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Invitrogen
Phospho-Phospholamban (Ser16) Polyclonal Antibody
Product Details
PA1-25784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Rabbit
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, KLH-conjugated, corresponding to residues R(14) A [pS] T I E M P Q Q A R(25) C of human cardiac Phospholamban.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 30% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_795167
Product Specific Information
Recommended positive controls: Bovine cardiac preparation.
PA1-25784 is expected to cross react with rabbit, mouse, rat, canine, and porcine due to sequence homology.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cardiac CMH18; Cardiac phospholamban; PLB
Gene Aliases: CMD1P; CMH18; PLB; PLN
UniProt ID: (Rabbit) P61015, (Bovine) A4IFH6, (Human) P26678
Entrez Gene ID: (Rabbit) 100009299, (Bovine) 100125240, (Human) 5350
calcium ion transport
negative regulation of catalytic activity
negative regulation of calcium-transporting ATPase activity
negative regulation of calcium ion import into sarcoplasmic reticulum
regulation of the force of heart contraction
Notch signaling pathway
blood circulation
regulation of heart contraction
response to zinc ion
negative regulation of heart rate
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
negative regulation of ATPase activity
response to insulin
response to testosterone
cardiac muscle tissue development
protein homooligomerization
regulation of cytosolic calcium ion concentration
regulation of calcium ion transport
negative regulation of calcium ion transport
relaxation of cardiac muscle
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in heart process
regulation of cardiac muscle cell membrane potential
regulation of the force of heart contraction by cardiac conduction
negative regulation of calcium ion import
negative regulation of calcium ion transmembrane transporter activity
negative regulation of calcium ion binding
regulation of calcium-transporting ATPase activity
regulation of relaxation of cardiac muscle
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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