Product References
ATF3 regulates SPHK1 in cardiomyocyte injury via endoplasmic reticulum stress.
Immunity, inflammation and disease
Chen H,Luo S,Chen H,Zhang C
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Fri Sep 01 00:00:00 EDT 2023
PARP16-Mediated Stabilization of Amyloid Precursor Protein mRNA Exacerbates Alzheimer's Disease Pathogenesis.
Aging and disease
Wang J,Cheng Q,Zhang Y,Hong C,Liu J,Liu X,Chang J
PA1-16927 was used in Western Blotting to reveal an unanticipated role of PARP16 in the pathogenesis of AD, and at least in part, its association with increased APP mRNA stability.
Tue Aug 01 00:00:00 EDT 2023
Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling.
Frontiers in cell and developmental biology
Shen WB,Wang B,Yao R,Goetzinger KR,Wu S,Gao H,Yang P
PA1-16927 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In vitro Assay, Western Blot to suggest that upregulated p-IRE1α and XBP1s signaling, and UPR chaperone genes may play an important role in maternal obesity-induced placental pathology.
Wed Mar 01 00:00:00 EST 2023
Differential ER stress as a driver of cell fate following ricin toxin exposure.
FASEB bioAdvances
Peterson-Reynolds C,Mantis NJ
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Differential ER stress as a driver of cell fate following ricin toxin exposure.
FASEB bioAdvances
Peterson-Reynolds C,Mantis NJ
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Sat Jan 01 00:00:00 EST 2022
Maprotiline restores ER homeostasis and rescues neurodegeneration via Histamine Receptor H1 inhibition in retinal ganglion cells.
Nature communications
Chen W,Liu P,Liu D,Huang H,Feng X,Fang F,Li L,Wu J,Liu L,Solow-Cordero DE,Hu Y
PA1-16927 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In vitro Assay, Western Blot to establish maprotiline as a candidate neuroprotectant and HRH1 as a potential therapeutic target for glaucoma.
Thu Nov 10 00:00:00 EST 2022
Gestational cholestasis induced intrauterine growth restriction through triggering IRE1α-mediated apoptosis of placental trophoblast cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Gao XX,Lin S,Jiang PY,Ye MY,Chen W,Hu CX,Chen YH
PA1-16927 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In vitro Assay, Western Blot to provide evidence that gestational cholestasis induces placental insufficiency and IUGR may be via triggering IRE1α-mediated apoptosis of placental trophoblast cells.
Fri Jul 01 00:00:00 EDT 2022
4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Duran I,Zieba J,Csukasi F,Martin JH,Wachtell D,Barad M,Dawson B,Fafilek B,Jacobsen CM,Ambrose CG,Cohn DH,Krejci P,Lee BH,Krakow D
PA1-16927 was used in Western Blotting to suggest the potential use of chemical chaperones as an adjunct treatment for forms of osteogenesis imperfecta associated with endoplasmic reticulum stress.
Fri Apr 01 00:00:00 EDT 2022
Involvement of the unfolded protein response in the protective effects of growth hormone releasing hormone antagonists in the lungs.
Journal of cell communication and signaling
Akhter MS,Uddin MA,Schally AV,Kubra KT,Barabutis N
PA1-16927 was used in Western Blot to demonstrate how the unfolded protein response contributes to the protective effects of growth hormone releasing hormone antagonists in human disease.
Mon Mar 01 00:00:00 EST 2021
Restoring the endothelial barrier function in the elderly.
Mechanisms of ageing and development
Barabutis N,Akhter MS,Kubra KT,Uddin MA
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Tue Jun 01 00:00:00 EDT 2021
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Journal of cellular and molecular medicine
Li W,Wang Y,Zhu L,Du S,Mao J,Wang Y,Wang S,Bo Q,Tu Y,Yi Q
PA1-16927 was used in Western Blot to investigate the role of the p300/XBP1s/Herpud1 axis in the pathogenesis of choroidal neovascularization.
Thu Jul 01 00:00:00 EDT 2021
Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells.
Analytical cellular pathology (Amsterdam)
Yi S,Shi W,Zuo M,Wang S,Ma R,Bi H,Cong B,Li Y
PA1-16927 was used in Immunocytochemistry to show that high-concentration GC exposure can significantly inhibit the viability of PC12 cells and induce apoptosis.
Tue Nov 16 00:00:00 EST 2021
High doses of dexamethasone induce endoplasmic reticulum stress-mediated apoptosis by promoting calcium ion influx-dependent CHOP expression in osteoblasts.
Molecular biology reports
Guo Y,Hao D,Hu H
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Wed Dec 01 00:00:00 EST 2021
Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs.
Pharmaceuticals (Basel, Switzerland)
Akhter MS,Uddin MA,Kubra KT,Barabutis N
PA1-16927 was used in Western Blot to investigate the effects of the Hsp90 inhibitor AUY-922 in the major inflammatory pathways of mouse lungs.
Sat May 29 00:00:00 EDT 2021
Elucidation of the Molecular Pathways Involved in the Protective Effects of AUY-922 in LPS-Induced Inflammation in Mouse Lungs.
Pharmaceuticals (Basel, Switzerland)
Akhter MS,Uddin MA,Kubra KT,Barabutis N
PA1-16927 was used in Western Blot to investigate the effects of the Hsp90 inhibitor AUY-922 in the major inflammatory pathways of mouse lungs.
Sat May 29 00:00:00 EDT 2021
Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints.
PloS one
Tan L,Harper LR,Armstrong A,Carlson CS,Yammani RR
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Immunohistochemistry
Mon Aug 23 00:00:00 EDT 2021
Dietary saturated fatty acid palmitate promotes cartilage lesions and activates the unfolded protein response pathway in mouse knee joints.
PloS one
Tan L,Harper LR,Armstrong A,Carlson CS,Yammani RR
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Immunohistochemistry
Mon Aug 23 00:00:00 EDT 2021
Aging and Hypercholesterolemia Differentially Affect the Unfolded Protein Response in the Vasculature of ApoE-/- Mice.
Journal of the American Heart Association
Zhou Y,Wan X,Seidel K,Zhang M,Goodman JB,Seta F,Hamburg N,Han J
PA1-16927 was used in Western Blot to provide the first in vivo evidence that aging and an atherogenic diet activate differential aortic UPR pathways, leading to distinct vascular responses.
Tue Sep 21 00:00:00 EDT 2021
SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response.
Viruses
Su WQ,Yu XJ,Zhou CM
PA1-16927 was used in Western Blot to demonstrate that the ability ofSARS-CoV-2 ORF3a induce incomplete autophagy in a FIP200/Beclin-1-dependent manner.
Thu Dec 09 00:00:00 EST 2021
The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS).
Molecular neurobiology
Thomson S,Waters KA,Machaalani R
PA1-16927 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In vitro Assay, Western Blot to indicate that subgroups of SIDS infants, defined by risk exposure had activation of the UPR in several nuclei relating to proprioception and motor control suggesting that the UPR underlies the neuroreceptor system changes responsible for these physiological functions, leading to compromise in the pathogenesis of SIDS.
Sat May 01 00:00:00 EDT 2021
Neuronal VCP loss of function recapitulates FTLD-TDP pathology.
Cell reports
Wani A,Zhu J,Ulrich JD,Eteleeb A,Sauerbeck AD,Reitz SJ,Arhzaouy K,Ikenaga C,Yuede CM,Pittman SK,Wang F,Li S,Benitez BA,Cruchaga C,Kummer TT,Harari O,Chou TF,Schröder R,Clemen CS,Weihl CC
PA1-16927 was used in Western Blot to identify a loss of VCP-dependent functions as a mediator of FTLD-TDP and reveal an unexpected biochemical similarity with progranulin deficiency.
Tue Jul 20 00:00:00 EDT 2021
Elucidation of ER stress and UPR pathway in sialic acid-deficient cells: Pathological relevance to GNEM.
Journal of cellular biochemistry
Chaudhary P,Sharma S,Singh R,Arya R
PA1-16927 was used in Western Blotting to indicate a balance of cell death and survival that decides cell fate and offers potential therapeutic targets to combat ER stress in diseases associated with dysfunctional UPR pathway.
Wed Dec 01 00:00:00 EST 2021
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer.
Cancer cell
McGrail DJ,Garnett J,Yin J,Dai H,Shih DJH,Lam TNA,Li Y,Sun C,Li Y,Schmandt R,Wu JY,Hu L,Liang Y,Peng G,Jonasch E,Menter D,Yates MS,Kopetz S,Lu KH,Broaddus R,Mills GB,Sahni N,Lin SY
PA1-16927 was used in Western Blot to demonstrate if deficient DNA mismatch repair induces destabilizing mutations leading to proteome instability in deficient DNA mismatch repair tumors.
Mon Mar 16 00:00:00 EDT 2020
Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP.
Nature immunology
Pokatayev V,Yang K,Tu X,Dobbs N,Wu J,Kalb RG,Yan N
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Sat Feb 01 00:00:00 EST 2020
Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage.
Aging and disease
Tan L,Register TC,Yammani RR
PA1-16927 was used in Immunohistochemistry (Paraffin) to demonstrate that aging promotes loss of proteostasis and induces endoplasmic reticulum stress and chondrocyte apoptosis in articular cartilage.
Thu Oct 01 00:00:00 EDT 2020
Age-Related Decline in Expression of Molecular Chaperones Induces Endoplasmic Reticulum Stress and Chondrocyte Apoptosis in Articular Cartilage.
Aging and disease
Tan L,Register TC,Yammani RR
PA1-16927 was used in Immunohistochemistry (Paraffin) to demonstrate that aging promotes loss of proteostasis and induces endoplasmic reticulum stress and chondrocyte apoptosis in articular cartilage.
Thu Oct 01 00:00:00 EDT 2020
PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.
Oncogenesis
Soni H,Bode J,Nguyen CDL,Puccio L,Neßling M,Piro RM,Bub J,Phillips E,Ahrends R,Eipper BA,Tews B,Goidts V
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Immunoprecipitation
Thu Feb 13 00:00:00 EST 2020
PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.
Oncogenesis
Soni H,Bode J,Nguyen CDL,Puccio L,Neßling M,Piro RM,Bub J,Phillips E,Ahrends R,Eipper BA,Tews B,Goidts V
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Immunoprecipitation
Thu Feb 13 00:00:00 EST 2020
Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer's Disease.
Molecular neurobiology
Buchanan H,Mackay M,Palmer K,Tothová K,Katsur M,Platt B,Koss DJ
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Sat Aug 01 00:00:00 EDT 2020
Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer's Disease.
Molecular neurobiology
Buchanan H,Mackay M,Palmer K,Tothová K,Katsur M,Platt B,Koss DJ
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Sat Aug 01 00:00:00 EDT 2020
Increased proliferation of hepatic periportal ductal progenitor cells contributes to persistent hypermetabolism after trauma.
Journal of cellular and molecular medicine
Diao L,Yousuf Y,Amini-Nik S,Jeschke MG
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Wed Jan 01 00:00:00 EST 2020
Inositol-requiring enzyme 1α links palmitate-induced mTOR activation and lipotoxicity in hepatocytes.
American journal of physiology. Cell physiology
Chen Y,Griffiths A,Wang J,Zhang T,Song Q,Song Z
PA1-16927 was used in Cell Culture to suggest that this pathway may potentially serve as a therapeutic target for the treatment of NAFLD as well as other metabolic disorders involving lipotoxicity.
Tue Dec 01 00:00:00 EST 2020
Inhibition of USP14 induces ER stress-mediated autophagy without apoptosis in lung cancer cell line A549.
Cell stress & chaperones
Moghadami AA,Aboutalebi Vand Beilankouhi E,Kalantary-Charvadeh A,Hamzavi M,Mosayyebi B,Sedghi H,Ghorbani Haghjo A,Nazari Soltan Ahmad S
PA1-16927 was used in Western Blotting to determine whether the accumulation of ubiquitinated proteins results in endoplasmic reticulum stress-mediated autophagy.
Sun Nov 01 00:00:00 EDT 2020
Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM.
Diabetes, metabolic syndrome and obesity : targets and therapy
Zhang Z,Cui D,Zhang T,Sun Y,Ding S
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Thu Apr 14 00:00:00 EDT 2022
Swimming Differentially Affects T2DM-Induced Skeletal Muscle ER Stress and Mitochondrial Dysfunction Related to MAM.
Diabetes, metabolic syndrome and obesity : targets and therapy
Zhang Z,Cui D,Zhang T,Sun Y,Ding S
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Thu Apr 14 00:00:00 EDT 2022
Antifungal itraconazole ameliorates experimental autoimmune encephalomyelitis through a novel mechanism of action.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Huang H,Tian X,Peng X,Huang L,Mei L,Zhan Y,Chen S,Wu H,Wei G,Cai X
PA1-16927 was used in Western Blotting to reveal a new method for treating MS using currently approved antifungal drugs.
Fri May 01 00:00:00 EDT 2020
High-fat diet induces endoplasmic reticulum stress to promote chondrocyte apoptosis in mouse knee joints.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tan L,Harper L,McNulty MA,Carlson CS,Yammani RR
PA1-16927 was used in ChIP Assay, ELISA, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, In vitro Assay, Western Blot to demonstrate that HFD induces ER stress to promote chondrocyte death and subchondral bone thickening, playing an important role in obesity-linked OA.
Wed Apr 01 00:00:00 EDT 2020
Towards Age-Related Anti-Inflammatory Therapy: Klotho Suppresses Activation of ER and Golgi Stress Response in Senescent Monocytes.
Cells
Mytych J,Sołek P,Będzińska A,Rusinek K,Warzybok A,Tabęcka-Łonczyńska A,Koziorowski M
PA1-16927 was used in Western Blotting to provide evidence of klotho involvement in the crosstalk on the line ER-Golgi, which may, in turn, affect activation of SASP.
Tue Jan 21 00:00:00 EST 2020
IRE1α Promotes Zika Virus Infection via XBP1.
Viruses
Kolpikova EP,Tronco AR,Hartigh ABD,Jackson KJ,Iwawaki T,Fink SL
PA1-16927 was used in Immunocytochemistry-immunoflourescence to show Zika virus infection can be promoted by the ER stress response component IRE1α through activating nonconventional cytoplasmic splicing of XBP1 mRNA.
Tue Mar 03 00:00:00 EST 2020
Calbindin-D9k is a Novel Risk Gene for Neurodegenerative Disease.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Jung EM,Yoo YM,Park SY,Ahn C,Jeon BH,Hong EJ,Kim WY,Jeung EB
PA1-16927 was used in Western Blotting to investigate the importance of calbindin-D9k and downstream calcium regulation in neurodegenerative diseases.
Sat May 02 00:00:00 EDT 2020
Endoplasmic Reticulum Stress Activation in Alport Syndrome Varies Between Genotype and Cell Type.
Frontiers in genetics
Wang C,Liang S,Xing S,Xu K,Xiao H,Deng H,Wang X,Chen L,Ding J,Wang F
PA1-16927 was used in Western Blot to explore the relationship between the COL4A5 genotype and cell type in endoplasmic reticulum stress activation in X-linked Alport syndrome.
Mon Sep 28 00:00:00 EDT 2020
Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.
Nature cell biology
Liu L,Zhao M,Jin X,Ney G,Yang KB,Peng F,Cao J,Iwawaki T,Del Valle J,Chen X,Li Q
PA1-16927 was used in Western Blotting to illuminate how the adaptive endoplasmic reticulum stress response is advantageous in sustaining self-renewal of HSCs and promoting pre-leukaemic clonal dominance.
Fri Mar 01 00:00:00 EST 2019
Adaptive endoplasmic reticulum stress signalling via IRE1α-XBP1 preserves self-renewal of haematopoietic and pre-leukaemic stem cells.
Nature cell biology
Liu L,Zhao M,Jin X,Ney G,Yang KB,Peng F,Cao J,Iwawaki T,Del Valle J,Chen X,Li Q
PA1-16927 was used in Western Blotting to illuminate how the adaptive endoplasmic reticulum stress response is advantageous in sustaining self-renewal of HSCs and promoting pre-leukaemic clonal dominance.
Fri Mar 01 00:00:00 EST 2019
Tumor necrosis factor-α triggers opposing signals in head and neck squamous cell carcinoma and induces apoptosis via mitochondrial- and non-mitochondrial-dependent pathways.
International journal of oncology
Selimovic D,Wahl RU,Ruiz E,Aslam R,Flanagan TW,Hassan SY,Santourlidis S,Haikel Y,Friedlander P,Megahed M,Kandil E,Hassan M
PA1-16927 was used in Western Blotting to elucidate the mechanisms regulating TNF-α‚induced opposing signals and their biological consequences in HNSCC cell lines.
Sun Dec 01 00:00:00 EST 2019
Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Agrawal M,Yeo CR,Shabbir A,Chhay V,Silver DL,Magkos F,Vidal-Puig A,Toh SA
PA1-16927 was used in Western Blotting to show for the first time that FIT2 is associated with T2DM in humans and plays an integral role in maintaining metabolically healthy AT function.
Tue Jan 01 00:00:00 EST 2019
TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling.
Cell reports
Kasitinon SY,Eskiocak U,Martin M,Bezwada D,Khivansara V,Tasdogan A,Zhao Z,Mathews T,Aurora AB,Morrison SJ
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Tue Aug 27 00:00:00 EDT 2019
Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma.
Cancers
Huang C,Lan W,Fraunhoffer N,Meilerman A,Iovanna J,Santofimia-Castaño P
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Tue Nov 26 00:00:00 EST 2019
The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.
PloS one
Trotta MC,Maisto R,Guida F,Boccella S,Luongo L,Balta C,D'Amico G,Herman H,Hermenean A,Bucolo C,D'Amico M
PA1-16927 was used in Western Blotting to study the mechanism of β-hydroxybutyrate treatment of local diabetic retinal damage.
Mon Oct 21 00:00:00 EDT 2019
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
Nature communications
Sheng X,Nenseth HZ,Qu S,Kuzu OF,Frahnow T,Simon L,Greene S,Zeng Q,Fazli L,Rennie PS,Mills IG,Danielsen H,Theis F,Patterson JB,Jin Y,Saatcioglu F
PA1-16927 was used in Western Blotting to establish IRE1α-XBP1s signaling as a central pathway in prostate cancer (PCa) and indicate that its targeting may offer novel treatment strategies.
Thu Jan 24 00:00:00 EST 2019
Comparative proteomic profiling reveals a role for Cisd2 in skeletal muscle aging.
Aging cell
Huang YL,Shen ZQ,Wu CY,Teng YC,Liao CC,Kao CH,Chen LK,Lin CH,Tsai TF
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Thu Feb 01 00:00:00 EST 2018
The Human Cytomegalovirus Endoplasmic Reticulum-Resident Glycoprotein UL148 Activates the Unfolded Protein Response.
Journal of virology
Siddiquey MNA,Zhang H,Nguyen CC,Domma AJ,Kamil JP
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Mon Oct 15 00:00:00 EDT 2018
RNA Splicing in the Transition from B Cells to Antibody-Secreting Cells: The Influences of ELL2, Small Nuclear RNA, and Endoplasmic Reticulum Stress.
Journal of immunology (Baltimore, Md. : 1950)
Nelson AM,Carew NT,Smith SM,Milcarek C
PA1-16927 was used in Western Blotting to deduce that RNA splicing patterns in antibody secreting cells are shaped early by endo-reticular stress and Ire1 phosphorylation and later by ELL2 induction.
Thu Nov 15 00:00:00 EST 2018
Featured Article: Deterioration of visual function mediated by senescence-associated endoplasmic reticulum stress in inflammatory tie2-TNF mice.
Experimental biology and medicine (Maywood, N.J.)
Lenin R,Nagy PG,Gentry J,Gangaraju R
PA1-16927 was used in Western Blotting to investigate the relationship between endothelial dysfunction, endoplasmic reticulum (ER) stress, and cellular senescence in the development of retinal dysfunction.
Wed Aug 01 00:00:00 EDT 2018
Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease.
American journal of physiology. Renal physiology
Ren G,Tardi NJ,Matsuda F,Koh KH,Ruiz P,Wei C,Altintas MM,Ploegh H,Reiser J
PA1-16927 was used in Western Blotting to show that podocytes employ derlin-2 to mediate the endoplasmic reticulum quality control system to maintain cellular homeostasis in both mouse and human glomeruli.
Thu Mar 01 00:00:00 EST 2018
Novel β-phenylacrylic acid derivatives exert anti-cancer activity by inducing Src-mediated apoptosis in wild-type KRAS colon cancer.
Cell death & disease
Kim SJ,Noh TH,Son S,Kim DH,Kim W,Lee Y,Choo J,Heo G,Kim MJ,Chung HY,Jung Y,Jung JH,Moon HR,Im E
PA1-16927 was used in Western Blotting to show Src can play a key role in apoptosis induced by the novel EGFR inhibitor MHYs.
Wed Aug 29 00:00:00 EDT 2018
PDI regulates seizure activity via NMDA receptor redox in rats.
Scientific reports
Kim JY,Ko AR,Hyun HW,Min SJ,Kim JE
PA116927 was used in western blot to show protein disulfide isomerases bind to N-methyl-D-aspartate receptor in the normal hippocampus, and that this binding is increased in chronic epileptic rats
Wed Feb 15 00:00:00 EST 2017
Anti-inflammatory actions of (-)-epicatechin in the adipose tissue of obese mice.
The international journal of biochemistry & cell biology
Bettaieb A,Cremonini E,Kang H,Kang J,Haj FG,Oteiza PI
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Thu Dec 01 00:00:00 EST 2016
Imiquimod-induced apoptosis of melanoma cells is mediated by ER stress-dependent Noxa induction and enhanced by NF-κB inhibition.
Journal of cellular and molecular medicine
El-Khattouti A,Selimovic D,Hannig M,Taylor EB,Abd Elmageed ZY,Hassan SY,Haikel Y,Kandil E,Leverkus M,Brodell RT,Megahed M,Hassan M
PA1-16927 was used in western blot to report the mechanism by which imiquimod induces apoptosis in melanoma cells
Mon Feb 01 00:00:00 EST 2016
LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes.
The Journal of biological chemistry
Hamlin AN,Basford JE,Jaeschke A,Hui DY
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Fri Aug 05 00:00:00 EDT 2016
HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response.
Scientific reports
Chusri P,Kumthip K,Hong J,Zhu C,Duan X,Jilg N,Fusco DN,Brisac C,Schaefer EA,Cai D,Peng LF,Maneekarn N,Lin W,Chung RT
PA1-16927 was used in western blot to determine the induction of transforming growth factor beta1 through activation of endoplasmic reticulum stress and the unfolded protein response due to HCV
Tue Mar 01 00:00:00 EST 2016
Divergent androgen regulation of unfolded protein response pathways drives prostate cancer.
EMBO molecular medicine
Sheng X,Arnoldussen YJ,Storm M,Tesikova M,Nenseth HZ,Zhao S,Fazli L,Rennie P,Risberg B,Wæhre H,Danielsen H,Mills IG,Jin Y,Hotamisligil G,Saatcioglu F
PA1-16927 was used in western blot to demonstrate that androgen receptor signaling modulates the unfolded protein response in prostate cancer cells.
Mon Jun 01 00:00:00 EDT 2015
CD133⁺ melanoma subpopulation acquired resistance to caffeic acid phenethyl ester-induced apoptosis is attributed to the elevated expression of ABCB5: significance for melanoma treatment.
Cancer letters
El-Khattouti A,Sheehan NT,Monico J,Drummond HA,Haikel Y,Brodell RT,Megahed M,Hassan M
PA1-16927 was used in western blot to study the effect of caffeic acid phenethyl ester on CD133+ melanoma
Sun Feb 01 00:00:00 EST 2015
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Breast cancer research and treatment
Sakabe I,Hu R,Jin L,Clarke R,Kasid UN
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Tue Sep 01 00:00:00 EDT 2015
TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling.
Breast cancer research and treatment
Sakabe I,Hu R,Jin L,Clarke R,Kasid UN
Published figure using Phospho-IRE1 alpha (Ser724) polyclonal antibody (Product # PA1-16927) in Western Blot
Tue Sep 01 00:00:00 EDT 2015
Attenuation of oxygen fluctuation-induced endoplasmic reticulum stress in human lens epithelial cells.
Experimental and therapeutic medicine
Zheng XY,Xu J,Chen XI,Li W,Wang TY
PA1-16927 was used in western blot to study oxygen-induced endoplasmic reticulum stress in the lens
Sun Nov 01 00:00:00 EDT 2015
Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21.
Aging cell
Lees EK,Król E,Grant L,Shearer K,Wyse C,Moncur E,Bykowska AS,Mody N,Gettys TW,Delibegovic M
PA1-16927 was used in western blot to examine the ability of methionine restriction to reverse age-induced obesity and insulin resistance in adult mice
Wed Oct 01 00:00:00 EDT 2014
Inhibition of JNK by novel curcumin analog C66 prevents diabetic cardiomyopathy with a preservation of cardiac metallothionein expression.
American journal of physiology. Endocrinology and metabolism
Wang Y,Zhou S,Sun W,McClung K,Pan Y,Liang G,Tan Y,Zhao Y,Liu Q,Sun J,Cai L
PA1-16927 was used in western blot to study the role of cardiac metallothionein expression maintenance in the mechanisms by which inhibition of JNK by a curcumin analog protects against cardiomyopathy in a rat model of diabetes
Sun Jun 01 00:00:00 EDT 2014
Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Reinhardt S,Schuck F,Grösgen S,Riemenschneider M,Hartmann T,Postina R,Grimm M,Endres K
PA1-16927 was used in western blot to study the regulation of ADAM10 expression by the unfolded protein response transcription factor XBP-1 and the implications for Alzheimer's disease
Sat Feb 01 00:00:00 EST 2014
Dipeptidyl petidase-IV inhibitor (gemigliptin) inhibits tunicamycin-induced endoplasmic reticulum stress, apoptosis and inflammation in H9c2 cardiomyocytes.
Molecular and cellular endocrinology
Hwang HJ,Jung TW,Ryu JY,Hong HC,Choi HY,Seo JA,Kim SG,Kim NH,Choi KM,Choi DS,Baik SH,Yoo HJ
PA1-16927 was used in western blot to study the ability of pharmacological inhibition of DPP IV to protect cardiomyocytes against apoptosis and inflammation caused by tunicamycin-induced ER stress
Sat Jul 05 00:00:00 EDT 2014
CYP2J2-derived epoxyeicosatrienoic acids suppress endoplasmic reticulum stress in heart failure.
Molecular pharmacology
Wang X,Ni L,Yang L,Duan Q,Chen C,Edin ML,Zeldin DC,Wang DW
PA1-16927 was used in western blot to study the suppression of ER stress in the failing heart by epoxyeicosatrienoic acids generated from arachidonic acid by CYP2J2
Wed Jan 01 00:00:00 EST 2014
Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.
FEBS letters
Liu L,Chowdhury S,Fang X,Liu JL,Srikant CB
PA1-16927 was used in western blot to study the ability of mReg2-induced expression of GPR78 to protect murine insulinoma cells against endoplasmic reticulum stress
Thu May 29 00:00:00 EDT 2014
Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice.
Journal of lipid research
Guo F,Ma Y,Kadegowda AKG,Betters JL,Xie P,Liu G,Liu X,Miao H,Ou J,Su X,Zheng Z,Xue B,Shi H,Yu L
PA1-16927 was used in western blot to study the role of CGI-58 in hepatic steatosis and fibrosis using liver-specific knockout mice
Thu Aug 01 00:00:00 EDT 2013
Vinblastine-induced apoptosis of melanoma cells is mediated by Ras homologous A protein (Rho A) via mitochondrial and non-mitochondrial-dependent mechanisms.
Apoptosis : an international journal on programmed cell death
Selimovic D,Badura HE,El-Khattouti A,Soell M,Porzig BB,Spernger A,Ghanjati F,Santourlidis S,Haikel Y,Hassan M
PA1-16927 was used in western blot to study the role of Rho A-mediated mitochondrial and non-mitochondrial pathways in the induction of melanoma cell apoptosis by vinblastine
Thu Aug 01 00:00:00 EDT 2013
PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response.
Nature cell biology
Jwa M,Chang P
PA1-16927 was used in immunocytochemistry and immunoprecipitation to study the unfolded protein response mediated by PERK and IRE1-alpha and the key role of PARP16
Thu Nov 01 00:00:00 EDT 2012
Monitoring endoplasmic reticulum stress responsive mRNAs by RNA sequencing.
Gene
Okuda T,Wakaguri H,Suzuki Y,Sugano S
PA1-16927 was used in western blot to identify endoplasmic reticulum stress responsive mRNAs by RNA sequencing.
Fri May 25 00:00:00 EDT 2012
ER stress negatively modulates the expression of the miR-199a/214 cluster to regulates tumor survival and progression in human hepatocellular cancer.
PloS one
Duan Q,Wang X,Gong W,Ni L,Chen C,He X,Chen F,Yang L,Wang P,Wang DW
PA1-16927 was used in western blot to study the role of ER stress in the downregulation of the miRNA-199a/214 cluster observed in human hepaticellular cancer
Fri Aug 03 00:00:00 EDT 2012
HDLs inhibit endoplasmic reticulum stress and autophagic response induced by oxidized LDLs.
Cell death and differentiation
Muller C,Salvayre R,Nègre-Salvayre A,Vindis C
PA1-16927 was used in western blot to investigate the inhibitory effect of HDLs on the endoplasmic reticulum stress and autophagic response induced by oxidized LDLs
Sun May 01 00:00:00 EDT 2011
Constitutive role for IRE1α-XBP1 signaling pathway in the insulin-mediated hepatic lipogenic program.
Endocrinology
Ning J,Hong T,Ward A,Pi J,Liu Z,Liu HY,Cao W
PA1-16927 was used in western blot to study the involvement of IRE1-XBP1 signaling pathway in hepatic lipogenesis
Wed Jun 01 00:00:00 EDT 2011
Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation.
Carcinogenesis
Selimovic D,Ahmad M,El-Khattouti A,Hannig M,Haïkel Y,Hassan M
PA1-16927 was used in western blot to investigate the mechanism for the cell apoptosis stimulated by APR 2 in cancer cells
Mon Aug 01 00:00:00 EDT 2011
Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.
International journal of cancer
Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH
PA1-16927 was used in western blot to study the mechanism for the resistance against adenoviral REIC/Dkk-3 gene therapy in a subpopulation of prostate cancer cells
Thu Apr 01 00:00:00 EDT 2010
