Invitrogen

Phospho-FLT3 (Tyr969) Monoclonal Antibody (T.602.6)

View all (47) FLT3 (CD135) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-14961

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

T.602.6

Immunogen

Synthetic phosphopeptide corresponding to the sequence surrounding pTyr969 of human FLT3
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

63 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10988512

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD135; CD135 antigen; Fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2

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Gene Aliases: B230315G04; CD135; FLK-2; FLK2; Flt-3; FLT3; Ly72; STK1; wmfl

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UniProt ID: (Human) P36888, (Mouse) Q00342

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Entrez Gene ID: (Human) 2322, (Mouse) 14255

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Function(s)
transmembrane receptor protein tyrosine kinase activity cytokine receptor activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding protein complex binding glucocorticoid receptor binding protein homodimerization activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding phosphatidylinositol 3-kinase binding transmembrane signal receptor
Process(es)
leukocyte homeostasis myeloid progenitor cell differentiation pro-B cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation response to organonitrogen compound positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway hemopoiesis B cell differentiation organ regeneration common myeloid progenitor cell proliferation vascular endothelial growth factor signaling pathway positive regulation of tyrosine phosphorylation of STAT protein regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity lymphocyte proliferation protein autophosphorylation cellular response to cytokine stimulus cellular response to glucocorticoid stimulus dendritic cell differentiation positive regulation of protein phosphorylation lymphoid progenitor cell differentiation pro-T cell differentiation protein phosphorylation negative regulation of cell proliferation phosphorylation lymphocyte differentiation cell differentiation negative regulation of B cell differentiation
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