Invitrogen

Phospho-C/EBP beta (Thr188, Thr235) Polyclonal Antibody

View all (25) C/EBP beta antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-36629

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide derived from human C/EBP-beta around the phosphorylation site of Threonine 235
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2553624

Product Specific Information

This antibody detects endogenous levels of human LAP only when phosphorylated at Thr235, mouse and rat LAP only when phosphorylated at Thr188, and LIP only when phosphorylated at Thr37 (molecular weight of 19, 36 and 38 kDa).

Purity is >95% by SDS-PAGE.

Target Information

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C EBP; C/EBP beta; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; interleukin 6-dependent DNA-binding protein; LAP; LIP; Liver activator protein; Liver-enriched inhibitory protein; Nuclear factor NF-IL6; nuclear factor of interleukin 6; OTTMUSP00000017503; TCF-5; Transcription factor 5; transcription factor C/EBP beta

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Gene Aliases: C/EBP-beta; CEBPB; IL6DBP; NF-IL6; PP9092; TCF5

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UniProt ID: (Human) P17676

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Entrez Gene ID: (Human) 1051

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding kinase binding histone acetyltransferase binding glucocorticoid receptor binding protein homodimerization activity histone deacetylase binding ubiquitin-like protein ligase binding protein heterodimerization activity basic leucine zipper transcription factor
Process(es)
ovarian follicle development embryonic placenta development granuloma formation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter acute-phase response inflammatory response immune response memory neuron differentiation positive regulation of interleukin-4 production mammary gland epithelial cell proliferation response to endoplasmic reticulum stress T-helper 1 cell activation negative regulation of T cell proliferation defense response to bacterium negative regulation of neuron apoptotic process regulation of interleukin-6 biosynthetic process positive regulation of fat cell differentiation positive regulation of osteoblast differentiation regulation of osteoclast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter brown fat cell differentiation mammary gland epithelial cell differentiation regulation of transcription involved in cell fate commitment intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to interleukin-1 cellular response to organic cyclic compound hepatocyte proliferation liver regeneration positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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