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Invitrogen
Phospho-SIK2 (Thr175, Thr163) Polyclonal Antibody
Product Details
PA5-64607
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human QIK/QSK (Phospho-Thr182/Thr175/Thr221).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2663937
Product Specific Information
Phospho-SIK2 (Thr175, Thr163) Polyclonal Antibody detects endogenous levels of SIK2 only when phosphorylated at Thr175, Thr163.
Target Information
SNF1LK2 (QIK) is a serine/threonine kinase and is a salt-inducible kinase that belongs to the AMP-activated protein kinase family. SNF1LK2 negatively regulates CRE-binding protein (CREB) activity by phosphorylating the CREB-specific coactivator transducer of regulated CREB activity (TORC). SIK2 is thought to be part of a signaling cascade that regulates the expression and activity of the insulin-induced genes PGC-1'alpha and UCP-1 in brown adipocytes, impairment of which has been implicated in obesity and insulin resistance in human and animal models. SIK2 has also been reported as a key regulator for neuronal survival after ischemia, suppressing CREB-mediated gene expression after oxygen-glucose deprivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Qin-induced kinase; salt induceable kinase 2; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2
Gene Aliases: G630080D20Rik; KIAA0781; LOH11CR1I; QIK; RGD1559698; SIK-2; SIK2; SNF1LK2
UniProt ID: (Human) Q9H0K1, (Mouse) Q8CFH6
Entrez Gene ID: (Human) 23235, (Mouse) 235344, (Rat) 315649
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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