Invitrogen

Phospho-GSK3 alpha (Ser21) Monoclonal Antibody (R.726.2)

View all (24) GSK3 alpha antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-15021

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

R.726.2

Immunogen

Synthetic phosphopeptide corresponding to residues around pSer21 of human GSK-3a
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10983171

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Glycogen synthase kinase 3 alpha (GSK3A) is a multifunctional protein serine/threonine kinase implicated in the control of several regulatory proteins and transcription factors. (GSK3A Alias: DKFZp686D0638). Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZp686D0638; FA; Factor A; Glycogen synthase kinase-3 alpha; GSK-3 alpha; gsk-3-alpha; OTTHUMP00000198368; Serine/threonine-protein kinase GSK3A

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Gene Aliases: 2700086H06Rik; GSK3A

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UniProt ID: (Human) P49840, (Rat) P18265, (Mouse) Q2NL51

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Entrez Gene ID: (Human) 2931, (Rat) 50686, (Mouse) 606496

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Function(s)
protein serine/threonine kinase activity protein binding ATP binding protein kinase A catalytic subunit binding tau-protein kinase activity protein kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
regulation of systemic arterial blood pressure cardiac left ventricle morphogenesis glycogen metabolic process protein phosphorylation dopamine receptor signaling pathway nervous system development insulin receptor signaling pathway negative regulation of UDP-glucose catabolic process Wnt signaling pathway positive regulation of cAMP biosynthetic process negative regulation of TOR signaling cellular response to insulin stimulus cellular response to interleukin-3 IRE1-mediated unfolded protein response proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of glycogen biosynthetic process positive regulation of protein catabolic process positive regulation of heart contraction negative regulation of glucose import negative regulation of insulin receptor signaling pathway negative regulation of cell growth involved in cardiac muscle cell development positive regulation of adrenergic receptor signaling pathway negative regulation of canonical Wnt signaling pathway extrinsic apoptotic signaling pathway in absence of ligand chemical synaptic transmission, postsynaptic positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitophagy positive regulation of protein targeting to mitochondrion negative regulation of glycogen synthase activity, transferring glucose-1-phosphate negative regulation of type B pancreatic cell development negative regulation of glycogen (starch) synthase activity positive regulation of glycogen (starch) synthase activity regulation of gene expression by genetic imprinting signal transduction positive regulation of peptidyl-threonine phosphorylation cell migration positive regulation of peptidyl-serine phosphorylation hypermethylation of CpG island positive regulation of transcription from RNA polymerase II promoter negative regulation of transferase activity cellular response to lithium ion cellular response to organic cyclic compound carbohydrate metabolic process negative regulation of signal transduction phosphorylation
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