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7TM Antibodies
Phospho-Tachykinin Receptor 3 (Thr402, Thr404) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-Tachykinin Receptor 3 (Thr402, Thr404) Antibody (7TM0362C) in WB
Agonist-induced Threonine402/Threonine404 phosphorylation of the NK 3 Receptor. Upper panel, HEK293 cells stably expressing the NK3-Receptor (NK3) were either not exposed or exposed to 1 µM of specific NK3-Receptor Agonist Neurokinin B for 30 minutes. Cells were lysed and immunoblotted with the anti-pT402/pT404-NK3 antibody (7TM0362C) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed wit... View More
Product Details
7TM0362C
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human NK3 around the phosphorylation site of Thr402/Thr404.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurokinin B; Neurokinin B receptor; neurokinin beta receptor; Neuromedin-K receptor; NK-3 receptor; NK-3R; NK3R TAC3R; NKR; Nmk-r; Tachykinin receptor 3
Gene Aliases: HH11; NK-3R; NK3R; NKR; TAC3R; TAC3RL; TACR3
UniProt ID: (Human) P29371
Entrez Gene ID: (Human) 6870
tachykinin receptor signaling pathway
aging
positive regulation of heart rate
response to estradiol
regulation of dopamine metabolic process
response to cocaine
hyperosmotic salinity response
response to morphine
positive regulation of blood pressure
regulation of feeding behavior
positive regulation of uterine smooth muscle contraction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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