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Phospho-LATS1 (Thr1079) Antibody (28998-1-AP100UL) in WB
Non-treated and Calyculin A treated HeLa cells were subjected to SDS PAGE followed by western blot with (Product # 28998-1-AP100UL) (Phospho-LATS1 (Thr1079) antibody) at dilution of 1:20,000 incubated at room temperature for 1.5 hours.
Product Details
28998-1-AP100UL
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis which is phosphorylated in a cell-cycle dependent manner. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity which indicating a role as a negative regulator of CDC2/cyclin A and the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. LATS1 act as a tumor suppressor and play an important role in the development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1; LATS1; Serine/threonine-protein kinase LATS1; WARTS protein kinase
Gene Aliases: LATS1; WARTS; wts
UniProt ID: (Human) O95835
Entrez Gene ID: (Human) 9113
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
sister chromatid segregation
inner cell mass cell fate commitment
inner cell mass cellular morphogenesis
protein phosphorylation
mitotic nuclear division
hormone-mediated signaling pathway
keratinocyte differentiation
regulation of actin filament polymerization
positive regulation of peptidyl-serine phosphorylation
hippo signaling
positive regulation of apoptotic process
regulation of protein complex assembly
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of organ growth
cytoplasmic sequestering of protein
cell division
negative regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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