Mon Nov 01 00:00:00 EDT 2021
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Journal of cellular and molecular medicine
Chen W,Zhao S,Yu W,Rao T,Ruan Y,Zhu S,Xia Y,Song H,Cheng F
Mon Nov 01 00:00:00 EDT 2021
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Journal of cellular and molecular medicine
Chen W,Zhao S,Yu W,Rao T,Ruan Y,Zhu S,Xia Y,Song H,Cheng F
Mon Nov 01 00:00:00 EDT 2021
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Journal of cellular and molecular medicine
Chen W,Zhao S,Yu W,Rao T,Ruan Y,Zhu S,Xia Y,Song H,Cheng F
Mon Nov 01 00:00:00 EDT 2021
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer.
Oncogene
Li J,Chen X,Zhu L,Lao Z,Zhou T,Zang L,Ge W,Jiang M,Xu J,Cao Y,Du S,Yu Y,Fan G,Wang H
Thu Jul 01 00:00:00 EDT 2021
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Clinical and experimental pharmacology & physiology
Lu C,Liu L,Chen S,Niu J,Li S,Xie W,Cheng X
Wed Dec 01 00:00:00 EST 2021
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Clinical and experimental pharmacology & physiology
Lu C,Liu L,Chen S,Niu J,Li S,Xie W,Cheng X
Wed Dec 01 00:00:00 EST 2021
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Frontiers in pharmacology
Liao W,Yang W,Xu J,Yan Z,Pan M,Xu X,Zhou S,Zhu Y,Lan J,Zeng M,Han X,Li S,Li Y,Liang K,Gao Y,Peng Q
Wed Nov 17 00:00:00 EST 2021
Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.
International journal of biological sciences
Song A,Wu Y,Chu W,Yang X,Zhu Z,Yan E,Zhang W,Zhou J,Ding X,Liu J,Zhu H,Ye J,Wu Y,Zheng Y,Song X
Fri Jan 14 00:00:00 EST 2022
Network pharmacology and molecular docking reveal the effective substances and active mechanisms of Dalbergia Odoriferain protecting against ischemic stroke.
PloS one
Liu K,Tao X,Su J,Li F,Mu F,Zhao S,Lu X,Li J,Chen S,Dong T,Duan J,Wei P,Xi M
Tue Nov 16 00:00:00 EST 2021
The EIF4A3/CASC2/RORA Feedback Loop Regulates the Aggressive Phenotype in Glioblastomas.
Frontiers in oncology
Zhao J,Jiang Y,Chen L,Ma Y,Zhang H,Zhou J,Li H,Jing Z
Fri Aug 20 00:00:00 EDT 2021
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Frontiers in cell and developmental biology
Xi X,Li Z,Liu H,Chen S,Liu D
Tue Jan 25 00:00:00 EST 2022
Long non-coding RNA IGF2-AS represses breast cancer tumorigenesis by epigenetically regulating IGF2.
Experimental biology and medicine (Maywood, N.J.)
Zhang Y,Yan H,Jiang Y,Chen T,Ma Z,Li F,Lin M,Xu Y,Zhang X,Zhang J,He H
Mon Feb 01 00:00:00 EST 2021
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Molecular medicine reports
Lv W,Wu M,Ren Y,Luo X,Hu W,Zhang Q,Wu Y
Fri Jan 01 00:00:00 EST 2021
Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway.
Oncology reports
Zhang ZQ,Wang X,Xue BH,Zhao Y,Xie F,Wang SD,Xue C,Wang Y,Zhang YS,Qian LJ
Wed Sep 01 00:00:00 EDT 2021
NCX3 alleviates ethanol-induced apoptosis of SK-N-SH cells via the elimination of intracellular calcium ions.
Toxicology in vitro : an international journal published in association with BIBRA
Xia Z,Wang C,Wang X,Yu H,Yao H,Shen H,Lan X,Wu X,Zhang G
Thu Apr 01 00:00:00 EDT 2021
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Ecotoxicology and environmental safety
Zhao G,Qi L,Wang Y,Li X,Li Q,Tang X,Wang X,Wu C
Fri Oct 01 00:00:00 EDT 2021
Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation.
Biochemical and biophysical research communications
Feng J,Xie L,Yu X,Liu C,Dong H,Lu W,Kong R
Fri Mar 12 00:00:00 EST 2021
The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
Frontiers in oncology
Zhang W,Li X,Zhang W,Lu Y,Lin W,Yang L,Zhang Z,Li X
Fri Apr 22 00:00:00 EDT 2022
The LncRNA CASC11 Promotes Colorectal Cancer Cell Proliferation and Migration by Adsorbing miR-646 and miR-381-3p to Upregulate Their Target RAB11FIP2.
Frontiers in oncology
Zhang W,Li X,Zhang W,Lu Y,Lin W,Yang L,Zhang Z,Li X
Fri Apr 22 00:00:00 EDT 2022
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
IUBMB life
Wang L,Chen X,Wang L,Wang S,Li W,Liu Y,Zhang J
Mon Nov 01 00:00:00 EDT 2021
Edaravone Alleviated Propofol-Induced Neurotoxicity in Developing Hippocampus by mBDNF/TrkB/PI3K Pathway.
Drug design, development and therapy
Yang Y,Yi J,Pan M,Hu B,Duan H
Tue Oct 26 00:00:00 EDT 2021
Luteolin Alleviates Methamphetamine-Induced Hepatotoxicity by Suppressing the p53 Pathway-Mediated Apoptosis, Autophagy, and Inflammation in Rats.
Frontiers in pharmacology
Zhang KK,Wang H,Qu D,Chen LJ,Wang LB,Li JH,Liu JL,Xu LL,Yoshida JS,Xu JT,Xie XL,Li DR
Wed Mar 10 00:00:00 EST 2021
miR-30b-5p inhibits proliferation, invasion, and migration of papillary thyroid cancer by targeting GALNT7 via the EGFR/PI3K/AKT pathway.
Cancer cell international
Wang Y,Wang C,Fu Z,Zhang S,Chen J
Wed Nov 24 00:00:00 EST 2021
Tanshinone IIA Combined With Cyclosporine A Alleviates Lung Apoptosis Induced by Renal Ischemia-Reperfusion in Obese Rats.
Frontiers in medicine
Tai H,Jiang XL,Song N,Xiao HH,Li Y,Cheng MJ,Yin XM,Chen YR,Yang GL,Jiang XY,Kuang JS,Lan ZM,Jia LQ
Sat May 22 00:00:00 EDT 2021
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Marine drugs
Hou JR,Wang YH,Zhong YN,Che TT,Hu Y,Bao J,Meng N
Sat Dec 18 00:00:00 EST 2021
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Oxidative medicine and cellular longevity
Chen Z,Wang C,Lin C,Zhang L,Zheng H,Zhou Y,Li X,Li C,Zhang X,Yang X,Guan M,Xi Y
Tue Feb 15 00:00:00 EST 2022
Silencing FYVE, RhoGEF, and PH domain containing 1 (FGD1) suppresses melanoma progression by inhibiting PI3K/AKT signaling pathway.
Bioengineered
Niu Z,Li Y,Xu Y,Jiang W,Tao R,Chen Y,Han Y
Wed Dec 01 00:00:00 EST 2021
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Pharmaceutical biology
Cui Y,Wang Y,Liu G
Wed Dec 01 00:00:00 EST 2021
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Translational neuroscience
Ma Y,Wu T,Zhou H,He G,Li Y,Wang B,Guo Q,Chen B,Li W
Fri Jan 01 00:00:00 EST 2021
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Frontiers in cell and developmental biology
Chen J,Hu Y,Teng Y,Yang B
Sat Oct 16 00:00:00 EDT 2021
The Establishment of Quantitatively Regulating Expression Cassette with sgRNA Targeting BIRC5 to Elucidate the Synergistic Pathway of Survivin with P-Glycoprotein in Cancer Multi-Drug Resistance.
Frontiers in cell and developmental biology
Deng C,Hu F,Zhao Z,Zhou Y,Liu Y,Zhang T,Li S,Zheng W,Zhang W,Wang T,Ma X
Fri Jan 21 00:00:00 EST 2022
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Journal of agricultural and food chemistry
Zhu Y,Yang H,Deng J,Fan D
Wed Aug 04 00:00:00 EDT 2021
A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke.
Evidence-based complementary and alternative medicine : eCAM
Wang C,Chen H,Ma ST,Mao BB,Chen Y,Xu HN,Yu H
Tue Apr 26 00:00:00 EDT 2022
MicroRNA-889-3p restrains the proliferation and epithelial-mesenchymal transformation of lung cancer cells via down-regulation of Homeodomain-interacting protein kinase 1.
Bioengineered
Zhu Q,Li Y,Li L,Guo M,Zou C,Xu Y,Yang Z
Wed Dec 01 00:00:00 EST 2021
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Toxicology letters
Tan X,Cai D,Chen N,Du S,Qiao D,Yue X,Wang T,Li J,Xie W,Wang H
Sun Oct 10 00:00:00 EDT 2021
PSMA-targeted nanoparticles for specific penetration of blood-brain tumor barrier and combined therapy of brain metastases.
Journal of controlled release : official journal of the Controlled Release Society
Ni J,Miao T,Su M,Khan NU,Ju X,Chen H,Liu F,Han L
Sun Jan 10 00:00:00 EST 2021
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Experimental eye research
Li J,Du S,Shi Y,Han J,Niu Z,Wei L,Yang P,Chen L,Tian H,Gao L
Mon Feb 01 00:00:00 EST 2021
A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties.
Journal of hematology & oncology
Liu S,Sun Y,Hou Y,Yang L,Wan X,Qin Y,Liu Y,Wang R,Zhu P,Teng Y,Liu M
Fri Oct 29 00:00:00 EDT 2021
Helicobacter urease suppresses cytotoxic CD8+ T-cell responses through activating Myh9-dependent induction of PD-L1.
International immunology
Wu J,Zhu X,Guo X,Yang Z,Cai Q,Gu D,Luo W,Yuan C,Xiang Y
Mon Aug 23 00:00:00 EDT 2021
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Frontiers in cell and developmental biology
Dang NN,Li XB,Zhang M,Han C,Fan XY,Huang SH
Tue Sep 07 00:00:00 EDT 2021
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Journal of medicinal chemistry
Zhou Z,Li Y,Ma X,Cao B,Peng T,Sheng Y,Peng H,Li R,Cao Y,Xi R,Li F,Wang M,Sun H,Zhang G,Zhang H,Hu K,Xiao W,Wang F
Thu Jun 10 00:00:00 EDT 2021
βKlotho, a direct target of miR-206, contributes to the growth of hepatoblastoma through augmenting PI3K/Akt/mTOR signaling.
American journal of cancer research
Chen T,Chen J,Zhao X,Zhou J,Sheng Q,Zhu L,Lv Z
Tue Jun 08 00:00:00 EDT 2021
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
ACS chemical neuroscience
Sun Y,Zhang H,Wu Z,Yu X,Yin Y,Qian S,Wang Z,Huang J,Wang W,Liu T,Xue W,Chen G
Wed Sep 15 00:00:00 EDT 2021
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Journal of agricultural and food chemistry
Zhang Q,Su G,Yang Q,Wei Z,Wang J,Zheng L,Zhao M
Wed Sep 15 00:00:00 EDT 2021
DNAJC2 is reversely regulated by miR‑627‑3p, promoting the proliferation of colorectal cancer.
Molecular medicine reports
Liu H,Li J,Zhao H,Liu X,Ye X
Sun Aug 01 00:00:00 EDT 2021
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Frontiers in pharmacology
Luo LF,Qin LY,Wang JX,Guan P,Wang N,Ji ES
Sat Jun 12 00:00:00 EDT 2021
Astragaloside IV Attenuates the Myocardial Injury Caused by Adriamycin by Inhibiting Autophagy.
Frontiers in pharmacology
Luo LF,Qin LY,Wang JX,Guan P,Wang N,Ji ES
Sat Jun 12 00:00:00 EDT 2021
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Bioorganic chemistry
Ma Y,Yang X,Han H,Wen Z,Yang M,Zhang Y,Fu J,Wang X,Yin T,Lu G,Qi J,Lin H,Wang X,Yang Y
Tue Jun 01 00:00:00 EDT 2021
Inhibition of Growth of Colon Tumors and Proliferation of HT-29 Cells by Warburgia ugandensis Extract through Mediating G0/G1 Cell Cycle Arrest, Cell Apoptosis, and Intracellular ROS Generation.
Oxidative medicine and cellular longevity
Zhang Y,Chen G,Zhuang X,Guo M
Fri Mar 04 00:00:00 EST 2022
CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27kip1 Axis.
Journal of hepatocellular carcinoma
Zhou X,Li TM,Luo JZ,Lan CL,Wei ZL,Fu TH,Liao XW,Zhu GZ,Ye XP,Peng T
Thu Apr 28 00:00:00 EDT 2022
Polyphyllin VII induces mitochondrial apoptosis by regulating the PP2A/AKT/DRP1 signaling axis in human ovarian cancer.
Oncology reports
Zhao L,Liu Z,Deng X,Wang J,Sun L,Fan L,Zhang Y
Mon Feb 01 00:00:00 EST 2021
Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.
International journal of molecular sciences
Labeit S,Hirner S,Bogomolovas J,Cruz A,Myrzabekova M,Moriscot A,Bowen TS,Adams V
Tue Feb 23 00:00:00 EST 2021
Calreticulin: a potential diagnostic and therapeutic biomarker in gallbladder cancer.
Aging
Ye J,Qi L,Du Z,Yu L,Chen K,Li R,Feng R,Zhai W
Thu Feb 11 00:00:00 EST 2021
Calreticulin: a potential diagnostic and therapeutic biomarker in gallbladder cancer.
Aging
Ye J,Qi L,Du Z,Yu L,Chen K,Li R,Feng R,Zhai W
Thu Feb 11 00:00:00 EST 2021
GTW inhibits the Epithelial to Mesenchymal Transition of Epithelial Ovarian Cancer via ILK/AKT/GSK3β/Slug Signalling Pathway.
Journal of Cancer
Feng Y,Le F,Tian P,Zhong Y,Zhan F,Huang G,Hu H,Chen T,Tan B
Sat Feb 06 00:00:00 EST 2021
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Journal of cellular and molecular medicine
Liu S,Hu J,Shi C,Sun L,Yan W,Song Y
Tue Jun 01 00:00:00 EDT 2021
The effects of Omarigliptin on promoting osteoblastic differentiation.
Bioengineered
Liao F,Hu X,Chen R
Wed Dec 01 00:00:00 EST 2021
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Journal of Cancer
Sun M,Xie J,Zhang D,Chen C,Lin S,Chen Y,Zhang G
Sat Feb 19 00:00:00 EST 2022
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10.
Experimental and therapeutic medicine
Qu G,He T,Dai A,Zhao Y,Guan D,Li S,Shi H,Gan W,Zhang A
Wed Dec 01 00:00:00 EST 2021
Role of epigenetic m6 A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR-AKT signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Parial R,Li H,Li J,Archacki S,Yang Z,Wang IZ,Chen Q,Xu C,Wang QK
Sat May 01 00:00:00 EDT 2021
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Cytokine
Wang Z,Li B,Jiang H,Ma Y,Bao Y,Zhu X,Xia H,Jin Y
Mon Feb 01 00:00:00 EST 2021
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Cytokine
Wang Z,Li B,Jiang H,Ma Y,Bao Y,Zhu X,Xia H,Jin Y
Mon Feb 01 00:00:00 EST 2021
ACTG1 regulates intervertebral disc degeneration via the NF-κB-p65 and Akt pathways.
Biochemical and biophysical research communications
Wu T,Jia X,Feng H,Wu D
Fri Mar 19 00:00:00 EDT 2021
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
European journal of medicinal chemistry
Wang S,Zhang RH,Zhang H,Wang YC,Yang D,Zhao YL,Yan GY,Xu GB,Guan HY,Zhou YH,Cui DB,Liu T,Li YJ,Liao SG,Zhou M
Fri Oct 15 00:00:00 EDT 2021
Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway.
International immunopharmacology
Wen L,Yang QH,Ma XL,Li T,Xiao S,Sun CF
Fri Oct 01 00:00:00 EDT 2021
Hawthorn polyphenols, D-chiro-inositol, and epigallocatechin gallate exert a synergistic hypoglycemic effect.
Journal of food biochemistry
Xin C,Zhao M,Wang J,Wang Z
Thu Jul 01 00:00:00 EDT 2021
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Science China. Life sciences
Feng Y,Cao X,Zhao B,Song C,Pang B,Hu L,Zhang C,Wang J,He J,Wang S
Mon Nov 01 00:00:00 EDT 2021
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Science China. Life sciences
Feng Y,Cao X,Zhao B,Song C,Pang B,Hu L,Zhang C,Wang J,He J,Wang S
Mon Nov 01 00:00:00 EDT 2021
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Science China. Life sciences
Feng Y,Cao X,Zhao B,Song C,Pang B,Hu L,Zhang C,Wang J,He J,Wang S
Mon Nov 01 00:00:00 EDT 2021
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Science China. Life sciences
Feng Y,Cao X,Zhao B,Song C,Pang B,Hu L,Zhang C,Wang J,He J,Wang S
Mon Nov 01 00:00:00 EDT 2021
MicroRNA‑223‑induced inhibition of the FBXW7 gene affects the proliferation and apoptosis of colorectal cancer cells via the Notch and Akt/mTOR pathways.
Molecular medicine reports
Liu Z,Ma T,Duan J,Liu X,Liu L
Mon Feb 01 00:00:00 EST 2021
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
Human cell
Wang Y,Wang Z,Lu J,Zhang H
Thu Jul 01 00:00:00 EDT 2021
Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.
Human cell
Wang Y,Wang Z,Lu J,Zhang H
Thu Jul 01 00:00:00 EDT 2021
Parthenolide inhibits the tumor characteristics of renal cell carcinoma.
International journal of oncology
Liu D,Han Y,Liu L,Ren X,Zhang H,Fan S,Qin T,Li L
Fri Jan 01 00:00:00 EST 2021
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Evidence-based complementary and alternative medicine : eCAM
Zhao J,Lan W,Peng J,Guan B,Liu J,Zhang M,Zhan Z,Lin J
Tue Jul 27 00:00:00 EDT 2021
Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.
Antioxidants (Basel, Switzerland)
Liang Y,Chen G,Zhang F,Yang X,Chen Y,Duan Y,Yu M,Zhang S,Han J
Sat Jun 05 00:00:00 EDT 2021
Low-dose naltrexone plays antineoplastic role in cervical cancer progression through suppressing PI3K/AKT/mTOR pathway.
Translational oncology
Liu N,Yan L,Shan F,Wang X,Qu N,Handley MK,Ma M
Thu Apr 01 00:00:00 EDT 2021
Adiponectin Attenuates Lipopolysaccharide-induced Apoptosis by Regulating the Cx43/PI3K/AKT Pathway.
Frontiers in pharmacology
Liu L,Yan M,Yang R,Qin X,Chen L,Li L,Si J,Li X,Ma K
Sat Jun 05 00:00:00 EDT 2021
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
European review for medical and pharmacological sciences
Hou Y,Li FZ
Wed Dec 01 00:00:00 EST 2021
FNDC4 acts as an extracellular factor to promote the invasiveness of hepatocellular carcinoma partly via the PI3K/Akt signalling pathway.
Cancer medicine
Wang B,Zheng B,Lu Y,Huang D,Liu J,Song J,Zheng S
Fri Oct 01 00:00:00 EDT 2021
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Frontiers in neuroscience
Wang C,Chen H,Jiang HH,Mao BB,Yu H
Tue Dec 28 00:00:00 EST 2021
Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway.
Pathology oncology research : POR
Lin H,Zeng W,Lei Y,Chen D,Nie Z
Mon Jan 03 00:00:00 EST 2022
OSU-03012 Disrupts Akt Signaling and Prevents Endometrial Carcinoma Progression in vitro and in vivo.
Drug design, development and therapy
Ding L,Ren C,Yang L,Wu Z,Li F,Jiang D,Zhu Y,Lu J
Thu Nov 04 00:00:00 EDT 2021
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Gene
Smith AL,Gjoka E,Izhar M,Novo KJ,Mason BC,De Las Casas A,Waddell DS
Wed Oct 20 00:00:00 EDT 2021
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke.
Journal of cellular and molecular medicine
Li L,Cheng SQ,Guo W,Cai ZY,Sun YQ,Huang XX,Yang J,Ji J,Chen YY,Dong YF,Cheng H,Sun XL
Fri Oct 01 00:00:00 EDT 2021
The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis.
Mediators of inflammation
Guo X,Xu Y,Tan HL,Wang XJ,Xiao L
Mon Feb 07 00:00:00 EST 2022
The Key Ingredient Acacetin in Weishu Decoction Alleviates Gastrointestinal Motility Disorder Based on Network Pharmacology Analysis.
Mediators of inflammation
Guo X,Xu Y,Tan HL,Wang XJ,Xiao L
Mon Feb 07 00:00:00 EST 2022
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Frontiers in medicine
Yao M,Zhang J,Li Z,Bai X,Ma J,Li Y
Wed Mar 10 00:00:00 EST 2021
CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP-9/PI3K/AKT pathway.
Cell biology international
Chen H,Pan R,Li H,Zhang W,Ren C,Lu Q,Chen H,Zhang X,Nie Y
Mon Mar 01 00:00:00 EST 2021
Clusterin inhibits Cr(VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes.
Ecotoxicology and environmental safety
Liang N,Li S,Liang Y,Ma Y,Tang S,Ye S,Xiao F
Wed Sep 15 00:00:00 EDT 2021
TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis.
Cell death & disease
Chen H,He A,Li H,Chen H,Xie H,Luo L,Huang Y,Chen J,Guan J,He Q,Ma J,Ou C,Tao A,Yan J
Wed Oct 13 00:00:00 EDT 2021
Concentrated growth factor regulates the macrophage-mediated immune response.
Regenerative biomaterials
Luo H,Liu W,Zhou Y,Jiang X,Liu Y,Yang Q,Shao L
Fri Oct 01 00:00:00 EDT 2021
Galectin-3 mediates cardiac remodeling caused by impaired glucose and lipid metabolism through inhibiting two pathways of activating Akt.
American journal of physiology. Heart and circulatory physiology
Sun Z,Zhang L,Li L,Shao C,Liu J,Zhou M,Wang Z
Fri Jan 01 00:00:00 EST 2021
miR-20b and miR-125a promote tumorigenesis in radioresistant esophageal carcinoma cells.
Aging
Chen D,Su H,Li Y,Wu X,Li Y,Wei C,Shi D,Gao Y,Zhou Q,Wang Q,Jin X,Xie C
Wed Mar 10 00:00:00 EST 2021
Manual Acupuncture at ST37 Modulates TRPV1 in Rats with Acute Visceral Hyperalgesia via Phosphatidylinositol 3-Kinase/Akt Pathway.
Evidence-based complementary and alternative medicine : eCAM
Chen C,Yu Z,Lin D,Wang X,Zhang X,Ji F,He L,Xu B
Fri Oct 15 00:00:00 EDT 2021
Esculetin inhibits endometrial cancer proliferation and promotes apoptosis via hnRNPA1 to downregulate BCLXL and XIAP.
Cancer letters
Jiang R,Su G,Chen X,Chen S,Li Q,Xie B,Zhao Y
Wed Sep 01 00:00:00 EDT 2021
Midkine promotes glioblastoma progression via PI3K-Akt signaling.
Cancer cell international
Hu B,Qin C,Li L,Wei L,Mo X,Fan H,Lei Y,Wei F,Zou D
Thu Sep 23 00:00:00 EDT 2021
PPP1CA/YAP/GS/Gln/mTORC1 pathway activates retinal Müller cells during diabetic retinopathy.
Experimental eye research
Guo Y,Cang X,Zhu L,Zhu M,Li A,Wang Z,Zhang Y,Wang X,Song E
Wed Sep 01 00:00:00 EDT 2021
T-lymphoma invasion and metastasis 1 promotes invadopodia formation and is regulated by the PI3K/Akt signaling pathway in hepatocellular carcinoma.
Experimental cell research
Wang B,Zheng B,Cao L,Liao K,Huang D,Zhang Y,Jiang Y,Zheng S
Fri Oct 15 00:00:00 EDT 2021
Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice.
Acta pharmaceutica Sinica. B
Zhu Y,Wan N,Shan X,Deng G,Xu Q,Ye H,Sun Y
Sat May 01 00:00:00 EDT 2021
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Alcohol (Fayetteville, N.Y.)
Chen M,Sun X,Wei W,Cucarella C,Martín-Sanz P,Casado M,Pi L,Ren B,Cao Q
Sat May 01 00:00:00 EDT 2021
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
International immunopharmacology
Zhao P,Cai Z,Tian Y,Li J,Li K,Li M,Bai Y,Li J
Wed Dec 01 00:00:00 EST 2021
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
International journal of medical sciences
Du P,Luo K,Li G,Zhu J,Xiao Q,Li Y,Zhang X
Tue Mar 15 00:00:00 EDT 2022
Effects of total flavonoids from Eucommia ulmoides Oliv. leaves on polycystic ovary syndrome with insulin resistance model rats induced by letrozole combined with a high-fat diet.
Journal of ethnopharmacology
Peng MF,Tian S,Song YG,Li CX,Miao MS,Ren Z,Li M
Sat Jun 12 00:00:00 EDT 2021
Polyphenol-Rich Extract from Litchi chinensis Seeds Alleviates Hypertension-Induced Renal Damage in Rats.
Journal of agricultural and food chemistry
Yao Y,Liu T,Yin L,Man S,Ye S,Ma L
Wed Feb 24 00:00:00 EST 2021
Blocking VRK2 suppresses pulmonary adenocarcinoma progression via ERK1/2/AKT signal pathway by targeting miR-145-5p.
European review for medical and pharmacological sciences
Mu Y,Liu WJ,Bie LY,Mu XQ,Zhao YQ
Fri Jan 01 00:00:00 EST 2021
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Translational oncology
Niu LT,Wang YQ,Wong CCL,Gao SX,Mo XD,Huang XJ
Wed Sep 01 00:00:00 EDT 2021
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Journal of bone oncology
Guo H,Peng J,Hu J,Chang S,Liu H,Luo H,Chen X,Tang H,Chen Y
Wed Dec 01 00:00:00 EST 2021
Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis.
The Journal of biological chemistry
Pang H,Li J,Wang Y,Su X,Gao Y,Li SJ
Fri Oct 01 00:00:00 EDT 2021
Osthole Ameliorates Estrogen Deficiency-Induced Cognitive Impairment in Female Mice.
Frontiers in pharmacology
Adu-Nti F,Gao X,Wu JM,Li J,Iqbal J,Ahmad R,Ma XM
Wed May 26 00:00:00 EDT 2021
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Journal of cellular physiology
Wang M,Liu H,Zhang X,Zhao W,Li D,Xu C,Wu Z,Xie F,Li X
Wed Sep 01 00:00:00 EDT 2021
MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis.
IUBMB life
Wang W,Wang J,Yang C,Wang J
Tue Jun 01 00:00:00 EDT 2021
Down-Regulating the Expression of miRNA-21 Inhibits the Glucose Metabolism of A549/DDP Cells and Promotes Cell Death Through the PI3K/AKT/mTOR/HIF-1α Pathway.
Frontiers in oncology
Sun Y,Liu W,Zhao Q,Zhang R,Wang J,Pan P,Shang H,Liu C,Wang C
Sun May 30 00:00:00 EDT 2021
SPOP promotes CDCA5 degradation to regulate prostate cancer progression via the AKT pathway.
Neoplasia (New York, N.Y.)
Luo Z,Wang J,Zhu Y,Sun X,He C,Cai M,Ma J,Wang Y,Han S
Fri Oct 01 00:00:00 EDT 2021
Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways.
Cell and tissue research
Cao Y,Zhang Y,Ma L,Wang J,Guo W,Cheng J,Hu G,Fu S,Liu J
Sat May 01 00:00:00 EDT 2021
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Molecular medicine reports
Zhao W,Chen L,Zhou H,Deng C,Han Q,Chen Y,Wu Q,Li S
Mon Nov 01 00:00:00 EDT 2021
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Molecular medicine reports
Zhao W,Chen L,Zhou H,Deng C,Han Q,Chen Y,Wu Q,Li S
Mon Nov 01 00:00:00 EDT 2021
Protective effect of carvacrol on liver injury in type 2 diabetic db/db mice.
Molecular medicine reports
Zhao W,Chen L,Zhou H,Deng C,Han Q,Chen Y,Wu Q,Li S
Mon Nov 01 00:00:00 EDT 2021
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Journal of biochemical and molecular toxicology
Man S,Wu Z,Sun R,Guan Q,Li Z,Zuo D,Zhang W,Wu Y
Sun Aug 01 00:00:00 EDT 2021
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.
Food & nutrition research
Sun Y,Qin H,Zhang H,Feng X,Yang L,Hou DX,Chen J
Fri Apr 22 00:00:00 EDT 2022
miR-497 defect contributes to gastric cancer tumorigenesis and progression via regulating CDC42/ITGB1/FAK/PXN/AKT signaling.
Molecular therapy. Nucleic acids
Zhang L,Yao L,Zhou W,Tian J,Ruan B,Lu Z,Deng Y,Li Q,Zeng Z,Yang D,Shang R,Xu M,Zhang M,Cheng D,Yang Y,Ding Q,Yu H
Fri Sep 03 00:00:00 EDT 2021
Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling.
BioMed research international
Tsai TH,Lieu AS,Wang YW,Yang SF,Hsu YC,Lin CL
Wed May 26 00:00:00 EDT 2021
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.
The Journal of experimental medicine
Chen Z,Huo D,Li L,Liu Z,Li Z,Xu S,Huang Y,Wu W,Zhou C,Liu Y,Kuang M,Wu F,Li H,Qian P,Song G,Wu X,Chen J,Hou Y
Mon May 03 00:00:00 EDT 2021
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.
Journal of ethnopharmacology
Wang Y,Chu F,Lin J,Li Y,Johnson N,Zhang J,Gai C,Su Z,Cheng H,Wang L,Ding X
Thu Oct 28 00:00:00 EDT 2021
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Life sciences
Zhou J,Zhao Y,Guo YJ,Zhao YS,Liu H,Ren J,Li JR,Ji ES
Thu Jul 01 00:00:00 EDT 2021
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Aging
Cao W,Zeng Z,He Z,Lei S
Fri Feb 26 00:00:00 EST 2021
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Frontiers in pharmacology
Wang T,Dong J,Yuan X,Wen H,Wu L,Liu J,Sui H,Deng W
Sun May 02 00:00:00 EDT 2021
Amplification and expression of c-MET correlate with poor prognosis of patients with gastric cancer and upregulate the expression of PDL1.
Acta biochimica et biophysica Sinica
Yang Y,Wang C,Dai C,Liu X,Li W,Huang M,Zhao X,Ji D,Li J,Guo W
Thu Apr 15 00:00:00 EDT 2021
Overexpression of FOXA2 attenuates cigarette smoke-induced cellular senescence and lung inflammation through inhibition of the p38 and Erk1/2 MAPK pathways.
International immunopharmacology
Tao Y,Sun Y,Wu B,Xu D,Yang J,Gu L,Du C
Sat May 01 00:00:00 EDT 2021
Downregulation of TAF9B by miR-7-5p Inhibits the Progression of Osteosarcoma.
OncoTargets and therapy
Gu W,Chen P,Ren P,Wang Y,Li X,Gong M
Fri Apr 22 00:00:00 EDT 2022
Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Xian Z,Tian J,Zhang Y,Meng J,Zhao Y,Li C,Yi Y,Han J,Liu S,Wang L,Pan C,Wang D,Wang F,Liang A
Fri Oct 01 00:00:00 EDT 2021
Peroxisome Proliferator-Activated Receptor-Gamma Reduces ER Stress and Inflammation via Targeting NGBR Expression.
Frontiers in pharmacology
Ma J,Zeng P,Liu L,Zhu M,Zheng J,Wang C,Zhao X,Hu W,Yang X,Duan Y,Han J,Miao QR,Chen Y
Fri Feb 04 00:00:00 EST 2022
Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.
International journal of molecular sciences
Ji J,Wang Z,Sun W,Li Z,Cai H,Zhao E,Cui H
Tue Nov 09 00:00:00 EST 2021
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Acta biomaterialia
Ma S,Zhou J,Huang T,Zhang Z,Xing Q,Zhou X,Zhang K,Yao M,Cheng T,Wang X,Wen X,Guan F
Wed Sep 01 00:00:00 EDT 2021
Sulfiredoxin-1 protects retinal ganglion cells from high glucose-induced oxidative stress and inflammatory injury by potentiating Nrf2 signaling via the Akt/GSK-3β pathway.
International immunopharmacology
Zhu F,Shao J,Tian Y,Xu Z
Wed Dec 01 00:00:00 EST 2021
Baicalein Inhibits Gastric Cancer Cell Proliferation and Migration through a FAK Interaction via AKT/mTOR Signaling.
The American journal of Chinese medicine
Qiao D,Jin J,Xing J,Zhang Y,Jia N,Ren X,Lin Z,Jin N,Chen L,Piao Y
Thu Aug 26 00:00:00 EDT 2021
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
American journal of translational research
Deng L,Wu X,Zhu X,Yu Z,Liu Z,Wang J,Zheng Y
Wed Feb 03 00:00:00 EST 2021
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Chinese medicine
Wu C,Huang ZH,Meng ZQ,Fan XT,Lu S,Tan YY,You LM,Huang JQ,Stalin A,Ye PZ,Wu ZS,Zhang JY,Liu XK,Zhou W,Zhang XM,Wu JR
Mon Nov 22 00:00:00 EST 2021
Evodiamine Inhibits Gastric Cancer Cell Proliferation via PTEN-Mediated EGF/PI3K Signaling Pathway.
Evidence-based complementary and alternative medicine : eCAM
Yang R,Wen J,Yang T,Dai C,Zhao Y
Thu Apr 28 00:00:00 EDT 2022
KLF5-mediated Eppk1 expression promotes cell proliferation in cervical cancer via the p38 signaling pathway.
BMC cancer
Ma D,Pan Z,Chang Q,Zhang JJ,Liu X,Hua N,Li GH
Thu Apr 08 00:00:00 EDT 2021
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Cancer science
Du W,Gao A,Herman JG,Wang L,Zhang L,Jiao S,Guo M
Thu Jul 01 00:00:00 EDT 2021
Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer.
Cancer science
Du W,Gao A,Herman JG,Wang L,Zhang L,Jiao S,Guo M
Thu Jul 01 00:00:00 EDT 2021
Diosgenin From Dioscorea Nipponica Rhizoma Against Graves' Disease-On Network Pharmacology and Experimental Evaluation.
Frontiers in pharmacology
Xin J,Cheng W,Yu Y,Chen J,Zhang X,Shao S
Wed Feb 16 00:00:00 EST 2022
Exosomal circRNAs contribute to intestinal development via the VEGF signalling pathway in human term and preterm colostrum.
Aging
Zhou Y,Yu Z,Wang X,Chen W,Liu Y,Zhang Y,Yin J,Han S
Sun Apr 04 00:00:00 EDT 2021
6-gingerol protects nucleus pulposus-derived mesenchymal stem cells from oxidative injury by activating autophagy.
World journal of stem cells
Nan LP,Wang F,Liu Y,Wu Z,Feng XM,Liu JJ,Zhang L
Sat Dec 26 00:00:00 EST 2020
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Sun X,Yang S,Song W
Wed Apr 01 00:00:00 EDT 2020
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Journal of cellular biochemistry
Zheng Y,Nie P,Xu S
Mon Jun 01 00:00:00 EDT 2020
Dihydrotanshinone I inhibits ovarian cancer cell proliferation and migration by transcriptional repression of PIK3CA gene.
Journal of cellular and molecular medicine
Wang X,Xu X,Jiang G,Zhang C,Liu L,Kang J,Wang J,Owusu L,Zhou L,Zhang L,Li W
Thu Oct 01 00:00:00 EDT 2020
Diabetes mellitus is associated with liver metastasis of colorectal cancer through production of biglycan-rich cancer stroma.
Oncotarget
Fujiwara-Tani R,Sasaki T,Fujii K,Luo Y,Mori T,Kishi S,Mori S,Matsushima-Otsuka S,Nishiguchi Y,Goto K,Kawahara I,Kondoh M,Sho M,Kuniyasu H
Tue Aug 04 00:00:00 EDT 2020
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Cancer management and research
Xu F,Xu Y,Xiong JH,Zhang JH,Wu J,Luo J,Xiong JP
Wed Apr 13 00:00:00 EDT 2022
LETM1 Promotes Gastric Cancer Cell Proliferation, Migration, and Invasion via the PI3K/Akt Signaling Pathway.
Journal of gastric cancer
Zhang Y,Chen L,Cao Y,Chen S,Xu C,Xing J,Zhang K
Mon Jun 01 00:00:00 EDT 2020
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Amino acids
Wu P,Shi X,Luo M,Li K,Zhang M,Ma J,Li Y,Liu Y,Zhang C,Liu X,Li S,Li Q,Chen X,Che X,Piao F
Wed Jan 01 00:00:00 EST 2020
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
International immunopharmacology
Wu Y,Wang Z,Fu X,Lin Z,Yu K
Tue Sep 01 00:00:00 EDT 2020
Melatonin improves hypoxic-ischemic brain damage through the Akt/Nrf2/Gpx4 signaling pathway.
Brain research bulletin
Gou Z,Su X,Hu X,Zhou Y,Huang L,Fan Y,Li J,Lu L
Thu Oct 01 00:00:00 EDT 2020
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Experimental cell research
Song S,Qiu D,Wang Y,Wei J,Wu H,Wu M,Wang S,Zhou X,Shi Y,Duan H
Sun Mar 15 00:00:00 EDT 2020
TXNIP deficiency mitigates podocyte apoptosis via restraining the activation of mTOR or p38 MAPK signaling in diabetic nephropathy.
Experimental cell research
Song S,Qiu D,Wang Y,Wei J,Wu H,Wu M,Wang S,Zhou X,Shi Y,Duan H
Sun Mar 15 00:00:00 EDT 2020
DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.
Journal of cellular biochemistry
Gong FL,Wang L,Yu LG,Dang YF,Jiang XN,Zhao L,Guo XL
Tue Dec 01 00:00:00 EST 2020
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Endocrine pathology
Gucer H,Caliskan S,Kefeli M,Mete O
Sun Mar 01 00:00:00 EST 2020
Endosulfan promotes cell migration via PTP4A3-mediated signaling pathways in HUVECs.
Ecotoxicology and environmental safety
Li H,Liu S,Hu Y,Zhao B,Sun Y,Xu D
Wed Apr 01 00:00:00 EDT 2020
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Pathology, research and practice
Zhao L,Kong X,Zhong W,Wang Y,Li P
Tue Sep 01 00:00:00 EDT 2020
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
American journal of cancer research
Li Z,Zhou Z,Wu X,Zhou Q,Liao C,Liu Y,Li D,Shen L,Feng D,Yang L
Mon Sep 28 00:00:00 EDT 2020
S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome.
Pharmacological research
An L,Zhao J,Sun X,Zhou Y,Zhao Z
Tue Sep 01 00:00:00 EDT 2020
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Li T,Zhang L,Jin C,Xiong Y,Cheng YY,Chen K
Sun Nov 01 00:00:00 EDT 2020
Rutaecarpine Ameliorates Ethanol-Induced Gastric Mucosal Injury in Mice by Modulating Genes Related to Inflammation, Oxidative Stress and Apoptosis.
Frontiers in pharmacology
Ren S,Wei Y,Wang R,Wei S,Wen J,Yang T,Chen X,Wu S,Jing M,Li H,Wang M,Zhao Y
Thu Dec 17 00:00:00 EST 2020
Suppressive effect of Aurantii Fructus Immaturus and Atractylodis Macrocephalae Rhizoma on glutamic acid-induced autophagy of interstitial cells of Cajal.
Journal of integrative medicine
Yan S,Yue YZ,Sun MM,Wu BS,Wang XP
Wed Jul 01 00:00:00 EDT 2020
Metformin activates the STING/IRF3/IFN-β pathway by inhibiting AKT phosphorylation in pancreatic cancer.
American journal of cancer research
Ren D,Qin G,Zhao J,Sun Y,Zhang B,Li D,Wang B,Jin X,Wu H
Tue Oct 13 00:00:00 EDT 2020
The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
Experimental and therapeutic medicine
Luo C,Wang Y,Wei C,Chen Y,Ji Z
Wed Jan 01 00:00:00 EST 2020
Naringin alleviates H2O2-induced apoptosis via the PI3K/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells.
Connective tissue research
Nan LP,Wang F,Ran D,Zhou SF,Liu Y,Zhang Z,Huang ZN,Wang ZY,Wang JC,Feng XM,Zhang L
Sun Nov 01 00:00:00 EDT 2020
The parthenolide derivative ACT001 synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson's disease in mice.
Behavioural brain research
Liu Q,Zhang S,Zhu D,Tang X,Che Y,Feng X
Mon Feb 03 00:00:00 EST 2020
Kindlin‑2 suppresses cervical cancer cell migration through AKT/mTOR‑mediated autophagy induction.
Oncology reports
Wu G,Long Y,Lu Y,Feng Y,Yang X,Xu X,Yao D
Wed Jul 01 00:00:00 EDT 2020
Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway.
Cancer cell international
Wei B,Wang Y,Wang J,Cai X,Xu L,Wu J,Wang Y,Liu W,Gu Y,Guo W,Xu Q
Thu Apr 14 00:00:00 EDT 2022
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
Cancer cell international
An Y,Zhang J,Cheng X,Li B,Tian Y,Zhang X,Zhao F
Fri Apr 15 00:00:00 EDT 2022
Wnt5a/ROR1 activates DAAM1 and promotes the migration in osteosarcoma cells.
Oncology reports
Dai B,Shen Y,Yan T,Zhang A
Sat Feb 01 00:00:00 EST 2020
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Journal of experimental & clinical cancer research : CR
Liu JZ,Hu YL,Feng Y,Jiang Y,Guo YB,Liu YF,Chen X,Yang JL,Chen YY,Mao QS,Xue WJ
Tue Jun 30 00:00:00 EDT 2020
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Journal of experimental & clinical cancer research : CR
Liu JZ,Hu YL,Feng Y,Jiang Y,Guo YB,Liu YF,Chen X,Yang JL,Chen YY,Mao QS,Xue WJ
Tue Jun 30 00:00:00 EDT 2020
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Cancer management and research
Jing X,Chen Y,Chen Y,Shi G,Lv S,Cheng N,Feng C,Xin Z,Zhang L,Wu J
Wed Apr 13 00:00:00 EDT 2022
Serpina3c protects against high-fat diet-induced pancreatic dysfunction through the JNK-related pathway.
Cellular signalling
Ji JJ,Qian LL,Zhu Y,Wu YP,Guo JQ,Ma GS,Yao YY
Sun Nov 01 00:00:00 EDT 2020
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cellular signalling
Cooper LM,Hanson A,Kavanagh JA,Waddell DS
Mon Jun 01 00:00:00 EDT 2020
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Cell proliferation
Wang X,Liu M,Zhu MJ,Shi L,Liu L,Zhao YL,Cheng L,Gu YJ,Zhou MY,Chen L,Kumar A,Wang Y
Sun Mar 01 00:00:00 EST 2020
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Journal of ethnopharmacology
Li J,Ma J,Tian Y,Zhao P,Liu X,Dong H,Zheng W,Feng S,Zhang L,Wu M,Zhu L,Liu S,Zhao D
Wed Jul 15 00:00:00 EDT 2020
Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics.
Frontiers in pharmacology
Zhao F,Tao W,Shang Z,Zhang W,Ruan J,Zhang C,Zhou L,Aiello H,Lai H,Qu R
Thu Oct 01 00:00:00 EDT 2020
KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway.
Neoplasma
Liu XR,Wang W,Li HM
Tue Sep 01 00:00:00 EDT 2020
Ethanol extract of Ophiorrhiza pumila suppresses liver cancer cell proliferation and migration.
Chinese medicine
Liu H,Liao W,Fan L,Zheng Z,Liu D,Zhang QW,Yang A,Liu F
Tue Apr 12 00:00:00 EDT 2022
Platelet P-selectin initiates cross-presentation and dendritic cell differentiation in blood monocytes.
Science advances
Han P,Hanlon D,Arshad N,Lee JS,Tatsuno K,Robinson E,Filler R,Sobolev O,Cote C,Rivera-Molina F,Toomre D,Fahmy T,Edelson R
Sun Mar 01 00:00:00 EST 2020
Exploration of the Effects of Substrate Stiffness on Biological Responses of Neural Cells and Their Mechanisms.
ACS omega
Zhang C,Tan Y,Feng J,Huang C,Liu B,Fan Z,Xu B,Lu T
Tue Dec 08 00:00:00 EST 2020
NCOA5 is a master regulator of amino acid-induced mTOR activation and β-casein synthesis in bovine mammary epithelial cells.
Biochemical and biophysical research communications
Yuan X,Zhang L,Cui Y,Yu Y,Gao X,Ao J
Thu Aug 27 00:00:00 EDT 2020
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Animals : an open access journal from MDPI
Zhao Y,Lin Z,Lin Z,Zhou C,Liu G,Lin J,Zhang D,Lin D
Sun Dec 27 00:00:00 EST 2020
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Animals : an open access journal from MDPI
Zhao Y,Lin Z,Lin Z,Zhou C,Liu G,Lin J,Zhang D,Lin D
Sun Dec 27 00:00:00 EST 2020
METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway.
Oncology letters
Liang S,Guan H,Lin X,Li N,Geng F,Li J
Wed Apr 01 00:00:00 EDT 2020
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
International journal of molecular medicine
Jiang ZH,Tang YZ,Song HN,Yang M,Li B,Ni CL
Wed Jan 01 00:00:00 EST 2020
AMPH1 functions as a tumour suppressor in ovarian cancer via the inactivation of PI3K/AKT pathway.
Journal of cellular and molecular medicine
Chen Y,Cao W,Wang L,Zhong T
Wed Jul 01 00:00:00 EDT 2020
lncRNA PVT1 Promotes Tumorigenesis of Colorectal Cancer by Stabilizing miR-16-5p and Interacting with the VEGFA/VEGFR1/AKT Axis.
Molecular therapy. Nucleic acids
Wu H,Wei M,Jiang X,Tan J,Xu W,Fan X,Zhang R,Ding C,Zhao F,Shao X,Zhang Z,Shi R,Zhang W,Wu G
Fri Jun 05 00:00:00 EDT 2020
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Cancer biotherapy & radiopharmaceuticals
Zhan D,Zhang X,Li J,Ding X,Cui Y,Jia J
Wed Apr 01 00:00:00 EDT 2020
LHPP suppresses proliferation, migration, and invasion and promotes apoptosis in pancreatic cancer.
Bioscience reports
Wu F,Chen Y,Zhu J
Fri Mar 27 00:00:00 EDT 2020
Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors.
Cell death & disease
Ma Z,Liu K,Li XR,Wang C,Liu C,Yan DY,Deng Y,Liu W,Xu B
Thu Oct 08 00:00:00 EDT 2020
RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.
Carcinogenesis
Huang G,Song C,Wang N,Qin T,Sui S,Obr A,Zeng L,Wood TL,Leroith D,Li M,Wu Y
Thu Sep 24 00:00:00 EDT 2020
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu J,Shangguan Y,Sun J,Cong W,Xie Y
Tue Sep 01 00:00:00 EDT 2020
Pea-derived peptides, VLP, LLP, VA, and LL, improve insulin resistance in HepG2 cells via activating IRS-1/PI3K/AKT and blocking ROS-mediated p38MAPK signaling.
Journal of food biochemistry
Zhu Y,Zhang H,Wei Y,Cai M,Gu R,Wang Y,Ma Y,Chen L
Sun Nov 01 00:00:00 EDT 2020
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
American journal of translational research
Chen L,Peng J,Wang Y,Jiang H,Wang W,Dai J,Tang M,Wei Y,Kuang H,Xu G,Xu H,Zhou F
Mon Sep 28 00:00:00 EDT 2020
The roles of SHANK1 in the development of colon cancer.
Cell biochemistry and function
Wang L,Lv Y,Liu G
Wed Jul 01 00:00:00 EDT 2020
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Technology in cancer research & treatment
Zhu Y,Shi F,Wang M,Ding J
Fri Nov 20 00:00:00 EST 2020
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Journal of cell science
Hua R,Zhang X,Li W,Lian W,Liu Q,Gao D,Wang Y,Lei M
Wed Dec 09 00:00:00 EST 2020
Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Cancer letters
Guo SS,Liu R,Wen YF,Liu LT,Yuan L,Li YX,Li Y,Hao WW,Peng JY,Chen DN,Tang QN,Sun XS,Guo L,Mo HY,Qian CN,Zeng MS,Bei JX,Sun SY,Chen QY,Tang LQ,Mai HQ
Wed Jan 01 00:00:00 EST 2020
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Molecular medicine reports
Cui H,Cheng Y,He Y,Cheng W,Zhao W,Zhao H,Zhou FH,Wang L,Dong J,Cai S
Sun Nov 01 00:00:00 EDT 2020
The AKT inhibitor MK2206 suppresses airway inflammation and the pro‑remodeling pathway in a TDI‑induced asthma mouse model.
Molecular medicine reports
Cui H,Cheng Y,He Y,Cheng W,Zhao W,Zhao H,Zhou FH,Wang L,Dong J,Cai S
Sun Nov 01 00:00:00 EDT 2020
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Tan XH,Zhang KK,Xu JT,Qu D,Chen LJ,Li JH,Wang Q,Wang HJ,Xie XL
Sun Mar 01 00:00:00 EST 2020
SPANXN2 functions a cell migration inhibitor in testicular germ cell tumor cells.
PeerJ
Zhu F,Bo H,Liu G,Li R,Liu Z,Fan L
Fri Apr 15 00:00:00 EDT 2022
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Cell death & disease
Zhao R,Tian L,Zhao B,Sun Y,Cao J,Chen K,Li F,Li M,Shang D,Liu M
Fri Apr 24 00:00:00 EDT 2020
FADS1 promotes the progression of laryngeal squamous cell carcinoma through activating AKT/mTOR signaling.
Cell death & disease
Zhao R,Tian L,Zhao B,Sun Y,Cao J,Chen K,Li F,Li M,Shang D,Liu M
Fri Apr 24 00:00:00 EDT 2020
Proanthocyanidin B2 inhibits proliferation and induces apoptosis of osteosarcoma cells by suppressing the PI3K/AKT pathway.
Journal of cellular and molecular medicine
Wu X,Yu H,Zhou H,Li Z,Huang H,Xiao F,Xu S,Yang Y
Thu Oct 01 00:00:00 EDT 2020
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
BioMed research international
Jing X,Du L,Niu A,Wang Y,Wang Y,Wang C
Fri Jan 29 00:00:00 EST 2021
RPL38 Regulates the Proliferation and Apoptosis of Gastric Cancer via miR-374b-5p/VEGF Signal Pathway.
OncoTargets and therapy
Ji H,Zhang X
Thu Aug 25 00:00:00 EDT 2022
TGF‑β1 induces CREB1‑mediated miR‑1290 upregulation to antagonize lung fibrosis via Napsin A.
International journal of molecular medicine
Guan S,Wu Y,Zhang Q,Zhou J
Wed Jul 01 00:00:00 EDT 2020
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Human & experimental toxicology
Chen M,Zhu LL,Su JL,Li GL,Wang J,Zhang YN
Sat Feb 01 00:00:00 EST 2020
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Biology open
Yang ZY,Yang L,Xu CW,Wang XJ,Lei L
Fri Jan 24 00:00:00 EST 2020
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Biology open
Yang ZY,Yang L,Xu CW,Wang XJ,Lei L
Fri Jan 24 00:00:00 EST 2020
Fluid shear stress induces Runx-2 expression via upregulation of PIEZO1 in MC3T3-E1 cells.
Cell biology international
Song J,Liu L,Lv L,Hu S,Tariq A,Wang W,Dang X
Wed Jul 01 00:00:00 EDT 2020
ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway.
PeerJ
Luo J,Zeng B,Tao C,Lu M,Ren G
Wed Apr 13 00:00:00 EDT 2022
LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN.
Histology and histopathology
Li Y,Zhang M,Li F
Thu Oct 01 00:00:00 EDT 2020
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.
Redox biology
Xu F,Guo M,Huang W,Feng L,Zhu J,Luo K,Gao J,Zheng B,Kong LD,Pang T,Wu X,Xu Q
Tue Sep 01 00:00:00 EDT 2020
Activation of BDNF/TrkB pathway promotes prostate cancer progression via induction of epithelial-mesenchymal transition and anoikis resistance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li T,Yu Y,Song Y,Li X,Lan D,Zhang P,Xiao Y,Xing Y
Wed Jul 01 00:00:00 EDT 2020
HPV16 E6/E7 promote the translocation and glucose uptake of GLUT1 by PI3K/AKT pathway via relieving miR-451 inhibitory effect on CAB39 in lung cancer cells.
Therapeutic advances in chronic disease
Wang HM,Lu YJ,He L,Gu NJ,Wang SY,Qiu XS,Wang EH,Wu GP
Sun Apr 17 00:00:00 EDT 2022
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Journal of hazardous materials
Wang C,Le Y,Lu D,Zhao M,Dou X,Zhang Q
Wed Apr 15 00:00:00 EDT 2020
Pyrroline-5-carboxylate reductase 1 (PYCR1) upregulation contributes to gastric cancer progression and indicates poor survival outcome.
Annals of translational medicine
Xiao S,Li S,Yuan Z,Zhou L
Sat Aug 01 00:00:00 EDT 2020
miR‑96 exerts an oncogenic role in the progression of cervical cancer by targeting CAV‑1.
Molecular medicine reports
Chen Y,Liu C,Xie B,Chen S,Zhuang Y,Zhang S
Wed Jul 01 00:00:00 EDT 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Eurocristatine, a plant alkaloid from Eurotium cristatum, alleviates insulin resistance in db/db diabetic mice via activation of PI3K/AKT signaling pathway.
European journal of pharmacology
Zhang H,Hui J,Yang J,Deng J,Fan D
Sun Nov 15 00:00:00 EST 2020
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
The Journal of endocrinology
You B,Dun Y,Zhang W,Jiang L,Li H,Xie M,Liu Y,Liu S
Sat Feb 01 00:00:00 EST 2020
Therapeutic effect of GLP-1 engineered strain on mice model of Alzheimer's disease and Parkinson's disease.
AMB Express
Fang X,Zhou X,Miao Y,Han Y,Wei J,Chen T
Fri Apr 24 00:00:00 EDT 2020
Tumor-Derived EV-Encapsulated miR-181b-5p Induces Angiogenesis to Foster Tumorigenesis and Metastasis of ESCC.
Molecular therapy. Nucleic acids
Wang Y,Lu J,Chen L,Bian H,Hu J,Li D,Xia C,Xu H
Fri Jun 05 00:00:00 EDT 2020
Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.
Molecular therapy. Nucleic acids
Guo Q,Wang T,Yang Y,Gao L,Zhao Q,Zhang W,Xi T,Zheng L
Fri Sep 04 00:00:00 EDT 2020
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Oncology reports
Yan X,Yang C,Hu W,Chen T,Wang Q,Pan F,Qiu B,Tang B
Wed Jul 01 00:00:00 EDT 2020
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu YC,Tsai JJ,Weng YS,Hsu FT
Sat Aug 01 00:00:00 EDT 2020
Regorafenib suppresses epidermal growth factor receptor signaling-modulated progression of colorectal cancer.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu YC,Tsai JJ,Weng YS,Hsu FT
Sat Aug 01 00:00:00 EDT 2020
Prenatal High-Salt Diet-Induced Metabolic Disorders via Decreasing Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring.
Molecular nutrition & food research
Liu Y,Yang C,Feng X,Qi L,Guo J,Zhu D,Thai PN,Zhang Y,Zhang P,Sun M,Lv J,Zhang L,Xu Z,Lu X
Wed Jul 01 00:00:00 EDT 2020
Vascular Smooth Muscle FTO Promotes Aortic Dissecting Aneurysms via m6A Modification of Klf5.
Frontiers in cardiovascular medicine
Ma D,Liu X,Zhang JJ,Zhao JJ,Xiong YJ,Chang Q,Wang HY,Su P,Meng J,Zhao YB
Fri Dec 18 00:00:00 EST 2020
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
BioMed research international
Tian R,Jiang H,Shao L,Yu Y,Guo Q,Cao B,Guo S
Wed Mar 31 00:00:00 EDT 2021
Overexpression of Ubiquitin-Specific Protease 2 (USP2) in the Heart Suppressed Pressure Overload-Induced Cardiac Remodeling.
Mediators of inflammation
Xing J,Li P,Hong J,Wang M,Liu Y,Gao Y,Dong J,Gu H,Li L
Mon Aug 02 00:00:00 EDT 2021
Berberine inhibits proliferation and induces G0/G1 phase arrest in colorectal cancer cells by downregulating IGF2BP3.
Life sciences
Zhang Y,Liu X,Yu M,Xu M,Xiao Y,Ma W,Huang L,Li X,Ye X
Sun Nov 01 00:00:00 EDT 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Clinical epigenetics
Liu Y,Zhang M,He T,Yang W,Wang L,Zhang L,Guo M
Mon Feb 10 00:00:00 EST 2020
Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Li D,Lv B,Wang D,Xu D,Qin S,Zhang Y,Chen J,Zhang W,Zhang Z,Xu F
Wed Jul 01 00:00:00 EDT 2020
Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Li D,Lv B,Wang D,Xu D,Qin S,Zhang Y,Chen J,Zhang W,Zhang Z,Xu F
Wed Jul 01 00:00:00 EDT 2020
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Life sciences
Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z
Wed Jul 15 00:00:00 EDT 2020
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Life sciences
Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z
Wed Jul 15 00:00:00 EDT 2020
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Life sciences
Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z
Wed Jul 15 00:00:00 EDT 2020
MiR-455-3p reduces apoptosis and alleviates degeneration of chondrocyte through regulating PI3K/AKT pathway.
Life sciences
Wen X,Li H,Sun H,Zeng A,Lin R,Zhao J,Zhang Z
Wed Jul 15 00:00:00 EDT 2020
Calcium Channel Blocker Nifedipine Suppresses Colorectal Cancer Progression and Immune Escape by Preventing NFAT2 Nuclear Translocation.
Cell reports
Wu L,Lin W,Liao Q,Wang H,Lin C,Tang L,Lian W,Chen Z,Li K,Xu L,Zhou R,Ding Y,Zhao L
Tue Oct 27 00:00:00 EDT 2020
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer's disease models.
The journal of physiological sciences : JPS
Zhang H,Wang X,Xu P,Ji X,Chi T,Liu P,Zou L
Tue Jun 09 00:00:00 EDT 2020
Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain.
Journal of neuroinflammation
Li T,Liu T,Chen X,Li L,Feng M,Zhang Y,Wan L,Zhang C,Yao W
Tue Jul 14 00:00:00 EDT 2020
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
Theranostics
Jiang W,Li H,Liu X,Zhang J,Zhang W,Li T,Liu L,Yu X
Tue Jun 01 00:00:00 EDT 2021
Precise and efficient silencing of mutant KrasG12D by CRISPR-CasRx controls pancreatic cancer progression.
Theranostics
Jiang W,Li H,Liu X,Zhang J,Zhang W,Li T,Liu L,Yu X
Tue Jun 01 00:00:00 EDT 2021
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Feng AL,Han X,Meng X,Chen Z,Li Q,Shu W,Dai H,Zhu J,Yang Z
Thu Oct 01 00:00:00 EDT 2020
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Oxidative medicine and cellular longevity
Meng X,Zhang C,Guo Y,Han Y,Wang C,Chu H,Kong L,Ma H
Thu Feb 04 00:00:00 EST 2021
VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling.
Cancer letters
Zhou Z,Zhou Q,Wu X,Xu S,Hu X,Tao X,Li B,Peng J,Li D,Shen L,Cao Y,Yang L
Tue Mar 31 00:00:00 EDT 2020
VCAM-1 secreted from cancer-associated fibroblasts enhances the growth and invasion of lung cancer cells through AKT and MAPK signaling.
Cancer letters
Zhou Z,Zhou Q,Wu X,Xu S,Hu X,Tao X,Li B,Peng J,Li D,Shen L,Cao Y,Yang L
Tue Mar 31 00:00:00 EDT 2020
Protective effect of astaxanthin against La2O3 nanoparticles induced neurotoxicity by activating PI3K/AKT/Nrf-2 signaling in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yuan L,Qu Y,Li Q,An T,Chen Z,Chen Y,Deng X,Bai D
Thu Oct 01 00:00:00 EDT 2020
Curcumin metabolites contribute to the effect of curcumin on ameliorating insulin sensitivity in high-glucose-induced insulin-resistant HepG2 cells.
Journal of ethnopharmacology
Li P,Ding L,Cao S,Feng X,Zhang Q,Chen Y,Zhang N,Qiu F
Tue Sep 15 00:00:00 EDT 2020
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
Gene
Labuzan SA,Lynch SA,Cooper LM,Waddell DS
Wed May 20 00:00:00 EDT 2020
ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
Biochimica et biophysica acta. Molecular cell research
Gou W,Li Z,Xu X,Shen J,Guo M,Zhou X,Zhang X,Wu Y,Zhai X,Zuo D
Wed Jul 01 00:00:00 EDT 2020
Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival.
Cells
Su YL,Luo HL,Huang CC,Liu TT,Huang EY,Sung MT,Lin JJ,Chiang PH,Chen YT,Kang CH,Cheng YT
Thu Mar 26 00:00:00 EDT 2020
Long non-coding RNA LPP-AS2 promotes glioma tumorigenesis via miR-7-5p/EGFR/PI3K/AKT/c-MYC feedback loop.
Journal of experimental & clinical cancer research : CR
Zhang X,Niu W,Mu M,Hu S,Niu C
Tue Sep 22 00:00:00 EDT 2020
MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury.
Life sciences
Yan Z,Zang B,Gong X,Ren J,Wang R
Wed Jan 15 00:00:00 EST 2020
Knockdown of lncRNA OGFRP1 Inhibits Proliferation and Invasion of JEG-3 Cells Via AKT/mTOR Pathway.
Technology in cancer research & treatment
Meng Q,Xue H
Mon Sep 21 00:00:00 EDT 2020
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Aging
Dai H,Li M,Yang W,Sun X,Wang P,Wang X,Su J,Wang X,Hu X,Zhao M
Fri Jun 12 00:00:00 EDT 2020
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Translational cancer research
Jiang L,He C,Zhang X,Chen Y,Li G
Sun Mar 01 00:00:00 EST 2020
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Cell biochemistry and function
Yang ZH,Li J,Chen WZ,Kong FS
Thu Oct 01 00:00:00 EDT 2020
Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis.
Cancer science
Shi Y,Fang N,Li Y,Guo Z,Jiang W,He Y,Ma Z,Chen Y
Sat Aug 01 00:00:00 EDT 2020
Phosphatidylinositol 4-kinase β is required for the ciliogenesis of zebrafish otic vesicle.
Journal of genetics and genomics = Yi chuan xue bao
Feng Y,Yu P,Li J,Cao Y,Zhang J
Tue Oct 20 00:00:00 EDT 2020
FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.
Journal of cellular and molecular medicine
Chen R,Li D,Zheng M,Chen B,Wei T,Wang Y,Li M,Huang W,Tong Q,Wang Q,Zhu Y,Fang W,Guo L,Fang S
Sat Feb 01 00:00:00 EST 2020
Transcriptomic Analysis of Glycolysis-Related Genes Reveals an Independent Signature of Bladder Carcinoma.
Frontiers in genetics
Mou Z,Yang C,Zhang Z,Wu S,Xu C,Cheng Z,Dai X,Chen X,Ou Y,Jiang H
Tue Apr 19 00:00:00 EDT 2022
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma.
BioMed research international
Jiang H,Guo W,Yuan S,Song L
Thu May 06 00:00:00 EDT 2021
Daucosterol linolenate from Sweet Potato Suppresses MCF7-Xenograft-Tumor Growth through Regulating PI3K/AKT Pathway.
Planta medica
Han B,Jiang L,Jiang P,Zhou D,Jia X,Li X,Ye X
Wed Jul 01 00:00:00 EDT 2020
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Molecular medicine reports
Chen X,Ji S,Si J,Zhang X,Wang X,Guo Y,Zou X
Tue Dec 01 00:00:00 EST 2020
Kp-10 promotes bovine mammary epithelial cell proliferation by activating GPR54 and its downstream signaling pathways.
Journal of cellular physiology
Li Y,Cao Y,Wang J,Fu S,Cheng J,Ma L,Zhang Q,Guo W,Kan X,Liu J
Fri May 01 00:00:00 EDT 2020
Tianma Gouteng Decoction Exerts Cardiovascular Protection by Upregulating OPG and TRAIL in Spontaneously Hypertensive Rats.
Evidence-based complementary and alternative medicine : eCAM
Deng LH,Li L,Zhai Y,Michael S,Yang CY,Guo R,Chen SF,Fan GW,Zhao YQ,Liu W
Tue Nov 03 00:00:00 EST 2020
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Oncogene
Sun B,Zhao X,Ming J,Liu X,Liu D,Jiang C
Thu Aug 01 00:00:00 EDT 2019
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Neural regeneration research
Li XG,Du JH,Lu Y,Lin XJ
Mon Apr 01 00:00:00 EDT 2019
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Neural regeneration research
Li XG,Du JH,Lu Y,Lin XJ
Mon Apr 01 00:00:00 EDT 2019
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Neural regeneration research
Li XG,Du JH,Lu Y,Lin XJ
Mon Apr 01 00:00:00 EDT 2019
Neuroprotective effects of rapamycin on spinal cord injury in rats by increasing autophagy and Akt signaling.
Neural regeneration research
Li XG,Du JH,Lu Y,Lin XJ
Mon Apr 01 00:00:00 EDT 2019
Interaction of estrogen receptor β5 and interleukin 6 receptor in the progression of non-small cell lung cancer.
Journal of cellular biochemistry
Tang H,Bai Y,Xiong L,Zhang L,Wei Y,Zhu M,Wu X,Long D,Yang J,Yu L,Xu S,Zhao J
Fri Feb 01 00:00:00 EST 2019
Interaction of estrogen receptor β5 and interleukin 6 receptor in the progression of non-small cell lung cancer.
Journal of cellular biochemistry
Tang H,Bai Y,Xiong L,Zhang L,Wei Y,Zhu M,Wu X,Long D,Yang J,Yu L,Xu S,Zhao J
Fri Feb 01 00:00:00 EST 2019
Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression.
Journal of cellular biochemistry
Yuquan B,Hexiao T,Laiyi W,Gaofeng P,Xuefeng Z,Ming X,Yanhong W,Li Z,Jinping Z
Tue Jan 01 00:00:00 EST 2019
Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression.
Journal of cellular biochemistry
Yuquan B,Hexiao T,Laiyi W,Gaofeng P,Xuefeng Z,Ming X,Yanhong W,Li Z,Jinping Z
Tue Jan 01 00:00:00 EST 2019
Combined detection of estrogen and tumor markers is an important reference factor in the diagnosis and prognosis of lung cancer.
Journal of cellular biochemistry
Bai Y,Shen W,Zhu M,Zhang L,Wei Y,Tang H,Zhao J
Tue Jan 01 00:00:00 EST 2019
Combined detection of estrogen and tumor markers is an important reference factor in the diagnosis and prognosis of lung cancer.
Journal of cellular biochemistry
Bai Y,Shen W,Zhu M,Zhang L,Wei Y,Tang H,Zhao J
Tue Jan 01 00:00:00 EST 2019
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Cell biology international
Zhang X,Liu J,Gu Y,Sun C,Qu F
Fri Feb 01 00:00:00 EST 2019
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Cell biology international
Zhang X,Liu J,Gu Y,Sun C,Qu F
Fri Feb 01 00:00:00 EST 2019
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Human pathology
Wang Y,Piao J,Wang Q,Cui X,Meng Z,Jin T,Lin Z
Mon Apr 01 00:00:00 EDT 2019
Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma.
Human pathology
Wang Y,Piao J,Wang Q,Cui X,Meng Z,Jin T,Lin Z
Mon Apr 01 00:00:00 EDT 2019
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Biochemical and biophysical research communications
Zhang Y,Li Q,Yu S,Zhu C,Zhang Z,Cao H,Xu J
Tue Feb 12 00:00:00 EST 2019
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Biochemical and biophysical research communications
Zhang Y,Li Q,Yu S,Zhu C,Zhang Z,Cao H,Xu J
Tue Feb 12 00:00:00 EST 2019
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Cardiovascular toxicology
Wan GX,Cheng L,Qin HL,Zhang YZ,Wang LY,Zhang YG
Sat Jun 01 00:00:00 EDT 2019
MiR-15b-5p is Involved in Doxorubicin-Induced Cardiotoxicity via Inhibiting Bmpr1a Signal in H9c2 Cardiomyocyte.
Cardiovascular toxicology
Wan GX,Cheng L,Qin HL,Zhang YZ,Wang LY,Zhang YG
Sat Jun 01 00:00:00 EDT 2019
VEGF Induce Vasculogenic Mimicry of Choroidal Melanoma through the PI3k Signal Pathway.
BioMed research international
Xu X,Zong Y,Gao Y,Sun X,Zhao H,Luo W,Jia S
Thu Jan 02 00:00:00 EST 2020
Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway.
Experimental cell research
Li K,Shi X,Luo M,Wu P,Zhang M,Zhang C,Li Q,Wang Y,Piao F
Tue Oct 15 00:00:00 EDT 2019
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
British journal of pharmacology
Mao Z,Han X,Chen D,Xu Y,Xu L,Yin L,Sun H,Qi Y,Fang L,Liu K,Peng J
Mon Apr 01 00:00:00 EDT 2019
Astragaloside IV Regulates the PI3K/Akt/HO-1 Signaling Pathway and Inhibits H9c2 Cardiomyocyte Injury Induced by Hypoxia-Reoxygenation.
Biological & pharmaceutical bulletin
Yang P,Zhou Y,Xia Q,Yao L,Chang X
Wed May 01 00:00:00 EDT 2019
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Translational cancer research
Geng F,Fan MJ,Li J,Liang SM,Li CY,Li N
Tue Oct 01 00:00:00 EDT 2019
The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells.
American journal of physiology. Endocrinology and metabolism
Fujimoto BA,Young M,Carter L,Pang APS,Corley MJ,Fogelgren B,Polgar N
Sun Dec 01 00:00:00 EST 2019
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway.
Frontiers in pharmacology
Lin J,Jiao A,Lv W,Zhang C,Shi Y,Yang Z,Sun N,Li X,Zhang J
Tue Sep 29 00:00:00 EDT 2020
Brain-derived neurotrophic factor induces thioredoxin-1 expression through TrkB/Akt/CREB pathway in SH-SY5Y cells.
Biochimie
Bai L,Zhang S,Zhou X,Li Y,Bai J
Wed May 01 00:00:00 EDT 2019
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Brain : a journal of neurology
Zhu BL,Long Y,Luo W,Yan Z,Lai YJ,Zhao LG,Zhou WH,Wang YJ,Shen LL,Liu L,Deng XJ,Wang XF,Sun F,Chen GJ
Tue Jan 01 00:00:00 EST 2019
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
Cancer cell international
Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S
Fri Apr 08 00:00:00 EDT 2022
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
Cancer cell international
Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S
Fri Apr 08 00:00:00 EDT 2022
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Frontiers in physiology
Yang Z,Huang C,Wu Y,Chen B,Zhang W,Zhang J
Thu Oct 01 00:00:00 EDT 2020
Dynasore suppresses cell proliferation, migration, and invasion and enhances the antitumor capacity of cisplatin via STAT3 pathway in osteosarcoma.
Cell death & disease
Zhong B,Shi D,Wu F,Wang S,Hu H,Cheng C,Qing X,Huang X,Luo X,Zhang Z,Shao Z
Wed Sep 18 00:00:00 EDT 2019
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
BioMed research international
Ma Q,Gao Y,Xu P,Li K,Xu X,Gao J,Qi Y,Xu J,Yang Y,Song W,He X,Liu S,Yuan X,Yin W,He Y,Pan W,Wei L,Zhang J
Thu Aug 15 00:00:00 EDT 2019
Atorvastatin Inhibits Breast Cancer Cells by Downregulating PTEN/AKT Pathway via Promoting Ras Homolog Family Member B (RhoB).
BioMed research international
Ma Q,Gao Y,Xu P,Li K,Xu X,Gao J,Qi Y,Xu J,Yang Y,Song W,He X,Liu S,Yuan X,Yin W,He Y,Pan W,Wei L,Zhang J
Thu Aug 15 00:00:00 EDT 2019
Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by suppressing PI3K /Akt/mTOR pathway.
Experimental cell research
Liu JZ,Hu YL,Feng Y,Guo YB,Liu YF,Yang JL,Mao QS,Xue WJ
Sun Dec 15 00:00:00 EST 2019
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Experimental cell research
Wu Y,Tan X,Liu P,Yang Y,Huang Y,Liu X,Meng X,Yu B,Wu M,Jin H
Sat Jun 01 00:00:00 EDT 2019
Overexpressed MAGP1 Is Associated With a Poor Prognosis and Promotes Cell Migration and Invasion in Gastric Cancer.
Frontiers in oncology
Wu M,Ding Y,Jiang X,Chen Y,Wu N,Li L,Wang H,Huang Y,Xu N,Teng L
Mon Sep 28 00:00:00 EDT 2020
miR-96-5p promotes the proliferation and migration of ovarian cancer cells by suppressing Caveolae1.
Journal of ovarian research
Liu B,Zhang J,Yang D
Sat Jun 22 00:00:00 EDT 2019
Filamin A regulates EGFR/ERK/Akt signaling and affects colorectal cancer cell growth and migration.
Molecular medicine reports
Wang K,Zhu TN,Zhao RJ
Tue Oct 01 00:00:00 EDT 2019
Metformin reverses the schizophrenia-like behaviors induced by MK-801 in rats.
Brain research
Wang X,Luo C,Mao XY,Li X,Yin JY,Zhang W,Zhou HH,Liu ZQ
Sun Sep 15 00:00:00 EDT 2019
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Experimental and therapeutic medicine
Li F,Wu JT,Wang PF,Qu LZ
Tue Oct 01 00:00:00 EDT 2019
Resveratrol prevents chronic intermittent hypoxia-induced cardiac hypertrophy by targeting the PI3K/AKT/mTOR pathway.
Life sciences
Guan P,Sun ZM,Wang N,Zhou J,Luo LF,Zhao YS,Ji ES
Sun Sep 15 00:00:00 EDT 2019
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Biological research
Li L,Liu M,Zhang Z,Zhang W,Liu N,Sheng X,Wei P
Wed Feb 27 00:00:00 EST 2019
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Cancer management and research
Ma Y,Guan L,Han Y,Zhou Y,Li X,Liu Y,Zhang X,Zhang W,Li X,Wang S,Lu W
Thu Oct 01 00:00:00 EDT 2020
Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.
International journal of biological macromolecules
Hu HY,Yu CH,Zhang HH,Zhang SZ,Yu WY,Yang Y,Chen Q
Mon Jul 01 00:00:00 EDT 2019
Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.
Molecular cancer
Lu Q,Liu T,Feng H,Yang R,Zhao X,Chen W,Jiang B,Qin H,Guo X,Liu M,Li L,Guo H
Sat Jun 22 00:00:00 EDT 2019
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Medical science monitor : international medical journal of experimental and clinical research
Chen L,Yang G,Dong H
Thu Jan 03 00:00:00 EST 2019
Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway.
Medical science monitor : international medical journal of experimental and clinical research
Chen L,Yang G,Dong H
Thu Jan 03 00:00:00 EST 2019
IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart.
Oxidative medicine and cellular longevity
Gong Y,Yang J,Liu Q,Cai J,Zheng Y,Zhang Y,Yu D,Liu H,Zhang Z
Mon Jun 29 00:00:00 EDT 2020
Structural Characterization and Antioxidant Activity of Polysaccharides from Athyrium multidentatum (Doll.) Ching in d-Galactose-Induced Aging Mice via PI3K/AKT Pathway.
Molecules (Basel, Switzerland)
Jing L,Jiang JR,Liu DM,Sheng JW,Zhang WF,Li ZJ,Wei LY
Mon Sep 16 00:00:00 EDT 2019
Paeonol induces cytoprotective autophagy via blocking the Akt/mTOR pathway in ovarian cancer cells.
Cell death & disease
Gao L,Wang Z,Lu D,Huang J,Liu J,Hong L
Tue Aug 13 00:00:00 EDT 2019
Retinol binding protein 4 mediates MEHP-induced glucometabolic abnormalities in HepG2 cells.
Toxicology
Wang F,Chang C,Li R,Zhang Z,Jiang H,Zeng N,Li D,Chen L,Xiao Y,Chen W,Wang Q
Thu Aug 01 00:00:00 EDT 2019
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Molecular medicine reports
Yue G,Chen C,Bai L,Wang G,Huang Y,Wang Y,Cui H,Xiao Y
Fri Nov 01 00:00:00 EDT 2019
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Cancer cell international
Zhang C,Wang B,Wang X,Sheng X,Cui Y
Tue Apr 12 00:00:00 EDT 2022
DpdtbA-Induced Growth Inhibition in Human Esophageal Cancer Cells Involved Inactivation of the p53/EGFR/AKT Pathway.
Oxidative medicine and cellular longevity
Wang Z,Li C,Li Y,Guo X,Yan Z,Gao F,Li C
Fri Feb 21 00:00:00 EST 2020
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
Cancer medicine
Cao Z,Ji J,Zhang C,Wang F,Xu H,Yu Y,Sun Y
Fri Mar 01 00:00:00 EST 2019
Palmitic Acid Induces MicroRNA-221 Expression to Decrease Glucose Uptake in HepG2 Cells via the PI3K/AKT/GLUT4 Pathway.
BioMed research international
Huang F,Chen J,Wang J,Zhu P,Lin W
Mon Apr 20 00:00:00 EDT 2020
A New Possible Mechanism by Which Punicalagin Protects against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the Akt/FoxO3a Signaling Pathway.
Journal of agricultural and food chemistry
Zhang Y,Cao Y,Chen J,Qin H,Yang L
Wed Dec 18 00:00:00 EST 2019
Identification of UGP2 as a progression marker that promotes cell growth and motility in human glioma.
Journal of cellular biochemistry
Zeng C,Xing W,Liu Y
Thu Aug 01 00:00:00 EDT 2019
CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK½/mTOR signaling pathways in oral squamous cell carcinomas.
Cell death & disease
Gao L,Dou ZC,Ren WH,Li SM,Liang X,Zhi KQ
Thu Oct 03 00:00:00 EDT 2019
Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway.
International journal of clinical and experimental pathology
Zeng J,Li X,Cheng Y,Ke B,Wang R
Fri Jan 17 00:00:00 EST 2020
Hydroxychloroquine Improves Obesity-Associated Insulin Resistance and Hepatic Steatosis by Regulating Lipid Metabolism.
Frontiers in pharmacology
Qiao X,Zhou ZC,Niu R,Su YT,Sun Y,Liu HL,Teng JL,Ye JN,Shi H,Yang CD,Cheng XB
Tue Sep 29 00:00:00 EDT 2020
Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis.
Cellular and molecular gastroenterology and hepatology
Quilichini E,Fabre M,Dirami T,Stedman A,De Vas M,Ozguc O,Pasek RC,Cereghini S,Morillon L,Guerra C,Couvelard A,Gannon M,Haumaitre C
Mon Jul 20 00:00:00 EDT 2020
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Technology in cancer research & treatment
Liu C,Wang X,Zhang Y
Tue Jan 01 00:00:00 EST 2019
Ectopic expression of miR-944 impairs colorectal cancer cell proliferation and invasion by targeting GATA binding protein 6.
Journal of cellular and molecular medicine
Tang JT,Zhao J,Sheng W,Zhou JP,Dong Q,Dong M
Wed May 01 00:00:00 EDT 2019
Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout.
Journal of immunology (Baltimore, Md. : 1950)
Yu Y,Yang J,Fu S,Xue Y,Liang M,Xuan D,Zhu X,Wan W,Lv L,Zou H
Wed May 01 00:00:00 EDT 2019
Oroxin B Induces Apoptosis by Down-Regulating MicroRNA-221 Resulting in the Inactivation of the PTEN/PI3K/AKT Pathway in Liver Cancer.
Molecules (Basel, Switzerland)
Li N,Men W,Zheng Y,Wang H,Meng X
Sat Nov 30 00:00:00 EST 2019
Immunomodulatory effects of an acidic polysaccharide fraction from herbal Gynostemma pentaphyllum tea in RAW264.7 cells.
Food & function
Ren D,Zhao Y,Zheng Q,Alim A,Yang X
Mon Apr 01 00:00:00 EDT 2019
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Frontiers in endocrinology
Suo L,Chang X,Xu N,Ji H
Tue Feb 25 00:00:00 EST 2020
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
Cell death & disease
Luo X,Jiang X,Li J,Bai Y,Li Z,Wei P,Sun S,Liang Y,Han S,Li X,Zhang B
Thu Jun 06 00:00:00 EDT 2019
Injectable hydrogels for the sustained delivery of a HER2-targeted antibody for preventing local relapse of HER2+ breast cancer after breast-conserving surgery.
Theranostics
Chen X,Wang M,Yang X,Wang Y,Yu L,Sun J,Ding J
Mon Sep 28 00:00:00 EDT 2020
Thioredoxin-interacting protein deficiency alleviates phenotypic alterations of podocytes via inhibition of mTOR activation in diabetic nephropathy.
Journal of cellular physiology
Song S,Qiu D,Shi Y,Wang S,Zhou X,Chen N,Wei J,Wu M,Wu H,Duan H
Sun Sep 01 00:00:00 EDT 2019
Resveratrol synergizes with low doses of L-DOPA to improve MPTP-induced Parkinson disease in mice.
Behavioural brain research
Liu Q,Zhu D,Jiang P,Tang X,Lang Q,Yu Q,Zhang S,Che Y,Feng X
Tue Jul 23 00:00:00 EDT 2019
Role of Paip1 on angiogenesis and invasion in pancreatic cancer.
Experimental cell research
Guan H,Li N,Wang X,Shan X,Li Z,Lin Z
Fri Mar 15 00:00:00 EDT 2019
Yu Jin Pulvis inhibits carbon tetrachloride-induced liver fibrosis by blocking the MAPK and PI3K/Akt signaling pathways.
American journal of translational research
Wu W,Piao H,Wu F,Han Y,An D,Wu Y,Lin Z,Piao Y,Jin J
Thu Oct 01 00:00:00 EDT 2020
Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway.
Scientific reports
Yang F,Lin ZW,Huang TY,Chen TT,Cui J,Li MY,Hua YQ
Mon May 06 00:00:00 EDT 2019
Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model.
Annals of translational medicine
Wang J,Wan D,Wan G,Wang J,Zhang J,Zhu H
Sun Dec 01 00:00:00 EST 2019
PD-L1 regulates tumorigenesis and autophagy of ovarian cancer by activating mTORC signaling.
Bioscience reports
Gao H,Zhang J,Ren X
Fri Dec 20 00:00:00 EST 2019
Rutin suppresses FNDC1 expression in bone marrow mesenchymal stem cells to inhibit postmenopausal osteoporosis.
American journal of translational research
Xiao Y,Wei R,Yuan Z,Lan X,Kuang J,Hu D,Song Y,Luo J
Thu Oct 01 00:00:00 EDT 2020
ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.
OncoTargets and therapy
Ye Z,Zeng Z,Shen Y,Yang Q,Chen D,Chen Z,Shen S
Thu Oct 01 00:00:00 EDT 2020
Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy.
Journal of medicinal food
Luo J,Long Y,Ren G,Zhang Y,Chen J,Huang R,Yang L
Sun Dec 01 00:00:00 EST 2019
Paeonol Ameliorates Glucose and Lipid Metabolism in Experimental Diabetes by Activating Akt.
Frontiers in pharmacology
Xu F,Xiao H,Liu R,Yang Y,Zhang M,Chen L,Chen Z,Liu P,Huang H
Wed Sep 30 00:00:00 EDT 2020
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Pharmacological research
Yan J,Wang C,Jin Y,Meng Q,Liu Q,Liu Z,Liu K,Sun H
Sun Apr 01 00:00:00 EDT 2018
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Pharmacological research
Yan J,Wang C,Jin Y,Meng Q,Liu Q,Liu Z,Liu K,Sun H
Sun Apr 01 00:00:00 EDT 2018
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
Molecular therapy. Nucleic acids
Nie X,Fan J,Li H,Yin Z,Zhao Y,Dai B,Dong N,Chen C,Wang DW
Fri Sep 07 00:00:00 EDT 2018
miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN.
Molecular therapy. Nucleic acids
Nie X,Fan J,Li H,Yin Z,Zhao Y,Dai B,Dong N,Chen C,Wang DW
Fri Sep 07 00:00:00 EDT 2018
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu Y,Gao Y,Li D,He L,Iw L,Hao B,Chen X,Cao Y
Sat Dec 01 00:00:00 EST 2018
LASP1 promotes glioma cell proliferation and migration and is negatively regulated by miR-377-3p.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Liu Y,Gao Y,Li D,He L,Iw L,Hao B,Chen X,Cao Y
Sat Dec 01 00:00:00 EST 2018
Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Mou JJ,Peng J,Shi YY,Li N,Wang Y,Ke Y,Zhou YF,Zhou FX
Sun Jul 01 00:00:00 EDT 2018
Mitochondrial DNA content reduction induces aerobic glycolysis and reversible resistance to drug-induced apoptosis in SW480 colorectal cancer cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Mou JJ,Peng J,Shi YY,Li N,Wang Y,Ke Y,Zhou YF,Zhou FX
Sun Jul 01 00:00:00 EDT 2018
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Journal of cellular physiology
Song Y,Gao L,Tang Z,Li H,Sun B,Chu P,Qaed E,Ma X,Peng J,Wang S,Hu M,Tang Z
Mon Jan 01 00:00:00 EST 2018
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Journal of cellular physiology
Song Y,Gao L,Tang Z,Li H,Sun B,Chu P,Qaed E,Ma X,Peng J,Wang S,Hu M,Tang Z
Mon Jan 01 00:00:00 EST 2018
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Frontiers in endocrinology
Suo L,Chang X,Zhao Y
Wed Nov 20 00:00:00 EST 2019
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Frontiers in endocrinology
Suo L,Chang X,Zhao Y
Wed Nov 20 00:00:00 EST 2019
A somatic mutation of RasGRP3 decreases Na+/I- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
American journal of cancer research
Song J,Qiu W,Deng X,Qiu Z,Fan Y,Yang Z
Wed Sep 30 00:00:00 EDT 2020
A somatic mutation of RasGRP3 decreases Na+/I- symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
American journal of cancer research
Song J,Qiu W,Deng X,Qiu Z,Fan Y,Yang Z
Wed Sep 30 00:00:00 EDT 2020
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Journal of agricultural and food chemistry
Xu H,Li Y,Han B,Li Z,Wang B,Jiang P,Zhang J,Ma W,Zhou D,Li X,Ye X
Wed Sep 19 00:00:00 EDT 2018
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Journal of agricultural and food chemistry
Xu H,Li Y,Han B,Li Z,Wang B,Jiang P,Zhang J,Ma W,Zhou D,Li X,Ye X
Wed Sep 19 00:00:00 EDT 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
International immunopharmacology
Jia YN,Lu HP,Peng YL,Zhang BS,Gong XB,Su J,Zhou Y,Pan MH,Xu L
Thu Mar 01 00:00:00 EST 2018
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
International immunopharmacology
Wu XY,Tian F,Su MH,Wu M,Huang Y,Hu LH,Jin L,Zhu XJ
Thu Nov 01 00:00:00 EDT 2018
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
International immunopharmacology
Wu XY,Tian F,Su MH,Wu M,Huang Y,Hu LH,Jin L,Zhu XJ
Thu Nov 01 00:00:00 EDT 2018
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
The international journal of biochemistry & cell biology
Ke M,Dong J,Wang Y,Zhang J,Zhang M,Wu Z,Lv Y,Wu R
Wed Aug 01 00:00:00 EDT 2018
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
The international journal of biochemistry & cell biology
Ke M,Dong J,Wang Y,Zhang J,Zhang M,Wu Z,Lv Y,Wu R
Wed Aug 01 00:00:00 EDT 2018
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
International journal of molecular medicine
Liu F,Wen Y,Kang J,Wei C,Wang M,Zheng Z,Peng J
Sat Sep 01 00:00:00 EDT 2018
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
International journal of molecular medicine
Liu F,Wen Y,Kang J,Wei C,Wang M,Zheng Z,Peng J
Sat Sep 01 00:00:00 EDT 2018
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Chemico-biological interactions
Yang G,Bai Y,Wu X,Sun X,Sun M,Liu X,Yao X,Zhang C,Chu Q,Jiang L,Wang S
Fri May 25 00:00:00 EDT 2018
Patulin induced ROS-dependent autophagic cell death in Human Hepatoma G2 cells.
Chemico-biological interactions
Yang G,Bai Y,Wu X,Sun X,Sun M,Liu X,Yao X,Zhang C,Chu Q,Jiang L,Wang S
Fri May 25 00:00:00 EDT 2018
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Biochimica et biophysica acta. Molecular cell research
Kong F,Ma J,Yang H,Yang D,Wang C,Ma X
Thu Jul 19 00:00:00 EDT 2018
Long non-coding RNA PVT1 promotes malignancy in human endometrial carcinoma cells through negative regulation of miR-195-5p.
Biochimica et biophysica acta. Molecular cell research
Kong F,Ma J,Yang H,Yang D,Wang C,Ma X
Thu Jul 19 00:00:00 EDT 2018
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Journal of cellular biochemistry
Zhou BG,Wei CS,Zhang S,Zhang Z,Gao HM
Tue May 01 00:00:00 EDT 2018
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Journal of cellular biochemistry
Zhou BG,Wei CS,Zhang S,Zhang Z,Gao HM
Tue May 01 00:00:00 EDT 2018
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
OncoTargets and therapy
Jiang T,Zhou ML,Fan J
Wed Mar 30 00:00:00 EDT 2022
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
OncoTargets and therapy
Jiang T,Zhou ML,Fan J
Wed Mar 30 00:00:00 EDT 2022
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Toxicology letters
Deng T,Zhang Y,Wu Y,Ma P,Duan J,Qin W,Yang X,Chen M
Fri Jun 15 00:00:00 EDT 2018
Dibutyl phthalate exposure aggravates type 2 diabetes by disrupting the insulin-mediated PI3K/AKT signaling pathway.
Toxicology letters
Deng T,Zhang Y,Wu Y,Ma P,Duan J,Qin W,Yang X,Chen M
Fri Jun 15 00:00:00 EDT 2018
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Metabolic brain disease
Xu N,Fan W,Zhou X,Liu Y,Ma P,Qi S,Gu B
Mon Oct 01 00:00:00 EDT 2018
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Metabolic brain disease
Xu N,Fan W,Zhou X,Liu Y,Ma P,Qi S,Gu B
Mon Oct 01 00:00:00 EDT 2018
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Molecular medicine reports
Wang AL,Li Y,Zhao Q,Fan LQ
Fri Jun 01 00:00:00 EDT 2018
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Molecular medicine reports
Wang AL,Li Y,Zhao Q,Fan LQ
Fri Jun 01 00:00:00 EDT 2018
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Molecular medicine reports
Mu Z,Sun Q
Thu Nov 01 00:00:00 EDT 2018
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Molecular medicine reports
Mu Z,Sun Q
Thu Nov 01 00:00:00 EDT 2018
Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.
Molecular medicine reports
Deng G,Li K,Chen S,Chen P,Zheng H,Yu B,Zhang K
Sat Dec 01 00:00:00 EST 2018
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Biochemical and biophysical research communications
Xue Y,Jia X,Li L,Dong X,Ling J,Yuan J,Li Q
Tue Sep 18 00:00:00 EDT 2018
DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway.
Biochemical and biophysical research communications
Xue Y,Jia X,Li L,Dong X,Ling J,Yuan J,Li Q
Tue Sep 18 00:00:00 EDT 2018
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Thoracic cancer
Liu C,Xing J,Gao Y
Mon Jan 01 00:00:00 EST 2018
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Thoracic cancer
Liu C,Xing J,Gao Y
Mon Jan 01 00:00:00 EST 2018
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Oncology letters
Zhang H,Cao Y,Chen Y,Li G,Yu H
Sun Apr 01 00:00:00 EDT 2018
Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression.
Autoimmunity
Bai Y,Shen W,Zhang L,Yang Z,Xiong L,Tang H,Zhao J
Fri Jun 01 00:00:00 EDT 2018
Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression.
Autoimmunity
Bai Y,Shen W,Zhang L,Yang Z,Xiong L,Tang H,Zhao J
Fri Jun 01 00:00:00 EDT 2018
Clinical significance of combined detection of interleukin-6 and tumour markers in lung cancer.
Autoimmunity
Tang H,Bai Y,Shen W,Wei Y,Xu M,Zhou X,Zhao J
Fri Jun 01 00:00:00 EDT 2018
Clinical significance of combined detection of interleukin-6 and tumour markers in lung cancer.
Autoimmunity
Tang H,Bai Y,Shen W,Wei Y,Xu M,Zhou X,Zhao J
Fri Jun 01 00:00:00 EDT 2018
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Journal of molecular neuroscience : MN
Huang L,Chen C,Zhang X,Li X,Chen Z,Yang C,Liang X,Zhu G,Xu Z
Mon Jan 01 00:00:00 EST 2018
Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation.
Journal of molecular neuroscience : MN
Huang L,Chen C,Zhang X,Li X,Chen Z,Yang C,Liang X,Zhu G,Xu Z
Mon Jan 01 00:00:00 EST 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Experimental and therapeutic medicine
Feng J,Niu P,Chen K,Wu L,Liu T,Xu S,Li J,Li S,Wang W,Lu X,Yu Q,Liu N,Xu L,Wang F,Dai W,Xia Y,Fan X,Guo C
Fri Jun 01 00:00:00 EDT 2018
Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway.
Translational neuroscience
Zhao G,Li K,Chen J,Li L
Thu Mar 31 00:00:00 EDT 2022
Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.
Autoimmunity
Tang H,Bai Y,Pan G,Wang X,Wei Y,Yang Z,Zhao J
Sat Dec 01 00:00:00 EST 2018
Matrine inhibits the invasive and migratory properties of human hepatocellular carcinoma by regulating epithelial‑mesenchymal transition.
Molecular medicine reports
Wang Y,Zhang S,Liu J,Fang B,Yao J,Cheng B
Sun Jul 01 00:00:00 EDT 2018
Establishment of a novel hepatic steatosis cell model by Cas9/sgRNA-mediated DGKθ gene knockout.
Molecular medicine reports
Zhang J,Zhao J,Zheng X,Cai K,Mao Q,Xia H
Thu Feb 01 00:00:00 EST 2018
Triptolide protects podocytes via autophagy in immunoglobulin A nephropathy.
Experimental and therapeutic medicine
Liang S,Jin J,Shen X,Jiang X,Li Y,He Q
Sat Sep 01 00:00:00 EDT 2018
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Medical science monitor : international medical journal of experimental and clinical research
Jiang Y,Liu J,Zhou Z,Liu K,Liu C
Tue Oct 02 00:00:00 EDT 2018
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Medical science monitor : international medical journal of experimental and clinical research
Jiang Y,Liu J,Zhou Z,Liu K,Liu C
Tue Oct 02 00:00:00 EDT 2018
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Medecine sciences : M/S
Jiang QQ,Liu WB
Mon Oct 01 00:00:00 EDT 2018
AAED1 modulates proliferation and glycolysis in gastric cancer.
Oncology reports
Zhang B,Wu J,Cai Y,Luo M,Wang B,Gu Y
Wed Aug 01 00:00:00 EDT 2018
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Oncology research
Liu X,Tan X,Liu P,Wu Y,Qian S,Zhang X
Thu Aug 23 00:00:00 EDT 2018
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca2+Production.
International journal of molecular sciences
Wang J,Yang C,Yuan Z,Yi J,Wu J
Sat Oct 27 00:00:00 EDT 2018
T-2 Toxin Exposure Induces Apoptosis in TM3 Cells by Inhibiting Mammalian Target of Rapamycin/Serine/Threonine Protein Kinase(mTORC2/AKT) to Promote Ca2+Production.
International journal of molecular sciences
Wang J,Yang C,Yuan Z,Yi J,Wu J
Sat Oct 27 00:00:00 EDT 2018
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Journal of hematology & oncology
Li Y,Zeng C,Hu J,Pan Y,Shan Y,Liu B,Jia L
Tue Jul 03 00:00:00 EDT 2018
Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.
Journal of hematology & oncology
Li Y,Zeng C,Hu J,Pan Y,Shan Y,Liu B,Jia L
Tue Jul 03 00:00:00 EDT 2018
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Oncotarget
Sun X,Huang S,Wang X,Zhang X,Wang X
Fri Jun 08 00:00:00 EDT 2018
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Oncotarget
Sun X,Huang S,Wang X,Zhang X,Wang X
Fri Jun 08 00:00:00 EDT 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway.
Stem cell research & therapy
Yin N,Wang Y,Lu X,Liu R,Zhang L,Zhao W,Yuan W,Luo Q,Wu H,Luan X,Zhang H
Wed Feb 14 00:00:00 EST 2018
ZKSCAN3 promotes breast cancer cell proliferation, migration and invasion.
Biochemical and biophysical research communications
Chi Y,Xu H,Wang F,Chen X,Shan Z,Sun Y,Fan Q
Tue Sep 18 00:00:00 EDT 2018
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Molecular medicine reports
Shi X,Yang L,Xie J,Zhao Y,Cong J,Li Z,Li H,Cheng X,Fan J
Sat Sep 01 00:00:00 EDT 2018
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Food & function
Ren D,Lin D,Alim A,Zheng Q,Yang X
Wed Mar 22 00:00:00 EDT 2017
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages.
American journal of cancer research
Wei X,Nie S,Liu H,Sun J,Liu J,Li J,Li S,Wang S,Han S,Wang J,Sun Y
Sat Apr 09 00:00:00 EDT 2022
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages.
American journal of cancer research
Wei X,Nie S,Liu H,Sun J,Liu J,Li J,Li S,Wang S,Han S,Wang J,Sun Y
Sat Apr 09 00:00:00 EDT 2022
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Cell biology international
Song Y,Kong L,Sun B,Gao L,Chu P,Ahsan A,Qaed E,Lin Y,Peng J,Ma X,Zhang J,Wang S,Tang Z
Fri Dec 01 00:00:00 EST 2017
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Cell biology international
Song Y,Kong L,Sun B,Gao L,Chu P,Ahsan A,Qaed E,Lin Y,Peng J,Ma X,Zhang J,Wang S,Tang Z
Fri Dec 01 00:00:00 EST 2017
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Gene
Qiu W,Xia X,Qiu Z,Guo M,Yang Z
Mon Oct 30 00:00:00 EDT 2017
RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
Gene
Qiu W,Xia X,Qiu Z,Guo M,Yang Z
Mon Oct 30 00:00:00 EDT 2017
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
BioMed research international
Sheng C,Xu P,Zhou K,Deng D,Zhang C,Wang Z
Thu Jun 07 00:00:00 EDT 2018
Icariin Attenuates Synaptic and Cognitive Deficits in an Aβ1-42-Induced Rat Model of Alzheimer's Disease.
BioMed research international
Sheng C,Xu P,Zhou K,Deng D,Zhang C,Wang Z
Thu Jun 07 00:00:00 EDT 2018
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Experimental and therapeutic medicine
Gu YP,Yang XM,Duan ZH,Luo P,Shang JH,Xiao W,Tao YX,Zhang DY,Zhang YB,Liu HZ
Fri Dec 01 00:00:00 EST 2017
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Experimental and therapeutic medicine
Gu YP,Yang XM,Duan ZH,Luo P,Shang JH,Xiao W,Tao YX,Zhang DY,Zhang YB,Liu HZ
Fri Dec 01 00:00:00 EST 2017
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Oncotarget
Wang X,Li D,Fan L,Xiao Q,Zuo H,Li Z
Fri Dec 29 00:00:00 EST 2017
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Oncotarget
Wang X,Li D,Fan L,Xiao Q,Zuo H,Li Z
Fri Dec 29 00:00:00 EST 2017
GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy.
Oncotarget
Zhang Q,Zhuang J,Deng Y,Zhao X,Tang B,Yao D,Zhao W,Chang C,Lu Q,Chen W,Zhang S,Ji C,Cao L,Guo H
Tue Oct 13 00:00:00 EDT 2015