Product References
Methyl donor supplementation reduces phospho-Tau, Fyn and demethylated protein phosphatase 2A levels and mitigates learning and motor deficits in a mouse model of tauopathy.
Neuropathology and applied neurobiology
van Hummel A,Taleski G,Sontag JM,Feiten AF,Ke YD,Ittner LM,Sontag E
Published figure using Phospho-Tau (Ser422) polyclonal antibody (Product # 44-764G) in Western Blot
Tue Aug 01 00:00:00 EDT 2023
Herpes Simplex Virus Type 1 Induces AD-like Neurodegeneration Markers in Human Progenitor and Differentiated ReNcell VM Cells.
Microorganisms
Salgado B,Sastre I,Bullido MJ,Aldudo J
44-764G was used in Immunocytochemistry to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease.
Thu May 04 00:00:00 EDT 2023
Herpes Simplex Virus Type 1 Induces AD-like Neurodegeneration Markers in Human Progenitor and Differentiated ReNcell VM Cells.
Microorganisms
Salgado B,Sastre I,Bullido MJ,Aldudo J
44-764G was used in Immunocytochemistry to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease.
Thu May 04 00:00:00 EDT 2023
Herpes Simplex Virus Type 1 Induces AD-like Neurodegeneration Markers in Human Progenitor and Differentiated ReNcell VM Cells.
Microorganisms
Salgado B,Sastre I,Bullido MJ,Aldudo J
44-764G was used in Immunocytochemistry to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease.
Thu May 04 00:00:00 EDT 2023
Herpes Simplex Virus Type 1 Induces AD-like Neurodegeneration Markers in Human Progenitor and Differentiated ReNcell VM Cells.
Microorganisms
Salgado B,Sastre I,Bullido MJ,Aldudo J
44-764G was used in Immunocytochemistry to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease.
Thu May 04 00:00:00 EDT 2023
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
44-764G was used in Immunohistochemistry to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 EST 2022
Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation.
CNS neuroscience & therapeutics
Li L,Miao J,Chu D,Jin N,Tung YC,Dai CL,Hu W,Gong CX,Iqbal K,Liu F
44-764G was used in Immunohistochemistry to indicate that 77G7 can effectively suppress the seeding activity of AD O-tau and thus could be developed as a potential immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
Thu Dec 01 00:00:00 EST 2022
Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer's disease and dementia with Lewy bodies.
Acta neuropathologica communications
Fixemer S,Ameli C,Hammer G,Salamanca L,Uriarte Huarte O,Schwartz C,Gérardy JJ,Mechawar N,Skupin A,Mittelbronn M,Bouvier DS
44-764G was used in Immunohistochemistry to suggest that combinations and severity of subregional pTau, Aβ and pSyn pathologies transform local microglia phenotypic composition in the hippocampus.
Wed Mar 16 00:00:00 EDT 2022
Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.
Molecular neurodegeneration
Kim DW,Tu KJ,Wei A,Lau AJ,Gonzalez-Gil A,Cao T,Braunstein K,Ling JP,Troncoso JC,Wong PC,Blackshaw S,Schnaar RL,Li T
44-764G was used in Western Blot, Immunohistochemistry to suggest that both Aβ and tau pathologies are required for the disease stage-specific induction of early-stage AD-Associated Microglia (EADAM) and late-stage AD-Associated Microglia (LADAM), and reveal Siglecs as biomarkers of Alzheimer's disease progression.
Sat Dec 17 00:00:00 EST 2022
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
Brain : a journal of neurology
Ruan Z,Pathak D,Venkatesan Kalavai S,Yoshii-Kitahara A,Muraoka S,Bhatt N,Takamatsu-Yukawa K,Hu J,Wang Y,Hersh S,Ericsson M,Gorantla S,Gendelman HE,Kayed R,Ikezu S,Luebke JI,Ikezu T
44-764G was used in Immunocytochemistry to propose a novel mechanism for the spread of tau in hippocampal GABAergic interneurons via brain-derived extracellular vesicles and their subsequent neuronal dysfunction.
Fri Feb 12 00:00:00 EST 2021
Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging.
NeuroImage
Chen L,van Zijl PCM,Wei Z,Lu H,Duan W,Wong PC,Li T,Xu J
44-764G was used in Immunohistochemistry to investigate if reduced creatine chemical exchange saturation transfer (CrCEST) contrast has the potential to serve as a new biomarker for early detection of Alzheimer''s disease.
Sun Aug 01 00:00:00 EDT 2021
Early detection of Alzheimer's disease using creatine chemical exchange saturation transfer magnetic resonance imaging.
NeuroImage
Chen L,van Zijl PCM,Wei Z,Lu H,Duan W,Wong PC,Li T,Xu J
44-764G was used in Immunohistochemistry to investigate if reduced creatine chemical exchange saturation transfer (CrCEST) contrast has the potential to serve as a new biomarker for early detection of Alzheimer''s disease.
Sun Aug 01 00:00:00 EDT 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
44-764G was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 EDT 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
44-764G was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 EDT 2021
Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice.
Journal of Alzheimer's disease : JAD
Guglielmotto M,Manassero G,Vasciaveo V,Venezia M,Tabaton M,Tamagno E
44-764G was used in Western Blot to find that biological sex influences the effect of amyloid-β42 (Aβ42) monomers on pathological tau conformational change.
Thu Sep 09 00:00:00 EDT 2021
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
44-764G was used in Western Blot, Immunohistochemistry to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 EDT 2019
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
44-764G was used in Western Blot, Immunohistochemistry to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 EDT 2019
Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.
Neurobiology of disease
Tiernan CT,Ginsberg SD,He B,Ward SM,Guillozet-Bongaarts AL,Kanaan NM,Mufson EJ,Counts SE
44-764G was used in Immunohistochemistry to study the molecular and cellular relationships between the evolution of tau pathology and nucleus basalis of Meynert neuronal survival.
Sat Sep 01 00:00:00 EDT 2018
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.
Molecular psychiatry
Dourlen P,Fernandez-Gomez FJ,Dupont C,Grenier-Boley B,Bellenguez C,Obriot H,Caillierez R,Sottejeau Y,Chapuis J,Bretteville A,Abdelfettah F,Delay C,Malmanche N,Soininen H,Hiltunen M,Galas MC,Amouyel P,Sergeant N,Buée L,Lambert JC,Dermaut B
Published figure using Phospho-Tau (Ser422) polyclonal antibody (Product # 44-764G) in Western Blot
Thu Jun 01 00:00:00 EDT 2017
Rab7A regulates tau secretion.
Journal of neurochemistry
Rodriguez L,Mohamed NV,Desjardins A,Lippé R,Fon EA,Leclerc N
Published figure using Phospho-Tau (Ser422) polyclonal antibody (Product # 44-764G) in Western Blot
Mon May 01 00:00:00 EDT 2017
Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein.
Aging cell
Manassero G,Guglielmotto M,Zamfir R,Borghi R,Colombo L,Salmona M,Perry G,Odetti P,Arancio O,Tamagno E,Tabaton M
Published figure using Phospho-Tau (Ser422) polyclonal antibody (Product # 44-764G) in Western Blot
Sat Oct 01 00:00:00 EDT 2016
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model.
Nature communications
Li T,Braunstein KE,Zhang J,Lau A,Sibener L,Deeble C,Wong PC
44-764G was used in immunohistochemistry - paraffin section to elucidate the pathological conversion of tau facilitated by the neuritic plaque in an Alzheimer's disease mouse model
Mon Jul 04 00:00:00 EDT 2016
High Resolution Dissection of Reactive Glial Nets in Alzheimer's Disease.
Scientific reports
Bouvier DS,Jones EV,Quesseveur G,Davoli MA,A Ferreira T,Quirion R,Mechawar N,Murai KK
44-764G was used in immunohistochemistry - free floating to analyze reactive glial nets in Alzheimer's disease by high resolution dissection
Tue Apr 19 00:00:00 EDT 2016
Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain.
Nature communications
Takeda S,Wegmann S,Cho H,DeVos SL,Commins C,Roe AD,Nicholls SB,Carlson GA,Pitstick R,Nobuhara CK,Costantino I,Frosch MP,Müller DJ,Irimia D,Hyman BT
44-764G was used in western blot to research Alzheimer's disease brain and neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau
Tue Oct 13 00:00:00 EDT 2015
Reelin immunoreactivity in neuritic varicosities in the human hippocampal formation of non-demented subjects and Alzheimer's disease patients.
Acta neuropathologica communications
Notter T,Knuesel I
44-764G was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to investigate whether a Reelin-associated neuropathology is observed in the aged human hippocampus and whether it correlated with dementia status.
Wed Jun 26 00:00:00 EDT 2013
Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.
Autophagy
Congdon EE,Wu JW,Myeku N,Figueroa YH,Herman M,Marinec PS,Gestwicki JE,Dickey CA,Yu WH,Duff KE
Published figure using Phospho-Tau (Ser422) polyclonal antibody (Product # 44-764G) in Western Blot
Sun Apr 01 00:00:00 EDT 2012
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Current Alzheimer research
Troquier L,Caillierez R,Burnouf S,Fernandez-Gomez FJ,Grosjean ME,Zommer N,Sergeant N,Schraen-Maschke S,Blum D,Buee L
Tue May 01 00:00:00 EDT 2012
Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach.
Current Alzheimer research
Troquier L,Caillierez R,Burnouf S,Fernandez-Gomez FJ,Grosjean ME,Zommer N,Sergeant N,Schraen-Maschke S,Blum D,Buee L
Tue May 01 00:00:00 EDT 2012
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
Endocrinology
Kim B,Backus C,Oh S,Hayes JM,Feldman EL
44-764G was used in immunohistochemistry and western blot to assess tau modification in type 1 and type 2 mouse models of diabetes
Tue Dec 01 00:00:00 EST 2009
Nature of "Tau" immunoreactivity in normal myonuclei and inclusion body myositis.
Muscle & nerve
Salajegheh M,Pinkus JL,Nazareno R,Amato AA,Parker KC,Greenberg SA
Thu Oct 01 00:00:00 EDT 2009
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities.
Molecular and cellular biology
Lambourne SL,Sellers LA,Bush TG,Choudhury SK,Emson PC,Suh YH,Wilkinson LS
Sat Jan 01 00:00:00 EST 2005
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
Pseudophosphorylation of tau protein alters its ability for self-aggregation.
Journal of neurochemistry
Haase C,Stieler JT,Arendt T,Holzer M
Mon Mar 01 00:00:00 EST 2004
Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils.
Science (New York, N.Y.)
Götz J,Chen F,van Dorpe J,Nitsch RM
44-764G was used in immunohistochemistry - paraffin section to assess induction by Abeta 42 fibrils on the formation of neurofibrillary tangles in P301I tau transgenic mice
Fri Aug 24 00:00:00 EDT 2001
