Invitrogen

Phospho-PERK (Thr982) Recombinant Rabbit Monoclonal Antibody (0A1E6)

View all (33) PERK antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-55319

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

0A1E6

Immunogen

A synthetic phosphorylated peptide around T982 of human PERK.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.25 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Dry ice (international)

Target Information

EIF2AK3 (PERK) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses, leading to a decrease in protein sythesis. In the case of EIF2AK3, signaling is initiated by misfolded proteins in the ER. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), also known as multiple epiphyseal dysplasia with early-onset diabetes mellitus. WRS is a rare autosomal recessive disorder, characterized by permanent neonatal or early infancy insulin-dependent diabetes and, at a later age, epiphyseal dysplasia, osteoporosis, growth retardation and other multisystem manifestations, such as hepatic and renal dysfunctions, mental retardation and cardiovascular abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 3; HsPEK; OTTHUMP00000207187; OTTHUMP00000207188; Pancreatic eIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase

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Gene Aliases: AI427929; EIF2AK3; PEK; PERK; WRS

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UniProt ID: (Human) Q9NZJ5, (Rat) Q9Z1Z1, (Mouse) Q9Z2B5

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Entrez Gene ID: (Human) 9451, (Rat) 29702, (Mouse) 13666

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Function(s)
protein kinase activity protein serine/threonine kinase activity eukaryotic translation initiation factor 2alpha kinase activity protein binding ATP binding enzyme binding protein phosphatase binding identical protein binding protein homodimerization activity Hsp90 protein binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups eukaryotic initiation factor eIF2 binding non-receptor serine/threonine protein kinase
Process(es)
skeletal system development ossification angiogenesis chondrocyte development protein phosphorylation activation of cysteine-type endopeptidase activity involved in apoptotic process ER overload response endoplasmic reticulum organization positive regulation of vascular endothelial growth factor production positive regulation of gene expression regulation of translational initiation by eIF2 alpha phosphorylation negative regulation of translation peptidyl-serine phosphorylation calcium-mediated signaling insulin secretion bone mineralization endoplasmic reticulum unfolded protein response endocrine pancreas development negative regulation of myelination negative regulation of translational initiation in response to stress cellular response to amino acid starvation response to endoplasmic reticulum stress eiF2alpha phosphorylation in response to endoplasmic reticulum stress PERK-mediated unfolded protein response cellular response to glucose starvation positive regulation of transcription from RNA polymerase I promoter protein autophosphorylation insulin-like growth factor receptor signaling pathway protein homooligomerization regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation cellular response to cold positive regulation of protein localization to nucleus regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway response to manganese-induced endoplasmic reticulum stress translation lactation positive regulation of signal transduction negative regulation of gene expression regulation of fatty acid metabolic process pancreas development negative regulation of translation in response to stress positive regulation of protein binding SREBP signaling pathway negative regulation of apoptotic process fat cell differentiation intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of translation response to unfolded protein phosphorylation negative regulation of translation in response to endoplasmic reticulum stress positive regulation of glutathione biosynthetic process positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
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