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Phospho-TRPV1 (Ser502) Antibody (PA5-106215) in IHC (P)
Immunohistochemistry analysis of Phospho-TRPV1 (Ser502) in human colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-TRPV1 (Ser502) polyclonal antibody (Product # PA5-106215) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106215
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TRPV1(Accession Q8NER1), corresponding to amino acid residues around phosphorylated Ser502.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817613
Product Specific Information
Antibody detects endogenous levels of VR1 only when phosphorylated at Ser502.
Target Information
TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons. TRPV1 is a non-selective cation channel that is structurally related to members of the TRP family of ion channels such as TRPC3 and TRPC6. TRPV1 is permeable to calcium, magnesium, and monovalent cations of sodium and potassium. Structurally, TRPV1 contains 6 trans-membrane domains, a P-loop membrane domain and 3 ankyrin repeat domains. TRPV1 is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. TRPV1 seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. The expression of TRPV1 appears to be limited to neurons within the sensory ganglia. Four transcript variants encoding TRPV1 with variations in th 5' UTR sequence have been described. Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Capsaicin receptor; cation channel; DKFZp434K0220; Osm-9-like TRP channel 1; OTRPC1; Transient receptor potential cation channel subfamily V member 1; transient receptor potential cation channel V1; transient receptor potential cation channel, subfamily V, member 1; transient receptor potential vanilloid 1 supraoptic nucleus; transient receptor potential vanilloid 1a; transient receptor potential vanilloid 1b; TrpV1; Vanilloid receptor; Vanilloid receptor 1; vanilloid receptor subtype 1; vanilloid receptor type 1 like protein 1; Vanilloid receptor type 1-like; vanilloid type 1 receptor
Gene Aliases: OTRPC1; TRPV1; TRPV1_SON; TRPV1alpha; TRPV1beta; VR-1; VR.5'sv; VR1; Vr1l; Vr1l1
UniProt ID: (Human) Q9NQ74, (Rat) O35433, (Mouse) Q704Y3
Entrez Gene ID: (Human) 7442, (Rat) 83810, (Mouse) 193034
transmembrane signaling receptor activity
excitatory extracellular ligand-gated ion channel activity
calcium channel activity
calmodulin binding
ATP binding
calcium-release channel activity
phosphoprotein binding
ion channel activity
cation channel activity
protein binding
cation transmembrane transporter activity
ligand-gated ion channel activity
chloride channel regulator activity
identical protein binding
nucleotide binding
ion channel
transport
cell surface receptor signaling pathway
chemosensory behavior
thermoception
release of sequestered calcium ion into cytosol
calcium ion transmembrane transport
cellular response to alkaloid
cellular response to ATP
temperature homeostasis
fever generation
microglial cell activation
diet induced thermogenesis
peptide secretion
lipid metabolic process
calcium ion transport
inflammatory response
signal transduction
positive regulation of cytosolic calcium ion concentration
response to pH
response to heat
response to organonitrogen compound
glutamate secretion
urinary bladder smooth muscle contraction
sensory perception of pain
ion transmembrane transport
positive regulation of apoptotic process
response to peptide hormone
positive regulation of nitric oxide biosynthetic process
response to pain
behavioral response to pain
sensory perception of mechanical stimulus
detection of chemical stimulus involved in sensory perception of pain
smooth muscle contraction involved in micturition
positive regulation of gastric acid secretion
cellular response to cytokine stimulus
cellular response to tumor necrosis factor
cellular response to growth factor stimulus
cellular response to temperature stimulus
negative regulation of establishment of blood-brain barrier
cellular response to nerve growth factor stimulus
ion transport
cation transport
catagen
transmembrane transport
cation transmembrane transport
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