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Invitrogen
Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody
Product Details
PA5-40270
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2608093
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase; c-mer proto-oncogene tyrosine kinase; EC 2.7.10.2; Etk2/tyro3; kinase Syk; KSYK; MER receptor tyrosine kinase; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; TK19-2; Tyro 12; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF
Gene Aliases: AI323366; Brt; BYK; c-Eyk; c-mer; DTK; Etk-2; etk2/tyro3; Eyk; MER; MERTK; nmf12; Nyk; rdy; Rek; RP38; RSE; SKY; TIF; TK19-2; Tyro12; TYRO3
UniProt ID: (Human) Q12866, (Mouse) Q60805, (Rat) P57097, (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 10461, (Mouse) 17289, (Rat) 65037, (Human) 7301, (Mouse) 22174, (Rat) 25232
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
virus receptor activity
receptor signaling protein tyrosine kinase activity
phosphatidylinositol 3-kinase binding
protein heterodimerization activity
transmembrane signal receptor
natural killer cell differentiation
protein phosphorylation
phagocytosis
cell surface receptor signaling pathway
cell-cell signaling
spermatogenesis
peptidyl-tyrosine phosphorylation
platelet activation
secretion by cell
substrate adhesion-dependent cell spreading
apoptotic cell clearance
protein kinase B signaling
positive regulation of phagocytosis
leukocyte migration
negative regulation of lymphocyte activation
retina development in camera-type eye
vagina development
negative regulation of leukocyte apoptotic process
phosphorylation
cell adhesion
signal transduction
phosphatidylinositol 3-kinase signaling
forebrain cell migration
signal transduction by protein phosphorylation
negative regulation of toll-like receptor signaling pathway
ovulation cycle
negative regulation of neuron apoptotic process
negative regulation of innate immune response
viral entry into host cell
protein autophosphorylation
negative regulation of inflammatory response
neuron cellular homeostasis
platelet aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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