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Invitrogen
Phospho-GATA4 (Ser105) Polyclonal Antibody
Advanced Verification
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
Phospho-GATA4 (Ser105) Antibody (44-948) in IHC (P)
Immunohistochemistry analysis of GATA 4 (PS105) showing staining in the nucleus of paraffin-embedded mouse lymph node (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature... View More
Product Details
44-948
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human GATA-4 that contains serine 105.
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.3, with 1mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533804
Target Information
GATA4 is a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in the gene encoding GATA4 have been associated with cardiac septal defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GAT4; GATA-binding factor 4; GATA-binding protein 4; MGC126629; Transcription factor GATA-4
Gene Aliases: ASD2; Gata-4; GATA4; TACHD; TOF; VSD1
UniProt ID: (Human) P43694, (Mouse) Q08369
Entrez Gene ID: (Human) 2626, (Mouse) 14463
RNA polymerase II regulatory region sequence-specific DNA binding
transcription factor activity, RNA polymerase II transcription factor binding
RNA polymerase II transcription factor binding
enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
transcription factor binding
zinc ion binding
protein kinase binding
activating transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
NFAT protein binding
co-SMAD binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
metal ion binding
DNA-binding transcription factor
heart looping
endocardial cushion development
cardiac ventricle morphogenesis
cardiac right ventricle morphogenesis
ventricular septum development
atrial septum primum morphogenesis
atrial septum secundum morphogenesis
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell-cell signaling
endoderm development
blood coagulation
male gonad development
response to mechanical stimulus
negative regulation of autophagy
positive regulation of vascular endothelial growth factor production
positive regulation of BMP signaling pathway
response to vitamin A
embryonic heart tube anterior/posterior pattern specification
response to drug
cell fate commitment
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
embryonic foregut morphogenesis
anatomical structure formation involved in morphogenesis
positive regulation of cardioblast differentiation
transdifferentiation
atrial septum morphogenesis
intestinal epithelial cell differentiation
cell growth involved in cardiac muscle cell development
cellular response to glucose stimulus
regulation of cardiac muscle cell contraction
in utero embryonic development
gastrulation with mouth forming second
endoderm formation
heart morphogenesis
outflow tract morphogenesis
atrioventricular valve morphogenesis
atrioventricular valve formation
mitral valve formation
tricuspid valve formation
ventricular cardiac muscle tissue development
cardiac septum development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
spermatogenesis
heart development
regulation of gene expression
cardiac muscle hypertrophy in response to stress
signal transduction involved in regulation of gene expression
BMP signaling pathway
response to retinoic acid
embryonic heart tube development
tube morphogenesis
skeletal muscle cell differentiation
atrioventricular canal development
response to estrogen
embryonic digestive tract morphogenesis
embryonic morphogenesis
cardiac muscle tissue development
cardiac muscle cell differentiation
Sertoli cell differentiation
regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
canonical Wnt signaling pathway
SMAD protein signal transduction
lung morphogenesis
lung lobe formation
diaphragm morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
cellular response to gonadotropin stimulus
cellular response to follicle-stimulating hormone stimulus
epithelial cell fate commitment
seminiferous tubule development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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