Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-Synapsin 1 (Ser603) Polyclonal Antibody
FIGURE: 1 / 2
Phospho-Synapsin 1 (Ser603) Antibody (PA1-4604) in WB
Western blot of Synapsin 1 in rat cortical lysate showing specific immunolabeling of a ~78 kDa band corresponding to Phospho-Synapsin 1 (Ser603) polyclonal antibody (Product # PA1-4604) in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 minutes).
Product Details
PA1-4604
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rhesus monkey
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser603 of rat SYN1 conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_560615
Product Specific Information
This antibody is predicted to react with human, Xenopus, bovine, mouse and zebrafish based on 100% sequence homology.
In Western blot, this antibody detects an ~78 kDa protein representing Phospho-Ser603 Synapsin I protein.
Target Information
SYN1 (synapsin 1) is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins that associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains and are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. Synapsin 1 plays a role in regulation of axonogenesis and synaptogenesis. It serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Brain protein 4.1; synapsin 1; Synapsin I; Synapsin-1; truncated synapsin 1-S
Gene Aliases: Syn-1; SYN1; Syn1-S; SYN1a; SYN1b; SYNI
UniProt ID: (Human) P17600, (Rat) P09951, (Mouse) O88935
Entrez Gene ID: (Human) 6853, (Rat) 24949, (Mouse) 20964
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support