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Phospho-SHIP1 (Tyr865) Antibody (PA5-105684) in WB
Western blot analysis of Phospho-SHIP1 (Tyr865) in extracts from serum starvation treated EC304 cells. Samples were incubated with Phospho-SHIP1 (Tyr865) polyclonal antibody (Product # PA5-105684). The lane on the left was treated with blocking peptide. Observed bands: 80 kDa.
Product Details
PA5-105684
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human INPP5D(Accession Q92835), corresponding to amino acid residues around phosphorylated Tyr865.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817112
Product Specific Information
Antibody detects endogenous levels of SHIP1 only when phosphorylated at Tyr865.
Target Information
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hp51CN; Inositol polyphosphate-5-phosphatase D; Inositol polyphosphate-5-phosphatase of 145 kDa; inositol polyphosphate-5-phosphatase, 145kD; inositol polyphosphate-5-phosphatase, 145kDa; MGC104855; MGC142140; MGC142142; OTTHUMP00000165069; OTTHUMP00000165070; OTTHUMP00000165071; OTTHUMP00000165072; OTTHUMP00000203442; p150Ship; phosphatidylin; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; signaling inositol polyphosphate 5 phosphatase SIP-145; signaling inositol polyphosphate phosphatase SHIP II; SIP-145
Gene Aliases: hp51CN; INPP5D; p150Ship; SHIP; SHIP-1; SHIP1; SIP-145
UniProt ID: (Human) Q92835
Entrez Gene ID: (Human) 3635
phosphatidylinositol biosynthetic process
phosphate-containing compound metabolic process
apoptotic process
signal transduction
determination of adult lifespan
negative regulation of signal transduction
immunoglobulin mediated immune response
negative regulation of B cell proliferation
intracellular signal transduction
positive regulation of apoptotic process
inositol phosphate metabolic process
negative regulation of interleukin-6 biosynthetic process
positive regulation of B cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of monocyte differentiation
negative regulation of neutrophil differentiation
negative regulation of osteoclast differentiation
negative regulation of bone resorption
phosphatidylinositol dephosphorylation
negative regulation of immune response
T cell receptor signaling pathway
leukocyte migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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