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Invitrogen
Phospho-Stat6 (Tyr641) Recombinant Rabbit Monoclonal Antibody (Stat6Y641-G12), APC
FIGURE: 1 / 1
Phospho-Stat6 (Tyr641) Antibody (MA5-36910) in Flow
Flow cytometry of Phospho-Stat6 (Tyr641) using U937 cells. Samples were incubated in monoclonal Phospho-Stat6 (Tyr641) antibody (Product # MA5-36910). Images correspond with the following conditions: negative control (blue), stained and untreated (red), treated with IFNa and IL-4 (green).
Product Details
MA5-36910
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
Stat6Y641-G12
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr641 of human phospho Stat6.
Conjugate
Excitation/Emission Max
651/660 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2896845
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. (Stat6-/-) were found to be deficient in IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response. STAT6 is crucial for IL-4-mediated biological responses, and naturally in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 12S1644; IL-4 Stat; IL4 STAT; Signal transducer and activator of transcription 6; signal transducer and activator of transcription 6, interleukin-4 induced; Signal transducer and transcription activator 6; STAT; STAT, interleukin4-induced; STAT-6; transcription factor IL-4 STAT
Gene Aliases: D12S1644; IL-4-STAT; STAT6; STAT6B; STAT6C
UniProt ID: (Human) P42226, (Mouse) P52633
Entrez Gene ID: (Human) 6778, (Mouse) 20852
negative regulation of transcription from RNA polymerase II promoter
T-helper 1 cell lineage commitment
negative regulation of type 2 immune response
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
signal transduction
positive regulation of type I interferon production
mammary gland epithelial cell proliferation
interleukin-4-mediated signaling pathway
regulation of cell proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of isotype switching to IgE isotypes
mammary gland morphogenesis
cellular response to hydrogen peroxide
cellular response to reactive nitrogen species
regulation of transcription, DNA-templated
cytokine-mediated signaling pathway
response to cytokine
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