Invitrogen

Phospho-NFATC1 (Ser294) Polyclonal Antibody

View all (18) NFATC1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105755

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NFATC1(Accession O95644), corresponding to amino acid residues around phosphorylated Ser294.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817154

Product Specific Information

Antibody detects endogenous levels of NFAT2 only when phosphorylated at Ser294.

Target Information

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC138448; NF-ATc; NF-ATc1; NFAT tra; NFAT trans; NFAT transcription complex cytosolic component; nuclear factor of activated T-cells 'c'; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; transcription factor NF-ATc

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Gene Aliases: 2210017P03Rik; AI449492; AV076380; NF-ATC; NF-ATc1.2; NFAT2; NFATC; NFATC1; Nfatcb

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UniProt ID: (Human) O95644

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Entrez Gene ID: (Human) 4772, (Rat) 100361818, (Mouse) 18018

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Function(s)
RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding FK506 binding mitogen-activated protein kinase p38 binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription coactivator binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor binding sequence-specific DNA binding transcription regulatory region DNA binding Rel homology transcription factor
Process(es)
transcription from RNA polymerase II promoter Wnt signaling pathway, calcium modulating pathway negative regulation of Wnt signaling pathway calcineurin-NFAT signaling cascade intracellular signal transduction Fc-epsilon receptor signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter G1/S transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter epithelial to mesenchymal transition lymphangiogenesis B-1a B cell differentiation heart valve morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis regulation of transcription from RNA polymerase II promoter calcium ion transport heart development positive regulation of gene expression transition between fast and slow fiber osteoclast differentiation regulation of hair cycle negative regulation of osteoblast differentiation ventricular septum morphogenesis patterning of lymph vessels heart trabecula morphogenesis negative regulation of stem cell proliferation transcription, DNA-templated regulation of transcription, DNA-templated cell quiescence
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