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Invitrogen
Phospho-Ship2 (Tyr1135) Recombinant Rabbit Monoclonal Antibody (Ship2Y1135-1D2)
FIGURE: 1 / 3
Phospho-Ship2 (Tyr1135) Antibody (MA5-37042) in Flow
Flow cytometry of Phospho-Ship2 (Tyr1135) using U937 cells. Samples were incubated in monoclonal Phospho-Ship2 (Tyr1135) antibody (Product # MA5-37042) with a dilution of 0.5 µg/mL. Images correspond with the following conditions: negative control (light blue), untreated (red), treated with IFNa IL-4 and pervanadate (green), untreated and blocked with phospho-peptide (black), treated and blocked with phosph... View More
Product Details
MA5-37042
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Ship2Y1135-1D2
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr1135 of human phospho Ship2.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2896977
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodeling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 51C protein; ablSH3-binding protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2
Gene Aliases: 51C; INPPL1; OPSMD; SHIP2
UniProt ID: (Human) O15357, (Mouse) Q6P549
Entrez Gene ID: (Human) 3636, (Mouse) 16332
actin binding
protein binding
SH3 domain binding
phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
SH2 domain binding
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
inositol-polyphosphate 5-phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate binding
hydrolase activity
endochondral ossification
immune system process
glucose metabolic process
phosphatidylinositol biosynthetic process
endocytosis
actin filament organization
cell adhesion
negative regulation of cell proliferation
post-embryonic development
negative regulation of gene expression
response to insulin
inositol phosphate metabolic process
phosphatidylinositol dephosphorylation
ruffle assembly
negative regulation of DNA replication
negative regulation of platelet-derived growth factor receptor signaling pathway
negative regulation of neuron projection development
dephosphorylation
inositol trisphosphate metabolic process
negative regulation of MAP kinase activity
negative regulation of insulin-like growth factor receptor signaling pathway
cellular lipid metabolic process
negative regulation of insulin receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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