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Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 4
Positive Control: NIH3T3 starvation for 16 hr, NIH3T3(starvation for 16 hr and 5 ng/mL PDGF treatment for 15 min)
Predicted Reactivity: Rat (100%), Zebrafish (100%), Xenopus laevis (100%), Pig (100%), Sheep (100%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 2.7.11.26; Glycogen synthase kinase-3 beta; GSK 3 beta; GSK 3B; GSK-3 beta; GSK-3 beta GSK3B; GSK-3b; GSK3 beta; GSK3beta isoform; Serine/threonine-protein kinase GSK3B
Gene Aliases: 7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3; GSK3B
UniProt ID: (Human) P49841, (Mouse) Q9WV60
Entrez Gene ID: (Human) 2932, (Mouse) 56637
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