Product References
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1050 was used in Western Blot to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 EDT 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1050 was used in Western Blot to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1050 was used in Western Blot to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.
Acta neuropathologica
Kim YA,Siddiqui T,Blaze J,Cosacak MI,Winters T,Kumar A,Tein E,Sproul AA,Teich AF,Bartolini F,Akbarian S,Kizil C,Hargus G,Santa-Maria I
MN1050 was used in Western Blot to indicate that neuronal NSun2 deficiency promotes dysregulation of miR-125b and tau phosphorylation in AD and highlights a novel avenue for therapeutic targeting.
Sun Jan 01 00:00:00 EST 2023
Predictive blood biomarkers and brain changes associated with age-related cognitive decline.
Brain communications
Saunders TS,Pozzolo FE,Heslegrave A,King D,McGeachan RI,Spires-Jones MP,Harris SE,Ritchie C,Muniz-Terrera G,Deary IJ,Cox SR,Zetterberg H,Spires-Jones TL
MN1050 was used in Western Blotting to test whether plasma levels of tau phosphorylated at threonine 181, amyloid-β, neurofilament light and fibrillary acidic protein predict cognitive decline between ages 72 and 82 in 195 participants in the Lothian birth cohorts 1936 study of cognitive ageing.
Wed Sep 20 00:00:00 EDT 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1050 was used in Western Blot to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1050 was used in Western Blot to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome.
Alzheimer's & dementia (New York, N. Y.)
Curtis ME,Smith T,Blass BE,Praticò D
MN1050 was used in Western Blotting to investigate whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of Down syndrome.
Tue Aug 02 00:00:00 EDT 2022
Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease.
Annals of clinical and translational neurology
Brickman AM,Manly JJ,Honig LS,Sanchez D,Reyes-Dumeyer D,Lantigua RA,Vonsattel JP,Teich AF,Kang MS,Dage JL,Mayeux R
MN1050 was used in Enzyme-linked immunosorbent assay to suggest that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.
Sun May 01 00:00:00 EDT 2022
Tau protein is differentially phosphorylated in young- and old-aged rats with experimentally induced hyperthyroidism.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Tan B,Babur E,Toy N,Günaydın B,Dursun N,Süer C
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to study long-term potentiation (LTP) and accompanying phosphorylation of Tau protein in different residues in the hippocampus of young and old rats with experimentally induced hyperthyroidism.
Tue Nov 01 00:00:00 EDT 2022
Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Saroja SR,Sharma A,Hof PR,Pereira AC
MN1050 was used in Western Blot to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.
Thu Sep 01 00:00:00 EDT 2022
Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease.
EBioMedicine
Ashton NJ,Benedet AL,Pascoal TA,Karikari TK,Lantero-Rodriguez J,Brum WS,Mathotaarachchi S,Therriault J,Savard M,Chamoun M,Stoops E,Francois C,Vanmechelen E,Gauthier S,Zimmer ER,Zetterberg H,Blennow K,Rosa-Neto P
MN1050 was used in Functional assay to demonstrate that CSF p-tau231 increases early in development of AD pathology and is a principal candidate for detecting incipient Aβ pathology for therapeutic trial application.
Tue Feb 01 00:00:00 EST 2022
Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum.
Brain : a journal of neurology
Moscoso A,Grothe MJ,Ashton NJ,Karikari TK,Rodriguez JL,Snellman A,Suárez-Calvet M,Zetterberg H,Blennow K,Schöll M
MN1050 was used in Immunoprecipitation to show increased plasma p-tau181 is associated with the presence of cortical amyloid-β pathology in Alzheimer's disease.
Fri Feb 12 00:00:00 EST 2021
Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids.
Molecular psychiatry
Pérez MJ,Ivanyuk D,Panagiotakopoulou V,Di Napoli G,Kalb S,Brunetti D,Al-Shaana R,Kaeser SA,Fraschka SA,Jucker M,Zeviani M,Viscomi C,Deleidi M
MN1050 was used in Western Blotting to support a mechanistic link between mitochondrial function and common neurodegenerative proteinopathies.
Fri Oct 01 00:00:00 EDT 2021
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Brain pathology (Zurich, Switzerland)
Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH
MN1050 was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.
Fri Jan 01 00:00:00 EST 2021
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
Acta neuropathologica communications
McMillan PJ,Strovas TJ,Baum M,Mitchell BK,Eck RJ,Hendricks N,Wheeler JM,Latimer CS,Keene CD,Kraemer BC
MN1050 was used in Immunohistochemistry (Paraffin) to to identify Alzheimer's disease-specific cellular changes related to nuclear speckles.
Tue Jun 29 00:00:00 EDT 2021
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
Acta neuropathologica communications
McMillan PJ,Strovas TJ,Baum M,Mitchell BK,Eck RJ,Hendricks N,Wheeler JM,Latimer CS,Keene CD,Kraemer BC
MN1050 was used in Immunohistochemistry (Paraffin) to to identify Alzheimer's disease-specific cellular changes related to nuclear speckles.
Tue Jun 29 00:00:00 EDT 2021
Synergistic Association between Plasma Aβ1-42 and p-tau in Alzheimer's Disease but Not in Parkinson's Disease or Frontotemporal Dementia.
ACS chemical neuroscience
Chiu MJ,Yang SY,Chen TF,Lin CH,Yang FC,Chen WP,Zetterberg H,Blennow K
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to investigate the relation in AD, Parkinson’s disease, frontotemporal dementia, and controls using immunomagnetic reduction assays to measure plasma Aβ and p-tau.
Wed Apr 21 00:00:00 EDT 2021
Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression.
Alzheimer's research & therapy
Clark C,Lewczuk P,Kornhuber J,Richiardi J,Maréchal B,Karikari TK,Blennow K,Zetterberg H,Popp J
MN1050 was used in Immunocytochemistry-immunoflourescence to assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology.
Thu Mar 25 00:00:00 EDT 2021
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein.
International journal of molecular sciences
Lin G,Zhu F,Kanaan NM,Asano R,Shirafuji N,Sasaki H,Yamaguchi T,Enomoto S,Endo Y,Ueno A,Ikawa M,Hayashi K,Yamamura O,Yen SH,Nakamoto Y,Hamano T
MN1050 was used in Western Blot to examine the effects of Clioquinol on tau metabolism in M1C cell, a human neuroblastoma cell line.
Mon Nov 08 00:00:00 EST 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
MN1050 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 EDT 2021
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Nature communications
Subramanian M,Hyeon SJ,Das T,Suh YS,Kim YK,Lee JS,Song EJ,Ryu H,Yu K
MN1050 was used in Western Blot to demonstrate that UBE4B, a miR-9 target gene, promotes autophagy-mediated Tau degradation together with STUB1, and is thus an innovative therapeutic approach for AD.
Wed Jun 02 00:00:00 EDT 2021
Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia.
Nature medicine
Janelidze S,Mattsson N,Palmqvist S,Smith R,Beach TG,Serrano GE,Chai X,Proctor NK,Eichenlaub U,Zetterberg H,Blennow K,Reiman EM,Stomrud E,Dage JL,Hansson O
MN1050 was used in Electrochemiluminescence to investigate if plasma phosphorylated tau181 is a noninvasive diagnostic and prognostic biomarker of alzheimer's disease.
Sun Mar 01 00:00:00 EST 2020
Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.
The Lancet. Neurology
Karikari TK,Pascoal TA,Ashton NJ,Janelidze S,Benedet AL,Rodriguez JL,Chamoun M,Savard M,Kang MS,Therriault J,Schöll M,Massarweh G,Soucy JP,Höglund K,Brinkmalm G,Mattsson N,Palmqvist S,Gauthier S,Stomrud E,Zetterberg H,Hansson O,Rosa-Neto P,Blennow K
MN1050 was used in Immunoprecipitation to show that blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer''s disease from other neurodegenerative disorders, and identify Alzheimer''s disease across the clinical continuum.
Fri May 01 00:00:00 EDT 2020
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease.
Journal of medicinal chemistry
de Matos AM,Blázquez-Sánchez MT,Bento-Oliveira A,de Almeida RFM,Nunes R,Lopes PEM,Machuqueiro M,Cristóvão JS,Gomes CM,Souza CS,El Idrissi IG,Colabufo NA,Diniz A,Marcelo F,Oliveira MC,López Ó,Fernandez-Bolaños JG,Dätwyler P,Ernst B,Ning K,Garwood C,Chen B,Rauter AP
MN1050 was used in Immunocytochemistry to investigate the potential of nature-inspired glucosylpolyphenols against relevant targets, including islet amyloid polypeptide, glucosidases, and cholinesterases.
Thu Oct 22 00:00:00 EDT 2020
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Neurobiology of aging
Hamano T,Shirafuji N,Yen SH,Yoshida H,Kanaan NM,Hayashi K,Ikawa M,Yamamura O,Fujita Y,Kuriyama M,Nakamoto Y
MN1050 was used in Western Blot to examine the effects of ROCK inhibitors (H1152, Y-27632, and fasudil [HA-1077]) on tau protein phosphorylation in detail.
Fri May 01 00:00:00 EDT 2020
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
International journal of molecular sciences
Nam E,Lee YB,Moon C,Chang KA
MN1050 was used in Western Blotting to suggest that serum tau proteins, especially NEX tau proteins, are useful biomarkers for monitoring AD progression.
Wed Jul 15 00:00:00 EDT 2020
Yeast surface display of full-length human microtubule-associated protein tau.
Biotechnology progress
Wang S,Cho YK
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to show that yeast-displayed tau enables robust measurement of protein interactions and is of particular interest for characterizing conformational change.
Wed Jan 01 00:00:00 EST 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1050 was used in Western Blot to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 EST 2020
A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles.
Molecular neurodegeneration
Li JG,Chiu J,Ramanjulu M,Blass BE,Praticò D
MN1050 was used in Western Blot to demonstrate that vacuolar protein sorting 35 genetic manipulation modulates the phenotype of mouse models of Alzheimer's disease.
Wed Jan 22 00:00:00 EST 2020
Screening of tau protein kinase inhibitors in a tauopathy-relevant cell-based model of tau hyperphosphorylation and oligomerization.
PloS one
Yadikar H,Torres I,Aiello G,Kurup M,Yang Z,Lin F,Kobeissy F,Yost R,Wang KK
MN1050 was used in Western Blotting to provide a comprehensive view of potential drug candidates (TBB, CsA, AR, and Saracatinib), and their efficacy against tau hyperphosphorylation and oligomerization processes.
Fri Sep 04 00:00:00 EDT 2020
Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization.
Scientific reports
Dominguez-Meijide A,Vasili E,König A,Cima-Omori MS,Ibáñez de Opakua A,Leonov A,Ryazanov S,Zweckstetter M,Griesinger C,Outeiro TF
MN1050 was used in Western Blotting to assess the effects of different pharmacological interventions on the aggregation and internalization of tau and aSyn.
Thu Jul 30 00:00:00 EDT 2020
Neurofilament light chain in the vitreous humor of the eye.
Alzheimer's research & therapy
Subramanian ML,Vig V,Chung J,Fiorello MG,Xia W,Zetterberg H,Blennow K,Zetterberg M,Shareef F,Siegel NH,Ness S,Jun GR,Stein TD
MN1050 was used in Immunocytochemistry to investigate the presence of NfL in the vitreous humor and its associations with amyloid beta, tau, inflammatory cytokines and vascular proteins, apolipoprotein E (APOE) genotypes, Mini-Mental State Examination (MMSE) scores, systemic disease, and ophthalmic diseases.
Thu Sep 17 00:00:00 EDT 2020
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 EDT 2019
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1050 was used in Western Blot to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 EDT 2023
Hibernation Impairs Odor Discrimination - Implications for Alzheimer's Disease.
Frontiers in neuroanatomy
Bullmann T,Feneberg E,Kretzschmann TP,Ogunlade V,Holzer M,Arendt T
MN1050 was used in Western Blot to conclude that hibernation is associated with a specific olfactory memory deficit, which might not be attributed to the formation of PHF-like phosphorylated tau within the olfactory bulb as seen in Alzheimer's Disease.
Fri Oct 13 00:00:00 EDT 2023
Highly sensitive quantification of Alzheimer's disease biomarkers by aptamer-assisted amplification.
Theranostics
Chan HN,Xu D,Ho SL,He D,Wong MS,Li HW
MN1050 was used in an ELISA assay to show how the developed assay holds tremendous clinical potential for early diagnosis of AD and monitoring of its progression.
Thu Jun 18 00:00:00 EDT 2020
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Nature communications
Jadiya P,Kolmetzky DW,Tomar D,Di Meco A,Lombardi AA,Lambert JP,Luongo TS,Ludtmann MH,Praticò D,Elrod JW
MN1050 was used in Western Blotting to provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of Alzheimer's disease (AD) and suggest mCa2+ exchange as potential therapeutic target in AD.
Thu Aug 29 00:00:00 EDT 2019
Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein.
Neuropathology and applied neurobiology
Soe K,Beard H,Neumann D,Trim PJ,Duplock S,Snel MF,Hopwood JJ,Hemsley KM
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to reveal that the rate, location and nature of deposition of other proteinaceous lesions, the disruption to endolysosomal protein expression and the inflammatory response seen in the brain of α-synuclein-deficient MPS IIIA mice reflected that seen in MPS IIIA mice homo- or heterozygous for α-synuclein.
Sun Dec 01 00:00:00 EST 2019
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Paspalas CD,Carlyle BC,Leslie S,Preuss TM,Crimins JL,Huttner AJ,van Dyck CH,Rosene DL,Nairn AC,Arnsten AFT
MN1050 was used in Immunocytochemistry to study the progression of tau and amyloid cortical pathology in the ageing rhesus macaque.
Tue May 01 00:00:00 EDT 2018
Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Mielke MM,Hagen CE,Xu J,Chai X,Vemuri P,Lowe VJ,Airey DC,Knopman DS,Roberts RO,Machulda MM,Jack CR,Petersen RC,Dage JL
MN1050 was used in Mass Spectrometry to investigate if plasma phospho-tau181 has a utility as a biomarker of Alzheimer''s disease pathophysiology and as a noninvasive screener for elevated brain amyloid β.
Wed Aug 01 00:00:00 EDT 2018
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
EMBO molecular medicine
Kidana K,Tatebe T,Ito K,Hara N,Kakita A,Saito T,Takatori S,Ouchi Y,Ikeuchi T,Makino M,Saido TC,Akishita M,Iwatsubo T,Hori Y,Tomita T
MN1050 was used in Western Blotting to suggest that KLK7 aids in the degradation and clearance of deposited AΒ by astrocytes involved in the pathogenesis of AD.
Thu Mar 01 00:00:00 EST 2018
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America
Hou Y,Lautrup S,Cordonnier S,Wang Y,Croteau DL,Zavala E,Zhang Y,Moritoh K,O'Connell JF,Baptiste BA,Stevnsner TV,Mattson MP,Bohr VA
MN1050 was used in Western Blotting to examine the role of compromised cellular bioenergetics and DNA repair in the pathogenesis of Alzheimer's disease.
Tue Feb 20 00:00:00 EST 2018
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bardai FH,Wang L,Mutreja Y,Yenjerla M,Gamblin TC,Feany MB
MN1050 was used in Western Blotting to determine the mechanism by whichFTDP-17 mutations promote disease in vivo.
Wed Jan 03 00:00:00 EST 2018
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion.
Frontiers in molecular neuroscience
Turnbull MT,Boskovic Z,Coulson EJ
MN1050 was used in Western Blotting to suggest that the cognitive decline and AΒ pathology induced by BFCN loss occur independent of dysfunctional neuronal BDNF signaling, and may therefore be directly underpinned by reduced cholinergic neurotransmission.
Thu Oct 01 00:00:00 EDT 2020
Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports.
Journal of neuropathology and experimental neurology
Adams JW,Alvarez VE,Mez J,Huber BR,Tripodis Y,Xia W,Meng G,Kubilus CA,Cormier K,Kiernan PT,Daneshvar DH,Chua AS,Svirsky S,Nicks R,Abdolmohammadi B,Evers L,Solomon TM,Cherry JD,Aytan N,Mahar I,Devine S,Auerbach S,Alosco ML,Nowinski CJ,Kowall NW,Goldstein LE,Dwyer B,Katz DI,Cantu RC,Stern RA,Au R,McKee AC,Stein TD
MN1050 was used in an ELISA assay to examine whether contact sports and chronic traumatic encephalopathy are associated with Lewy body disease.
Sat Sep 01 00:00:00 EDT 2018
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.
Neuropathology and applied neurobiology
Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG
MN1050 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.
Sun Apr 01 00:00:00 EDT 2018
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Biological psychiatry
Di Meco A,Li JG,Blass BE,Abou-Gharbia M,Lauretti E,Praticò D
MN1050 was used in western blot to discuss the contribution of 12/15-lipoxygenase to Alzheimer's disease
Sun Jan 15 00:00:00 EST 2017
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Molecular neurobiology
Chanu SI,Sarkar S
MN1050 was used in immunohistochemistry - paraffin section and western blot to study suppression of pathogenesis of human neuronal tauopathies in drosophila by limiting tau hyperphosphorylation and heterochromatin relaxation by targeted downregulation of
Mon May 01 00:00:00 EDT 2017
Genetic absence of ALOX5 protects from homocysteine-induced memory impairment, tau phosphorylation and synaptic pathology.
Human molecular genetics
Li JG,Barrero C,Merali S,Praticò D
MN1050 was used in Western Blotting to determine the role of the ALOX5 gene in the development of the neuropathological, biochemical and behavioural sequelae of increased homocysteine.
Mon May 15 00:00:00 EDT 2017
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Scientific reports
Li JG,Barrero C,Merali S,Praticò D
MN1050 was used in immunohistochemistry and western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype
Thu Apr 06 00:00:00 EDT 2017
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1050 was used in Immuno-assay to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 EDT 2017
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
EMBO molecular medicine
Salta E,Sierksma A,Vanden Eynden E,De Strooper B
MN1050 was used in western blot to describe the role of miR-132 in amyloid and TAU pathology associated with Alzheimer's disease
Thu Sep 01 00:00:00 EDT 2016
The identification of raft-derived tau-associated vesicles that are incorporated into immature tangles and paired helical filaments.
Neuropathology and applied neurobiology
Nishikawa T,Takahashi T,Nakamori M,Hosomi N,Maruyama H,Miyazaki Y,Izumi Y,Matsumoto M
MN1050 was used in immunohistochemistry - paraffin section to study the relationship between neurofibrillary tangles and raft domains
Thu Dec 01 00:00:00 EST 2016
Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models.
Cell death & disease
Lipton SA,Rezaie T,Nutter A,Lopez KM,Parker J,Kosaka K,Satoh T,McKercher SR,Masliah E,Nakanishi N
MN1050 was used in immunohistochemistry to examine the effects of carnosic acid in models of Alzheimer's disease
Thu Dec 01 00:00:00 EST 2016
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Brain : a journal of neurology
Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D
MN1050 was used in western blot to characterize Alzheimer's disease-related tau pathology by HS3ST2 expression in critical for the abonormal phosphorylation of tau
Fri May 01 00:00:00 EDT 2015
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hunt JB,Nash KR,Placides D,Moran P,Selenica ML,Abuqalbeen F,Ratnasamy K,Slouha N,Rodriguez-Ospina S,Savlia M,Ranaweera Y,Reid P,Dickey CA,Uricia R,Yang CG,Sandusky LA,Gordon MN,Morgan D,Lee DC
MN1050 was used in Western Blotting to study the effects of Arginase 1 overexperssion in the central nervous system of rTg4510 tau transgenic mice.
Wed Nov 04 00:00:00 EST 2015
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Journal of neurochemistry
Ittner A,Bertz J,Suh LS,Stevens CH,Götz J,Ittner LM
MN1050 was used in immunohistochemistry - paraffin section and western blot to determine the pathology in tau transgenic mice due to tau-targeting passive immunization
Thu Jan 01 00:00:00 EST 2015
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Neurobiology of aging
Lauretti E,Di Meco A,Chu J,Praticò D
MN1050 was used in immunohistochemistry - paraffin section and western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease
Sun Feb 01 00:00:00 EST 2015
Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2.
Journal of neuroscience research
Hamm M,Bailey R,Shaw G,Yen SH,Lewis J,Giasson BI
MN1050 was used in western blot to study how microtubules and cations impact LRRK2-tau interactions.
Thu Oct 01 00:00:00 EDT 2015
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Journal of Alzheimer's disease : JAD
Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R
MN1050 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.
Fri Aug 21 00:00:00 EDT 2015
Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer's disease.
Journal of neural transmission (Vienna, Austria : 1996)
Riise J,Plath N,Pakkenberg B,Parachikova A
MN1050 was used in western blot to perform the first comprehensive Wnt pathway-focused evaluation using the entorhinal cortex and hippocampus from Alzheimer's diseased brains
Tue Sep 01 00:00:00 EDT 2015
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Molecular neurodegeneration
Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L
MN1050 was used in western blot to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.
Thu Mar 26 00:00:00 EDT 2015
Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
The EMBO journal
Kondadi AK,Wang S,Montagner S,Kladt N,Korwitz A,Martinelli P,Herholz D,Baker MJ,Schauss AC,Langer T,Rugarli EI
MN1050 was used in western blot to study the mitochondrial import defects and hyperphosphorylation of tau that result from depletion of the AFG(3)L(2) subunit of the m-AAA proteinase in neurons
Fri May 02 00:00:00 EDT 2014
Visualizing the microtubule-associated protein tau in the nucleus.
Science China. Life sciences
Lu J,Li T,He R,Bartlett PF,Götz J
MN1050 was used in western blot to perform a comparative study of methods for the detection of nuclear tau protein
Tue Apr 01 00:00:00 EDT 2014
Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders.
British journal of pharmacology
Wrasidlo W,Crews LA,Tsigelny IF,Stocking E,Kouznetsova VL,Price D,Paulino A,Gonzales T,Overk CR,Patrick C,Rockenstein E,Masliah E
MN1050 was used in Western Blotting to study the neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity.
Mon Dec 01 00:00:00 EST 2014
Huntington's disease (HD): degeneration of select nuclei, widespread occurrence of neuronal nuclear and axonal inclusions in the brainstem.
Brain pathology (Zurich, Switzerland)
Rüb U,Hentschel M,Stratmann K,Brunt E,Heinsen H,Seidel K,Bouzrou M,Auburger G,Paulson H,Vonsattel JP,Lange H,Korf HW,den Dunnen W
MN1050 was used in Immunohistochemistry-immunofluorescence to show that the formation of axonal aggregates may represent a crucial event in the cascades of pathological events leading to neurodegeneration in Huntington's disease.
Tue Apr 01 00:00:00 EDT 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1050 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 EST 2014
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
The American journal of pathology
Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM
MN1050 was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects
Sat Mar 01 00:00:00 EST 2014
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
The American journal of pathology
Medeiros R,Castello NA,Cheng D,Kitazawa M,Baglietto-Vargas D,Green KN,Esbenshade TA,Bitner RS,Decker MW,LaFerla FM
MN1050 was used in Western Blotting to determine the effect of long-term treatment with the selective α7 nAChR agonist A-582941 in aged 3xTg-AD mice with robust Alzheimer's disease-like pathology.
Sat Feb 01 00:00:00 EST 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1050 was used in immunohistochemistry to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 EST 2014
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Neurobiology of aging
Di Meco A,Joshi YB,Praticò D
MN1050 was used in western blot to study the deleterious effects of sleep deprivation on memory and Tau pathology in a murine Alzheimer's disease model
Fri Aug 01 00:00:00 EDT 2014
Age-related downregulation of the CaV3.1 T-type calcium channel as a mediator of amyloid beta production.
Neurobiology of aging
Rice RA,Berchtold NC,Cotman CW,Green KN
MN1050 was used in western blot to study the potential mechanism by which the age-related decline in CaV3.1 T-type calcium channel expression leads to increased production of beta-amyloid
Thu May 01 00:00:00 EDT 2014
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
FEBS letters
Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K
MN1050 was used in immunohistochemistry to study the role of Tau phosphorylation in murine spermatogenesis during meiosis
Thu May 29 00:00:00 EDT 2014
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1050 was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 EDT 2013
Clinical correlates in an experimental model of repetitive mild brain injury.
Annals of neurology
Mannix R,Meehan WP,Mandeville J,Grant PE,Gray T,Berglass J,Zhang J,Bryant J,Rezaie S,Chung JY,Peters NV,Lee C,Tien LW,Kaplan DL,Feany M,Whalen M
MN1050 was used in immunohistochemistry to use a murine model of repetetive mild brain injury to study whether the observed congnitive deficits are associated with beta-amyloid/tau pathology or ApoE allele
Mon Jul 01 00:00:00 EDT 2013
NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model.
Aging cell
Burnouf S,Martire A,Derisbourg M,Laurent C,Belarbi K,Leboucher A,Fernandez-Gomez FJ,Troquier L,Eddarkaoui S,Grosjean ME,Demeyer D,Muhr-Tailleux A,Buisson A,Sergeant N,Hamdane M,Humez S,Popoli P,Buée L,Blum D
MN1050 was used in immunoprecipitation to study the role of impaired NMDA receptor function in the blunted effect of BDNF on synaptic enhancement in a model of tau pathology
Fri Feb 01 00:00:00 EST 2013
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Diabetes
Leboucher A,Laurent C,Fernandez-Gomez FJ,Burnouf S,Troquier L,Eddarkaoui S,Demeyer D,Caillierez R,Zommer N,Vallez E,Bantubungi K,Breton C,Pigny P,Buée-Scherrer V,Staels B,Hamdane M,Tailleux A,Buée L,Blum D
MN1050 was used in western blot to study the effects of diet-induced obesity on tau pathology
Wed May 01 00:00:00 EDT 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1050 was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 EDT 2013
SorLA deficiency dissects amyloid pathology from tau and cholinergic neurodegeneration in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Capsoni S,Carlo AS,Vignone D,Amato G,Criscuolo C,Willnow TE,Cattaneo A
MN1050 was used in immunohistochemistry to study the effect of SorLA-deficiency to dissociate amyloid and tau neurodegeneration in a novel murine model of Alzheimer's disease
Tue May 28 00:00:00 EDT 2013
Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.
Brain structure & function
Engelhardt M,Vorwald S,Sobotzik JM,Bennett V,Schultz C
MN1050 was used in immunohistochemistry to study the expression and role of ankyrin-B in peripheral somatosensory neurons
Mon Jul 01 00:00:00 EDT 2013
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.
Neuro-degenerative diseases
Flunkert S,Hierzer M,Löffler T,Rabl R,Neddens J,Duller S,Schofield EL,Ward MA,Posch M,Jungwirth H,Windisch M,Hutter-Paier B
MN1050 was used in western blot to study the role of soluble total and hyperphosphorylated tau in brain pathology and behaviour in a transgenic mouse model
Wed Nov 13 00:00:00 EST 2013
Characterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.
PloS one
Meredith JE,Sankaranarayanan S,Guss V,Lanzetti AJ,Berisha F,Neely RJ,Slemmon JR,Portelius E,Zetterberg H,Blennow K,Soares H,Ahlijanian M,Albright CF
MN1050 was used in ELISA to study the potential utility of CSF tau and phospho181 tau as Alzheimer's disease biomarkers
Sat Aug 02 00:00:00 EDT 2014
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
PloS one
Guo Q,Li H,Cole AL,Hur JY,Li Y,Zheng H
MN1050 was used in western blot to generate a novel humanized murine model of Alzheimer's disease that does not rely on mutant protein overexpression
Wed Dec 10 00:00:00 EST 2014
Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease.
Biological psychiatry
Mouton-Liger F,Paquet C,Dumurgier J,Lapalus P,Gray F,Laplanche JL,Hugon J
MN1050 was used in western blot to investigate the predictive values of CSF T-PKR and pPKR in the diagnosis of Alzheimer disease
Tue May 01 00:00:00 EDT 2012
The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies.
The Journal of pathology
Nijholt DA,van Haastert ES,Rozemuller AJ,Scheper W,Hoozemans JJ
MN1050 was used in immunohistochemistry to investigate the unfolded protein response in the hippocampus of tauopathies.
Sun Apr 01 00:00:00 EDT 2012
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang HY,Bakshi K,Frankfurt M,Stucky A,Goberdhan M,Shah SM,Burns LH
MN1050 was used in western blot to study the ability of a small molecule that binds filamin A with high affinity to reduce beta-amyloid-associated Alzheimer's disease pathology
Wed Jul 18 00:00:00 EDT 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1050 was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 EDT 2012
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Joshi YB,Chu J,Praticò D
MN1050 was used in western blot to study the effects of glucocorticoids on memory, tau phosphorylation and beta-amyloid levels in a murine model of Alzheimer's disease
Mon Dec 03 00:00:00 EST 2012
Hippocampal BDNF expression in a tau transgenic mouse model.
Current Alzheimer research
Burnouf S,Belarbi K,Troquier L,Derisbourg M,Demeyer D,Leboucher A,Laurent C,Hamdane M,Buee L,Blum D
MN1050 was used in western blot to study whether tau pathology is associated with BDNF downregulation in a transgenic mouse model
Tue May 01 00:00:00 EDT 2012
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Journal of molecular neuroscience : MN
Löffler T,Flunkert S,Taub N,Schofield EL,Ward MA,Windisch M,Hutter-Paier B
MN1050 was used in western blot to develop a cell line stably expressing mutant tau441 for screening Alzheimer's disease drug candidates
Tue May 01 00:00:00 EDT 2012
Sex-dependent alterations in social behaviour and cortical synaptic activity coincide at different ages in a model of Alzheimer's disease.
PloS one
Bories C,Guitton MJ,Julien C,Tremblay C,Vandal M,Msaid M,De Koninck Y,Calon F
MN1050 was used in western blot to study gender-based differences in the temporal appearance of psychiatric/behavioural symptoms in a murine model of Alzheimer's disease
Tue Mar 05 00:00:00 EST 2013
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Molecular neurodegeneration
Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A
MN1050 was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration
Fri Sep 21 00:00:00 EDT 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1050 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 EDT 2012
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
PloS one
Castello NA,Green KN,LaFerla FM
MN1050 was used in western blot to study the lack of effect of BDNF knockdown on Abeta or tau pathology in a model of Alzheimer's disease
Tue Feb 19 00:00:00 EST 2013
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
PloS one
Schön C,Hoffmann NA,Ochs SM,Burgold S,Filser S,Steinbach S,Seeliger MW,Arzberger T,Goedert M,Kretzschmar HA,Schmidt B,Herms J
MN1050 was used in immunohistochemistry to develop an imaging system for long-term monitoring of retinal fibrillar tau in P301S tau transgenic mice and to study whether retinal tau is diagnostic in Alzheimer's disease
Mon Jun 24 00:00:00 EDT 2013
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Scientific reports
Bretteville A,Marcouiller F,Julien C,El Khoury NB,Petry FR,Poitras I,Mouginot D,Lévesque G,Hébert SS,Planel E
MN1050 was used in western blot to test if hypothermia could be used to assess tau kinase inhibitors efficacy
Sun Mar 17 00:00:00 EDT 2013
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Jin M,Shepardson N,Yang T,Chen G,Walsh D,Selkoe DJ
MN1050 was used in western blot to investigate the effect of Abeta on the regulation of tau modification and neuronal function
Tue Apr 05 00:00:00 EDT 2011
The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.
The Journal of cell biology
Gauthier-Kemper A,Weissmann C,Golovyashkina N,Sebö-Lemke Z,Drewes G,Gerke V,Heinisch JJ,Brandt R
MN1050 was used in western blot to investigate the effect of novel tau mutations on its interaction with membrane
Mon Feb 21 00:00:00 EST 2011
Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Sydow A,Van der Jeugd A,Zheng F,Ahmed T,Balschun D,Petrova O,Drexler D,Zhou L,Rune G,Mandelkow E,D'Hooge R,Alzheimer C,Mandelkow EM
MN1050 was used in immunohistochemistry to investigate the effect of Tau mutations on the behavior and electrophysiology of mice
Wed Feb 16 00:00:00 EST 2011
Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
Journal of neuroscience research
Wu G,Sankaranarayanan S,Hsieh SH,Simon AJ,Savage MJ
MN1050 was used in ELISA to study the sAPPb decrease in Alzheimer disease cortex
Wed Jun 01 00:00:00 EDT 2011
Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Lebbadi M,Julien C,Phivilay A,Tremblay C,Emond V,Kang JX,Calon F
MN1050 was used in western blot to investigate the effectiveness of dietary polyunsaturated fatty acids for the treatment of neuropathology in Alzheimer disease mouse model
Mon Apr 16 00:00:00 EDT 2012
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters
Koike MA,Garcia FG,Kitazawa M,Green KN,Laferla FM
MN1050 was used in western blot to investigate the phosphorylation and aggregation of tau protein in the 3xTg-AD mice
Mon May 09 00:00:00 EDT 2011
Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models.
Proceedings of the National Academy of Sciences of the United States of America
van Eersel J,Ke YD,Liu X,Delerue F,Kril JJ,Götz J,Ittner LM
MN1050 was used in western blot to investigate the effect of sodium selenate on tau pathology
Tue Aug 03 00:00:00 EDT 2010
Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Colodner KJ,Feany MB
MN1050 was used in western blot to investigate the usefulness of a novel Drosophila model to investigate the formation of tau tangle
Wed Dec 01 00:00:00 EST 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1050 was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 EST 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
MN1050 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 EDT 2010
Co-occurrence of Alzheimer's disease ß-amyloid and τ pathologies at synapses.
Neurobiology of aging
Takahashi RH,Capetillo-Zarate E,Lin MT,Milner TA,Gouras GK
MN1050 was used in immunohistochemistry to investigate the relationship between beta amyloid and phosphorylated tau in mouse Alzheimer disease model
Thu Jul 01 00:00:00 EDT 2010
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD
Parachikova A,Vasilevko V,Cribbs DH,LaFerla FM,Green KN
MN1050 was used in western blot to investigate the effect of minocycline on endogenous neuroinflammation and tau modification in Alzheimer disease mouse model
Mon Dec 20 00:00:00 EST 2010
The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Liu D,Pitta M,Lee JH,Ray B,Lahiri DK,Furukawa K,Mughal M,Jiang H,Villarreal J,Cutler RG,Greig NH,Mattson MP
MN1050 was used in immunohistochemistry to study the therapeutic effect of KATP channel activator diazoxide in Alzheimer disease mouse model
Wed Mar 09 00:00:00 EST 2011
Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.
Neuroscience
Lecanu L,Rammouz G,McCourty A,Sidahmed EK,Greeson J,Papadopoulos V
MN1050 was used in immunohistochemistry to study the effect of caprospinol on amyloid deposits and cognitive function in a rodent Alzheimer disease model
Wed Jan 20 00:00:00 EST 2010
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
PLoS genetics
Khurana V,Elson-Schwab I,Fulga TA,Sharp KA,Loewen CA,Mulkearns E,Tyynelä J,Scherzer CR,Feany MB
MN1050 was used in western blot to investigate the role of lysosomal dysfunction in tau cleavage and neurotoxicity in vivo
Thu Jul 15 00:00:00 EDT 2010
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments.
The Journal of biological chemistry
Caccamo A,Majumder S,Richardson A,Strong R,Oddo S
MN1050 was used in Western Blotting to elucidate the molecular mechanisms linking amyloid-beta to cognitive decline.
Fri Apr 23 00:00:00 EDT 2010
AnkyrinG is required to maintain axo-dendritic polarity in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Sobotzik JM,Sie JM,Politi C,Del Turco D,Bennett V,Deller T,Schultz C
MN1050 was used in immunohistochemistry to study the role of ankyrinG in the maintenance of axo-dendritic polarity
Tue Oct 13 00:00:00 EDT 2009
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Ohmi K,Kudo LC,Ryazantsev S,Zhao HZ,Karsten SL,Neufeld EF
MN1050 was used in immunohistochemistry to investigate the dysregulation of gene expression and tau phosphorylation in MPS III B mice
Tue May 19 00:00:00 EDT 2009
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Human molecular genetics
Chatterjee S,Sang TK,Lawless GM,Jackson GR
MN1050 was used in western blot to study the roles of GSK3 beta, MARK and Cdk5 in the relationship between tau toxicity and phosphorylation
Thu Jan 01 00:00:00 EST 2009
Anesthesia induces phosphorylation of tau.
Journal of Alzheimer's disease : JAD
Run X,Liang Z,Zhang L,Iqbal K,Grundke-Iqbal I,Gong CX
MN1050 was used in western blot to study the effect of anesthesia on tau phosphorylation
Mon May 18 00:00:00 EDT 2009
Development of a non invasive NGF-based therapy for Alzheimer's disease.
Current Alzheimer research
Covaceuszach S,Capsoni S,Ugolini G,Spirito F,Vignone D,Cattaneo A
MN1050 was used in immunohistochemistry to develop a non-invasive NGF-based therapy for Alzheimer's disease
Wed Apr 01 00:00:00 EDT 2009
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
PloS one
Rahman A,Ting K,Cullen KM,Braidy N,Brew BJ,Guillemin GJ
MN1050 was used in immunohistochemistry to study the effect of quinolinic acid on tau phosphorylation in neurons
Wed Jul 22 00:00:00 EDT 2009
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics
Matsuoka Y,Jouroukhin Y,Gray AJ,Ma L,Hirata-Fukae C,Li HF,Feng L,Lecanu L,Walker BR,Planel E,Arancio O,Gozes I,Aisen PS
MN1050 was used in western blot to investigate the effect of a neuronal microtubule-interacting agent NAPVSIPQ on tau pathology and cognitive function in an Alzheimer disease mouse model
Tue Apr 01 00:00:00 EDT 2008
Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice.
BMC neuroscience
Mastrangelo MA,Bowers WJ
MN1050 was used in immunohistochemistry to study the temporal and spatial progression of AD-like pathology in male 3xTg-AD mice
Tue Aug 12 00:00:00 EDT 2008
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
The Journal of clinical investigation
Dias-Santagata D,Fulga TA,Duttaroy A,Feany MB
MN1050 was used in western blot to study the role of oxidative stress in tau-induced neurodegeneration in Drosophila
Mon Jan 01 00:00:00 EST 2007
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Proceedings of the National Academy of Sciences of the United States of America
Luo W,Dou F,Rodina A,Chip S,Kim J,Zhao Q,Moulick K,Aguirre J,Wu N,Greengard P,Chiosis G
MN1050 was used in western blot to study the contribution of heat-shock protein 90 towards tauopathies
Tue May 29 00:00:00 EDT 2007
Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation.
British journal of pharmacology
Selenica ML,Jensen HS,Larsen AK,Pedersen ML,Helboe L,Leist M,Lotharius J
MN1050 was used in western blot to evaluate five glycogen synthase kinase-3beta inhibitors and lithium in lowering phosphorylated tau and glycogen synthase kinase-3beta enzyme activity levels in 12-day old postnatal rats
Thu Nov 01 00:00:00 EDT 2007
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM
MN1050 was used in western blot to study the effect of docosahexaenoic acid and docosapentaenoic acid on amyloid beta and tau pathology
Wed Apr 18 00:00:00 EDT 2007
Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shahani N,Subramaniam S,Wolf T,Tackenberg C,Brandt R
MN1050 was used in western blot to clarify the role of tau alterations and the sequence of tau-dependent neurodegeneration in Alzheimer's disease
Wed May 31 00:00:00 EDT 2006
The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.
The Journal of biological chemistry
Mi K,Dolan PJ,Johnson GV
MN1050 was used in western blot to investigate the role of LRP6 in the regulation of GSK3 activity
Fri Feb 24 00:00:00 EST 2006
FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation.
The Journal of biological chemistry
Stoothoff WH,Cho JH,McDonald RP,Johnson GV
MN1050 was used in western blot to investigate the role of FRAT protein for the regulation of GSK3 beta-induced tau phosphorylation
Fri Jan 07 00:00:00 EST 2005
Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner.
The Journal of biological chemistry
Stolovich M,Lerer T,Bolkier Y,Cohen H,Meyuhas O
MN1050 was used in western blot to investigate the effect of lithium for the regulation of TOP translation
Fri Feb 18 00:00:00 EST 2005
Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ.
The Journal of biological chemistry
Cho JH,Johnson GV
MN1050 was used in western blot to investigate the effect of glycogen synthase kinase 3 beta on tau aggregation
Fri Dec 24 00:00:00 EST 2004
Mutant (R406W) human tau is hyperphosphorylated and does not efficiently bind microtubules in a neuronal cortical cell model.
The Journal of biological chemistry
Krishnamurthy PK,Johnson GV
MN1050 was used in western blot to study the phosphorylation of mutant (R406W) human tau and its effect on microtubule binding
Fri Feb 27 00:00:00 EST 2004
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.
Journal of neurochemistry
Sahara N,Lewis J,DeTure M,McGowan E,Dickson DW,Hutton M,Yen SH
MN1050 was used in western blot to study the mechanism for tau protein assembly
Sun Dec 01 00:00:00 EST 2002
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Biochemistry
Yoshida H,Goedert M
MN1050 was used in western blot to investigate the function of chicken brain tau
Tue Dec 24 00:00:00 EST 2002
