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7TM Antibodies
Phospho-Gastric Inhibitory Polypeptide Receptor (Thr442, Ser443) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-Gastric Inhibitory Polypeptide Receptor (Thr442, Ser443) Antibody (7TM0248A) in WB
Agonist-induced Threonine442/Serine443 phosphorylation of GIPR. Upper panel, HEK293 cells stably expressing the GIP-Receptor (GIPR) were either not exposed or exposed to 1 µM of GIP receptor Agonist GIP for 30 minutes. Cells were lysed and immunoblotted with the anti-pT442/pS443-GIPR antibody (7TM0248A) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent... View More
Product Details
7TM0248A
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human GIPR around the phosphorylation site of Thr442/Ser443.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastric inhibitory polypeptide receptor; GIP receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor
Gene Aliases: GIPR; PGQTL2
UniProt ID: (Human) P48546
Entrez Gene ID: (Human) 2696
desensitization of G-protein coupled receptor protein signaling pathway
generation of precursor metabolites and energy
cell surface receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
response to nutrient
response to glucose
endocrine pancreas development
positive regulation of insulin secretion
gastric inhibitory peptide signaling pathway
response to axon injury
regulation of insulin secretion
response to calcium ion
response to fatty acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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