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Product Details
BS-9474R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The nuclear factor of activated T-cells (NFAT) transcription complex is required for the expression of a group of proteins that collectively regulate the immune response. Four NFAT proteins, encoded on separate genes and expressed as several splice variants, have been described: NFAT1 (also known as NFATp or NFATc2), NFAT2 (NFATc or NFATc1), NFAT3, and NFAT4 (NFATx or NFATc3). These proteins show a low level of sequence similarity with the Dorsal/Rel/NFkB family of transcription factors. Another NFAT-related protein termed NFAT5 differs from isoforms 1-4 in that it lacks many of the Fos/Jun contact sites observed in its predecessors and its subcellular localization is not calcineurin-dependent.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: glutamine rich protein H65; NF-AT5; NFAT-like protein 1; Nuclear factor of activated T-cells 5; osmotic response element-binding protein; Rel domain-containing transcription factor NFAT5; T-cell transcription factor NFAT5; TonE-binding protein; tonicity-responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein
Gene Aliases: AI225870; B130038B15Rik; CAG-8; CAG80; KIAA0827; mKIAA0827; NF-AT5; Nfat; NFAT5; NFATL1; NFATZ; OREBP; TONEBP
UniProt ID: (Human) O94916, (Mouse) Q9WV30, (Rat) D3ZGB1
Entrez Gene ID: (Human) 10725, (Mouse) 54446, (Rat) 307820
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
DNA binding
Rel homology transcription factor
cytokine production
transcription from RNA polymerase II promoter
response to osmotic stress
signal transduction
excretion
positive regulation of transcription from RNA polymerase II promoter
regulation of calcineurin-NFAT signaling cascade
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of gene expression
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