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Product Details
BS-7523R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated syntheticphosphopeptide derived from mouse Caveolin2 around the phosphorylation site of Tyr19.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are known to encode 21-24 kDa integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caveolae; Caveolin-2; MGC12294; Phospho-CAV2
Gene Aliases: AI447843; Cav2
UniProt ID: (Mouse) Q9WVC3, (Rat) Q2IBC5
Entrez Gene ID: (Mouse) 12390, (Rat) 363425
SNARE binding
protein kinase binding
syntaxin binding
protein binding, bridging
mitogen-activated protein kinase kinase kinase binding
D1 dopamine receptor binding
protein complex scaffold
protein homodimerization activity
protein heterodimerization activity
phosphoprotein binding
scaffold protein binding
protein binding
scaffold/adaptor protein
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
endocytosis
vesicle fusion
mitochondrion organization
endoplasmic reticulum organization
chemical synaptic transmission
negative regulation of cell proliferation
insulin receptor signaling pathway
vesicle organization
receptor-mediated endocytosis of virus by host cell
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of MAPK cascade
positive regulation of GTPase activity
vesicle docking
skeletal muscle fiber development
positive regulation of peptidyl-tyrosine phosphorylation
protein oligomerization
positive regulation of dopamine receptor signaling pathway
caveola assembly
positive regulation of protein localization to nucleus
regulation of mitotic nuclear division
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