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Phospho-Claudin 5 (Tyr217) Antibody (PA5-37756) in IHC (P)
Immunohistochemical analysis of Phospho-Claudin 5 (Tyr217) in paraffin-embedded Human brain tissue using Phospho-Claudin 5 (Tyr217) Polyclonal Antibody (Product # PA5-37756) (left) or the same antibody preincubated with blocking peptide (right).
Product Details
PA5-37756
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 217 (K-K-N-Y(p)-V) derived from Human Claudin 5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2554364
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain endothelial cell clone 1 protein; Claudin-5; Lung-specific membrane protein; TMDVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Gene Aliases: AI854493; AWAL; BEC1; CLDN5; CPETRL1; MBEC1; TMVCF
UniProt ID: (Human) O00501, (Rat) Q9JKD6, (Mouse) O54942
Entrez Gene ID: (Human) 7122, (Rat) 65131, (Mouse) 12741
outflow tract morphogenesis
cell-cell junction assembly
transforming growth factor beta receptor signaling pathway
learning
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
palate development
face morphogenesis
positive regulation of establishment of endothelial barrier
myelination
single organismal cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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