Product References
Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells.
Frontiers in oncology
Mori N,Jin J,Krishnamachary B,Mironchik Y,Wildes F,Vesuna F,Barnett JD,Bhujwalla ZM
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Western Blot
Sat Jul 01 00:00:00 EDT 2023
Functional roles of FAP-α in metabolism, migration and invasion of human cancer cells.
Frontiers in oncology
Mori N,Jin J,Krishnamachary B,Mironchik Y,Wildes F,Vesuna F,Barnett JD,Bhujwalla ZM
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Western Blot
Sat Jul 01 00:00:00 EDT 2023
Expression of pY397-FAK and Its miR Regulators Drive Dedifferentiation in the Thyroid Neoplasia Spectrum.
Cells
Ignjatović Jocić V,Janković Miljuš J,Išić Denčić T,Živaljević V,Tatić S,Đorić I,Šelemetjev S
700255 was used in Immunohistochemistry to investigate the regulation of focal adhesion kinase (FAK) and its correlation with histologic dedifferentiation, clinicopathological factors, and differential diagnosis in thyroid neoplasia, revealing that disturbances in FAK regulation contribute to neoplastic dedifferentiation and that specific factors can differentiate between classical and follicular variants of papillary thyroid carcinoma..
Mon Jun 26 00:00:00 EDT 2023
Expression of pY397-FAK and Its miR Regulators Drive Dedifferentiation in the Thyroid Neoplasia Spectrum.
Cells
Ignjatović Jocić V,Janković Miljuš J,Išić Denčić T,Živaljević V,Tatić S,Đorić I,Šelemetjev S
700255 was used in Immunohistochemistry to investigate the regulation of focal adhesion kinase (FAK) and its correlation with histologic dedifferentiation, clinicopathological factors, and differential diagnosis in thyroid neoplasia, revealing that disturbances in FAK regulation contribute to neoplastic dedifferentiation and that specific factors can differentiate between classical and follicular variants of papillary thyroid carcinoma..
Mon Jun 26 00:00:00 EDT 2023
KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer.
Molecular cancer research : MCR
Choi SH,Kim JK,Chen CT,Wu C,Marco MR,Barriga FM,O'Rourke K,Pelossof R,Qu X,Chang Q,de Stanchina E,Shia J,Smith JJ,Sanchez-Vega F,Garcia-Aguilar J
700255 was used in Western Blotting to show that KRAS mutant CRC upregulates integrin α6β4 through ERK/MEK signaling.
Fri Aug 05 00:00:00 EDT 2022
Effects of Titanium Implant Surface Topology on Bone Cell Attachment and Proliferation in vitro.
Medical devices (Auckland, N.Z.)
Levin M,Spiro RC,Jain H,Falk MM
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Immunocytochemistry
Sat Jul 16 00:00:00 EDT 2022
A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer.
American journal of cancer research
Ko S,Jung KH,Yoon YC,Han BS,Park MS,Lee YJ,Kim SE,Cho YJ,Lee P,Lim JH,Ryu JK,Kim K,Kim TY,Hong S,Lee SH,Hong SS
700255 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate that KI-301690 can inhibit aberrant ECM expression by DDR1/PYK2/FAK signaling pathway blockade and attenuation of ECM-induced chemoresistance observed in desmoplastic pancreatic tumors, resulting in enhanced antitumor effect through effective induction of gemcitabine apoptosis.
Fri Oct 14 00:00:00 EDT 2022
Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds.
Biomedicines
Betriu N,Andreeva A,Alonso A,Semino CE
700255 was used in Immunocytochemistry and Western Blotting to highlight how cell response to increased matrix stiffness greatly depends on the nature of the matrix used for 3D culture.
Fri Jul 29 00:00:00 EDT 2022
Increased Stiffness Downregulates Focal Adhesion Kinase Expression in Pancreatic Cancer Cells Cultured in 3D Self-Assembling Peptide Scaffolds.
Biomedicines
Betriu N,Andreeva A,Alonso A,Semino CE
700255 was used in Immunocytochemistry and Western Blotting to highlight how cell response to increased matrix stiffness greatly depends on the nature of the matrix used for 3D culture.
Fri Jul 29 00:00:00 EDT 2022
Morphological Phenotyping of Organotropic Brain- and Bone-Seeking Triple Negative Metastatic Breast Tumor Cells.
Frontiers in cell and developmental biology
DeCastro AJL,Pranda MA,Gray KM,Merlo-Coyne J,Girma N,Hurwitz M,Zhang Y,Stroka KM
700255 was used in Immunocytochemistry-immunofluorescence to show that MDA-BO cells have a distinct protrusive morphology not found in MDA-P or MDA-BR.
Tue Mar 08 00:00:00 EST 2022
Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice.
iScience
Alcantara MC,Suzuki K,Acebedo AR,Kajioka D,Hirohata S,Kaisho T,Hatano Y,Yamagata K,Takahashi S,Yamada G
700255 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to demonstrate the requirement of mesenchymal-derived androgen signaling on ECM-dependent cell migration, providing insights into the regulatory cellular mechanisms underlying androgen-driven sexual differentiation.
Thu Dec 22 00:00:00 EST 2022
Focal Adhesion Kinase Provides a Collateral Vulnerability That Can Be Leveraged to Improve mTORC1 Inhibitor Efficacy.
Cancers
Cuellar-Vite L,Weber-Bonk KL,Abdul-Karim FW,Booth CN,Keri RA
700255 was used in ELISA, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to reveal an innate dependency on FAK when mTORC1 signaling is lost in tumors that are resistant to mTORC1 inhibitors.
Mon Jul 11 00:00:00 EDT 2022
A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers.
Molecular cancer therapeutics
Kawakami M,Mustachio LM,Chen Y,Chen Z,Liu X,Wei CH,Roszik J,Kittai AS,Danilov AV,Zhang X,Fang B,Wang J,Heymach JV,Tyutyunyk-Massey L,Freemantle SJ,Kurie JM,Liu X,Dmitrovsky E
700255 was used in Immunohistochemistry to guide future trials of this novel CDK2/9 inhibitor in the cancer clinic.
Mon Mar 01 00:00:00 EST 2021
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation.
Journal of cell science
Brazzo JA,Biber JC,Nimmer E,Heo Y,Ying L,Zhao R,Lee K,Krause M,Bae Y
700255 was used in Western Blot to suggest that lamellipodin levels may be critical for regulating cell proliferation. This article has an associated First Person interview with the first author of the paper.
Tue Jun 15 00:00:00 EDT 2021
Oxygen Tension and the VHL-Hif1α Pathway Determine Onset of Neuronal Polarization and Cerebellar Germinal Zone Exit.
Neuron
Kullmann JA,Trivedi N,Howell D,Laumonnerie C,Nguyen V,Banerjee SS,Stabley DR,Shirinifard A,Rowitch DH,Solecki DJ
700255 was used in Immunocytochemistry-immunoflourescence to report that oxygen tension, which rises at birth, and the von Hippel-Lindau (VHL)-hypoxia-inducible factor 1α (Hif1α) pathway regulate polarization and maturation of post-mitotic cerebellar granule neurons (CGNs).
Wed May 20 00:00:00 EDT 2020
Surface Roughness Gradients Reveal Topography-Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells.
Small (Weinheim an der Bergstrasse, Germany)
Hou Y,Xie W,Yu L,Camacho LC,Nie C,Zhang M,Haag R,Wei Q
700255 was used in Immunocytochemistry to study the mechanotransduction and fate determination of human mesenchymal stem cells (MSCs) on surface roughness gradients.
Sun Mar 01 00:00:00 EST 2020
Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis.
Current biology : CB
Khadilkar RJ,Ho KYL,Venkatesh B,Tanentzapf G
700255 was used in Immunohistochemistry (PFA fixed) to provide mechanistic insight into how integrins can shape the signaling environment around hematopoietic progenitors.
Mon Sep 07 00:00:00 EDT 2020
Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.
eLife
Liu Y,Li L,Liu X,Wang Y,Liu L,Peng L,Liu J,Zhang L,Wang G,Li H,Liu DX,Huang B,Lu J,Zhang Y
700255 was used in Immunoprecipitation, Immunohistochemistry to characterize the PRMT7-dependent SHANK2 methylation as a key player in mediating endosomal FAK signals activation, also point to the value of SHANK2 R240 methylation as a target for breast cancer metastasis.
Wed Aug 26 00:00:00 EDT 2020
Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.
eLife
Liu Y,Li L,Liu X,Wang Y,Liu L,Peng L,Liu J,Zhang L,Wang G,Li H,Liu DX,Huang B,Lu J,Zhang Y
700255 was used in Immunoprecipitation, Immunohistochemistry to characterize the PRMT7-dependent SHANK2 methylation as a key player in mediating endosomal FAK signals activation, also point to the value of SHANK2 R240 methylation as a target for breast cancer metastasis.
Wed Aug 26 00:00:00 EDT 2020
Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.
eLife
Liu Y,Li L,Liu X,Wang Y,Liu L,Peng L,Liu J,Zhang L,Wang G,Li H,Liu DX,Huang B,Lu J,Zhang Y
700255 was used in Immunoprecipitation, Immunohistochemistry to characterize the PRMT7-dependent SHANK2 methylation as a key player in mediating endosomal FAK signals activation, also point to the value of SHANK2 R240 methylation as a target for breast cancer metastasis.
Wed Aug 26 00:00:00 EDT 2020
Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling.
eLife
Liu Y,Li L,Liu X,Wang Y,Liu L,Peng L,Liu J,Zhang L,Wang G,Li H,Liu DX,Huang B,Lu J,Zhang Y
700255 was used in Immunoprecipitation, Immunohistochemistry to characterize the PRMT7-dependent SHANK2 methylation as a key player in mediating endosomal FAK signals activation, also point to the value of SHANK2 R240 methylation as a target for breast cancer metastasis.
Wed Aug 26 00:00:00 EDT 2020
Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells.
The Journal of biological chemistry
Arous C,Mizgier ML,Rickenbach K,Pinget M,Bouzakri K,Wehrle-Haller B
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Western Blot
Fri Dec 04 00:00:00 EST 2020
Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells.
The Journal of biological chemistry
Arous C,Mizgier ML,Rickenbach K,Pinget M,Bouzakri K,Wehrle-Haller B
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Western Blot
Fri Dec 04 00:00:00 EST 2020
The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth.
eLife
Mondal B,Jin H,Kallappagoudar S,Sedkov Y,Martinez T,Sentmanat MF,Poet GJ,Li C,Fan Y,Pruett-Miller SM,Herz HM
700255 was used in Western Blotting to indicate a crucial role for the mitotic deacetylase complex (MiDAC) in regulating the ligands of the SLIT3 and NTN1 signaling axes to ensure the proper integrity of neurite development.
Thu Apr 16 00:00:00 EDT 2020
Differential nanoscale organisation of LFA-1 modulates T-cell migration.
Journal of cell science
Shannon MJ,Pineau J,Griffié J,Aaron J,Peel T,Williamson DJ,Zamoyska R,Cope AP,Cornish GH,Owen DM
700255 was used in Immunocytochemistry-immunoflourescence to present a paradigm where T-cells modulate the nanoscale organisation of adhesion and signalling molecules to fine tune their migration speed, with implications for the regulation of immune and inflammatory responses.
Wed Oct 16 00:00:00 EDT 2019
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
Nature biomedical engineering
Stowers RS,Shcherbina A,Israeli J,Gruber JJ,Chang J,Nam S,Rabiee A,Teruel MN,Snyder MP,Kundaje A,Chaudhuri O
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Immunofluorescence
Sun Dec 01 00:00:00 EST 2019
Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility.
Nature biomedical engineering
Stowers RS,Shcherbina A,Israeli J,Gruber JJ,Chang J,Nam S,Rabiee A,Teruel MN,Snyder MP,Kundaje A,Chaudhuri O
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Immunofluorescence
Sun Dec 01 00:00:00 EST 2019
The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.
Oncotarget
Aye JM,Stafman LL,Williams AP,Garner EF,Stewart JE,Anderson JC,Mruthyunjayappa S,Waldrop MG,Goolsby CD,Markert HR,Quinn C,Marayati R,Mroczek-Musulman E,Willey CD,Yoon KJ,Whelan KF,Beierle EA
700255 was used in Immunohistochemistry to study FAK and PDGFRβ inhibitors for treatment of metastatic Wilms tumour development and progression.
Tue Sep 17 00:00:00 EDT 2019
The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.
Oncotarget
Aye JM,Stafman LL,Williams AP,Garner EF,Stewart JE,Anderson JC,Mruthyunjayappa S,Waldrop MG,Goolsby CD,Markert HR,Quinn C,Marayati R,Mroczek-Musulman E,Willey CD,Yoon KJ,Whelan KF,Beierle EA
700255 was used in Immunohistochemistry to study FAK and PDGFRβ inhibitors for treatment of metastatic Wilms tumour development and progression.
Tue Sep 17 00:00:00 EDT 2019
The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor.
Oncotarget
Aye JM,Stafman LL,Williams AP,Garner EF,Stewart JE,Anderson JC,Mruthyunjayappa S,Waldrop MG,Goolsby CD,Markert HR,Quinn C,Marayati R,Mroczek-Musulman E,Willey CD,Yoon KJ,Whelan KF,Beierle EA
700255 was used in Immunohistochemistry to study FAK and PDGFRβ inhibitors for treatment of metastatic Wilms tumour development and progression.
Tue Sep 17 00:00:00 EDT 2019
Mechanical Durotactic Environment Enhances Specific Glioblastoma Cell Responses.
Cancers
Palamà IE,D'Amone S,Ratano P,Donatelli A,Liscio A,Antonacci G,Testini M,Di Angelantonio S,Ragozzino D,Cortese B
700255 was used in Western Blotting to determine the role of glioma cells in the regulation of the aggressive properties of glioblastoma cells.
Thu May 09 00:00:00 EDT 2019
Matrix Rigidity-Dependent Regulation of Ca2+ at Plasma Membrane Microdomains by FAK Visualized by Fluorescence Resonance Energy Transfer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Kim TJ,Lei L,Seong J,Suh JS,Jang YK,Jung SH,Sun J,Kim DH,Wang Y
700255 was used in Immunocytochemistry-immunoflourescence to study the underlying mechanisms that regulate Ca2+ and focal adhesion kinase signals in human mesenchymal stem cells under different mechanical microenvironments.
Wed Feb 20 00:00:00 EST 2019
Electromagnetic fields alter the motility of metastatic breast cancer cells.
Communications biology
Garg AA,Jones TH,Moss SM,Mishra S,Kaul K,Ahirwar DK,Ferree J,Kumar P,Subramaniam D,Ganju RK,Subramaniam VV,Song JW
700255 was used in Western Blotting to study the mechanisms underlying the mobility of metastatic breast cancer cells.
Tue Apr 14 00:00:00 EDT 2020
The Adhesion G-Protein-Coupled Receptor, GPR56/ADGRG1, Inhibits Cell-Extracellular Matrix Signaling to Prevent Metastatic Melanoma Growth.
Frontiers in oncology
Millar MW,Corson N,Xu L
700255 was used in Immunohistochemistry to suggest that GPR56 in melanoma metastases inhibits extracellular matrix accumulation and adhesion, contributing to its negative effects on metastatic growth.
Thu Oct 01 00:00:00 EDT 2020
Overexpression of eIF4F components in meningiomas and suppression of meningioma cell growth by inhibiting translation initiation.
Experimental neurology
Oblinger JL,Burns SS,Huang J,Pan L,Ren Y,Shen R,Kinghorn AD,Welling DB,Chang LS
700255 was used in Western Blotting to study the therapeutic potential of inhibiting protein translation in the treatment of meningiomas.
Mon Jan 01 00:00:00 EST 2018
MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells.
Journal of cell science
Van Itallie CM,Tietgens AJ,Aponte A,Gucek M,Cartagena-Rivera AX,Chadwick RS,Anderson JM
700255 was used in Western Blotting to identify relevant proteins mediating barrier disruption.
Fri Feb 02 00:00:00 EST 2018
Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells.
Investigative ophthalmology & visual science
Ho LTY,Skiba N,Ullmer C,Rao PV
700255 was used in Western Blotting to identify that Yes-associated protein/transcriptional coactivator with PDZ-binding domain complex induces increases in connective tissue growth factor and extracellular matrix production.
Sun Apr 01 00:00:00 EDT 2018
Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices.
Molecular biology of the cell
Gulvady AC,Dubois F,Deakin NO,Goreczny GJ,Turner CE
700255 was used in Immunohistochemistry to study the roles of Hic-5 and paxillin in a variety of cancer cell lines.
Sun Jul 15 00:00:00 EDT 2018
Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice.
Scientific reports
Sun S,Wu HJ,Guan JL
Published figure using Phospho-FAK (Tyr397) monoclonal antibody (Product # 700255) in Immunofluorescence
Wed Feb 07 00:00:00 EST 2018
Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice.
Scientific reports
Sun S,Wu HJ,Guan JL
Published figure using Phospho-FAK (Tyr397) monoclonal antibody (Product # 700255) in Immunofluorescence
Wed Feb 07 00:00:00 EST 2018
Downregulation of C-Terminal Tensin-Like Protein (CTEN) Suppresses Prostate Cell Proliferation and Contributes to Acinar Morphogenesis.
International journal of molecular sciences
Wu WM,Liao YC
700255 was used in Western Blotting to study the selective expression of C-terminal tensin-like protein in prostate epithelial cells and enrichment in the basal compartment.
Tue Oct 16 00:00:00 EDT 2018
Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation.
Scientific reports
Topal T,Hong X,Xue X,Fan Z,Kanetkar N,Nguyen JT,Fu J,Deng CX,Krebsbach PH
700255 was used in Immunocytochemistry-immunoflourescence to reveal a unique, rapid mechanoresponsiveness and community behaviour of human embryonic stem cells to integrin-targeted cyclic forces.
Tue Aug 28 00:00:00 EDT 2018
Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling.
Nature communications
Liu SC,Hsu T,Chang YS,Chung AK,Jiang SS,OuYang CN,Yuh CH,Hsueh C,Liu YP,Tsang NM
Published figure using Phospho-FAK (Tyr397) recombinant monoclonal antibody (Product # 700255) in Western Blot
Fri Nov 30 00:00:00 EST 2018
Polypharmacology-based ceritinib repurposing using integrated functional proteomics.
Nature chemical biology
Kuenzi BM,Remsing Rix LL,Stewart PA,Fang B,Kinose F,Bryant AT,Boyle TA,Koomen JM,Haura EB,Rix U
700255 was used in Western Blotting to characterise the anaplastic lymphoma kinase inhibitor, ceritinib, as having activity across several ALK-negative lung cancer cell lines, and identify new targets and network-wide signalling effects.
Fri Dec 01 00:00:00 EST 2017
Hic-5 remodeling of the stromal matrix promotes breast tumor progression.
Oncogene
Goreczny GJ,Ouderkirk-Pecone JL,Olson EC,Krendel M,Turner CE
Published figure using Phospho-FAK (Tyr397) monoclonal antibody (Product # 700255) in Immunofluorescence
Thu May 11 00:00:00 EDT 2017
Hic-5 remodeling of the stromal matrix promotes breast tumor progression.
Oncogene
Goreczny GJ,Ouderkirk-Pecone JL,Olson EC,Krendel M,Turner CE
Published figure using Phospho-FAK (Tyr397) monoclonal antibody (Product # 700255) in Immunofluorescence
Thu May 11 00:00:00 EDT 2017
In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate.
Molecular biology of the cell
Rodriguez D,Braden BP,Boyer SW,Taketa DA,Setar L,Calhoun C,Maio AD,Langenbacher A,Valentine MT,De Tomaso AW
700255 was used in Western Blotting to study the effects of extracellular matrix (ECM) manipulation on vascular regression in Botryllus schlosseri via apoptosis and extrusion through the basal lamina.
Fri Jul 07 00:00:00 EDT 2017
In vivo manipulation of the extracellular matrix induces vascular regression in a basal chordate.
Molecular biology of the cell
Rodriguez D,Braden BP,Boyer SW,Taketa DA,Setar L,Calhoun C,Maio AD,Langenbacher A,Valentine MT,De Tomaso AW
700255 was used in Western Blotting to study the effects of extracellular matrix (ECM) manipulation on vascular regression in Botryllus schlosseri via apoptosis and extrusion through the basal lamina.
Fri Jul 07 00:00:00 EDT 2017
Epithelial contribution to the profibrotic stiff microenvironment and myofibroblast population in lung fibrosis.
Molecular biology of the cell
Gabasa M,Duch P,Jorba I,Giménez A,Lugo R,Pavelescu I,Rodríguez-Pascual F,Molina-Molina M,Xaubet A,Pereda J,Alcaraz J
700255 was used in Western Blotting to examine epithelial-to-mesenchymal transition (EMT)-competent lung epithelial cells and lung fibroblasts from controls and from patients with idiopathic pulmonary fibrosis.
Fri Dec 15 00:00:00 EST 2017
LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration.
Molecular biology of the cell
Lin YH,Zhen YY,Chien KY,Lee IC,Lin WC,Chen MY,Pai LM
700255 was used in Immunoprecipitation to suggest that LIMCH1 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
Sat Apr 15 00:00:00 EDT 2017
LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration.
Molecular biology of the cell
Lin YH,Zhen YY,Chien KY,Lee IC,Lin WC,Chen MY,Pai LM
700255 was used in Immunoprecipitation to suggest that LIMCH1 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
Sat Apr 15 00:00:00 EDT 2017
LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration.
Molecular biology of the cell
Lin YH,Zhen YY,Chien KY,Lee IC,Lin WC,Chen MY,Pai LM
700255 was used in Immunoprecipitation to suggest that LIMCH1 plays a positive role in regulation of NM-II activity through effects on MRLC during cell migration.
Sat Apr 15 00:00:00 EDT 2017
Regulation of Focal Adhesion Kinase through a Direct Interaction with an Endogenous Inhibitor.
Biochemistry
Zak TJ,Koshman YE,Samarel AM,Robia SL
700255 was used in Functional Assay to suggest that FRNK limits growth and survival signaling pathways by binding directly to FAK in an inhibitory complex, and this inhibition is relieved by phosphorylation of FRNK at S217.
Tue Sep 05 00:00:00 EDT 2017
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
eLife
Chang TY,Chen C,Lee M,Chang YC,Lu CH,Lu ST,Wang DY,Wang A,Guo CL,Cheng PL
700255 was used in Immunofluorescence to reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner.
Fri Dec 22 00:00:00 EST 2017
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
eLife
Chang TY,Chen C,Lee M,Chang YC,Lu CH,Lu ST,Wang DY,Wang A,Guo CL,Cheng PL
700255 was used in Immunofluorescence to reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner.
Fri Dec 22 00:00:00 EST 2017
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
eLife
Chang TY,Chen C,Lee M,Chang YC,Lu CH,Lu ST,Wang DY,Wang A,Guo CL,Cheng PL
700255 was used in Immunofluorescence to reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner.
Fri Dec 22 00:00:00 EST 2017
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.
eLife
Chang TY,Chen C,Lee M,Chang YC,Lu CH,Lu ST,Wang DY,Wang A,Guo CL,Cheng PL
700255 was used in Immunofluorescence to reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner.
Fri Dec 22 00:00:00 EST 2017
Enhanced efficacy of AKT and FAK kinase combined inhibition in squamous cell lung carcinomas with stable reduction in PTEN.
Oncotarget
Cavazzoni A,La Monica S,Alfieri R,Ravelli A,Van Der Steen N,Sciarrillo R,Madeddu D,Lagrasta CAM,Quaini F,Bonelli M,Fumarola C,Cretella D,Digiacomo G,Tiseo M,Peters GJ,Ardizzoni A,Petronini PG,Giovannetti E
700255 was used in Immunohistochemistry to evaluate the relevance of PTEN loss in cancer progression, as well as the efficacy of a new combined treatment with the pan PI3K inhibitor, buparlisip, and the FAK inhibitor, defactinib.
Tue Aug 08 00:00:00 EDT 2017
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Cancer research
Budina-Kolomets A,Webster MR,Leu JI,Jennis M,Krepler C,Guerrini A,Kossenkov AV,Xu W,Karakousis G,Schuchter L,Amaravadi RK,Wu H,Yin X,Liu Q,Lu Y,Mills GB,Xu X,George DL,Weeraratna AT,Murphy ME
700255 was used in immunohistochemistry - paraffin section to determine limits on FAK-dependent invasion and enhancement of the response to melanoma treatment with BRAF inhibitors due to HSP70 inhibition
Sun May 01 00:00:00 EDT 2016
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Cancer research
Budina-Kolomets A,Webster MR,Leu JI,Jennis M,Krepler C,Guerrini A,Kossenkov AV,Xu W,Karakousis G,Schuchter L,Amaravadi RK,Wu H,Yin X,Liu Q,Lu Y,Mills GB,Xu X,George DL,Weeraratna AT,Murphy ME
700255 was used in immunohistochemistry - paraffin section to determine limits on FAK-dependent invasion and enhancement of the response to melanoma treatment with BRAF inhibitors due to HSP70 inhibition
Sun May 01 00:00:00 EDT 2016
HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Cancer research
Budina-Kolomets A,Webster MR,Leu JI,Jennis M,Krepler C,Guerrini A,Kossenkov AV,Xu W,Karakousis G,Schuchter L,Amaravadi RK,Wu H,Yin X,Liu Q,Lu Y,Mills GB,Xu X,George DL,Weeraratna AT,Murphy ME
700255 was used in immunohistochemistry - paraffin section to determine limits on FAK-dependent invasion and enhancement of the response to melanoma treatment with BRAF inhibitors due to HSP70 inhibition
Sun May 01 00:00:00 EDT 2016
Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament.
Journal of cellular physiology
Kaku M,Rosales Rocabado JM,Kitami M,Ida T,Akiba Y,Yamauchi M,Uoshima K
700255 was used in immunohistochemistry (paraffin) to test the effects of mechanical loading on the expression of collagen-modifying enzymes and subsequent tissue changes in periodontal ligament.
Fri Apr 01 00:00:00 EDT 2016
The FAK-Arp2/3 interaction promotes leading edge advance and haptosensing by coupling nascent adhesions to lamellipodia actin.
Molecular biology of the cell
Swaminathan V,Fischer RS,Waterman CM
700255 was used in Western Blotting to study the role of FAK in nascent integrin adhesion formation and lamellipodial dynamics.
Fri Apr 01 00:00:00 EDT 2016
αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells.
Cell death discovery
Chien JY,Tsen SD,Chien CC,Liu HW,Tung CY,Lin CH
700255 was used in western blot to assess the effect of three alpha-tubulin acetyltransferase 1-specific shRNAs on proliferation and morphology in HeLa and A549 cell lines
Tue Aug 23 00:00:00 EDT 2016
Spatiotemporal dynamics of traction forces show three contraction centers in migratory neurons.
The Journal of cell biology
Jiang J,Zhang ZH,Yuan XB,Poo MM
700255 was used in immunocytochemistry to study how traction force is generated and regulated during neuronal migration.
Mon Jun 08 00:00:00 EDT 2015
Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer.
Molecular cancer research : MCR
Puig M,Lugo R,Gabasa M,Giménez A,Velásquez A,Galgoczy R,Ramírez J,Gómez-Caro A,Busnadiego Ó,Rodríguez-Pascual F,Gascón P,Reguart N,Alcaraz J
700255 was used in western blot to elucidate the mechanical and soluble mitogenic cues that promote the accumulation of tumor-associated fibroblasts in non-small cell lung cancer subtypes.
Thu Jan 01 00:00:00 EST 2015
Focal adhesion kinase overexpression and its impact on human osteosarcoma.
Oncotarget
Ren K,Lu X,Yao N,Chen Y,Yang A,Chen H,Zhang J,Wu S,Shi X,Wang C,Sun X
700255 was used in immunohistochemistry - paraffin section and western blot to determine the impact on human osteosarcoma due to focal adhesion kinase overexpression
Tue Oct 13 00:00:00 EDT 2015
Focal adhesion kinase overexpression and its impact on human osteosarcoma.
Oncotarget
Ren K,Lu X,Yao N,Chen Y,Yang A,Chen H,Zhang J,Wu S,Shi X,Wang C,Sun X
700255 was used in immunohistochemistry - paraffin section and western blot to determine the impact on human osteosarcoma due to focal adhesion kinase overexpression
Tue Oct 13 00:00:00 EDT 2015
Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent.
The Journal of biological chemistry
Zaman G,Sunters A,Galea GL,Javaheri B,Saxon LK,Moustafa A,Armstrong VJ,Price JS,Lanyon LE
Fri Feb 03 00:00:00 EST 2012
Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent.
The Journal of biological chemistry
Zaman G,Sunters A,Galea GL,Javaheri B,Saxon LK,Moustafa A,Armstrong VJ,Price JS,Lanyon LE
Fri Feb 03 00:00:00 EST 2012
