Product References
PI3K/AKT signaling activation by roflumilast ameliorates rotenone-induced Parkinson's disease in rats.
Inflammopharmacology
Farid HA,Sayed RH,El-Shamarka ME,Abdel-Salam OME,El Sayed NS
44-604G was used in Western Blotting to reveal that roflumilast exerted neuroprotective effects in rotenone-induced neurotoxicity in rats.
Mon Apr 01 00:00:00 EDT 2024
AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment.
Journal of dental sciences
Xie H,Lin Y,Fang F
44-604G was used in Western Blot to suggest that AR-A014418 significantly mitigates LPS-induced inflammation of rDPSCs by blocking the activation of the NLRP3 inflammasome.
Sun Oct 01 00:00:00 EDT 2023
Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Smith M,Arthur B,Cikowski J,Holt C,Gonzalez S,Fisher NM,Vermudez SAD,Lindsley CW,Niswender CM,Gogliotti RG
44-604G was used in Western Blotting to suggest that M1 PAMs could represent a new class of RTT therapeutics.
Fri Jul 01 00:00:00 EDT 2022
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
Translational psychiatry
Lee SB,Park J,Kwak Y,Park YU,Nhung TTM,Suh BK,Woo Y,Suh Y,Cho E,Cho S,Park SK
44-604G was used in Immunoprecipitation to demonstrate that the oscillation of DISC1 expression is under the control of CLOCK and BMAL1, and that DISC1 contributes to the core circadian system by regulating BMAL1 stability.
Thu Feb 04 00:00:00 EST 2021
Disrupted-in-schizophrenia 1 enhances the quality of circadian rhythm by stabilizing BMAL1.
Translational psychiatry
Lee SB,Park J,Kwak Y,Park YU,Nhung TTM,Suh BK,Woo Y,Suh Y,Cho E,Cho S,Park SK
44-604G was used in Immunoprecipitation to demonstrate that the oscillation of DISC1 expression is under the control of CLOCK and BMAL1, and that DISC1 contributes to the core circadian system by regulating BMAL1 stability.
Thu Feb 04 00:00:00 EST 2021
Differential Characterization of Temozolomide-Resistant Human Glioma Cells.
International journal of molecular sciences
Lai SW,Huang BR,Liu YS,Lin HY,Chen CC,Tsai CF,Lu DY,Lin C
44-604G was used in Western Blotting to test for differential characteristics in the drug-resistant glioblastoma multiforme from the parental glioma cells.
Tue Jan 02 00:00:00 EST 2018
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Aging cell
Manassero G,Guglielmotto M,Zamfir R,Borghi R,Colombo L,Salmona M,Perry G,Odetti P,Arancio O,Tamagno E,Tabaton M
Published figure using Phospho-GSK3B (Tyr216, Tyr279) polyclonal antibody (Product # 44-604G) in Western Blot
Sat Oct 01 00:00:00 EDT 2016
The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.
Neuropathology and applied neurobiology
Nishikawa T,Takahashi T,Nakamori M,Hosomi N,Maruyama H,Miyazaki Y,Izumi Y,Matsumoto M
44-604G was used in immunohistochemistry - paraffin section to study the relationship between neurofibrillary tangles and raft domains
Thu Dec 01 00:00:00 EST 2016
DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.
Journal of neurochemistry
Rodríguez-Seoane C,Ramos A,Korth C,Requena JR
44-604G was used in western blot to characterize the routes involving AKT and CREB through which DISC alters VGF expression.
Sun Nov 01 00:00:00 EDT 2015
A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection.
Frontiers in microbiology
Chiang CY,Uzoma I,Lane DJ,Memišević V,Alem F,Yao K,Kota KP,Bavari S,Wallqvist A,Hakami RM,Panchal RG
44-604G was used to identify host signaling dynamics upon Burkholderia spp. infection by a reverse-phase protein microarray-based screen
Tue Aug 18 00:00:00 EDT 2015
Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Stancu IC,Ris L,Vasconcelos B,Marinangeli C,Goeminne L,Laporte V,Haylani LE,Couturier J,Schakman O,Gailly P,Pierrot N,Kienlen-Campard P,Octave JN,Dewachter I
44-604G was used in immunohistochemistry (free floating) to present data that suggests that pathological Aβ species induce changes in Tau that contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an Alzheimer's disease model.
Sun Jun 01 00:00:00 EDT 2014
Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
The European journal of neuroscience
Maurin H,Lechat B,Borghgraef P,Devijver H,Jaworski T,Van Leuven F
44-604G was used in western blot to study the lack of involvementof GSK3-alpha/beta in the elevated tau phosphorylation observed in Tau.P30L hypothermic mice
Tue Jul 01 00:00:00 EDT 2014
Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
Molecular brain
Maurin H,Lechat B,Dewachter I,Ris L,Louis JV,Borghgraef P,Devijver H,Jaworski T,Van Leuven F
44-604G was used in western blot to investigate the contribution of GSK3α to neurological diseases.
Sat May 25 00:00:00 EDT 2013
Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice.
Journal of neuropathology and experimental neurology
Tran HT,Sanchez L,Brody DL
44-604G was used in Immunohistochemistry to show that reduction of JNK activity by a peptide inhibitor, D-JNKi1, reduces total and phospho-tau accumulations in axons of mice with traumatic brain injury.
Wed Feb 01 00:00:00 EST 2012
Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo.
PloS one
Giliberto L,d'Abramo C,Acker CM,Davies P,D'Adamio L
44-604G was used in western blot to investigate the role of APP intracellular domain in gene transcription and apoptosis
Fri Jul 16 00:00:00 EDT 2010
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases.
Journal of neurochemistry
Yu Y,Run X,Liang Z,Li Y,Liu F,Liu Y,Iqbal K,Grundke-Iqbal I,Gong CX
Sun Mar 01 00:00:00 EST 2009
Glycogen synthase kinase-3 inactivation is not required for ischemic preconditioning or postconditioning in the mouse.
Circulation research
Nishino Y,Webb IG,Davidson SM,Ahmed AI,Clark JE,Jacquet S,Shah AM,Miura T,Yellon DM,Avkiran M,Marber MS
44-604G was used in Western Blotting to show that the inhibition of glycogen synthase kinase-3beta is unlikely to be the key determinant of cardioprotective signalling in either preconditioning or postconditioning in the mouse.
Fri Aug 01 00:00:00 EDT 2008
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells.
The Journal of biological chemistry
Ma C,Bower KA,Chen G,Shi X,Ke ZJ,Luo J
44-604G was used in western blot to elucidate how treatment with basic fibroblast growth factor suppresses the growth of Ewing's sarcoma family of tumors
Fri Apr 04 00:00:00 EDT 2008
Interaction between ERK and GSK3beta mediates basic fibroblast growth factor-induced apoptosis in SK-N-MC neuroblastoma cells.
The Journal of biological chemistry
Ma C,Bower KA,Chen G,Shi X,Ke ZJ,Luo J
44-604G was used in western blot to elucidate how treatment with basic fibroblast growth factor suppresses the growth of Ewing's sarcoma family of tumors
Fri Apr 04 00:00:00 EDT 2008
Measuring GSK3 expression and activity in cells.
Methods in molecular biology (Clifton, N.J.)
Cole AR,Sutherland C
44-604G was used in western blot to discuss the benefits and limitations of different assays to measure glycogen synthase kinase activity
Thu Jan 22 00:00:00 EST 2009
Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer's transgenic model Tg2576.
Journal of ethnopharmacology
Chauhan NB
44-604G was used in western blot to compare the anti-amyloidogenic, anti-inflammatory, and anti-tangle effects of dietary aged garlic extract with its prominent constituents in a mouse model of Alzheimer's disease
Wed Dec 06 00:00:00 EST 2006
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.
The Journal of biological chemistry
Pierrot N,Santos SF,Feyt C,Morel M,Brion JP,Octave JN
44-604G was used in western blot to investigate how cytosolic calcium alters neuronal metabolism of amyloid precursor protein
Fri Dec 29 00:00:00 EST 2006
Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao H,Shimohata T,Wang JQ,Sun G,Schaal DW,Sapolsky RM,Steinberg GK
44-604G was used in Western Blotting to investigate the role of Akt in the neuroprotective effect of hypothermia against cerebral ischaemia in rats.
Wed Oct 19 00:00:00 EDT 2005
Regulation and localization of tyrosine216 phosphorylation of glycogen synthase kinase-3beta in cellular and animal models of neuronal degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Bhat RV,Shanley J,Correll MP,Fieles WE,Keith RA,Scott CW,Lee CM
Tue Sep 26 00:00:00 EDT 2000