Product References
Coordination of canonical and noncanonical Hedgehog signalling pathways mediated by WDR11 during primordial germ cell development.
Scientific reports
Lee J,Kim Y,Ataliotis P,Kim HG,Kim DW,Bennett DC,Brown NA,Layman LC,Kim SH
44-660G was used in Western Blotting to provide evidence supporting a role for WDR11 in ciliogenesis through regulation of anterograde intraflagellar transport potentially via its interaction with IFT20.
Sat Jul 29 00:00:00 EDT 2023
VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1.
Neuron
Ruiz de Almodovar C,Fabre PJ,Knevels E,Coulon C,Segura I,Haddick PCG,Aerts L,Delattin N,Strasser G,Oh WJ,Lange C,Vinckier S,Haigh J,Fouquet C,Gu C,Alitalo K,Castellani V,Tessier-Lavigne M,Chedotal A,Charron F,Carmeliet P
44-660G was used in Immunocytochemistry to show that the prototypic angiogenic factor VEGF is secreted by the floor plate and is a chemoattractant for commissural axons in vitro and in vivo.
Wed Apr 19 00:00:00 EDT 2023
Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways.
American journal of cancer research
Lai Y,Chang H,Chen H,Chang G,Chen JJ
44-660G was used in Western Blotting to suggest that peruvoside suppresses non-small-cell lung carcinoma (NSCLC) malignancy by downregulating multiple Src-related pathways and could serve as a potential base molecule for developing new anticancer drugs and therapeutic strategies for lung cancer.
Sat Jul 16 00:00:00 EDT 2022
Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ.
The Journal of biological chemistry
Goob G,Adrian J,Cossu C,Hauck CR
44-660G was used in Western Blotting to identify the receptor-type protein tyrosine phosphatase PTPRJ as a negative regulator of Carcinoembryonic antigen-related cell adhesion molecule 3-mediated phagocytosis.
Thu Sep 01 00:00:00 EDT 2022
c-Kit Receptor Maintains Sensory Axon Innervation of the Skin through Src Family Kinases.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tuttle AM,Pomaville MB,Delgado KC,Wright KM,Nechiporuk AV
44-660G was used in Immunohistochemistry to discover that a specific receptor in sensory neurons, c-Kit, is required to maintain the density of nerve endings in the skin.
Mon Jul 25 00:00:00 EDT 2022
CK2β Is a Gatekeeper of Focal Adhesions Regulating Cell Spreading.
Frontiers in molecular biosciences
Filhol O,Hesse AM,Bouin AP,Albigès-Rizo C,Jeanneret F,Battail C,Pflieger D,Cochet C
44-660G was used in Immunocytochemistry to show that decreased expression of CK2β in MCF10A mammary epithelial cells triggers the phosphorylation of a number of proteins on tyrosine residues and promotes the striking activation of the FAK1-Src-PAX1 signaling pathway.
Tue Jul 19 00:00:00 EDT 2022
Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.
Journal of the American Heart Association
Staehr C,Rohde PD,Krarup NT,Ringgaard S,Laustsen C,Johnsen J,Nielsen R,Beck HC,Morth JP,Lykke-Hartmann K,Jespersen NR,Abramochkin D,Nyegaard M,Bøtker HE,Aalkjaer C,Matchkov V
44-660G was used in Western Blot to suggest that ATP1A2 mutation leads to disturbed cardiac metabolism and reduced cardiac function mediated via Na,K-ATPase-dependent reactive oxygen species signaling through the Src/Ras/Erk1/2 pathway.
Tue Apr 05 00:00:00 EDT 2022
Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila.
Developmental cell
Enomoto M,Takemoto D,Igaki T
44-660G was used in Immunohistochemistry-immunofluorescence to show in Drosophila imaginal epithelium that clones of Ras- or Src-activated benign tumors interact with each other to mutually promote tumor malignancy.
Mon Aug 09 00:00:00 EDT 2021
eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
eLife
Ninchoji T,Love DT,Smith RO,Hedlund M,Vestweber D,Sessa WC,Claesson-Welsh L
44-660G was used in Immunocytochemistry-immunoflourescence to investigate if nitric oxide destabilises adheren junctions, resulting in vascular hyperpermeability, by converging with the VEGFA/VEGFR2/c-Src/VE-cadherin pathway.
Wed Apr 28 00:00:00 EDT 2021
Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma.
Cancers
Aldaz P,Auzmendi-Iriarte J,Durántez M,Lasheras-Otero I,Carrasco-Garcia E,Zelaya MV,Bragado L,Olías-Arjona A,Egaña L,Samprón N,Morilla I,Redondo-Muñoz M,Rico M,Squatrito M,Maria-Alonso M,Fernández-Irigoyen J,Santamaria E,Larráyoz IM,Wellbrock C,Matheu A,Arozarena I
44-660G was used in Immunohistochemistry to reveal a novel DEXA-induced mechanism in GBM cells and provide a rationale for revisiting the use of tyrosine kinase inhibitors for the treatment of GBM.
Tue Jan 19 00:00:00 EST 2021
LY6D-induced macropinocytosis as a survival mechanism of senescent cells.
The Journal of biological chemistry
Nagano T,Iwasaki T,Onishi K,Awai Y,Terachi A,Kuwaba S,Asano S,Katasho R,Nagai K,Nakashima A,Kikkawa U,Kamada S
44-660G was used in Western Blot to analyse the functional relationship between lymphocyte antigen 6 complex, locus D and the senescence processes.
Tue Aug 03 00:00:00 EDT 2021
EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma.
Nature communications
Fang R,Chen X,Zhang S,Shi H,Ye Y,Shi H,Zou Z,Li P,Guo Q,Ma L,He C,Huang S
44-660G was used in Immunohistochemistry (Paraffin), Western Blot to extend the landscape of EGFR downstream circuit, uncover the function of YTHDF2 in GBM tumorigenesis, and highlight an essential role of RNA m6A methylation in cholesterol homeostasis.
Fri Jan 08 00:00:00 EST 2021
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Gastroenterology
Sorrentino G,Perino A,Yildiz E,El Alam G,Bou Sleiman M,Gioiello A,Pellicciari R,Schoonjans K
44-660G was used in Western Blot, Immunocytochemistry to study the role of BAs and TGR5 in intestinal renewal, and regulation of ISC function in mice and intestinal organoids.
Tue Sep 01 00:00:00 EDT 2020
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Gastroenterology
Sorrentino G,Perino A,Yildiz E,El Alam G,Bou Sleiman M,Gioiello A,Pellicciari R,Schoonjans K
44-660G was used in Western Blot, Immunocytochemistry to study the role of BAs and TGR5 in intestinal renewal, and regulation of ISC function in mice and intestinal organoids.
Tue Sep 01 00:00:00 EDT 2020
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination.
Nature cell biology
Montagner M,Bhome R,Hooper S,Chakravarty P,Qin X,Sufi J,Bhargava A,Ratcliffe CDH,Naito Y,Pocaterra A,Tape CJ,Sahai E
44-660G was used in Immunocytochemistry to reveal how the behaviour of indolent breast cancer cells in the lung is determined by their interactions with alveolar epithelial cells, in particular alveolar type 1 cells.
Sun Mar 01 00:00:00 EST 2020
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Development (Cambridge, England)
Schimmel L,Fukuhara D,Richards M,Jin Y,Essebier P,Frampton E,Hedlund M,Dejana E,Claesson-Welsh L,Gordon E
44-660G was used in Immunocytochemistry to demonstrate that c-Src signaling at specified endothelial cell membrane compartments control vascular processes in a tissue- and context-dependent manner.
Mon Apr 06 00:00:00 EDT 2020
A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.
Thrombosis and haemostasis
Izquierdo I,Barrachina MN,Hermida-Nogueira L,Casas V,Morán LA,Lacerenza S,Pinto-Llorente R,Eble JA,de Los Ríos V,Domínguez E,Loza MI,Casal JI,Carrascal M,Abián J,García A
44-660G was used in Western Blotting to analyze the tyrosine phosphoproteome of platelets activated with the CLEC-2 agonist rhodocytin to identify relevant phosphorylated tyrosine residues (p-Tyr) and proteins involved in platelet activation downstream of this receptor.
Sat Feb 01 00:00:00 EST 2020
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin.
eLife
Smith RO,Ninchoji T,Gordon E,André H,Dejana E,Vestweber D,Kvanta A,Claesson-Welsh L
44-660G was used in Immunohistochemistry-immunofluorescence to support a mechanism whereby VE-cadherin Y685 phosphorylation is selectively associated with excessive vascular leakage.
Tue Apr 21 00:00:00 EDT 2020
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
International journal of molecular sciences
Markov AG,Fedorova AA,Kravtsova VV,Bikmurzina AE,Okorokova LS,Matchkov VV,Cornelius V,Amasheh S,Krivoi II
44-660G was used in Western Blot to confirm that circulating ouabain can functionally and tissue-specifically affect barrier properties of epithelial and endothelial tissues via Na,K-ATPase-mediated modulation of claudins expression.
Fri Jul 17 00:00:00 EDT 2020
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Nature communications
Rambur A,Lours-Calet C,Beaudoin C,Buñay J,Vialat M,Mirouse V,Trousson A,Renaud Y,Lobaccaro JA,Baron S,Morel L,de Joussineau C
44-660G was used in Immunohistochemistry to demonstrate that both Ras/MAPK and PI3K/AKT/mTOR pathways are necessary for basal extrusion.
Fri May 08 00:00:00 EDT 2020
Formin mDia1 contributes to migration and epithelial-mesenchymal transition of tubular epithelial cells exposed to TGF-β1.
Journal of cellular biochemistry
Li YY,Jiang GT,Chen LJ,Jiang YH,Jiao JD
44-660G was used in Immunohistochemistry (Paraffin), Western Blot to explore the role of mDia1 in EMT of tubular epithelial cells.
Sat Aug 01 00:00:00 EDT 2020
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Huang YA,Zhou B,Nabet AM,Wernig M,Südhof TC
44-660G was used in Western Blot to study ApoE activity on neurons, as a glia-secreted signaling molecule that, among others, enhances synapse formation. Using human neurons (male embryonic stem cell-derived) cultured in the absence of glia to exclude indirect glial mechanisms, we show that ApoE broadly stimulates signal transduction cascades.
Wed Sep 11 00:00:00 EDT 2019
Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells.
Oncology letters
Dong G,Lin XH,Liu HH,Gao DM,Cui JF,Ren ZG,Chen RX
44-660G was used in Western Blotting to investigate the ability of intermittent hypoxia to alleviate the acute hypoxia-induced increase of VEGF and decrease the pro-angiogenic potential of liver cancer cells.
Thu Aug 01 00:00:00 EDT 2019
Src mediates TGF-β-induced intraocular pressure elevation in glaucoma.
Journal of cellular physiology
Tsukamoto T,Kajiwara K,Nada S,Okada M
44-660G was used in Immunohistochemistry (Paraffin), Western Blot to show that Src kinase is involved in TGF-β-induced IOP elevation.
Fri Feb 01 00:00:00 EST 2019
Src mediates TGF-β-induced intraocular pressure elevation in glaucoma.
Journal of cellular physiology
Tsukamoto T,Kajiwara K,Nada S,Okada M
44-660G was used in Immunohistochemistry (Paraffin), Western Blot to show that Src kinase is involved in TGF-β-induced IOP elevation.
Fri Feb 01 00:00:00 EST 2019
The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.
Cancers
Hermida-Prado F,Granda-Díaz R,Del-Río-Ibisate N,Villaronga MÁ,Allonca E,Garmendia I,Montuenga LM,Rodríguez R,Vallina A,Alvarez-Marcos C,Rodrigo JP,García-Pedrero JM
44-660G was used in Immunohistochemistry to provide evidence for the differential clinical impact of SRC expression in head and neck squamous cell carcinoma patients depending on the tumor site.
Fri Oct 25 00:00:00 EDT 2019
Pioneer axons employ Cajal's battering ram to enter the spinal cord.
Nature communications
Nichols EL,Smith CJ
44-660G was used in Immunohistochemistry to support the model that actin-rich invasion structures dynamically drive pioneer axon entry into the spinal cord.
Mon Feb 04 00:00:00 EST 2019
A phase I study of gemcitabine + dasatinib (gd) or gemcitabine + dasatinib + cetuximab (GDC) in refractory solid tumors.
Cancer chemotherapy and pharmacology
Mettu NB,Niedzwiecki D,Rushing C,Nixon AB,Jia J,Haley S,Honeycutt W,Hurwitz H,Bendell JC,Uronis H
44-660G was used in Enzyme-linked immunosorbent assay to define the maximum tolerated dose (MTD), recommended phase two dose (RPTD), and toxicities of gemcitabine + dasatinib (GD) and gemcitabine + dasatinib + cetuximab (GDC) in advanced solid tumor patients.
Sat Jun 01 00:00:00 EDT 2019
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Scientific reports
Jain PB,Guerreiro PS,Canato S,Janody F
44-660G was used in Western Blot to demonstrate that Dystonin is a candidate tumour suppressor in breast cancer and provide an underlying molecular mechanism.
Fri Dec 27 00:00:00 EST 2019
Microenvironmental Factors Drive Tenascin C and Src Cooperation to Promote Invadopodia Formation in Ewing Sarcoma.
Neoplasia (New York, N.Y.)
Hawkins AG,Julian CM,Konzen S,Treichel S,Lawlor ER,Bailey KM
44-660G was used in Western Blotting to report the impact of stress-induced TNC expression on enhancing cell invadopodia formation, provides evidence for a feed forward loop between TNC and Src to promote cell metastatic behavior, and highlights a pathway by which microenvironment-driven TNC expression could be therapeutically targeted in Ewing sarcoma.
Tue Oct 01 00:00:00 EDT 2019
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
International journal of molecular sciences
Yan Y,Wang J,Chaudhry MA,Nie Y,Sun S,Carmon J,Shah PT,Bai F,Pratt R,Brickman C,Sodhi K,Kim JH,Pierre S,Malhotra D,Rankin GO,Xie ZJ,Shapiro JI,Liu J
44-660G was used in Western Blot to investigate the role of Na/K-ATPase signaling in TH mice, focusing on susceptibility to hypertension due to chronic excess salt ingestion.
Tue Jul 16 00:00:00 EDT 2019
High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer.
Cells
Chen YC,Ou MC,Fang CW,Lee TH,Tzeng SL
44-660G was used in Western Blotting to evidence multiple signalling pathways being regulated through hyperglycaemia in colorectal cancer.
Mon Apr 08 00:00:00 EDT 2019
Na/K-ATPase/src complex mediates regulation of CD40 in renal parenchyma.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Xie JX,Zhang S,Cui X,Zhang J,Yu H,Khalaf FK,Malhotra D,Kennedy DJ,Shapiro JI,Tian J,Haller ST
44-660G was used in Western Blotting to study the regulation of CD40 in the pathogenesis of renal injury and fibrosis.
Sun Jul 01 00:00:00 EDT 2018
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes.
Journal of cell science
Hoch-Kraft P,White R,Tenzer S,Krämer-Albers EM,Trotter J,Gonsior C
44-660G was used in Western Blotting to investigate the role of RNA helicase DDX5 in the post-transcriptional control of myelin basic protein synthesis in immature oligodendrocytes.
Tue May 01 00:00:00 EDT 2018
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
BMC cancer
Takada M,Parys M,Gregory-Bryson E,Vilar Saavedra P,Kiupel M,Yuzbasiyan-Gurkan V
44-660G was used in Western Blotting to fully characterize a novel canine histiocytic sarcoma cell line, and utilize it as a tool to screen for potential therapeutic drugs.
Thu Mar 01 00:00:00 EST 2018
The α2 isoform Na,K-ATPase modulates contraction of rat mesenteric small artery via cSrc-dependent Ca2+ sensitization.
Acta physiologica (Oxford, England)
Bouzinova EV,Hangaard L,Staehr C,Mazur A,Ferreira A,Chibalin AV,Sandow SL,Xie Z,Aalkjaer C,Matchkov VV
44-660G was used in Immunohistochemistry (Paraffin), Western Blot to suggest that micromolar ouabain potentiates agonist-induced contraction of rat mesenteric small artery via Na,K-ATPase-dependent cSrc activation, which increases Ca2+ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation.
Sat Sep 01 00:00:00 EDT 2018
Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia.
The EMBO journal
Perea D,Guiu J,Hudry B,Konstantinidou C,Milona A,Hadjieconomou D,Carroll T,Hoyer N,Natarajan D,Kallijärvi J,Walker JA,Soba P,Thapar N,Burns AJ,Jensen KB,Miguel-Aliaga I
44-660G was used in Immunohistochemistry to uncover the role of Ret receptor tyrosine kinase in the intestinal epithelium.
Mon Oct 16 00:00:00 EDT 2017
Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma.
PLoS pathogens
Wang X,Zou Z,Deng Z,Liang D,Zhou X,Sun R,Lan K
44-660G was used in Immunocytochemistry to show that knockdown of androgen receptor expression or pre-treatment with 5α-dihydrotestosterone, causes considerable Kaposi''s sarcoma-associated herpesvirus infection dysregulation.
Fri Sep 01 00:00:00 EDT 2017
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Gross S,Devraj K,Feng Y,Macas J,Liebner S,Wieland T
44660G was used in western blot to ask if nucleoside diphosphate kinase B interacting with caveolin-1 in endothelial cells is required for the regulation of angiogenesis and adherens junction integrity
Sat Jul 01 00:00:00 EDT 2017
miR205 inhibits stem cell renewal in SUM159PT breast cancer cells.
PloS one
Mayoral-Varo V,Calcabrini A,Sánchez-Bailón MP,Martín-Pérez J
44-660G was used in Western Blotting to study the effect of miR205 ectopic expression in the initial tumourigenic processes of SUM159PT.
Tue Dec 26 00:00:00 EST 2017
Highly sensitive and specific protein detection via combined capillary isoelectric focusing and proximity ligation.
Scientific reports
Padhan N,Yan J,Boge A,Scrivener E,Birgisson H,Zieba A,Gullberg M,Kamali-Moghaddam M,Claesson-Welsh L,Landegren U
44-660G was used in Simple Western - IEF to demonstrate background rejection and enhanced specificity when protein detection depended on binding by pairs of antibodies using in situ PLA, compared to assays where each antibody preparation was used on its own.
Thu May 04 00:00:00 EDT 2017
Tumor endothelial cells promote metastasis and cancer stem cell-like phenotype through elevated Epiregulin in esophageal cancer.
American journal of cancer research
Sun L,Pan J,Yu L,Liu H,Shu X,Sun L,Lou J,Yang Z,Ran Y
44660G was used in western blot to investigate the molecular mechanisms by which human esophageal cancer endothelial cells contribute to esophageal carcinoma progression
Wed Mar 16 00:00:00 EDT 2022
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.
Disease models & mechanisms
Nakano M,Yahiro K,Yamasaki E,Kurazono H,Akada J,Yamaoka Y,Niidome T,Hatakeyama M,Suzuki H,Yamamoto T,Moss J,Isomoto H,Hirayama T
44-660G was used in Western Blot to conclude that VacA mediates CagA phosphorylation through RPTPα in AZ-521 cells.
Thu Dec 01 00:00:00 EST 2016
Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231.
Molecular carcinogenesis
Kozlova N,Samoylenko A,Drobot L,Kietzmann T
44-660G was used in western blot to study the effects of uPA and EGF in breast adenocarcinoma cell lines
Mon Feb 01 00:00:00 EST 2016
GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.
American journal of physiology. Heart and circulatory physiology
Egholm C,Khammy MM,Dalsgaard T,Mazur A,Tritsaris K,Hansen AJ,Aalkjaer C,Dissing S
44660G was used in western blot to test if GLP-1 released from intestinal l-cells governs endothelial vessel tone
Tue Nov 01 00:00:00 EDT 2016
Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic.
Cell reports
Levine BD,Cagan RL
44-660G was used in immunohistochemistry to study drosophila lung cancer models to identify statin and trametinib as therapeutic candidates
Tue Feb 16 00:00:00 EST 2016
Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.
Oncotarget
Barcus CE,Keely PJ,Eliceiri KW,Schuler LA
44660G was used in western blot to explore the extracellular matrix features that control prolactin signals
Tue Jul 26 00:00:00 EDT 2016
Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning.
Physiological reports
Belliard A,Gulati GK,Duan Q,Alves R,Brewer S,Madan N,Sottejeau Y,Wang X,Kalisz J,Pierre SV
44660G was used in western blot to examine the impact of ischemia/reperfusion injury on sodium potassium ATPase enzymatic and signaling functions
Sat Oct 01 00:00:00 EDT 2016
Ligand-induced growth and compaction of CD36 nanoclusters enriched in Fyn induces Fyn signaling.
Journal of cell science
Githaka JM,Vega AR,Baird MA,Davidson MW,Jaqaman K,Touret N
44-660G was used in Western Blotting to reveal a crucial role for the basal organization of a receptor into nanoclusters that are enriched with the signal-transducing downstream effectors of that receptor, such that enhancement of clustering by multivalent ligands is necessary and sufficient to activate the downstream effector without the need for its de novo recruitment.
Tue Nov 15 00:00:00 EST 2016
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.
Cancer cell
Girotti MR,Lopes F,Preece N,Niculescu-Duvaz D,Zambon A,Davies L,Whittaker S,Saturno G,Viros A,Pedersen M,Suijkerbuijk BM,Menard D,McLeary R,Johnson L,Fish L,Ejiama S,Sanchez-Laorden B,Hohloch J,Carragher N,Macleod K,Ashton G,Marusiak AA,Fusi A,Brognard J,Frame M,Lorigan P,Marais R,Springer C
44-660G was used in immunohistochemistry to investigate the use of paradox-breaking pan-RAF inhibitors to treat cancer
Mon Jan 12 00:00:00 EST 2015
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia.
Cardiovascular research
Andersson L,Scharin Täng M,Lundqvist A,Lindbom M,Mardani I,Fogelstrand P,Shahrouki P,Redfors B,Omerovic E,Levin M,Borén J,Levin MC
44-660G was used in western blot to assess the role of receptor-interacting protein 2 in VEGF signalling and myocardial ischaemia/reperfusion injury.
Tue Sep 01 00:00:00 EDT 2015
Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells.
PloS one
Barcus CE,Holt EC,Keely PJ,Eliceiri KW,Schuler LA
44-660G was used in western blot to use collagen matrices to investigate the effects of 17beta-estradiol activity and PRL/E2 interactions in breast cancer cell lines in vitro.
Mon Jan 04 00:00:00 EST 2016
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Biochimica et biophysica acta
Kwon H,Lee J,Jeong K,Jang D,Pak Y
44-660G was used in immunoprecipitation to show that fatty acylated cav-2 is a IR tyrosine kinase substrate during insulin signaling
Fri May 01 00:00:00 EDT 2015
TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
PloS one
Shaw AK,Pickup MW,Chytil A,Aakre M,Owens P,Moses HL,Novitskiy SV
44-660G was used in western blot to show that MDSCs promote invasion of mammary carcinoma cells by increasing fibroblast migration
Thu Feb 04 00:00:00 EST 2016
Dissecting motility signaling through activation of specific Src-effector complexes.
Nature chemical biology
Karginov AV,Tsygankov D,Berginski M,Chu PH,Trudeau ED,Yi JJ,Gomez S,Elston TC,Hahn KM
44-660G was used in western blot to describe a method to selectively and quickly activate a kinase in a specific protein complex or at a specific subcellular location within living cells.
Tue Apr 01 00:00:00 EDT 2014
c-Src drives intestinal regeneration and transformation.
The EMBO journal
Cordero JB,Ridgway RA,Valeri N,Nixon C,Frame MC,Muller WJ,Vidal M,Sansom OJ
44-660G was used in immunohistochemistry to demonstrate that Src drives intestinal stem cell proliferation by upregulating EGFR and activating Ras/MAPK and Stat3 signaling.
Tue Jul 01 00:00:00 EDT 2014
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Breast cancer research : BCR
Garimella SV,Gehlhaus K,Dine JL,Pitt JJ,Grandin M,Chakka S,Nau MM,Caplen NJ,Lipkowitz S
44-660G was used in western blot to identify molecular regulators of the TRAIL pathway in breast cancer cells.
Thu Apr 17 00:00:00 EDT 2014
The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
Development (Cambridge, England)
Mahbub Hasan AK,Hashimoto A,Maekawa Y,Matsumoto T,Kushima S,Ijiri TW,Fukami Y,Sato K
Tue Apr 01 00:00:00 EDT 2014
EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.
Development (Cambridge, England)
Steinecke A,Gampe C,Zimmer G,Rudolph J,Bolz J
44-660G was used in immunohistochemistry to study factors needed for interneuron migration during different embryonic stages.
Wed Jan 01 00:00:00 EST 2014
Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Secord AA,Teoh D,Jia J,Nixon AB,Grace L,Adams DJ,Murphy SK
44-660G was used in immunocytochemistry to determine the effect of dasatinib in combination with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells.
Sat Feb 01 00:00:00 EST 2014
c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
ACS chemical biology
Zhang X,Meyn MA,Smithgall TE
44-660G was used in western blot to test if c-Src and c-Yes act in biological opposition using embryonic stem cells.
Fri Jan 17 00:00:00 EST 2014
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Experimental cell research
Rincon-Heredia R,Flores-Benitez D,Flores-Maldonado C,Bonilla-Delgado J,García-Hernández V,Verdejo-Torres O,Castillo AM,Larré I,Poot-Hernández AC,Franco M,Gariglio P,Reyes JL,Contreras RG
44-660G was used in western blot to investigate the effect of ouabain on endocytosis and degradation of tight junction proteins.
Wed Jan 01 00:00:00 EST 2014
Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase.
Biochemical and biophysical research communications
Gable ME,Abdallah SL,Najjar SM,Liu L,Askari A
44-660G was used in western blot to study the effect of ouabain on Src kinase and Na(+)/K(+)-ATPase.
Fri Apr 18 00:00:00 EDT 2014
Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization.
Developmental biology
Bates RC,Fees CP,Holland WL,Winger CC,Batbayar K,Ancar R,Bergren T,Petcoff D,Stith BJ
44-660G was used in western blot to study the role of phosphatidic acid during fertilization and membrane fusion situations
Sat Feb 01 00:00:00 EST 2014
SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.
Nature communications
Naudin C,Sirvent A,Leroy C,Larive R,Simon V,Pannequin J,Bourgaux JF,Pierre J,Robert B,Hollande F,Roche S
44-660G was used in western blot to demonstrate a tumor-suppressive role for SLAP in colorectal cancer.
Mon Mar 07 00:00:00 EST 2016
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Cancer discovery
Girotti MR,Pedersen M,Sanchez-Laorden B,Viros A,Turajlic S,Niculescu-Duvaz D,Zambon A,Sinclair J,Hayes A,Gore M,Lorigan P,Springer C,Larkin J,Jorgensen C,Marais R
Fri Feb 01 00:00:00 EST 2013
Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dasgupta S,Menezes ME,Das SK,Emdad L,Janjic A,Bhatia S,Mukhopadhyay ND,Shao C,Sarkar D,Fisher PB
44-660G was used in immunohistochemistry and western blot to identify a role for the metastasis-associated gene MDA-9/Syntenin in UCC progression.
Sun Sep 01 00:00:00 EDT 2013
Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
The Journal of biological chemistry
Tugues S,Honjo S,König C,Padhan N,Kroon J,Gualandi L,Li X,Barkefors I,Thijssen VL,Griffioen AW,Claesson-Welsh L
Fri Jun 28 00:00:00 EDT 2013
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
The Journal of biological chemistry
Thapa N,Choi S,Hedman A,Tan X,Anderson RA
44-660G was used in immunoprecipitation and western blot to study how tumor cells sustain oncogenic signals in the absence of cell matrix interactions.
Fri Nov 29 00:00:00 EST 2013
Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.
Nature cell biology
Nelson KS,Khan Z,Molnár I,Mihály J,Kaschube M,Beitel GJ
44-660G was used in immunohistochemistry to study how intestinal tube dimensions are regulated.
Sun Mar 25 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Annals of neurology
Lin MY,Frieboes LS,Forootan M,Palispis WA,Mozaffar T,Jafari M,Steward O,Gall CM,Gupta R
Sun Jul 01 00:00:00 EDT 2012
Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio.
Biochimica et biophysica acta
Weigand KM,Swarts HG,Fedosova NU,Russel FG,Koenderink JB
44-660G was used in western blot to investigate the relationship between the Na,K-ATPase and Src.
Tue May 01 00:00:00 EDT 2012
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Neuron
Ruiz de Almodovar C,Fabre PJ,Knevels E,Coulon C,Segura I,Haddick PC,Aerts L,Delattin N,Strasser G,Oh WJ,Lange C,Vinckier S,Haigh J,Fouquet C,Gu C,Alitalo K,Castellani V,Tessier-Lavigne M,Chedotal A,Charron F,Carmeliet P
44-660G was used in immunocytochemistry and western blot to report that secreted VEGF is a chemoattractant for commissural axons in vitro and in vivo.
Thu Jun 09 00:00:00 EDT 2011
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
Autophagy
Chen SY,Chiu LY,Maa MC,Wang JS,Chien CL,Lin WW
44-660G was used in western blot to clarify the role of autophagy in necroptosis
Tue Feb 01 00:00:00 EST 2011
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tan CL,Kwok JC,Patani R,Ffrench-Constant C,Chandran S,Fawcett JW
44-660G was used in immunocytochemistry to test if chondroitin sulfate proteoglycans inhibit regeneration in the central nervous system by inactivating integrins.
Wed Apr 27 00:00:00 EDT 2011
Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line.
The Journal of endocrinology
Hamzeh M,Robaire B
44-660G was used in western blot to study the effect of 5alpha-dihydrotestosterone treatment on epididymal structure and functions.
Fri Apr 01 00:00:00 EDT 2011
Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines.
BMC cancer
Fossey SL,Bear MD,Kisseberth WC,Pennell M,London CA
Mon Apr 11 00:00:00 EDT 2011
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.
Molecular and cellular biology
Yang X,Dutta U,Shaw LM
Mon Nov 01 00:00:00 EDT 2010
The simian virus 40 large tumor antigen activates cSrc and requires cSrc for full neoplastic transformation.
Anticancer research
Arulanandam R,Geletu M,Raptis L
44-660G was used in western blot to explore the role of cSrc in neoplastic transformation by the large tumor antigen of simian virus 40
Fri Jan 01 00:00:00 EST 2010
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
The Journal of biological chemistry
Carver KC,Piazza TM,Schuler LA
44-660G was used in western blot to elucidate the mechanism of cross-talk between PRL and IGF-I in breast cancer cells
Fri Mar 12 00:00:00 EST 2010
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
van Miltenburg MH,Lalai R,de Bont H,van Waaij E,Beggs H,Danen EH,van de Water B
44-660G was used in western blot to determine the role and mechanism of focal adhesion kinase-mediated signaling in mammary gland development and differentiation.
Thu Oct 01 00:00:00 EDT 2009
HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.
DNA repair
Ferrandiz N,Martin-Perez J,Blanco R,Donertas D,Weber A,Eilers M,Dotto P,Delgado MD,Leon J
44-660G was used in western blot to test if p21 protects from cell death induced by non-genotoxic drugs
Sun Mar 01 00:00:00 EST 2009
Src inhibition ameliorates polycystic kidney disease.
Journal of the American Society of Nephrology : JASN
Sweeney WE,von Vigier RO,Frost P,Avner ED
Tue Jul 01 00:00:00 EDT 2008
Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
Development (Cambridge, England)
Shindo M,Wada H,Kaido M,Tateno M,Aigaki T,Tsuda L,Hayashi S
Tue Apr 01 00:00:00 EDT 2008
Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.
Cellular signalling
Huang YT,Chen SU,Chou CH,Lee H
44-660G was used in immunocytochemistry and western blot to investigate S1P and PECAM-1 signaling in endothelial cells
Fri Aug 01 00:00:00 EDT 2008
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
Journal of immunology (Baltimore, Md. : 1950)
Allingham MJ,van Buul JD,Burridge K
Sat Sep 15 00:00:00 EDT 2007
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
Journal of immunology (Baltimore, Md. : 1950)
Allingham MJ,van Buul JD,Burridge K
Sat Sep 15 00:00:00 EDT 2007
Platelet integrin adhesive functions and signaling.
Methods in enzymology
Prévost N,Kato H,Bodin L,Shattil SJ
44-660G was used in western blot to report protocols and reagents currently used to study alphaIIbbeta3 adhesive responses and signaling in both human and murine cell models
Thu Oct 11 00:00:00 EDT 2007
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Chemistry & biology
Hu X,Dang Y,Tenney K,Crews P,Tsai CW,Sixt KM,Cole PA,Liu JO
44-660G was used in western blot to examine the effects of N-myristoylation on c-Src
Sun Jul 01 00:00:00 EDT 2007
Analyzing FAK and Pyk2 in early integrin signaling events.
Current protocols in cell biology
Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D
Sat Apr 01 00:00:00 EST 2006
Analyzing FAK and Pyk2 in early integrin signaling events.
Current protocols in cell biology
Bernard-Trifilo JA,Lim ST,Hou S,Schlaepfer DD,Ilic D
Sat Apr 01 00:00:00 EST 2006
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress.
Nature
Tzima E,Irani-Tehrani M,Kiosses WB,Dejana E,Schultz DA,Engelhardt B,Cao G,DeLisser H,Schwartz MA
Thu Sep 15 00:00:00 EDT 2005
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress.
Nature
Tzima E,Irani-Tehrani M,Kiosses WB,Dejana E,Schultz DA,Engelhardt B,Cao G,DeLisser H,Schwartz MA
Thu Sep 15 00:00:00 EDT 2005
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.
The Journal of experimental medicine
Huntington ND,Xu Y,Nutt SL,Tarlinton DM
Mon May 02 00:00:00 EDT 2005
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.
The Journal of experimental medicine
Huntington ND,Xu Y,Nutt SL,Tarlinton DM
Mon May 02 00:00:00 EDT 2005
(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Molecular endocrinology (Baltimore, Md.)
Sekimoto H,Eipper-Mains J,Pond-Tor S,Boney CM
44-660G was used in western blot to assess the mediation of insulin-like growth factor 1 activation of Src and mitogen-activated protein kinase in 3T3-L1 cells by Pyk2 and alpha-v-beta3 integrins
Fri Jul 01 00:00:00 EDT 2005
Reelin activates SRC family tyrosine kinases in neurons.
Current biology : CB
Bock HH,Herz J
Wed Jan 08 00:00:00 EST 2003
The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.
Oncogene
Feuillet V,Semichon M,Restouin A,Harriague J,Janzen J,Magee A,Collette Y,Bismuth G
44-660G was used in immunoprecipitation and western blot to examine the ability of Fyn and Lck to phosphorylate Sam68
Thu Oct 17 00:00:00 EDT 2002
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Molecular and cellular biology
Cary LA,Klinghoffer RA,Sachsenmaier C,Cooper JA
Mon Apr 01 00:00:00 EST 2002
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Molecular and cellular biology
Cary LA,Klinghoffer RA,Sachsenmaier C,Cooper JA
Mon Apr 01 00:00:00 EST 2002
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
The Journal of biological chemistry
Morel JC,Park CC,Zhu K,Kumar P,Ruth JH,Koch AE
Fri Sep 20 00:00:00 EDT 2002
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
The Journal of biological chemistry
Morel JC,Park CC,Zhu K,Kumar P,Ruth JH,Koch AE
Fri Sep 20 00:00:00 EDT 2002
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
The Journal of biological chemistry
Bourguignon LY,Zhu H,Shao L,Chen YW
Fri Mar 09 00:00:00 EST 2001
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
The Journal of biological chemistry
Bourguignon LY,Zhu H,Shao L,Chen YW
Fri Mar 09 00:00:00 EST 2001