Product References
A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.
Heliyon
Estep JA,Sun LO,Riccomagno MM
44-624G was used in Western Blotting and Immunocytochemistry to present the design and characterization of simple, reversible, and scalable Bimolecular Complementation sensors to monitor FAK phosphorylation in living cells.
Sat Apr 01 00:00:00 EDT 2023
A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.
Heliyon
Estep JA,Sun LO,Riccomagno MM
44-624G was used in Western Blotting and Immunocytochemistry to present the design and characterization of simple, reversible, and scalable Bimolecular Complementation sensors to monitor FAK phosphorylation in living cells.
Sat Apr 01 00:00:00 EDT 2023
A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.
Heliyon
Estep JA,Sun LO,Riccomagno MM
44-624G was used in Western Blotting and Immunocytochemistry to present the design and characterization of simple, reversible, and scalable Bimolecular Complementation sensors to monitor FAK phosphorylation in living cells.
Sat Apr 01 00:00:00 EDT 2023
VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry.
Cell death & disease
Delgado-Bellido D,Zamudio-Martínez E,Fernández-Cortés M,Herrera-Campos AB,Olmedo-Pelayo J,Perez CJ,Expósito J,de Álava E,Amaral AT,Valle FO,Diaz AG,Oliver FJ
44-624G was used in Western Blotting to find that the anomalous expression of VE-Cadherin in metastatic melanoma cells (from both uveal and cutaneous origins), together with its permanent phosphorylation at Y658, favors the induction of the aggressive VM phenotype through the cooperation of β-catenin with VE-Cadherin and by enhancing TCF-4 genes-dependent transcription.
Fri Feb 17 00:00:00 EST 2023
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein.
Nature communications
Kuhn CC,Basnet N,Bodakuntla S,Alvarez-Brecht P,Nichols S,Martinez-Sanchez A,Agostini L,Soh YM,Takagi J,Biertümpfel C,Mizuno N
44-624G was used in Western Blotting to infer that the stochastic activation of platelets is due to weak interactions of S protein with integrin, which can attribute to the pathogenesis of COVID-19 and the occurrence of rare but severe coagulopathies.
Sat Feb 04 00:00:00 EST 2023
A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mehta S,Fiorelli R,Bao X,Pennington-Krygier C,Derogatis A,Kim S,Yoo W,Li J,Sanai N
44-624G was used in Immunohistochemistry to conclude that ceritinib is highly bound to plasma proteins and tumor tissues. Unbound drug concentrations achieved in brain metastases and patients with recurrent glioblastoma were insufficient for target modulation.
Sat Jan 15 00:00:00 EST 2022
Zyxin protects from hypertension-induced cardiac dysfunction.
Cellular and molecular life sciences : CMLS
Al-Hasani J,Sens-Albert C,Ghosh S,Trogisch FA,Nahar T,Friede PAP,Reil JC,Hecker M
44-624G was used in Western Blot to analyze cardiac function during experimental hypertension in zyxin knockout (KO) mice.
Mon Jan 24 00:00:00 EST 2022
MARK2 regulates directed cell migration through modulation of myosin II contractility and focal adhesion organization.
Current biology : CB
Pasapera AM,Heissler SM,Eto M,Nishimura Y,Fischer RS,Thiam HR,Waterman CM
44-624G was used in Western Blotting to define MARK2 as a master regulator of the actomyosin and microtubule cytoskeletal systems and focal adhesions to mediate directional cancer cell migration.
Mon Jun 20 00:00:00 EDT 2022
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
44-624G was used in Western Blot, Immunocytochemistry to show that matrix stiffness modulates tip cell formation through p-PXN-Rac1-YAP signaling axis, shedding light on the role of mechanotransduction in tip cell formation.
Sat Jan 01 00:00:00 EST 2022
Matrix stiffness modulates tip cell formation through the p-PXN-Rac1-YAP signaling axis.
Bioactive materials
Guo Y,Mei F,Huang Y,Ma S,Wei Y,Zhang X,Xu M,He Y,Heng BC,Chen L,Deng X
44-624G was used in Western Blot, Immunocytochemistry to show that matrix stiffness modulates tip cell formation through p-PXN-Rac1-YAP signaling axis, shedding light on the role of mechanotransduction in tip cell formation.
Sat Jan 01 00:00:00 EST 2022
LGL1 binds to Integrin β1 and inhibits downstream signaling to promote epithelial branching in the mammary gland.
Cell reports
Ma R,Gong D,You H,Xu C,Lu Y,Bergers G,Werb Z,Klein OD,Petritsch CK,Lu P
44-624G was used in Western Blot to emonstrate that Lgl1 modulation of Integrin β1 signaling is essential for directional migration and that epithelial branching in invertebrates and the mammary gland is fundamentally distinct.
Tue Feb 15 00:00:00 EST 2022
G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4.
The Journal of biological chemistry
Zhuo Y,Crecelius JM,Marchese A
44-624G was used in Western Blotting to provide evidence that distal C-tail phosphorylation sites specify GRK-βarrestin-mediated signaling by CXCR4 and other GPCRs.
Thu Sep 01 00:00:00 EDT 2022
The TLK1-MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells.
Cancers
Khalil MI,De Benedetti A
44-624G was used in Western Blotting to support that the TLK1-MK5 axis is functionally involved in driving PCa cell metastasis and clinical aggressiveness; hence, disruption of this axis may inhibit the metastatic capacity of PCa.
Tue Nov 22 00:00:00 EST 2022
CK2β Is a Gatekeeper of Focal Adhesions Regulating Cell Spreading.
Frontiers in molecular biosciences
Filhol O,Hesse AM,Bouin AP,Albigès-Rizo C,Jeanneret F,Battail C,Pflieger D,Cochet C
44-624G was used in Immunocytochemistry-immunofluorescence to show that decreased expression of CK2β in MCF10A mammary epithelial cells triggers the phosphorylation of a number of proteins on tyrosine residues and promotes the striking activation of the FAK1-Src-PAX1 signaling pathway.
Tue Jul 19 00:00:00 EDT 2022
Integrin α6β4 requires plectin and vimentin for adhesion complex distribution and invasive growth.
Journal of cell science
Qi L,Knifley T,Chen M,O'Connor KL
44-624G was used in Western Blotting to demonstrate the essential roles of plectin and vimentin in promoting an invasive phenotype downstream of integrin α6β4.
Sat Jan 15 00:00:00 EST 2022
The Synergistic Effect of Cyclic Tensile Force and Periodontal Ligament Cell-Laden Calcium Silicate/Gelatin Methacrylate Auxetic Hydrogel Scaffolds for Bone Regeneration.
Cells
Lee JJ,Ng HY,Lin YH,Lin TJ,Kao CT,Shie MY
44-624G was used in Western Blotting to show that novel auxetic scaffolds could be fabricated by combining different aspects of science and technology, in order to improve the future chances of clinical applications for bone regeneration.
Wed Jun 29 00:00:00 EDT 2022
Complexity of progranulin mechanisms of action in mesothelioma.
Journal of experimental & clinical cancer research : CR
Ventura E,Xie C,Buraschi S,Belfiore A,Iozzo RV,Giordano A,Morrione A
44-624G was used in Immunocytochemistry-immunofluorescence to highlight the complexity of progranulin oncogenic signaling in mesothelioma, where progranulin modulate functional cross-talks between multiple RTKs, thereby suggesting the need for combinatorial therapeutic approaches to improve treatments of this aggressive disease.
Mon Dec 05 00:00:00 EST 2022
Positive Phospho-Focal Adhesion Kinase in Gastric Cancer Associates With Poor Prognosis After Curative Resection.
Frontiers in oncology
Peng K,Li S,Li Q,Zhang C,Yuan Y,Liu M,Zhang L,Wang Y,Yu S,Zhang H,Liu T
44-624G was used in Immunohistochemistry to demonstrate that pFAK is a negative prognostic factor in GC, and a nomogram integrating pFAK could help predict OS for GC patients.
Sat Aug 20 00:00:00 EDT 2022
Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression.
Angiogenesis
Lees DM,Reynolds LE,Pedrosa AR,Roy-Luzarraga M,Hodivala-Dilke KM
44-624G was used in Western Blot to identify the role of pericyte FAK-Y861 in the regulation of tumour vessel regression and tumour growth control and that non-phosphorylatable FAK-Y861F in pericytes reduces tumour growth and blood vessel density.
Sun Aug 01 00:00:00 EDT 2021
Integrin α3β1 Is a Key Regulator of Several Protumorigenic Pathways during Skin Carcinogenesis.
The Journal of investigative dermatology
Ramovs V,Krotenberg Garcia A,Kreft M,Sonnenberg A
44-624G was used in Western Blotting to demonstrate the central role of α3β1 in promoting the activation of several protumorigenic signaling pathways during the initiation of DMBA/TPAdriven tumorigenesis.
Thu Apr 01 00:00:00 EDT 2021
Mechanical Loading Disrupts Focal Adhesion Kinase Activation in Mandibular Fibrochondrocytes During Murine Temporomandibular Joint Osteoarthritis.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
Reed DA,Zhao Y,Han M,Mercuri LG,Miloro M
44-624G was used in Immunohistochemistry to hypothesize that mechanical overloading disrupts TMJ homeostasis through dysregulation of FAK signaling.
Fri Oct 01 00:00:00 EDT 2021
Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling.
Cancers
Errico A,Stocco A,Riccardi VM,Gambalunga A,Bassetto F,Grigatti M,Ferlosio A,Tadini G,Garozzo D,Ferraresi S,Trevisan A,Giustini S,Rasola A,Chiara F
44-624G was used in Western Blot to investigate if cell–cell cooperativity and the dynamics of the extracellular matrix play important roles in the growth and transformation of plexiform neurofibromas cells, directly through the cooperation of RAS and focal adhesion kinase (FAK) signaling.
Wed May 12 00:00:00 EDT 2021
Directional cues in the tumor microenvironment due to cell contraction against aligned collagen fibers.
Acta biomaterialia
Szulczewski JM,Inman DR,Proestaki M,Notbohm J,Burkel BM,Ponik SM
44-624G was used in Immunocytochemistry-immunofluorescence to define cell-scale stiffness and fiber deformations due to collagen architecture that may instruct cell communication within a broad range of tissue microenvironments.
Thu Jul 15 00:00:00 EDT 2021
FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity.
NPJ breast cancer
Timbrell S,Aglan H,Cramer A,Foden P,Weaver D,Pachter J,Kilgallon A,Clarke RB,Farnie G,Bundred NJ
44-624G was used in Immunohistochemistry (Paraffin) to identify that FAK inhibition and combined treatment with adjuvant therapies has the potential to improve breast cancer survival by reducing cancer stem cell activity and self-renewal.
Fri May 28 00:00:00 EDT 2021
Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome.
Disease models & mechanisms
Mao M,Popli T,Jeanne M,Hoff K,Sen S,Gould DB
44-624G was used in Western Blotting to suggest that tissue-specific mechanistic heterogeneity contributes to the variable expressivity of Gould syndrome and that perturbations in integrin signaling may play a role in ocular and muscular manifestations.
Thu Apr 01 00:00:00 EDT 2021
Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2.
Nature neuroscience
Zhou X,Wahane S,Friedl MS,Kluge M,Friedel CC,Avrampou K,Zachariou V,Guo L,Zhang B,He X,Friedel RH,Zou H
44-624G was used in Immunohistochemistry to elucidate a temporally distinct gene signature in injury-activated microglia and macrophages (IAMs) that engages axon guidance pathways.
Sun Mar 01 00:00:00 EST 2020
Basement Membrane Regulates Fibronectin Organization Using Sliding Focal Adhesions Driven by a Contractile Winch.
Developmental cell
Lu J,Doyle AD,Shinsato Y,Wang S,Bodendorfer MA,Zheng M,Yamada KM
44-624G was used in Immunocytochemistry to describe a type of dynamic cell-BM matrix assembly mechanism that produces rapid, extensive FN fibrillogenesis in a process that can explain the characteristic pattern of FN matrix deposition on BMs.
Mon Mar 09 00:00:00 EDT 2020
Basement membrane ligands initiate distinct signalling networks to direct cell shape.
Matrix biology : journal of the International Society for Matrix Biology
Randles MJ,Lausecker F,Humphries JD,Byron A,Clark SJ,Miner JH,Zent R,Humphries MJ,Lennon R
44-624G was used in Immunohistochemistry to define the switchable basement membrane adhesome and highlights two key signalling pathways within the systems that determine distinct cell morphologies.
Sat Aug 01 00:00:00 EDT 2020
An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.
Molecular biology of the cell
Su S,Begum S,Ezratty EJ
44-624G was used in Immunocytochemistry-immunoflourescence to examine the role of intraflagellar transport (IFT) 20 (Ift20) during polarized migration of epidermal cells.
Sat Aug 01 00:00:00 EDT 2020
An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.
Molecular biology of the cell
Su S,Begum S,Ezratty EJ
44-624G was used in Immunocytochemistry-immunoflourescence to examine the role of intraflagellar transport (IFT) 20 (Ift20) during polarized migration of epidermal cells.
Sat Aug 01 00:00:00 EDT 2020
Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src‑dependent pathway in MDA‑MB‑231 breast cancer cells.
Molecular medicine reports
Ramírez-Ricardo J,Leal-Orta E,Martínez-Baeza E,Ortiz-Mendoza C,Breton-Mora F,Herrera-Torres A,Elizalde-Acosta I,Cortes-Reynosa P,Thompson-Bonilla R,Perez Salazar E
44-624G was used in Western Blot, Immunocytochemistry to investigate whether EVs isolated from Mexican patients with breast cancer can induce cellular processes related to invasion in breast cancer.
Tue Sep 01 00:00:00 EDT 2020
Circulating extracellular vesicles from patients with breast cancer enhance migration and invasion via a Src‑dependent pathway in MDA‑MB‑231 breast cancer cells.
Molecular medicine reports
Ramírez-Ricardo J,Leal-Orta E,Martínez-Baeza E,Ortiz-Mendoza C,Breton-Mora F,Herrera-Torres A,Elizalde-Acosta I,Cortes-Reynosa P,Thompson-Bonilla R,Perez Salazar E
44-624G was used in Western Blot, Immunocytochemistry to investigate whether EVs isolated from Mexican patients with breast cancer can induce cellular processes related to invasion in breast cancer.
Tue Sep 01 00:00:00 EDT 2020
Engineering clinically-relevant human fibroblastic cell-derived extracellular matrices.
Methods in cell biology
Franco-Barraza J,Raghavan KS,Luong T,Cukierman E
44-624G was used in Immunocytochemistry-immunoflourescence to show that ECMs provide cells with biochemical and biomechanical cues to support and locally control cell function.
Thu Dec 24 00:00:00 EST 2020
Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model.
Cancers
Kim SK,Jang SD,Kim H,Chung S,Park JK,Kuh HJ
44-624G was used in Immunocytochemistry to investigate modes of cancer cell invasion using two pancreatic cancer cell lines with differential epithelial-mesenchymal status, PANC-1 and BxPC-3, under 3D culture conditions.
Thu May 21 00:00:00 EDT 2020
Fibronectin-containing High-Density Lipoprotein is Associated with Cancer Cell Adhesion and Proliferation.
The Kobe journal of medical sciences
Hisamatsu E,Nagao M,Toh R,Irino Y,Iino T,Hara T,Tanaka H,Satomi-Kobayashi S,Ishida T,Hirata KI
44-624G was used in Western Blotting to show FN-HDL promoted cancer cell proliferation and adhesion compared to HDL without fibronectin.
Mon Aug 17 00:00:00 EDT 2020
Hydrogel Network Dynamics Regulate Vascular Morphogenesis.
Cell stem cell
Wei Z,Schnellmann R,Pruitt HC,Gerecht S
44-624G was used in Immunocytochemistry, Immunohistochemistry, Western Blot to investigate the effect of hydrogel network dynamics on vasculation signalling.
Thu Nov 05 00:00:00 EST 2020
A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
The Journal of biological chemistry
Zhuo Y,Gurevich VV,Vishnivetskiy SA,Klug CS,Marchese A
44-624G was used in Western Blotting to understand the mechanism by which β-arr1 together with STAM1 activates FAK, using site-directed spin-labeling EPR spectroscopy-based studies coupled with bioluminescence resonance energy transfer-based cellular studies.
Fri Oct 09 00:00:00 EDT 2020
Matrix stiffness regulates vascular integrity through focal adhesion kinase activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Wang W,Lollis EM,Bordeleau F,Reinhart-King CA
44-624G was used in Immunocytochemistry to show extracellular matrix stiffness regulates endothelial barrier function by a mechanism using focal adhesion kinase activit.
Tue Jan 01 00:00:00 EST 2019
Loss of ASAP1 in mice impairs adipogenic and osteogenic differentiation of mesenchymal progenitor cells through dysregulation of FAK/Src and AKT signaling.
PLoS genetics
Schreiber C,Saraswati S,Harkins S,Gruber A,Cremers N,Thiele W,Rothley M,Plaumann D,Korn C,Armant O,Augustin HG,Sleeman JP
44-624G was used in Western Blotting to suggest that ASAP1 plays a decisive role during the differentiation of mesenchymal progenitor cells.
Sat Jun 01 00:00:00 EDT 2019
The post-abscission midbody is an intracellular signaling organelle that regulates cell proliferation.
Nature communications
Peterman E,Gibieža P,Schafer J,Skeberdis VA,Kaupinis A,Valius M,Heiligenstein X,Hurbain I,Raposo G,Prekeris R
44-624G was used in Immunocytochemistry-immunoflourescence to study the mechanisms regulating the post-mitotic internalisation of the midbody (MB), and reveal the functions of MB as an intracellular signalling organelle.
Thu Jul 18 00:00:00 EDT 2019
The human CIB1-EVER1-EVER2 complex governs keratinocyte-intrinsic immunity to β-papillomaviruses.
The Journal of experimental medicine
de Jong SJ,Créquer A,Matos I,Hum D,Gunasekharan V,Lorenzo L,Jabot-Hanin F,Imahorn E,Arias AA,Vahidnezhad H,Youssefian L,Markle JG,Patin E,D'Amico A,Wang CQF,Full F,Ensser A,Leisner TM,Parise LV,Bouaziz M,Maya NP,Cadena XR,Saka B,Saeidian AH,Aghazadeh N,Zeinali S,Itin P,Krueger JG,Laimins L,Abel L,Fuchs E,Uitto J,Franco JL,Burger B,Orth G,Jouanguy E,Casanova JL
44-624G was used in Immunocytochemistry to suggest that the disruption of CIB1-EVER1-EVER2-dependent keratinocyte-intrinsic immunity underlies the selective susceptibility to Β-HPVs of EV patients.
Mon Sep 03 00:00:00 EDT 2018
Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells.
Cancer research
Chen PY,Muzumdar MD,Dorans KJ,Robbins R,Bhutkar A,Del Rosario A,Mertins P,Qiao J,Schafer AC,Gertler F,Carr S,Jacks T
44-624G was used in Western Blotting to study reversible and adaptive resistance to Kras in pancreatic cancer cells.
Thu Feb 15 00:00:00 EST 2018
Immunohistochemical Expression of Cortactin and Focal Adhesion Kinase Predicts Recurrence Risk and Laryngeal Cancer Risk Beyond Histologic Grading.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Villaronga MÁ,Hermida-Prado F,Granda-Díaz R,Menéndez ST,Álvarez-Teijeiro S,Quer M,Vilaseca I,Allonca E,Garzón-Arango M,Sanz-Moreno V,Astudillo A,Rodrigo JP,García-Pedrero JM
44-624G was used in Western Blotting to determine the pathophysiologic role of cortactin and focal adhesion kinase in laryngeal cancer.
Sun Jul 01 00:00:00 EDT 2018
Actin cytoskeleton regulates functional anchorage-migration switch during T-cadherin-induced phenotype modulation of vascular smooth muscle cells.
Cell adhesion & migration
Frismantiene A,Kyriakakis E,Dasen B,Erne P,Resink TJ,Philippova M
44-624G was used in Western Blotting to demonstrate that the actin skeleton permissively regulates cell-matrix adhesive interactions and cell migration behaviour during T-cadherin-induced smooth muscle cells phenotype transition.
Tue Jan 02 00:00:00 EST 2018
Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Ruoss S,Möhl CB,Benn MC,von Rechenberg B,Wieser K,Meyer DC,Gerber C,Flück M
44-624G was used in Immunoprecipitation to study the effect of rotator cuff tears on costamere turnover in an ovine model.
Mon Jan 01 00:00:00 EST 2018
Involvement of aquaporin-4 in laminin-enhanced process formation of mouse astrocytes in 2D culture: Roles of dystroglycan and α-syntrophin in aquaporin-4 expression.
Journal of neurochemistry
Sato J,Horibe S,Kawauchi S,Sasaki N,Hirata KI,Rikitake Y
44-624G was used in Immunohistochemistry-immunofluorescence to indicate that the laminin-dystroglycan-α-syntrophin-AQP4 axis is important for process formation and branching of 2D cultured astrocytes.
Thu Nov 01 00:00:00 EDT 2018
Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Jamalpour M,Li X,Gustafsson K,Tyner JW,Welsh M
44-624G was used in Western Blotting to help explain the outcome of human disease in relation to Src homology-2 domain protein B mRNA content.
Sun Apr 01 00:00:00 EDT 2018
Inhibition of calpain delays early muscle atrophy after rotator cuff tendon release in sheep.
Physiological reports
Ruoss S,Kindt P,Oberholzer L,Rohner M,Jungck L,Abdel-Aziz S,Fitze D,Rosskopf AB,Klein K,von Rechenberg B,Gerber C,Wieser K,Flück M
44-624G was used in Western Blotting to study the effect of inhibition of the protease calpain on muscle atrophy.
Thu Nov 01 00:00:00 EDT 2018
Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy.
PloS one
Cordes N,Ney M,Beleites T,Aust D,Baretton G,Thames H,Baumann M,Krause M,Löck S,Appold S
44-624G was used in Immunohistochemistry to evaluate the expression of Β1 integrins and associated proteins as prognostic markers for primary radio(chemo)therapy outcome of patients with locally advanced head and neck squamous cell carcinomas.
Mon May 27 00:00:00 EDT 2019
Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores.
Cell
Elosegui-Artola A,Andreu I,Beedle AEM,Lezamiz A,Uroz M,Kosmalska AJ,Oria R,Kechagia JZ,Rico-Lastres P,Le Roux AL,Shanahan CM,Trepat X,Navajas D,Garcia-Manyes S,Roca-Cusachs P
44-624G was used in Immunocytochemistry to unveil a mechanosensing mechanism mediated directly by nuclear pores, demonstrated for YAP but with potential general applicability in transcriptional regulation.
Thu Nov 30 00:00:00 EST 2017
Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro.
International journal of oncology
Sato M,Kawana K,Adachi K,Fujimoto A,Yoshida M,Nakamura H,Nishida H,Inoue T,Taguchi A,Ogishima J,Eguchi S,Yamashita A,Tomio K,Wada-Hiraike O,Oda K,Nagamatsu T,Osuga Y,Fujii T
44-624G was used in Western Blotting to propose a rationale for the positive and negative effects of using FAK inhibitors in ovarian clear cell carcinomas and suggested that targeting glutamine metabolism could overcome the limitation of FAK inhibitors by additively inhibiting the mTOR pathway.
Sat Apr 01 00:00:00 EDT 2017
Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells.
Molecular medicine reports
Thang ND,Minh NV,Huong PT
44-624G was used in Western Blotting to study BBAP as a biomarker and therapeutic target for metastatic melanoma.
Sun Jan 01 00:00:00 EST 2017
15-Deoxy-Δ12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction.
Oncology letters
Wu YC,Jhao YT,Cheng YC,Chen Y
44624G was used in western blot to elucidate the mechanism by which 15d-PGJ2 suppresses human thyroid carcinoma cell migration
Sat Apr 01 00:00:00 EDT 2017
mTOR regulates peripheral nerve response to tensile strain.
Journal of neurophysiology
Love JM,Bober BG,Orozco E,White AT,Bremner SN,Lovering RM,Schenk S,Shah SB
44-624G was used in Western Blotting to investigate signalling mechanisms underlying peripheral nerve response to deformation using an in vivo rat model of sciatic nerve strain.
Mon May 01 00:00:00 EDT 2017
Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells.
Oncotarget
El Kharbili M,Robert C,Witkowski T,Danty-Berger E,Barbollat-Boutrand L,Masse I,Gadot N,de la Fouchardière A,McDonald PC,Dedhar S,Le Naour F,Degoul F,Berthier-Vergnes O
44624G was used in immunocytochemistry and western blot to see if tetraspanin 8 influences cell-matrix anchorage and regulates downstream molecular pathways leading to aggressive behavior of tumor progression in melanoma
Tue Mar 07 00:00:00 EST 2017
ARD1-mediated aurora kinase A acetylation promotes cell proliferation and migration.
Oncotarget
Vo TTL,Park JH,Seo JH,Lee EJ,Choi H,Bae SJ,Le H,An S,Lee HS,Wee HJ,Kim KW
44-624G was used in Western Blotting to examine the effects of arrest defective protein 1-mediated acetylation of aurora kinase A on cell proliferation and migration.
Tue Aug 22 00:00:00 EDT 2017
The fibronectin synergy site re-enforces cell adhesion and mediates a crosstalk between integrin classes.
eLife
Benito-Jardón M,Klapproth S,Gimeno-LLuch I,Petzold T,Bharadwaj M,Müller DJ,Zuchtriegel G,Reichel CA,Costell M
44624G was used in western blot to find that mice with a dysfunctional fibronectin-synergy motif suffer from surprisingly mild platelet adhesion and bleeding defects due to delayed thrombus formation after vessel injury
Mon Jan 16 00:00:00 EST 2017
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity.
Nature cell biology
Elosegui-Artola A,Oria R,Chen Y,Kosmalska A,Pérez-González C,Castro N,Zhu C,Trepat X,Roca-Cusachs P
44-624G was used in immunocytochemistry to study the response to matrix rigidity by mechanical regulation of a molecular clutch that defines force transmission and transduction
Sun May 01 00:00:00 EDT 2016
FAK, talin and PIPKIγ regulate endocytosed integrin activation to polarize focal adhesion assembly.
Nature cell biology
Nader GP,Ezratty EJ,Gundersen GG
44624G was used in immunohistochemistry to investigate how recycled integrins assemble into new adhesions
Sun May 01 00:00:00 EDT 2016
The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.
Journal of cellular physiology
Rooney N,Wang P,Brennan K,Gilmore AP,Streuli CH
44-624G was used in immunocytochemistry to learn about the control of differentiation in mammary epithelial cells by the integrin-mediated ILK-parvin-alpha-Pix signaling axis
Tue Nov 01 00:00:00 EDT 2016
Src Family Kinases Modulate the Loss of Endothelial Barrier Function in Response to TNF-α: Crosstalk with p38 Signaling.
PloS one
Adam AP,Lowery AM,Martino N,Alsaffar H,Vincent PA
44-624G was used in western blot investigate the effects of TNF treatment and SFK activation using human dermal microvascular endothelial cells
Wed Aug 02 00:00:00 EDT 2017
Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin.
eLife
Theodosiou M,Widmaier M,Böttcher RT,Rognoni E,Veelders M,Bharadwaj M,Lambacher A,Austen K,Müller DJ,Zent R,Fässler R
44-624G was used in immunocytochemistry and western blot to determine the role of Kindlin-2 tp activate integrins by cooperating with talin and induction of cell spreading by directly binding paxillin
Wed Jan 27 00:00:00 EST 2016
Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.
Oncotarget
Barcus CE,Keely PJ,Eliceiri KW,Schuler LA
44624G was used in western blot to explore the extracellular matrix features that control prolactin signals
Tue Jul 26 00:00:00 EDT 2016
Highly Multiplexed Imaging Uncovers Changes in Compositional Noise within Assembling Focal Adhesions.
PloS one
Harizanova J,Fermin Y,Malik-Sheriff RS,Wieczorek J,Ickstadt K,Grecco HE,Zamir E
44-624G was used in immunocytochemistry study the assembly of integrin adhesome protein complexes
Thu Jul 27 00:00:00 EDT 2017
Extracellular rigidity sensing by talin isoform-specific mechanical linkages.
Nature cell biology
Austen K,Ringer P,Mehlich A,Chrostek-Grashoff A,Kluger C,Klingner C,Sabass B,Zent R,Rief M,Grashoff C
44-624G was used in western blot to describe a role for talin in sensing tissue stiffness
Tue Dec 01 00:00:00 EST 2015
Conformational coupling of integrin and Thy-1 regulates Fyn priming and fibroblast mechanotransduction.
The Journal of cell biology
Fiore VF,Strane PW,Bryksin AV,White ES,Hagood JS,Barker TH
44-624G was used in western blot to report that Thy-1 is a regulator of fibroblast rigidity sensing
Mon Oct 12 00:00:00 EDT 2015
Insulin-like growth factor 1 increases apical fibronectin in blastocysts to increase blastocyst attachment to endometrial epithelial cells in vitro.
Human reproduction (Oxford, England)
Green CJ,Fraser ST,Day ML
44-624G was used in western blot to investigate the role of insulin-like growth factor 1 in the adhesion of blastocysts to uterine epithelial cells
Sun Feb 01 00:00:00 EST 2015
Collagen density regulates xenobiotic and hypoxic response of mammary epithelial cells.
Environmental toxicology and pharmacology
Curran CS,Carrillo ER,Ponik SM,Keely PJ
44-624G was used in western blot to determine the effect of high density or low density collagen gels on the xenobiotic or hypoxic responses of mammary cells.
Thu Jan 01 00:00:00 EST 2015
A novel type 3 secretion system effector, YspI of Yersinia enterocolitica, induces cell paralysis by reducing total focal adhesion kinase.
Cellular microbiology
LeGrand K,Matsumoto H,Young GM
44-624G was used in immunocytochemistry to study how YspI produced by Yersinia enterocolitica Biovar 1B inhibits cellular movement
Fri May 01 00:00:00 EDT 2015
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
PloS one
Fukumoto M,Kurisu S,Yamada T,Takenawa T
44-624G was used in immunocytochemistry to determine the mechanism by which ACTN4 drives development of malignant focal adhesions
Tue Apr 05 00:00:00 EDT 2016
Microgravity promotes osteoclast activity in medaka fish reared at the international space station.
Scientific reports
Chatani M,Mantoku A,Takeyama K,Abduweli D,Sugamori Y,Aoki K,Ohya K,Suzuki H,Uchida S,Sakimura T,Kono Y,Tanigaki F,Shirakawa M,Takano Y,Kudo A
44-624G was used in ChIP assay to study bone mineral density of transgenic medaka fish housed in a microgravity environment.
Mon Sep 21 00:00:00 EDT 2015
Dissecting motility signaling through activation of specific Src-effector complexes.
Nature chemical biology
Karginov AV,Tsygankov D,Berginski M,Chu PH,Trudeau ED,Yi JJ,Gomez S,Elston TC,Hahn KM
44-624G was used in western blot to describe a method to selectively and quickly activate a kinase in a specific protein complex or at a specific subcellular location within living cells.
Tue Apr 01 00:00:00 EDT 2014
Signaling events mediated by α3β1 integrin are essential for mammary tumorigenesis.
Oncogene
Cagnet S,Faraldo MM,Kreft M,Sonnenberg A,Raymond K,Glukhova MA
44-624G was used in western blot to study signaling pathways in tumor-resistant K5DeltaNbetacat mice.
Thu Aug 21 00:00:00 EDT 2014
Pelargonidin attenuates PDGF-BB-induced aortic smooth muscle cell proliferation and migration by direct inhibition of focal adhesion kinase.
Biochemical pharmacology
Son JE,Jeong H,Kim H,Kim YA,Lee E,Lee HJ,Lee KW
44-624G was used in western blot to study the preventive effects of pelargonidin toward atherosclerosis mechanistically.
Thu May 15 00:00:00 EDT 2014
FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.
Developmental biology
Bjerke MA,Dzamba BJ,Wang C,DeSimone DW
44-624G was used in western blot to examine the relation between focal adhesion kinase and Xenopus mesendoderm cells.
Wed Oct 15 00:00:00 EDT 2014
CDCP1 identifies a CD146 negative subset of marrow fibroblasts involved with cytokine production.
PloS one
Iwata M,Torok-Storb B,Wayner EA,Carter WG
44-624G was used in immunocytochemistry to examine the expression of CDCP1 in a unique subset of marrow fibroblasts
Tue Dec 22 00:00:00 EST 2015
Rigidity-patterned polyelectrolyte films to control myoblast cell adhesion and spatial organization.
Advanced functional materials
Monge C,Saha N,Boudou T,Pózos-Vásquez C,Dulong V,Glinel K,Picart C
44-624G was used in immunocytochemistry to evaluate polyelectrolyte films for the study of myoblast cell adhesion and spatial organization.
Fri Jul 19 00:00:00 EDT 2013
Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration.
Journal of cell science
Allaire PD,Seyed Sadr M,Chaineau M,Seyed Sadr E,Konefal S,Fotouhi M,Maret D,Ritter B,Del Maestro RF,McPherson PS
44-624G was used in western blot to examine the role of cadherin and integrin receptors on cell migration and differentiation.
Fri Feb 01 00:00:00 EST 2013
The ER Ca²⁺ sensor STIM1 regulates actomyosin contractility of migratory cells.
Journal of cell science
Chen YT,Chen YF,Chiu WT,Wang YK,Chang HC,Shen MR
44-624G was used in immunocytochemistry to elucidate the regulatory mechanisms by which STIM1-dependent Ca(2+) signaling controls cancer cell migration.
Fri Mar 01 00:00:00 EST 2013
Integrins regulate centrosome integrity and astrocyte polarization following a wound.
Developmental neurobiology
Peng H,Ong YM,Shah WA,Holland PC,Carbonetto S
44-624G was used in immunocytochemistry and western blot to discuss β1 integrin null astrocytes.
Wed May 01 00:00:00 EDT 2013
Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis.
Cell death & disease
Wiel C,Augert A,Vincent DF,Gitenay D,Vindrieux D,Le Calvé B,Arfi V,Lallet-Daher H,Reynaud C,Treilleux I,Bartholin L,Lelievre E,Bernard D
44-624G was used in western blot to investigate how benign tumors escape from oncogenic stress-induced senescence to become malignant.
Thu Oct 10 00:00:00 EDT 2013
Characterization of heparanase-induced phosphatidylinositol 3-kinase-AKT activation and its integrin dependence.
The Journal of biological chemistry
Riaz A,Ilan N,Vlodavsky I,Li JP,Johansson S
44-624G was used in western blot to study the activation of the PI3K-AKT pathway by latent heparanase.
Fri Apr 26 00:00:00 EDT 2013
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
The Journal of biological chemistry
Thapa N,Choi S,Hedman A,Tan X,Anderson RA
44-624G was used in western blot to study how tumor cells sustain oncogenic signals in the absence of cell matrix interactions
Fri Nov 29 00:00:00 EST 2013
Implanted adipose progenitor cells as physicochemical regulators of breast cancer.
Proceedings of the National Academy of Sciences of the United States of America
Chandler EM,Seo BR,Califano JP,Andresen Eguiluz RC,Lee JS,Yoon CJ,Tims DT,Wang JX,Cheng L,Mohanan S,Buckley MR,Cohen I,Nikitin AY,Williams RM,Gourdon D,Reinhart-King CA,Fischbach C
Tue Jun 19 00:00:00 EDT 2012
Kindlin-1 enhances axon growth on inhibitory chondroitin sulfate proteoglycans and promotes sensory axon regeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tan CL,Andrews MR,Kwok JC,Heintz TG,Gumy LF,Fässler R,Fawcett JW
Wed May 23 00:00:00 EDT 2012
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the β1 integrin-RACK1 axis.
Journal of cellular physiology
Trerotola M,Li J,Alberti S,Languino LR
44-624G was used in western blot to investigate the role of Trop-2 in cell adhesion.
Thu Nov 01 00:00:00 EDT 2012
β1 integrin gene excision in the adult murine cardiac myocyte causes defective mechanical and signaling responses.
The American journal of pathology
Li R,Wu Y,Manso AM,Gu Y,Liao P,Israeli S,Yajima T,Nguyen U,Huang MS,Dalton ND,Peterson KL,Ross RS
44-624G was used in western blot to examine the function of in the β integrin postnatal and mechanically stressed heart.
Thu Mar 01 00:00:00 EST 2012
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
Carcinogenesis
Golubovskaya VM,Figel S,Ho BT,Johnson CP,Yemma M,Huang G,Zheng M,Nyberg C,Magis A,Ostrov DA,Gelman IH,Cance WG
Tue May 01 00:00:00 EDT 2012
A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.
Carcinogenesis
Golubovskaya VM,Figel S,Ho BT,Johnson CP,Yemma M,Huang G,Zheng M,Nyberg C,Magis A,Ostrov DA,Gelman IH,Cance WG
Tue May 01 00:00:00 EDT 2012
LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation.
The Journal of pharmacology and experimental therapeutics
Sun X,Phan TN,Jung SH,Kim SY,Cho JU,Lee H,Woo SH,Park TK,Yang BS
Thu Mar 01 00:00:00 EST 2012
Enhanced integrin mediated signaling and cell cycle progression on fibronectin mimetic peptide amphiphile monolayers.
Langmuir : the ACS journal of surfaces and colloids
Shroff K,Pearce TR,Kokkoli E
44-624G was used in western blot to study the binding affinity of the PR_b peptide ligand with the α(5)β() integrin.
Tue Jan 24 00:00:00 EST 2012
Enhanced integrin mediated signaling and cell cycle progression on fibronectin mimetic peptide amphiphile monolayers.
Langmuir : the ACS journal of surfaces and colloids
Shroff K,Pearce TR,Kokkoli E
44-624G was used in western blot to study the binding affinity of the PR_b peptide ligand with the α(5)β() integrin.
Tue Jan 24 00:00:00 EST 2012
β1 integrins restrict the growth of foci and spheroids.
Histochemistry and cell biology
Gupta RK,Johansson S
44-624G was used in western blot to investigate the role of integrin subunit β in two-dimensional and three-dimensional cell cultures.
Sat Dec 01 00:00:00 EST 2012
Diversity of matriptase expression level and function in breast cancer.
PloS one
Welman A,Sproul D,Mullen P,Muir M,Kinnaird AR,Harrison DJ,Faratian D,Brunton VG,Frame MC
44-624G was used in western blot to study the role of matriptase in breast cancer.
Thu Aug 30 00:00:00 EDT 2012
Specific β-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells.
The Journal of biological chemistry
Jeanes AI,Wang P,Moreno-Layseca P,Paul N,Cheung J,Tsang R,Akhtar N,Foster FM,Brennan K,Streuli CH
Fri Jul 13 00:00:00 EDT 2012
MicroRNAs are essential for stretch-induced vascular smooth muscle contractile differentiation via microRNA (miR)-145-dependent expression of L-type calcium channels.
The Journal of biological chemistry
Turczynska KM,Sadegh MK,Hellstrand P,Swärd K,Albinsson S
44-624G was used in Western Blotting to show that microRNAs play a crucial role in stretch-induced contractile differentiation in the vascular wall in part via miR-145-dependent regulation of L-type calcium channels.
Fri Jun 01 00:00:00 EDT 2012
Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer.
The Journal of biological chemistry
Hance MW,Dole K,Gopal U,Bohonowych JE,Jezierska-Drutel A,Neumann CA,Liu H,Garraway IP,Isaacs JS
44-624G was used in western blot to show a role for eHsp90 in driving epithelial to mesenchymal transition events in prostate cancer.
Fri Nov 02 00:00:00 EDT 2012
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tan CL,Kwok JC,Patani R,Ffrench-Constant C,Chandran S,Fawcett JW
44-624G was used in immunocytochemistry and western blot to test if chondroitin sulfate proteoglycans inhibit regeneration in the central nervous system by inactivating integrins.
Wed Apr 27 00:00:00 EDT 2011
Role of tetraspanin CD151-α3/α6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.
The international journal of biochemistry & cell biology
Liu WF,Zuo HJ,Chai BL,Peng D,Fei YJ,Lin JY,Yu XH,Wang DW,Liu ZX
44-624G was used in western blot to determine the role and mechanism of CD151-integrin complex in angiogenesis.
Fri Apr 01 00:00:00 EDT 2011
PH006, a novel and selective Src kinase inhibitor, suppresses human breast cancer growth and metastasis in vitro and in vivo.
Breast cancer research and treatment
Ma JG,Huang H,Chen SM,Chen Y,Xin XL,Lin LP,Ding J,Liu H,Meng LH
44-624G was used in western blot to identify the Src kinase inhibitor, PH006, and explore its activity and mechanism of action in human breast cancer.
Tue Nov 01 00:00:00 EDT 2011
Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsion by MAG.
Nature neuroscience
Hines JH,Abu-Rub M,Henley JR
44-624G was used in Immunohistochemistry-immunofluorescence to identify beta(1)-integrin as an important functional cargo during Ca(2+)-dependent rapid endocytosis stimulated by a diffusible guidance cue.
Thu Jul 01 00:00:00 EDT 2010
Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.
Cell death and differentiation
Owens TW,Valentijn AJ,Upton JP,Keeble J,Zhang L,Lindsay J,Zouq NK,Gilmore AP
44-624G was used in western blot to identify p38MAPK as an activator of Bax
Sun Nov 01 00:00:00 EDT 2009
Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation.
Development (Cambridge, England)
Akhtar N,Marlow R,Lambert E,Schatzmann F,Lowe ET,Cheung J,Katz E,Li W,Wu C,Dedhar S,Naylor MJ,Streuli CH
44-624G was used in immunocytochemistry to identify factors that regulate connecting adhesion
Sun Mar 01 00:00:00 EST 2009
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B
44-624G was used in western blot to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
Thu Oct 01 00:00:00 EDT 2009
Nonessential role of beta3 and beta5 integrin subunits for efficient clearance of cellular debris after light-induced photoreceptor degeneration.
Investigative ophthalmology & visual science
Joly S,Samardzija M,Wenzel A,Thiersch M,Grimm C
44-624G was used in Western Blotting to investigate the question of whether the lack of beta5 and/or beta3 integrin subunits might influence the course of retinal degeneration and/or clearance of photoreceptor debris induced by acute exposure to light.
Sun Mar 01 00:00:00 EST 2009
Beta1 integrin deficiency results in multiple abnormalities of the knee joint.
The Journal of biological chemistry
Raducanu A,Hunziker EB,Drosse I,Aszódi A
44-624G was used in immunohistochemistry - paraffin section to study beta1 integrin-mediated cell-matrix interactions in adult knee joints
Fri Aug 28 00:00:00 EDT 2009
Differential dependence of stretch and shear stress signaling on caveolin-1 in the vascular wall.
American journal of physiology. Cell physiology
Albinsson S,Nordström I,Swärd K,Hellstrand P
44-624G was used in western blot to determine the role of caveolae in stretch- versus flow-induced vascular responses
Tue Jan 01 00:00:00 EST 2008
Dissection of the osteogenic effects of laminin-332 utilizing specific LG domains: LG3 induces osteogenic differentiation, but not mineralization.
Experimental cell research
Klees RF,Salasznyk RM,Ward DF,Crone DE,Williams WA,Harris MP,Boskey A,Quaranta V,Plopper GE
44-624G was used in western blot to study the role of laminins during osteogenic differentiation of human mesenchymal stem cells
Fri Feb 15 00:00:00 EST 2008
Increased chemotactic migration and growth in heparanase-overexpressing human U251n glioma cells.
Journal of experimental & clinical cancer research : CR
Hong X,Jiang F,Kalkanis SN,Zhang ZG,Zhang X,Zheng X,Jiang H,Mikkelsen T,Chopp M
44-624G was used in western blot to elucidate the roles of heparanase during invasion of cancer cells
Tue Jul 22 00:00:00 EDT 2008
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells.
Cancer research
Finlay D,Vuori K
44-624G was used in western blot to identify roles for caspase-8 in the modulation of cell adhesion and activation of Erk signaling
Sat Dec 15 00:00:00 EST 2007
Ionising radiation induces changes associated with epithelial-mesenchymal transdifferentiation and increased cell motility of A549 lung epithelial cells.
European journal of cancer (Oxford, England : 1990)
Jung JW,Hwang SY,Hwang JS,Oh ES,Park S,Han IO
44-624G was used in western blot to examine the radiation-induced alterations of human lung cancer cells
Tue May 01 00:00:00 EDT 2007
Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Kumai Y,Ooboshi H,Ibayashi S,Ishikawa E,Sugimori H,Kamouchi M,Kitazono T,Egashira K,Iida M
Fri Jun 01 00:00:00 EDT 2007
Semaphorin 3C regulates endothelial cell function by increasing integrin activity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Banu N,Teichman J,Dunlap-Brown M,Villegas G,Tufro A
44-624G was used in western blot to study sema 3C as regulator of endothelial cell function
Sun Oct 01 00:00:00 EDT 2006
Heat shock-induced cardioprotection activates cytoskeletal-based cell survival pathways.
American journal of physiology. Heart and circulatory physiology
Wei H,Campbell W,Vander Heide RS
44-624G was used in western blot to elucidate the mechanisms of heat shock-induced cardioprotection
Tue Aug 01 00:00:00 EDT 2006
Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion.
Experimental cell research
Dang D,Bamburg JR,Ramos DM
44-624G was used in western blot to explore the relationship between beta3-integrin expression, phosphorylation of cofilin, and metalloproteinase production
Wed Feb 15 00:00:00 EST 2006
Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma.
Human pathology
Madan R,Smolkin MB,Cocker R,Fayyad R,Oktay MH
44-624G was used in immunohistochemistry to assess the involvement of integrin signaling molecules FAK, c-Src, and paxillin in malignant transformation of the breast epithelium.
Sun Jan 01 00:00:00 EST 2006
Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish.
Developmental biology
Semina EV,Bosenko DV,Zinkevich NC,Soules KA,Hyde DR,Vihtelic TS,Willer GB,Gregg RG,Link BA
44-624G was used in immunohistochemistry to characterize bal(a69) mutant zebrafish which have severe eye defects and a shortened body axis
Wed Nov 01 00:00:00 EST 2006
Ad-fRNK and Ad-p53 cooperate to augment drug-induced death of a transformed cell line.
Anticancer research
Kornberg L
44-624G was used in western blot to test if treatment with wild-type p53 and a FAK inhibitor sensitizes cells to anticancer drugs
Tue Sep 19 00:00:00 EDT 2006
Analyzing FAK and Pyk2 in early integrin signaling events.
Current protocols in cell biology
Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D
Sat Apr 01 00:00:00 EST 2006
Analyzing FAK and Pyk2 in early integrin signaling events.
Current protocols in cell biology
Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D
Sat Apr 01 00:00:00 EST 2006
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization.
Nature cell biology
del Pozo MA,Balasubramanian N,Alderson NB,Kiosses WB,Grande-García A,Anderson RG,Schwartz MA
Thu Sep 01 00:00:00 EDT 2005
Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization.
Nature cell biology
del Pozo MA,Balasubramanian N,Alderson NB,Kiosses WB,Grande-García A,Anderson RG,Schwartz MA
Thu Sep 01 00:00:00 EDT 2005
Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection.
The Journal of infectious diseases
John M,Keller MJ,Fam EH,Cheshenko N,Hogarty K,Kasowitz A,Wallenstein S,Carlucci MJ,Tuyama AC,Lu W,Klotman ME,Lehrer RI,Herold BC
44-624G was used in western blot to investigate how cervicovaginal secretions contribute to innate resistance to HSV-2
Tue Nov 15 00:00:00 EST 2005
Crk-associated substrate tyrosine phosphorylation sites are critical for invasion and metastasis of SRC-transformed cells.
Molecular cancer research : MCR
Brábek J,Constancio SS,Siesser PF,Shin NY,Pozzi A,Hanks SK
Wed Jun 01 00:00:00 EDT 2005
In situ analysis of integrin and growth factor receptor signaling pathways in human glioblastomas suggests overlapping relationships with focal adhesion kinase activation.
The American journal of pathology
Riemenschneider MJ,Mueller W,Betensky RA,Mohapatra G,Louis DN
44-624G was used in immunohistochemistry - paraffin section to study focal adhesion kinase and extracellular regulated kinases in glioblastomas
Tue Nov 01 00:00:00 EST 2005
Focal adhesion kinase plays a pivotal role in herpes simplex virus entry.
The Journal of biological chemistry
Cheshenko N,Liu W,Satlin LM,Herold BC
Fri Sep 02 00:00:00 EDT 2005
p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV.
The Journal of biological chemistry
Sanders MA,Basson MD
Fri Jun 24 00:00:00 EDT 2005
(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Molecular endocrinology (Baltimore, Md.)
Sekimoto H,Eipper-Mains J,Pond-Tor S,Boney CM
Fri Jul 01 00:00:00 EDT 2005
(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Molecular endocrinology (Baltimore, Md.)
Sekimoto H,Eipper-Mains J,Pond-Tor S,Boney CM
Fri Jul 01 00:00:00 EDT 2005
Reelin activates SRC family tyrosine kinases in neurons.
Current biology : CB
Bock HH,Herz J
Wed Jan 08 00:00:00 EST 2003
Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Grace EA,Busciglio J
Wed Jan 15 00:00:00 EST 2003
Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.
Journal of molecular and cellular cardiology
Willey CD,Balasubramanian S,Rodríguez Rosas MC,Ross RS,Kuppuswamy D
44-624G was used in western blot to investigate the involvement of beta3 integrin and c-Src in focal adhesion complex formation in adult cardiomyocytes.
Sun Jun 01 00:00:00 EDT 2003
Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells.
Neoplasia (New York, N.Y.)
Kim B,van Golen CM,Feldman EL
Mon Jul 12 00:00:00 EDT 2004
Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells.
Neoplasia (New York, N.Y.)
Kim B,van Golen CM,Feldman EL
Mon Jul 12 00:00:00 EDT 2004
Inhibition of FAK signaling activated by urokinase receptor induces dormancy in human carcinoma cells in vivo.
Oncogene
Aguirre Ghiso JA
Thu Apr 11 00:00:00 EDT 2002
High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis.
The Journal of cell biology
Beqaj S,Jakkaraju S,Mattingly RR,Pan D,Schuger L
Mon Mar 04 00:00:00 EST 2002
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Molecular and cellular biology
Cary LA,Klinghoffer RA,Sachsenmaier C,Cooper JA
Mon Apr 01 00:00:00 EST 2002
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Molecular and cellular biology
Cary LA,Klinghoffer RA,Sachsenmaier C,Cooper JA
Mon Apr 01 00:00:00 EST 2002
Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.
Molecular biology of the cell
Abbi S,Ueda H,Zheng C,Cooper LA,Zhao J,Christopher R,Guan JL
Sun Sep 01 00:00:00 EDT 2002
Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling.
The Journal of biological chemistry
Berditchevski F,Odintsova E,Sawada S,Gilbert E
Fri Oct 04 00:00:00 EDT 2002
Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling.
The Journal of biological chemistry
Berditchevski F,Odintsova E,Sawada S,Gilbert E
Fri Oct 04 00:00:00 EDT 2002
Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt.
The Journal of biological chemistry
Kim B,Feldman EL
Fri Jul 26 00:00:00 EDT 2002
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
The Journal of biological chemistry
Camenisch G,Pisabarro MT,Sherman D,Kowalski J,Nagel M,Hass P,Xie MH,Gurney A,Bodary S,Liang XH,Clark K,Beresini M,Ferrara N,Gerber HP
Fri May 10 00:00:00 EDT 2002
ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo.
The Journal of biological chemistry
Camenisch G,Pisabarro MT,Sherman D,Kowalski J,Nagel M,Hass P,Xie MH,Gurney A,Bodary S,Liang XH,Clark K,Beresini M,Ferrara N,Gerber HP
Fri May 10 00:00:00 EDT 2002
Regulation of the expression of c-Myc by beta1 integrins in epithelial cells.
Oncogene
Benaud CM,Dickson RB
Thu Feb 08 00:00:00 EST 2001
Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies.
Oncogene
Nakamura K,Yano H,Schaefer E,Sabe H
44-624G was used in immunocytochemistry to study how phosphorylation of Fak and Pyk2 affects their localization
Thu May 10 00:00:00 EDT 2001
Direct cell adhesion to the angiopoietins mediated by integrins.
The Journal of biological chemistry
Carlson TR,Feng Y,Maisonpierre PC,Mrksich M,Morla AO
Fri Jul 13 00:00:00 EDT 2001
FAK integrates growth-factor and integrin signals to promote cell migration.
Nature cell biology
Sieg DJ,Hauck CR,Ilic D,Klingbeil CK,Schaefer E,Damsky CH,Schlaepfer DD
Mon May 01 00:00:00 EDT 2000
FAK integrates growth-factor and integrin signals to promote cell migration.
Nature cell biology
Sieg DJ,Hauck CR,Ilic D,Klingbeil CK,Schaefer E,Damsky CH,Schlaepfer DD
Mon May 01 00:00:00 EDT 2000
FAK integrates growth-factor and integrin signals to promote cell migration.
Nature cell biology
Sieg DJ,Hauck CR,Ilic D,Klingbeil CK,Schaefer E,Damsky CH,Schlaepfer DD
Mon May 01 00:00:00 EDT 2000
FAK integrates growth-factor and integrin signals to promote cell migration.
Nature cell biology
Sieg DJ,Hauck CR,Ilic D,Klingbeil CK,Schaefer E,Damsky CH,Schlaepfer DD
Mon May 01 00:00:00 EDT 2000
