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Invitrogen
Phospho-CD104 Integrin beta 4 (Tyr1526) Polyclonal Antibody
FIGURE: 1 / 2
Phospho-CD104 Integrin beta 4 (Tyr1526) Antibody (PA5-143712) in ICC/IF
Immunocytochemistry analysis of Phospho-CD104 Integrin beta 4 (Tyr1526) in control (Top) and pervanadate-treated A431 cells (Bottom). The cells were labeled with mouse monoclonal antibody anti-integrin beta4 (Cytoplasmic region) (left), rabbit Phospho-CD104 Integrin beta 4 (Tyr1494) polyclonal antibody (Product # PA5-143711) (middle), or Phospho-CD104 Integrin beta 4 (Tyr1526) polyclonal antibody (Product #... View More
Product Details
PA5-143712
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Phospho-Integrin beta4 (Tyr-1526) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 1526 of human Integrin beta4. This peptide sequence is found in all three Integrin beta4 isoforms and is highly conserved in rat and mouse Integrin beta4.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1mg/mL BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2942940
Product Specific Information
This antibody was cross-adsorbed to phospho-tyrosine coupled to agarose and to unphosphorylated Integrin beta4 (Tyr-1526) peptide before affinity purification using phospho-Integrin beta4 (Tyr-1526) peptide (without carrier). The purified antibody detects a 200kDa* protein corresponding to the molecular mass of Integrin beta4 on SDS-PAGE immunoblots of A431 and src-transformed Hct116 cells treated with pervanadate, but not in control cells.
Target Information
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD antigen CD104; CD104; CD104 antigen; GP150; Integrin beta-4
Gene Aliases: AA407042; C230078O20; CD104; GP150; ITGB4
UniProt ID: (Human) P16144, (Mouse) A2A863, (Rat) Q64632
Entrez Gene ID: (Human) 3691, (Mouse) 192897, (Rat) 25724
autophagy
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
response to wounding
extracellular matrix organization
hemidesmosome assembly
nail development
skin development
mesodermal cell differentiation
digestive tract development
cell motility
renal system development
amelogenesis
cell communication
filopodium assembly
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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