Product References
Direct and Indirect Effects of Filamin A on Tau Pathology in Neuronal Cells.
Molecular neurobiology
Levert S,Pilliod J,Aumont É,Armanville S,Tremblay C,Calon F,Leclerc N
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to indicate that in Tauopathies, FLNA could contribute to Tau pathology by acting on Tau and annexin A2.
Wed Feb 01 00:00:00 EST 2023
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1040 was used in Immunohistochemistry and Western Blotting to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 EDT 2023
Neuronal loss of NCLX-dependent mitochondrial calcium efflux mediates age-associated cognitive decline.
iScience
Jadiya P,Cohen HM,Kolmetzky DW,Kadam AA,Tomar D,Elrod JW
MN1040 was used in Immunohistochemistry and Western Blotting to demonstrate that loss of NCLX-dependent mCa2+ efflux alone is sufficient to induce an Alzheimer's disease-like pathology and highlights the promise of therapies targeting mCa2+ exchange.
Fri Mar 17 00:00:00 EDT 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1040 was used in Western Blotting to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
Quercetagitrin Inhibits Tau Accumulation and Reverses Neuroinflammation and Cognitive Deficits in P301S-Tau Transgenic Mice.
Molecules (Basel, Switzerland)
Zhong S,Ye J,Deng Y,Zhang M,Zou M,Yao X,Xiao S
MN1040 was used in Western Blotting to elucidate that quercetagitrin, a natural compound derived from African marigold (Tagetes erecta), could inhibit tau aggregation and reduce tau phosphorylation at multiple disease-related sites in vitro.
Mon May 08 00:00:00 EDT 2023
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Nature communications
Hussong SA,Banh AQ,Van Skike CE,Dorigatti AO,Hernandez SF,Hart MJ,Ferran B,Makhlouf H,Gaczynska M,Osmulski PA,McAllen SA,Dineley KT,Ungvari Z,Perez VI,Kayed R,Galvan V
MN1040 was used in Simple Western - Size to suggest that soluble pathogenic tau aggregates mediate AD-like brain microvascular deficits in a mouse model of tauopathy, which may arise from endothelial cell senescence and eNOS dysfunction triggered by internalization of soluble tau aggregates.
Tue Apr 25 00:00:00 EDT 2023
Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation.
Scientific reports
Williams D,Yan BQ,Wang H,Negm L,Sackmann C,Verkuyl C,Rezai-Stevens V,Eid S,Vediya N,Sato C,Watts JC,Wille H,Schmitt-Ulms G
MN1040 was used in Western Blotting to find that Sst had no influence on whole brain neprilysin transcript, protein or activity levels, an observation that cannot be accounted for by a compensatory upregulation of the Sst paralog, cortistatin (Cort), that we observed in 15-month-old Sst-deficient mice.
Thu Feb 09 00:00:00 EST 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1040 was used in Western Blotting and Immunohistochemistry to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.
Acta neuropathologica communications
Williams T,Bathe T,Vo Q,Sacilotto P,McFarland K,Ruiz AJ,Hery GP,Sullivan P,Borchelt DR,Prokop S,Chakrabarty P
MN1040 was used in Western Blotting and Immunohistochemistry to indicate that APOE3 genotype may confer some resilience to tauopathy, while APOE4 and APOE2 may act through multiple pathways to increase the pathogenicity in the context of tauopathy.
Mon Jun 19 00:00:00 EDT 2023
Machine learning prediction and tau-based screening identifies potential Alzheimer's disease genes relevant to immunity.
Communications biology
Binder J,Ursu O,Bologa C,Jiang S,Maphis N,Dadras S,Chisholm D,Weick J,Myers O,Kumar P,Yang JJ,Bhaskar K,Oprea TI
MN1040 was used in Western Blot to develop an electronic model to predict Alzheimer's immunity genes.
Fri Feb 11 00:00:00 EST 2022
Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology.
Brain pathology (Zurich, Switzerland)
Niu L,Zhang F,Xu X,Yang Y,Li S,Liu H,Le W
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to provide new insights into the potential link between the disruption of circadian rhythm and the development of AD.
Sun May 01 00:00:00 EDT 2022
Differential expression of tau species and the association with cognitive decline and synaptic loss in Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Saroja SR,Sharma A,Hof PR,Pereira AC
MN1040 was used in Western Blotting to propose that tau species from NFT-predominant tissues possess greater levels of degenerative properties, thereby causing synaptic loss and cognitive decline.
Thu Sep 01 00:00:00 EDT 2022
P38 initiates degeneration of midbrain GABAergic and glutamatergic neurons in diabetes models.
The European journal of neuroscience
Farhadi A,Totonchi M,Nabavi SM,Baharvand H,Pakdaman H,Hajizadeh-Saffar E,Mousavi SA,Hadi F,Al-Sinawi H,Li Q,Zhang JS,Tahamtani Y,Shahpasand K
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to elucidate accumulation of cis P-tau in midbrain and corpus callosum, and establish P38 as a central mediator of diabetes mellitus-induced tau pathology.
Fri Jul 01 00:00:00 EDT 2022
Decrease of neuronal FKBP4/FKBP52 modulates perinuclear lysosomal positioning and MAPT/Tau behavior during MAPT/Tau-induced proteotoxic stress.
Autophagy
Chambraud B,Daguinot C,Guillemeau K,Genet M,Dounane O,Meduri G,Poüs C,Baulieu EE,Giustiniani J
MN1040 was used in Immunocytochemistry-immunoflourescence to demonstrate that FKBP4 decrease in a human neuronal cell line (SH-SY5Y) and in dorsal root ganglion (DRG) neurons from human MAPTP301S transgenic mice affected the function of the autophagy-lysosomal system under MAPT induced proteotoxic stress conditions.
Mon Nov 01 00:00:00 EDT 2021
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation.
Brain pathology (Zurich, Switzerland)
Reimer L,Betzer C,Kofoed RH,Volbracht C,Fog K,Kurhade C,Nilsson E,Överby AK,Jensen PH
MN1040 was used in Western Blot to indicate that PKR, independent of other kinases and upon acute brain inflammation, is capable of triggering pathological modulation of tau, which, in turn, might form the initial pathologic seed in several tauopathies such as Alzheimer's disease and Chronic traumatic encephalopathy where inflammation is severe.
Fri Jan 01 00:00:00 EST 2021
Late-in-life neurodegeneration after chronic sleep loss in young adult mice.
Sleep
Owen JE,Zhu Y,Fenik P,Zhan G,Bell P,Liu C,Veasey S
MN1040 was used in Immunohistochemistry to demonstrate for the first time that CSS can induce lasting, significant neural injury consistent with some, but not all, features of late onset AD.
Fri Aug 13 00:00:00 EDT 2021
Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice.
Journal of Alzheimer's disease : JAD
Stojakovic A,Chang SY,Nesbitt J,Pichurin NP,Ostroot MA,Aikawa T,Kanekiyo T,Trushina E
MN1040 was used in Western Blotting to investigate the effect of specific MCI inhibitor tricyclic pyrone compound CP2 on levels of human pTau, memory function, long term potentiation (LTP), and energy homeostasis in 18-month-old 3xTg-AD mice and explore the potential mechanisms.
Mon Sep 27 00:00:00 EDT 2021
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
Acta neuropathologica communications
McMillan PJ,Strovas TJ,Baum M,Mitchell BK,Eck RJ,Hendricks N,Wheeler JM,Latimer CS,Keene CD,Kraemer BC
MN1040 was used in Immunohistochemistry (Paraffin) to to identify Alzheimer's disease-specific cellular changes related to nuclear speckles.
Tue Jun 29 00:00:00 EDT 2021
Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease.
Acta neuropathologica communications
McMillan PJ,Strovas TJ,Baum M,Mitchell BK,Eck RJ,Hendricks N,Wheeler JM,Latimer CS,Keene CD,Kraemer BC
MN1040 was used in Immunohistochemistry (Paraffin) to to identify Alzheimer's disease-specific cellular changes related to nuclear speckles.
Tue Jun 29 00:00:00 EDT 2021
Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.
The Journal of biological chemistry
Nies SH,Takahashi H,Herber CS,Huttner A,Chase A,Strittmatter SM
MN1040 was used in Western Blot to assesses the impact of Aβ copathology, of deleting loci known to modify Alzheimer's disease risk (Ptk2b, Grn, and Tmem106b) and of pharmacological intervention with an Fyn kinase inhibitor on tau spreading after injection of AD tau extracts.
Fri Oct 01 00:00:00 EDT 2021
Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging
Evans AK,Park HH,Saw NL,Singhal K,Ogawa G,Leib RD,Shamloo M
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to examine effects of age and acute beta-blocker administration on LC and hippocampus pathology, neuroinflammation and learning and memory behavior in mice.
Fri Oct 01 00:00:00 EDT 2021
Early alterations of neurovascular unit in the retina in mouse models of tauopathy.
Acta neuropathologica communications
Xia F,Ha Y,Shi S,Li Y,Li S,Luisi J,Kayed R,Motamedi M,Liu H,Zhang W
MN1040 was used in Immunohistochemistry (Frozen) to study molecular mechanisms of neurodegeneration.
Wed Mar 24 00:00:00 EDT 2021
Electronegative very-low-density lipoprotein induces brain inflammation and cognitive dysfunction in mice.
Scientific reports
Lin YS,Liu CK,Lee HC,Chou MC,Ke LY,Chen CH,Chen SL
MN1040 was used in Immunohistochemistry to suggest that electronegative-VLDL levels may represent a new therapeutic target for cognitive dysfunction.
Tue Mar 16 00:00:00 EDT 2021
Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literature.
Acta neuropathologica communications
Kahriman A,Bouley J,Smith TW,Bosco DA,Woerman AL,Henninger N
MN1040 was used in Immunohistochemistry to compare the mouse closed-head traumatic brain injury model with human traumatic brain injury-associated tauopathy.
Tue Jun 29 00:00:00 EDT 2021
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases.
Communications biology
Ye T,Duan Y,Tsang HWS,Xu H,Chen Y,Cao H,Chen Y,Fu AKY,Ip NY
MN1040 was used in Western Blot to demonstrate a simple and precise method to simultaneously generate iPSC lines with different gene dosages using paired Cas9 nickases.
Fri Feb 12 00:00:00 EST 2021
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein.
International journal of molecular sciences
Lin G,Zhu F,Kanaan NM,Asano R,Shirafuji N,Sasaki H,Yamaguchi T,Enomoto S,Endo Y,Ueno A,Ikawa M,Hayashi K,Yamamura O,Yen SH,Nakamoto Y,Hamano T
MN1040 was used in Western Blot to examine the effects of Clioquinol on tau metabolism in M1C cell, a human neuroblastoma cell line.
Mon Nov 08 00:00:00 EST 2021
Long-term depression links amyloid-β to the pathological hyperphosphorylation of tau.
Cell reports
Taylor HBC,Emptage NJ,Jeans AF
MN1040 was used in Western Blotting to study that an Aβo-mediated increase in glutamate release probability causes enhancement of synaptically evoked NMDAR dependent long-term depression.
Tue Aug 31 00:00:00 EDT 2021
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway.
Cell reports
Jiang S,Maphis NM,Binder J,Chisholm D,Weston L,Duran W,Peterson C,Zimmerman A,Mandell MA,Jett SD,Bigio E,Geula C,Mellios N,Weick JP,Rosenberg GA,Latz E,Heneka MT,Bhaskar K
MN1040 was used in Immunohistochemistry to investigate if pTau primes and activates interleukin-1β.
Tue Sep 21 00:00:00 EDT 2021
NK1 antagonists attenuate tau phosphorylation after blast and repeated concussive injury.
Scientific reports
Corrigan F,Cernak I,McAteer K,Hellewell SC,Rosenfeld JV,Turner RJ,Vink R
MN1040 was used in Immunohistochemistry to investigate the mechanisms linking concussive and blast TBI with tau hyperphosphorylation.
Fri Apr 23 00:00:00 EDT 2021
Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein.
Acta neuropathologica communications
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Marcilla I,Marti-Andres G,Caballero MC,Riverol M,Tuñon MT,Fraser PE,Luquin MR
MN1040 was used in Immunohistochemistry to show that the involvement of amylin, pancreatic α-synuclein, Aβ, PrP and tau in the complex pathophysiology of type two diabetes and in the appearance of insulin resistance in Alzheimer's and Parkinson's disease.
Thu Apr 08 00:00:00 EDT 2021
UBE4B, a microRNA-9 target gene, promotes autophagy-mediated Tau degradation.
Nature communications
Subramanian M,Hyeon SJ,Das T,Suh YS,Kim YK,Lee JS,Song EJ,Ryu H,Yu K
MN1040 was used in Western Blot to demonstrate that UBE4B, a miR-9 target gene, promotes autophagy-mediated Tau degradation together with STUB1, and is thus an innovative therapeutic approach for AD.
Wed Jun 02 00:00:00 EDT 2021
Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration.
The Journal of clinical investigation
Gratuze M,Leyns CE,Sauerbeck AD,St-Pierre MK,Xiong M,Kim N,Serrano JR,Tremblay MÈ,Kummer TT,Colonna M,Ulrich JD,Holtzman DM
MN1040 was used in Immunohistochemistry to suggest that impaired TREM2 signaling reduces microglia-mediated neurodegeneration in the setting of tauopathy.
Tue Sep 01 00:00:00 EDT 2020
SARS-CoV-2 targets neurons of 3D human brain organoids.
The EMBO journal
Ramani A,Müller L,Ostermann PN,Gabriel E,Abida-Islam P,Müller-Schiffmann A,Mariappan A,Goureau O,Gruell H,Walker A,Andrée M,Hauka S,Houwaart T,Dilthey A,Wohlgemuth K,Omran H,Klein F,Wieczorek D,Adams O,Timm J,Korth C,Schaal H,Gopalakrishnan J
MN1040 was used in Immunocytochemistry-immunoflourescence to show, with 3D human brain organoids, a Düsseldorf isolate of SARS-CoV-2 enters the brain within 2 days.
Thu Oct 15 00:00:00 EDT 2020
Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Fan Q,He W,Gayen M,Benoit MR,Luo X,Hu X,Yan R
MN1040 was used in Western Blot to explore the potential of CX3CL1 as a target for Alzheimer's disease or related neurodegenerative disease.
Wed Jan 29 00:00:00 EST 2020
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Neurobiology of aging
Hamano T,Shirafuji N,Yen SH,Yoshida H,Kanaan NM,Hayashi K,Ikawa M,Yamamura O,Fujita Y,Kuriyama M,Nakamoto Y
MN1040 was used in Western Blot to examine the effects of ROCK inhibitors (H1152, Y-27632, and fasudil [HA-1077]) on tau protein phosphorylation in detail.
Fri May 01 00:00:00 EDT 2020
Rho-kinase ROCK inhibitors reduce oligomeric tau protein.
Neurobiology of aging
Hamano T,Shirafuji N,Yen SH,Yoshida H,Kanaan NM,Hayashi K,Ikawa M,Yamamura O,Fujita Y,Kuriyama M,Nakamoto Y
MN1040 was used in Western Blot to examine the effects of ROCK inhibitors (H1152, Y-27632, and fasudil [HA-1077]) on tau protein phosphorylation in detail.
Fri May 01 00:00:00 EDT 2020
Fyn Kinase Controls Tau Aggregation In Vivo.
Cell reports
Briner A,Götz J,Polanco JC
MN1040 was used in Immunohistochemistry to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.
Tue Aug 18 00:00:00 EDT 2020
Fyn Kinase Controls Tau Aggregation In Vivo.
Cell reports
Briner A,Götz J,Polanco JC
MN1040 was used in Immunohistochemistry to identify Fyn as a key regulator of tau pathology independently of Aβ-induced toxicity.
Tue Aug 18 00:00:00 EDT 2020
Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression.
International journal of molecular sciences
Nam E,Lee YB,Moon C,Chang KA
MN1040 was used in Western Blotting to suggest that serum tau proteins, especially NEX tau proteins, are useful biomarkers for monitoring AD progression.
Wed Jul 15 00:00:00 EDT 2020
Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.
Science advances
Wang Y,Liu Y,Nham A,Sherbaf A,Quach D,Yahya E,Ranburger D,Bi X,Baudry M
MN1040 was used in Western Blotting to investigate the contribution of clapian-1 and calpain-2 on neurodegenration following a concussion using a mouse model of repeated concussions.
Wed Jul 01 00:00:00 EDT 2020
Yeast surface display of full-length human microtubule-associated protein tau.
Biotechnology progress
Wang S,Cho YK
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Flow Cytometry to show that yeast-displayed tau enables robust measurement of protein interactions and is of particular interest for characterizing conformational change.
Wed Jan 01 00:00:00 EST 2020
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer's disease, progressive supranuclear palsy and dementia with Lewy bodies.
Cell death & disease
Puangmalai N,Bhatt N,Montalbano M,Sengupta U,Gaikwad S,Ventura F,McAllen S,Ellsworth A,Garcia S,Kayed R
MN1040 was used in Western Blotting to demonstrate that the HSPG-mediated pathway regulates internalization of BDTOs from AD and DLB, while HSPG-mediated and other alternative pathways are involved in the internalization of PSP-derived tau oligomers.
Mon May 04 00:00:00 EDT 2020
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay.
Scientific reports
Lee KS,Choi M,Kwon DW,Kim D,Choi JM,Kim AK,Ham Y,Han SB,Cho S,Cheon CK
MN1040 was used in Western Blotting to suggest that the novel heterozygous mutation of DYRK1A resulted in loss-of-function of the kinase activity of DYRK1A and may contribute to the developmental delay observed in the patient.
Wed Jun 17 00:00:00 EDT 2020
A novel structure associated with aging is augmented in the DPP6-KO mouse brain.
Acta neuropathologica communications
Lin L,Petralia RS,Lake R,Wang YX,Hoffman DA
MN1040 was used in Immunohistochemistry-immunofluorescence to indicate that aging DPP6-KO mice have increased numbers of novel, abnormal presynaptic structures associated with several markers of Alzheimer's disease.
Mon Nov 23 00:00:00 EST 2020
Truncation of Tau selectively facilitates its pathological activities.
The Journal of biological chemistry
Gu J,Xu W,Jin N,Li L,Zhou Y,Chu D,Gong CX,Iqbal K,Liu F
MN1040 was used in Western Blotting to suggest that the first 150 aa and the last 50 aa protect Tau from pathological characteristics and that their deletions facilitate pathological activities.
Fri Oct 02 00:00:00 EDT 2020
Clearance of intracellular tau protein from neuronal cells via VAMP8-induced secretion.
The Journal of biological chemistry
Pilliod J,Desjardins A,Pernègre C,Jamann H,Larochelle C,Fon EA,Leclerc N
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot, Dot Blot to indicate that VAMP8 could be used to increase tau and α-synuclein clearance to prevent their intracellular accumulation.
Fri Dec 18 00:00:00 EST 2020
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia.
Nature medicine
Swarup V,Hinz FI,Rexach JE,Noguchi KI,Toyoshiba H,Oda A,Hirai K,Sarkar A,Seyfried NT,Cheng C,Haggarty SJ,Grossman M,Van Deerlin VM,Trojanowski JQ,Lah JJ,Levey AI,Kondou S,Geschwind DH
MN1040 was used in Immunohistochemistry to identify small molecules that can normalize the disease-associated modules.
Tue Jan 01 00:00:00 EST 2019
Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain.
Science translational medicine
Wheeler JM,McMillan P,Strovas TJ,Liachko NF,Amlie-Wolf A,Kow RL,Klein RL,Szot P,Robinson L,Guthrie C,Saxton A,Kanaan NM,Raskind M,Peskind E,Trojanowski JQ,Lee VMY,Wang LS,Keene CD,Bird T,Schellenberg GD,Kraemer B
MN1040 was used in Immunohistochemistry (Paraffin) to study susceptibility to tau toxicity in mouse models and the influence of mammalian suppressor of tauopathy 2 (MSUT2).
Wed Dec 18 00:00:00 EST 2019
BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation.
Acta neuropathologica
Sartori M,Mendes T,Desai S,Lasorsa A,Herledan A,Malmanche N,Mäkinen P,Marttinen M,Malki I,Chapuis J,Flaig A,Vreulx AC,Ciancia M,Amouyel P,Leroux F,Déprez B,Cantrelle FX,Maréchal D,Pradier L,Hiltunen M,Landrieu I,Kilinc D,Herault Y,Laporte J,Lambert JC
MN1040 was used in Western Blotting to support the idea that BIN1 modulates the AD risk through an intricate regulation of its interaction with Tau. Alteration in BIN1 expression or activity may disrupt this regulatory balance with Tau and have direct effects on learning and memory.
Tue Oct 01 00:00:00 EDT 2019
CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.
Brain : a journal of neurology
Mancuso R,Fryatt G,Cleal M,Obst J,Pipi E,Monzón-Sandoval J,Ribe E,Winchester L,Webber C,Nevado A,Jacobs T,Austin N,Theunis C,Grauwen K,Daniela Ruiz E,Mudher A,Vicente-Rodriguez M,Parker CA,Simmons C,Cash D,Richardson J,Jones DNC,Lovestone S,Gómez-Nicola D,Perry VH
MN1040 was used in Western Blot to tested the efficacy of the selective CSF1R inhibitor JNJ-40346527 in the P301S mouse tauopathy model.
Tue Oct 01 00:00:00 EDT 2019
Amylin as a potential link between type 2 diabetes and alzheimer disease.
Annals of neurology
Martinez-Valbuena I,Valenti-Azcarate R,Amat-Villegas I,Riverol M,Marcilla I,de Andrea CE,Sánchez-Arias JA,Del Mar Carmona-Abellan M,Marti G,Erro ME,Martínez-Vila E,Tuñon MT,Luquin MR
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to assess ed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with Alzheimer's disease, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of Alzheimer's disease patients.
Tue Oct 01 00:00:00 EDT 2019
Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
PloS one
Joseph DJ,Liu C,Peng J,Liang G,Wei H
MN1040 was used in Immunohistochemistry to show that repeated exposures of neonatal and old triple transgenic AD (3xTg) and non-transgenic (NonTg) mice to isoflurane (Iso) distinctly increased neurodegeneration as measured by S100β levels, intracellular Aβ, Tau oligomerization, and apoptotic markers.
Thu Mar 12 00:00:00 EDT 2020
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes.
Autophagy
Ji C,Tang M,Zeidler C,Höhfeld J,Johnson GV
MN1040 was used in Immunocytochemistry to demonstrate for the first time that BAG3 plays an important role in autophagic flux in the neurites of mature neurons (20-24 days in vitro [DIV]) through interaction with the post-synaptic cytoskeleton protein SYNPO (synaptopodin).
Mon Jul 01 00:00:00 EDT 2019
Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology.
Acta neuropathologica communications
Mendsaikhan A,Tooyama I,Bellier JP,Serrano GE,Sue LI,Lue LF,Beach TG,Walker DG
MN1040 was used in Immunohistochemistry-immunofluorescence to show the role and interactions of lysosomal proteins Progranulin and Prosaposin in the brains of aged patients and those with Alzheimer's.
Sat Dec 21 00:00:00 EST 2019
Activity-Dependent Reconnection of Adult-Born Dentate Granule Cells in a Mouse Model of Frontotemporal Dementia.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Terreros-Roncal J,Flor-García M,Moreno-Jiménez EP,Pallas-Bazarra N,Rábano A,Sah N,van Praag H,Giacomini D,Schinder AF,Ávila J,Llorens-Martín M
MN1040 was used in Immunohistochemistry to study the therapeutic potential of applying chemoactivation to adult-born dentate granule cells in a mouse model of a neurodegenerative disease.
Wed Jul 17 00:00:00 EDT 2019
A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation.
The Journal of biological chemistry
Ajit D,Trzeciakiewicz H,Tseng JH,Wander CM,Chen Y,Ajit A,King DP,Cohen TJ
MN1040 was used in Western Blotting to indicate that a complex tau PTM code likely regulates tau pathogenesis, highlighting the potential utility of manipulating and detoxifying tau strains through site-specific tau-targeting approaches.
Fri Nov 08 00:00:00 EST 2019
REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease.
Cell reports
Meyer K,Feldman HM,Lu T,Drake D,Lim ET,Ling KH,Bishop NA,Pan Y,Seo J,Lin YT,Su SC,Church GM,Tsai LH,Yankner BA
MN1040 was used in Western Blotting to propose that dysregulation of neural gene networks may set in motion the pathologic cascade that leads to AD.
Tue Jan 29 00:00:00 EST 2019
Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy.
NPJ vaccines
Maphis NM,Peabody J,Crossey E,Jiang S,Jamaleddin Ahmad FA,Alvarez M,Mansoor SK,Yaney A,Yang Y,Sillerud LO,Wilson CM,Selwyn R,Brigman JL,Cannon JL,Peabody DS,Chackerian B,Bhaskar K
MN1040 was used in Western Blotting to provide a valid scientific premise for the development of VLP-based immunotherapy to target pTau and potentially prevent Alzheimer's diseases and related tauopathies.
Wed Feb 03 00:00:00 EST 2021
Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.
Nature communications
Jadiya P,Kolmetzky DW,Tomar D,Di Meco A,Lombardi AA,Lambert JP,Luongo TS,Ludtmann MH,Praticò D,Elrod JW
MN1040 was used in Western Blotting to provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of Alzheimer's disease (AD) and suggest mCa2+ exchange as potential therapeutic target in AD.
Thu Aug 29 00:00:00 EDT 2019
Resistance and resilience to Alzheimer's disease pathology are associated with reduced cortical pTau and absence of limbic-predominant age-related TDP-43 encephalopathy in a community-based cohort.
Acta neuropathologica communications
Latimer CS,Burke BT,Liachko NF,Currey HN,Kilgore MD,Gibbons LE,Henriksen J,Darvas M,Domoto-Reilly K,Jayadev S,Grabowski TJ,Crane PK,Larson EB,Kraemer BC,Bird TD,Keene CD
MN1040 was used in Western Blot to develop stringent pathologic cutoffs for non-demented subjects to eliminate cases of borderline pathology for Alzheimer's disease.
Fri Jun 07 00:00:00 EDT 2019
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline.
Nature
Bussian TJ,Aziz A,Meyer CF,Swenson BL,van Deursen JM,Baker DJ
MN1040 was used in Immunohistochemistry-immunofluorescence to study the role of senescent cells in the aetiology of tau-dependent pathologies.
Mon Oct 01 00:00:00 EDT 2018
The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology.
Alzheimer's & dementia : the journal of the Alzheimer's Association
Paspalas CD,Carlyle BC,Leslie S,Preuss TM,Crimins JL,Huttner AJ,van Dyck CH,Rosene DL,Nairn AC,Arnsten AFT
MN1040 was used in Immunocytochemistry to study the progression of tau and amyloid cortical pathology in the ageing rhesus macaque.
Tue May 01 00:00:00 EDT 2018
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
EMBO molecular medicine
Kidana K,Tatebe T,Ito K,Hara N,Kakita A,Saito T,Takatori S,Ouchi Y,Ikeuchi T,Makino M,Saido TC,Akishita M,Iwatsubo T,Hori Y,Tomita T
MN1040 was used in Western Blotting to suggest that KLK7 aids in the degradation and clearance of deposited AΒ by astrocytes involved in the pathogenesis of AD.
Thu Mar 01 00:00:00 EST 2018
NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Proceedings of the National Academy of Sciences of the United States of America
Hou Y,Lautrup S,Cordonnier S,Wang Y,Croteau DL,Zavala E,Zhang Y,Moritoh K,O'Connell JF,Baptiste BA,Stevnsner TV,Mattson MP,Bohr VA
MN1040 was used in Immunohistochemistry-immunofluorescence to examine the role of compromised cellular bioenergetics and DNA repair in the pathogenesis of Alzheimer's disease.
Tue Feb 20 00:00:00 EST 2018
A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Bardai FH,Wang L,Mutreja Y,Yenjerla M,Gamblin TC,Feany MB
MN1040 was used in Western Blotting to determine the mechanism by whichFTDP-17 mutations promote disease in vivo.
Wed Jan 03 00:00:00 EST 2018
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S
MN1040 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.
Wed Nov 28 00:00:00 EST 2018
Chronic Sleep Disruption Advances the Temporal Progression of Tauopathy in P301S Mutant Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhu Y,Zhan G,Fenik P,Brandes M,Bell P,Francois N,Shulman K,Veasey S
MN1040 was used in Immunohistochemistry to study whether chronic short sleep influences locus ceruleus neurons tau and the biochemical, neuroanatomical, and/or behavioural progression of tauopathy in male and female P301S mice.
Wed Nov 28 00:00:00 EST 2018
Acute Down-regulation of BDNF Signaling Does Not Replicate Exacerbated Amyloid-β Levels and Cognitive Impairment Induced by Cholinergic Basal Forebrain Lesion.
Frontiers in molecular neuroscience
Turnbull MT,Boskovic Z,Coulson EJ
MN1040 was used in Western Blotting to suggest that the cognitive decline and AΒ pathology induced by BFCN loss occur independent of dysfunctional neuronal BDNF signaling, and may therefore be directly underpinned by reduced cholinergic neurotransmission.
Thu Oct 01 00:00:00 EDT 2020
Nrf2 mediates the expression of BAG3 and autophagy cargo adaptor proteins and tau clearance in an age-dependent manner.
Neurobiology of aging
Tang M,Ji C,Pallo S,Rahman I,Johnson GVW
MN1040 was used in Immunohistochemistry to indicate that Nrf2 regulation of autophagy-related genes likely plays a greater role in mediating the clearance of tau as an organism ages.
Thu Mar 01 00:00:00 EST 2018
Brain regional synchronous activity predicts tauopathy in 3×TgAD mice.
Neurobiology of aging
Liu D,Lu H,Stein E,Zhou Z,Yang Y,Mattson MP
MN1040 was used in Immunohistochemistry-immunofluorescence to demonstrate that age-related brain regional hypersynchronous activity is associated with early tau pathology in a mouse model.
Mon Oct 01 00:00:00 EDT 2018
Dihydrolipoamide dehydrogenase suppression induces human tau phosphorylation by increasing whole body glucose levels in a C. elegans model of Alzheimer's Disease.
Experimental brain research
Ahmad W
MN1040 was used in Western Blot to conclude that any abnormalities in energy metabolism were found to significantly affect the AD disease pathology.
Thu Nov 01 00:00:00 EDT 2018
The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome.
Neuropathology and applied neurobiology
Milenkovic I,Jarc J,Dassler E,Aronica E,Iyer A,Adle-Biassette H,Scharrer A,Reischer T,Hainfellner JA,Kovacs GG
MN1040 was used in ELISA, Immunohistochemistry (Paraffin), Western Blot to suggest functional tau disturbance in DS brains during development, rather than axonal loss.
Sun Apr 01 00:00:00 EDT 2018
Phosphorylation of different tau sites during progression of Alzheimer's disease.
Acta neuropathologica communications
Neddens J,Temmel M,Flunkert S,Kerschbaumer B,Hoeller C,Loeffler T,Niederkofler V,Daum G,Attems J,Hutter-Paier B
MN1040 was used in Immunohistochemistry to investigate total tau and phosphorylated tau as well as amyloid-Β plaques in human brain tissue of Alzheimer's disease patients and controls.
Fri Jun 29 00:00:00 EDT 2018
Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model.
Journal of neuroinflammation
Huang C,Irwin MG,Wong GTC,Chang RCC
MN1040 was used in Western Blotting to characterise the neuroinflammation and cellular changes induced by systemic inflammation, and their responses to anti-inflammatory treatment.
Thu May 17 00:00:00 EDT 2018
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease.
Neuron
Fu H,Rodriguez GA,Herman M,Emrani S,Nahmani E,Barrett G,Figueroa HY,Goldberg E,Hussaini SA,Duff KE
MN1040 was used in immunohistochemistry - free floating to report the formation of mature tangles in Alzheimer's diseases is associated with excitatory cell loss and deficits in grid cell function
Wed Feb 08 00:00:00 EST 2017
Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.
Acta neuropathologica
Takahashi H,Klein ZA,Bhagat SM,Kaufman AC,Kostylev MA,Ikezu T,Strittmatter SM
MN1040 was used in immunohistochemistry to see that the granulin Alzheimer's disease risk variant has no significant effects on florbetapir positron emission tomographic amyloid imaging and cerebrospinal fluid Abeta levels
Mon May 01 00:00:00 EDT 2017
Presence of tau pathology within foetal neural allografts in patients with Huntington's and Parkinson's disease.
Brain : a journal of neurology
Cisbani G,Maxan A,Kordower JH,Planel E,Freeman TB,Cicchetti F
MN1040 was used in Immunohistochemistry to study whether tau pathology can be seen in patients with Huntington's and Parkinson's disease who had received foetal neural allografts.
Wed Nov 01 00:00:00 EDT 2017
12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice.
Biological psychiatry
Di Meco A,Li JG,Blass BE,Abou-Gharbia M,Lauretti E,Praticò D
MN1040 was used in western blot to discuss the contribution of 12/15-lipoxygenase to Alzheimer's disease
Sun Jan 15 00:00:00 EST 2017
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology.
Frontiers in molecular neuroscience
Maphis NM,Jiang S,Binder J,Wright C,Gopalan B,Lamb BT,Bhaskar K
MN1040 was used in Western Blotting to suggest that MECP2 is a potential novel regulator of tau pathology relevant to AD and tauopathies.
Mon Sep 28 00:00:00 EDT 2020
Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation.
Molecular neurobiology
Chanu SI,Sarkar S
MN1040 was used in immunohistochemistry - paraffin section and western blot to study suppression of pathogenesis of human neuronal tauopathies in drosophila by limiting tau hyperphosphorylation and heterochromatin relaxation by targeted downregulation of
Mon May 01 00:00:00 EDT 2017
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
Cerebral cortex (New York, N.Y. : 1991)
Kolisnyk B,Al-Onaizi M,Soreq L,Barbash S,Bekenstein U,Haberman N,Hanin G,Kish MT,Souza da Silva J,Fahnestock M,Ule J,Soreq H,Prado VF,Prado MAM
MN1040 was used in immunohistochemistry to study cholinergic surveillance over Alzheimer's-like pathology and hippocampal RNA metabolism
Sat Jul 01 00:00:00 EDT 2017
Variable tau accumulation in murine models with abnormal prion protein deposits.
Journal of the neurological sciences
Piccardo P,King D,Brown D,Barron RM
MN1040 was used in Immunohistochemistry on paraffin embedded tissues-immunofluorescence to examine variable tau accumulation in murine models with abnormal prion protein deposits.
Fri Dec 15 00:00:00 EST 2017
Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology.
Journal of Alzheimer's disease : JAD
Rueli RH,Torres DJ,Dewing AS,Kiyohara AC,Barayuga SM,Bellinger MT,Uyehara-Lock JH,White LR,Moreira PI,Berry MJ,Perry G,Bellinger FP
MN1040 was used in western blot to test if increased SelS expression induced by selenate contributes to the beneficial actions of selenate in Alzheimer's disease
Thu Feb 22 00:00:00 EST 2018
In Vivo Detection of Gray Matter Neuropathology in the 3xTg Mouse Model of Alzheimer's Disease with Diffusion Tensor Imaging.
Journal of Alzheimer's disease : JAD
Snow WM,Dale R,O'Brien-Moran Z,Buist R,Peirson D,Martin M,Albensi BC
MN1040 was used in Immunohistochemistry to demonstrate diffusion tensor imaging abnormalities in gray matter in a mouse model of Alzheimer's disease.
Wed Mar 21 00:00:00 EDT 2018
Pazopanib Reduces Phosphorylated Tau Levels and Alters Astrocytes in a Mouse Model of Tauopathy.
Journal of Alzheimer's disease : JAD
Javidnia M,Hebron ML,Xin Y,Kinney NG,Moussa CE
MN1040 was used in Western Blotting to examine the role of pazopanib in mouse models that express either human mutant P301L tau or triple mutant amyloid precursor protein.
Mon Apr 09 00:00:00 EDT 2018
Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.
Scientific reports
Li JG,Barrero C,Merali S,Praticò D
MN1040 was used in immunohistochemistry and western blot to show that ALOX5 upregulation results in homocysteine-dependent worsening of the Alzheimer's disease phenotype
Thu Apr 06 00:00:00 EDT 2017
Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers.
eLife
Wang H,Muiznieks LD,Ghosh P,Williams D,Solarski M,Fang A,Ruiz-Riquelme A,Pomès R,Watts JC,Chakrabartty A,Wille H,Sharpe S,Schmitt-Ulms G
MN1040 was used in Western Blotting to identify proteins in human brain extract that bind to oligomeric Aβ1-42 (oAβ1-42) and/or monomeric Aβ1-42 (mAβ1-42) baits.
Mon Jun 26 00:00:00 EDT 2017
Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects.
Scientific reports
Lathuilière A,Valdés P,Papin S,Cacquevel M,Maclachlan C,Knott GW,Muhs A,Paganetti P,Schneider BL
MN1040 was used in Immuno-assay to demonstrate that motifs that are critical for tau conformation determine interaction with microtubules and subsequent pathological modifications.
Thu Oct 19 00:00:00 EDT 2017
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau.
Acta neuropathologica
Taniguchi-Watanabe S,Arai T,Kametani F,Nonaka T,Masuda-Suzukake M,Tarutani A,Murayama S,Saito Y,Arima K,Yoshida M,Akiyama H,Robinson A,Mann DMA,Iwatsubo T,Hasegawa M
MN1040 was used in western blot to assess using the biochemical properties of tau to classify tauopathies
Mon Feb 01 00:00:00 EST 2016
Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Brain : a journal of neurology
Müller-Schiffmann A,Herring A,Abdel-Hafiz L,Chepkova AN,Schäble S,Wedel D,Horn AH,Sticht H,de Souza Silva MA,Gottmann K,Sergeeva OA,Huston JP,Keyvani K,Korth C
MN1040 was used in western blot to assess the impairment in synaptic plasticity and learning due to amyloid-beta dimers in the absence of plaque pathology
Mon Feb 01 00:00:00 EST 2016
miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.
EMBO molecular medicine
Salta E,Sierksma A,Vanden Eynden E,De Strooper B
MN1040 was used in western blot to describe the role of miR-132 in amyloid and TAU pathology associated with Alzheimer's disease
Thu Sep 01 00:00:00 EDT 2016
Maternal dexamethasone exposure ameliorates cognition and tau pathology in the offspring of triple transgenic AD mice.
Molecular psychiatry
Di Meco A,Joshi YB,Lauretti E,Praticò D
MN1040 was used in western blot to study amelioration of tau pathology and cognition in the offspring of triple transgenic AD mice by maternal dexamethasone exposure
Tue Mar 01 00:00:00 EST 2016
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice.
Neurobiology of disease
El Khoury NB,Gratuze M,Petry F,Papon MA,Julien C,Marcouiller F,Morin F,Nicholls SB,Calon F,Hébert SS,Marette A,Planel E
MN1040 was used in western blot to examine the impact of type 2 diabetes on tau phosphorylation in diabetic mouse model
Fri Apr 01 00:00:00 EDT 2016
TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice.
Neuropharmacology
Jiang T,Zhang YD,Chen Q,Gao Q,Zhu XC,Zhou JS,Shi JQ,Lu H,Tan L,Yu JT
MN1040 was used in immunohistochemistry and western blot to elucidate modification microglial phenotype and neuroprotection in P301S tau transgenic mice via TREM2
Wed Jun 01 00:00:00 EDT 2016
Human Truncated Tau Induces Mature Neurofibrillary Pathology in a Mouse Model of Human Tauopathy.
Journal of Alzheimer's disease : JAD
Zimova I,Brezovakova V,Hromadka T,Weisova P,Cubinkova V,Valachova B,Filipcik P,Jadhav S,Smolek T,Novak M,Zilka N
MN1040 was used in immunohistochemistry - paraffin section to describe the molecular and behavioral features of R3m/4 transgenic mice expressing human non-mutated truncated tau protein and assess these mice as a model for Alzheimer's disease
Tue Sep 06 00:00:00 EDT 2016
Epigallocatechin-3-gallate enhances clearance of phosphorylated tau in primary neurons.
Nutritional neuroscience
Chesser AS,Ganeshan V,Yang J,Johnson GV
MN1040 was used in western blot to analyze the enhanced clearance of phosphorylated tau in primary neurons by epigallocatechin-3-gallate
Wed Oct 19 00:00:00 EDT 2016
Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease.
Neuroscience
Platt TL,Beckett TL,Kohler K,Niedowicz DM,Murphy MP
MN1040 was used in western blot to characterize tau pathology mouse models via obesity, diabetes, and leptin resistance
Fri Feb 19 00:00:00 EST 2016
Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia.
Neurobiology of learning and memory
Van der Jeugd A,Vermaercke B,Halliday GM,Staufenbiel M,Götz J
MN1040 was used in immunohistochemistry - paraffin section to elucidate a mouse model of frontotemporal dementia by decreased social exploration, impulsivity, and executive dysfunction
Fri Apr 01 00:00:00 EDT 2016
Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment.
The Journal of comparative neurology
Smolek T,Madari A,Farbakova J,Kandrac O,Jadhav S,Cente M,Brezovakova V,Novak M,Zilka N
MN1040 was used in immunohistochemistry - paraffin section to study canine cognitive impairment syndrome.
Tue Mar 01 00:00:00 EST 2016
Short and Long Term Behavioral and Pathological Changes in a Novel Rodent Model of Repetitive Mild Traumatic Brain Injury.
PloS one
McAteer KM,Corrigan F,Thornton E,Turner RJ,Vink R
MN1040 was used in immunohistochemistry - paraffin section develop and characterize a novel model of repetitive of traumatic brain injury
Mon Jul 31 00:00:00 EDT 2017
A local insult of okadaic acid in wild-type mice induces tau phosphorylation and protein aggregation in anatomically distinct brain regions.
Acta neuropathologica communications
Baker S,Götz J
MN1040 was used in immunohistochemistry - paraffin section and western blot to study tau phosphorylation and protein aggregation induced by okadaic acid
Thu Mar 31 00:00:00 EDT 2016
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.
Nucleic acids research
Sykora P,Misiak M,Wang Y,Ghosh S,Leandro GS,Liu D,Tian J,Baptiste BA,Cong WN,Brenerman BM,Fang E,Becker KG,Hamilton RJ,Chigurupati S,Zhang Y,Egan JM,Croteau DL,Wilson DM,Mattson MP,Bohr VA
MN1040 was used in western blot to determine how Alzheimer disease phenotypes are exacerbated and neurodegeneration occurs by DNA polymerase beta deficiency
Thu Jan 01 00:00:00 EST 2015
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
The Journal of experimental medicine
Jay TR,Miller CM,Cheng PJ,Graham LC,Bemiller S,Broihier ML,Xu G,Margevicius D,Karlo JC,Sousa GL,Cotleur AC,Butovsky O,Bekris L,Staugaitis SM,Leverenz JB,Pimplikar SW,Landreth GE,Howell GR,Ransohoff RM,Lamb BT
MN1040 was used in immunohistochemistry - free floating to elucidate the cell types and mechanisms underlying TREM2's contribution to neurodegeneration.
Mon Mar 09 00:00:00 EDT 2015
Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies.
Acta neuropathologica
Wagner J,Krauss S,Shi S,Ryazanov S,Steffen J,Miklitz C,Leonov A,Kleinknecht A,Göricke B,Weishaupt JH,Weckbecker D,Reiner AM,Zinth W,Levin J,Ehninger D,Remy S,Kretzschmar HA,Griesinger C,Giese A,Fuhrmann M
MN1040 was used in western blot to report that the di-phenyl-pyrazole anle138b binds to and inhibits tau aggregation in vitro and in vivo
Sun Nov 01 00:00:00 EDT 2015
Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain.
Brain : a journal of neurology
Maphis N,Xu G,Kokiko-Cochran ON,Jiang S,Cardona A,Ransohoff RM,Lamb BT,Bhaskar K
MN1040 was used in western blot to demonstrate that microglia promote tau pathology in a cell-autonomous manner.
Mon Jun 01 00:00:00 EDT 2015
HS3ST2 expression is critical for the abnormal phosphorylation of tau in Alzheimer's disease-related tau pathology.
Brain : a journal of neurology
Sepulveda-Diaz JE,Alavi Naini SM,Huynh MB,Ouidja MO,Yanicostas C,Chantepie S,Villares J,Lamari F,Jospin E,van Kuppevelt TH,Mensah-Nyagan AG,Raisman-Vozari R,Soussi-Yanicostas N,Papy-Garcia D
MN1040 was used in western blot to characterize Alzheimer's disease-related tau pathology by HS3ST2 expression in critical for the abonormal phosphorylation of tau
Fri May 01 00:00:00 EDT 2015
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Annals of neurology
Kaufman AC,Salazar SV,Haas LT,Yang J,Kostylev MA,Jeng AT,Robinson SA,Gunther EC,van Dyck CH,Nygaard HB,Strittmatter SM
MN1040 was used in immunohistochemistry - free floating to assess the Src family kinase inhibitor, AZD0530, for treatment of Alzheimer's disease
Mon Jun 01 00:00:00 EDT 2015
Sustained Arginase 1 Expression Modulates Pathological Tau Deposits in a Mouse Model of Tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hunt JB,Nash KR,Placides D,Moran P,Selenica ML,Abuqalbeen F,Ratnasamy K,Slouha N,Rodriguez-Ospina S,Savlia M,Ranaweera Y,Reid P,Dickey CA,Uricia R,Yang CG,Sandusky LA,Gordon MN,Morgan D,Lee DC
MN1040 was used in Western Blotting to study the effects of Arginase 1 overexperssion in the central nervous system of rTg4510 tau transgenic mice.
Wed Nov 04 00:00:00 EST 2015
Tau-targeting passive immunization modulates aspects of pathology in tau transgenic mice.
Journal of neurochemistry
Ittner A,Bertz J,Suh LS,Stevens CH,Götz J,Ittner LM
MN1040 was used in immunohistochemistry - paraffin section and western blot to determine the pathology in tau transgenic mice due to tau-targeting passive immunization
Thu Jan 01 00:00:00 EST 2015
Modulation of AD neuropathology and memory impairments by the isoprostane F2α is mediated by the thromboxane receptor.
Neurobiology of aging
Lauretti E,Di Meco A,Chu J,Praticò D
MN1040 was used in immunohistochemistry - paraffin section and western blot to characterize the behavioral, biochemical, and neuropathologic effects of 8ISO in the triple transgenic mouse model of Alzheimer's disease
Sun Feb 01 00:00:00 EST 2015
Dexmedetomidine directly increases tau phosphorylation.
Journal of Alzheimer's disease : JAD
Huang C,Ho YS,Ng OT,Irwin MG,Chang RC,Wong GT
MN1040 was used in immunohistochemistry - paraffin section and western blot to study tau phosphorylation and its direct increase by dexmedetomidine
Mon Oct 26 00:00:00 EDT 2015
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model.
Journal of Alzheimer's disease : JAD
Dunn HC,Ager RR,Baglietto-Vargas D,Cheng D,Kitazawa M,Cribbs DH,Medeiros R
MN1040 was used in western blot to assess the effect of aging on brain lipoxin A4 levels using non-transgenic and 3xTg-AD mice.
Fri Aug 21 00:00:00 EDT 2015
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.
Neuroscience
Li R,Xu DE,Ma T
MN1040 was used in western blot to elucidate the neuroprotective mechanism of statins
Thu May 21 00:00:00 EDT 2015
Identification and characterization of natural antibodies against tau protein in an intravenous immunoglobulin product.
Journal of neuroimmunology
Hromadkova L,Kolarova M,Jankovicova B,Bartos A,Ricny J,Bilkova Z,Ripova D
MN1040 was used in western blot to investigate the reactivity of isolated natural antibodies against tau protein
Tue Dec 15 00:00:00 EST 2015
Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice.
Neuroreport
Kim JM,Kim SS,Lee YD
MN1040 was used in immunohistochemistry - paraffin section to investigate the relationship between neurofibrillary changes and degeneration of septal cholinergic neurons in P301L tau transgenic mice
Wed Sep 09 00:00:00 EDT 2015
Analysis of tau post-translational modifications in rTg4510 mice, a model of tau pathology.
Molecular neurodegeneration
Song L,Lu SX,Ouyang X,Melchor J,Lee J,Terracina G,Wang X,Hyde L,Hess JF,Parker EM,Zhang L
MN1040 was used in western blot to use rTg4510 mice to elucidate pathogenesis of tau-induced disease.
Thu Mar 26 00:00:00 EDT 2015
PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.
Cell death & disease
Mouton-Liger F,Rebillat AS,Gourmaud S,Paquet C,Leguen A,Dumurgier J,Bernadelli P,Taupin V,Pradier L,Rooney T,Hugon J
MN1040 was used in western blot to use a mouse thiamine deficiency model to assess the contribution of PKR in neuronal death.
Thu Jan 15 00:00:00 EST 2015
Analysis of in vivo turnover of tau in a mouse model of tauopathy.
Molecular neurodegeneration
Yamada K,Patel TK,Hochgräfe K,Mahan TE,Jiang H,Stewart FR,Mandelkow EM,Holtzman DM
MN1040 was used in ELISA to study in vivo turnover of tau by use of a mouse model of tauopathy
Mon Oct 26 00:00:00 EDT 2015
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model.
Molecular neurodegeneration
Lee IS,Jung K,Kim IS,Lee H,Kim M,Yun S,Hwang K,Shin JE,Park KI
MN1040 was used in western blot to analyze a mouse model where human neural stem cells alleviate Alzheimer-like pathology
Fri Aug 21 00:00:00 EDT 2015
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.
Scientific reports
Luo W,Liu W,Hu X,Hanna M,Caravaca A,Paul SM
MN1040 was used in Immunohistochemistry to identify a potential role for microglia in the degradation and clearance of pathological tau species in the brain.
Tue Jun 09 00:00:00 EDT 2015
Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.
Scientific reports
Carret-Rebillat AS,Pace C,Gourmaud S,Ravasi L,Montagne-Stora S,Longueville S,Tible M,Sudol E,Chang RC,Paquet C,Mouton-Liger F,Hugon J
MN1040 was used in western blot to research A-beta accumulation and neuroinflammation linked to systemic inflammation that is decreased by genetic PKR down-regulation
Tue Feb 17 00:00:00 EST 2015
β-Secretase 1's Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice.
Frontiers in cellular neuroscience
Piedrahita D,Castro-Alvarez JF,Boudreau RL,Villegas-Lanau A,Kosik KS,Gallego-Gomez JC,Cardona-Gómez GP
MN1040 was used in western blot to study reduction of hyperphosphorilated Tau by beta-secretase 1's targeting implying autophagy actors in 3xTg-AD mice
Mon Jan 18 00:00:00 EST 2016
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease.
Molecular brain
Watanabe K,Uemura K,Asada M,Maesako M,Akiyama H,Shimohama S,Takahashi R,Kinoshita A
MN1040 was used in western blot to characterize the release of insulin-like growth factor-binding protein 3 from astrocytes in the pathology of Alzheimer's disease
Fri Dec 04 00:00:00 EST 2015
Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.
Annals of neurology
Li JG,Chu J,Barrero C,Merali S,Praticò D
MN1040 was used in immunohistochemistry and western blot to study the deleterious effect of high homocyteine levels on beta-amyloid and tau pathology and cognitive function in a murine model of Alzheimer's disease
Sun Jun 01 00:00:00 EDT 2014
Visualizing the microtubule-associated protein tau in the nucleus.
Science China. Life sciences
Lu J,Li T,He R,Bartlett PF,Götz J
MN1040 was used in western blot to perform a comparative study of methods for the detection of nuclear tau protein
Tue Apr 01 00:00:00 EDT 2014
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease.
Free radical biology & medicine
Farr SA,Ripley JL,Sultana R,Zhang Z,Niehoff ML,Platt TL,Murphy MP,Morley JE,Kumar V,Butterfield DA
MN1040 was used in western blot to study the benefecial effects on learning, memory and oxidative stress of GSK-3beta knockdown in the brain of SAMP8 mice
Sat Feb 01 00:00:00 EST 2014
Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease.
Neurobiology of disease
Chabrier MA,Cheng D,Castello NA,Green KN,LaFerla FM
MN1040 was used in western blot to study dendritic spine loss in a transgenic murine model of Alzheimer's disease and the synergistic effects of Abeta and tau
Tue Apr 01 00:00:00 EDT 2014
Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition.
Neurobiology of disease
Baglietto-Vargas D,Kitazawa M,Le EJ,Estrada-Hernandez T,Rodriguez-Ortiz CJ,Medeiros R,Green KN,LaFerla FM
MN1040 was used in western blot to study the effect of endogenous murine tau on cognition and neurofibrillary tangles in a murine Alzheimer's disease model transgenically expressing human tau
Sat Feb 01 00:00:00 EST 2014
Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Castillo-Carranza DL,Sengupta U,Guerrero-Muñoz MJ,Lasagna-Reeves CA,Gerson JE,Singh G,Estes DM,Barrett AD,Dineley KT,Jackson GR,Kayed R
MN1040 was used in immunohistochemistry and western blot to study the ability of an anti-oligomeric tau monoclonal antibody to specifically reduce oligomeric tau and improve memory and locomotion in a murine Alzheimer's disease model
Wed Mar 19 00:00:00 EDT 2014
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Shilling D,Müller M,Takano H,Mak DO,Abel T,Coulter DA,Foskett JK
MN1040 was used in immunohistochemistry and western blot to study the role of exagerated Ca(2+) signaling mediated by InsP3 receptor1 in the pathogenesis of mutant presenilin-linked Alzheimer's disease
Wed May 14 00:00:00 EDT 2014
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes.
The American journal of pathology
Abbondante S,Baglietto-Vargas D,Rodriguez-Ortiz CJ,Estrada-Hernandez T,Medeiros R,Laferla FM
MN1040 was used in western blot to study the cognitive defects observed in type 1 diabetes and the role of tau in mediating these effects
Sat Mar 01 00:00:00 EST 2014
α7 Nicotinic receptor agonist enhances cognition in aged 3xTg-AD mice with robust plaques and tangles.
The American journal of pathology
Medeiros R,Castello NA,Cheng D,Kitazawa M,Baglietto-Vargas D,Green KN,Esbenshade TA,Bitner RS,Decker MW,LaFerla FM
MN1040 was used in Western Blotting to determine the effect of long-term treatment with the selective α7 nAChR agonist A-582941 in aged 3xTg-AD mice with robust Alzheimer's disease-like pathology.
Sat Feb 01 00:00:00 EST 2014
Long- and short-term CDK5 knockdown prevents spatial memory dysfunction and tau pathology of triple transgenic Alzheimer's mice.
Frontiers in aging neuroscience
Castro-Alvarez JF,Uribe-Arias SA,Kosik KS,Cardona-Gómez GP
MN1040 was used in western blot to use triple transgenic Alzhemier's mice to study short- and long-term CDK5 knockdown and prevention of spatial memory dysfunction and tau pathology
Mon Oct 13 00:00:00 EDT 2014
Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice.
Experimental neurology
Yamada ES,Respondek G,Müssner S,de Andrade A,Höllerhage M,Depienne C,Rastetter A,Tarze A,Friguet B,Salama M,Champy P,Oertel WH,Höglinger GU
MN1040 was used in immunohistochemistry and western blot to study the increased tau phosphorylation following treatment with a mitochondrial complex I inhibitor in a tau transgenic mouse model
Sat Mar 01 00:00:00 EST 2014
Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance.
Neuropharmacology
Jiang T,Yu JT,Zhu XC,Zhang QQ,Cao L,Wang HF,Tan MS,Gao Q,Qin H,Zhang YD,Tan L
MN1040 was used in western blot to study the ability of the rapamycin analog temsirolimus to promote autophagic clearance of hyperphosphorylated tau and improve memory deficits in animal models
Wed Oct 01 00:00:00 EDT 2014
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles.
Neurobiology of aging
Di Meco A,Joshi YB,Praticò D
MN1040 was used in western blot to study the deleterious effects of sleep deprivation on memory and Tau pathology in a murine Alzheimer's disease model
Fri Aug 01 00:00:00 EDT 2014
Tau silencing by siRNA in the P301S mouse model of tauopathy.
Current gene therapy
Xu H,Rösler TW,Carlsson T,de Andrade A,Fiala O,Hollerhage M,Oertel WH,Goedert M,Aigner A,Höglinger GU
MN1040 was used in immunohistochemistry - free floating to investigate the cerebral delivery of small interfering RNAs targeting human tau
Tue Oct 13 00:00:00 EDT 2015
TFP5, a peptide derived from p35, a Cdk5 neuronal activator, rescues cortical neurons from glucose toxicity.
Journal of Alzheimer's disease : JAD
Binukumar BK,Zheng YL,Shukla V,Amin ND,Grant P,Pant HC
MN1040 was used in Western Blotting to suggest that TFP5 peptide may be a novel candidate for type 2 diabetes therapy.
Thu Oct 30 00:00:00 EDT 2014
Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis.
FEBS letters
Inoue H,Hiradate Y,Shirakata Y,Kanai K,Kosaka K,Gotoh A,Fukuda Y,Nakai Y,Uchida T,Sato E,Tanemura K
MN1040 was used in immunohistochemistry to study the role of Tau phosphorylation in murine spermatogenesis during meiosis
Thu May 29 00:00:00 EDT 2014
Long-term treadmill exercise attenuates tau pathology in P301S tau transgenic mice.
Molecular neurodegeneration
Ohia-Nwoko O,Montazari S,Lau YS,Eriksen JL
MN1040 was used in immunohistochemistry - paraffin section and western blot to evaluate motor function and tau pathology of P301S tau transgenic mice
Fri Nov 28 00:00:00 EST 2014
Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40.
Molecular neurodegeneration
Hu X,Li X,Zhao M,Gottesdiener A,Luo W,Paul S
MN1040 was used in immunohistochemistry and western blot to investigate the interactions between Abeta1-42 and Abeta1-40
Sun Nov 23 00:00:00 EST 2014
Doubly Phosphorylated Peptide Vaccines to Protect Transgenic P301S Mice against Alzheimer's Disease Like Tau Aggregation.
Vaccines
Richter M,Mewes A,Fritsch M,Krügel U,Hoffmann R,Singer D
MN1040 was used in western blot to study protection of transgenic P301S mice against tau aggregation in Alzheimer's disease by doubly phosphorylated peptied vaccines
Tue Jul 29 00:00:00 EDT 2014
Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.
Acta neuropathologica
Wu TH,Lu YN,Chuang CL,Wu CL,Chiang AS,Krantz DE,Chang HY
MN1040 was used in immunocytochemistry to report that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model
Wed May 01 00:00:00 EDT 2013
Mifepristone alters amyloid precursor protein processing to preclude amyloid beta and also reduces tau pathology.
Biological psychiatry
Baglietto-Vargas D,Medeiros R,Martinez-Coria H,LaFerla FM,Green KN
MN1040 was used in western blot to study the reduced alpha- and beta-cleavage of APP and reduced phosporylated tau accumulation in transgenic mice treated with mifepristone
Sun Sep 01 00:00:00 EDT 2013
Detrimental effects of diet-induced obesity on τ pathology are independent of insulin resistance in τ transgenic mice.
Diabetes
Leboucher A,Laurent C,Fernandez-Gomez FJ,Burnouf S,Troquier L,Eddarkaoui S,Demeyer D,Caillierez R,Zommer N,Vallez E,Bantubungi K,Breton C,Pigny P,Buée-Scherrer V,Staels B,Hamdane M,Tailleux A,Buée L,Blum D
MN1040 was used in western blot to study the effects of diet-induced obesity on tau pathology
Wed May 01 00:00:00 EDT 2013
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ghosh S,Wu MD,Shaftel SS,Kyrkanides S,LaFerla FM,Olschowka JA,O'Banion MK
MN1040 was used in Western Blotting to investigate the role of IL-1Β in Alzheimer's disease pathogenesis.
Wed Mar 13 00:00:00 EDT 2013
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans.
Journal of neurochemistry
Georgievska B,Sandin J,Doherty J,Mörtberg A,Neelissen J,Andersson A,Gruber S,Nilsson Y,Schött P,Arvidsson PI,Hellberg S,Osswald G,Berg S,Fälting J,Bhat RV
MN1040 was used in western blot to study the ability of a novel GSK3 inhibitor to restore synaptic plasticity in rat brain and inhibit PBMC GSK3 in a phase 1 clinical trial
Wed May 01 00:00:00 EDT 2013
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease.
Neurobiology of aging
Cancino GI,Miller FD,Kaplan DR
MN1040 was used in western blot to study the effects of p73 haploinsufficiency on tau phosphorylation status and the activity of GSK3-beta, c-Abl and Cdk5 in murine models of ageing and Alzheimer's disease
Fri Feb 01 00:00:00 EST 2013
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.
Neurobiology of aging
Nash KR,Lee DC,Hunt JB,Morganti JM,Selenica ML,Moran P,Reid P,Brownlow M,Guang-Yu Yang C,Savalia M,Gemma C,Bickford PC,Gordon MN,Morgan D
MN1040 was used in western blot to study the beneficial effects on tau pathology in a murine transgenic tauopathy model of the virally-mediated overexpression of soluble fractalkine
Sat Jun 01 00:00:00 EDT 2013
A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease.
Neurobiology of aging
Kashiwaya Y,Bergman C,Lee JH,Wan R,King MT,Mughal MR,Okun E,Clarke K,Mattson MP,Veech RL
MN1040 was used in immunohistochemistry to study the protective effects against anxiety, cognitive decline and disease pathology of a ketone ester diet in a murine model of Alzheimer's disease
Sat Jun 01 00:00:00 EDT 2013
Pattern of tau hyperphosphorylation and neurotransmitter markers in the brainstem of senescent tau filament forming transgenic mice.
Brain research
Morcinek K,Köhler C,Götz J,Schröder H
MN1040 was used in immunohistochemistry to study whether the expression of mutant human tau in tau filament-forming mice recapitulates the pathological chages observed in Alzheimer's disease brainstem
Mon Feb 25 00:00:00 EST 2013
Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease.
Brain research
Rothman SM,Herdener N,Frankola KA,Mughal MR,Mattson MP
MN1040 was used in western blot to study the accentuated memory deficits and elevated accumulation of beta-amyloid and phosphorylated tau following chronic mild sleep deprivation in a murine Alzheimer's disease model
Thu Sep 05 00:00:00 EDT 2013
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies.
The Journal of biological chemistry
Hawkins BE,Krishnamurthy S,Castillo-Carranza DL,Sengupta U,Prough DS,Jackson GR,DeWitt DS,Kayed R
MN1040 was used in ELISA, immunohistochemistry, and western blot to study the generation of oligomeric and phosphorylated forms of tau in a rat model of traumatic brain injury
Fri Jun 07 00:00:00 EDT 2013
Impaired plasticity of cortical dendritic spines in P301S tau transgenic mice.
Acta neuropathologica communications
Hoffmann NA,Dorostkar MM,Blumenstock S,Goedert M,Herms J
MN1040 was used in immunohistochemistry to study the potential involvement of pre-fibrilliary tau in the defective plasticity of cortical dendritic spines observed in transgenic mice bearing the P301S tau mutation
Tue Dec 17 00:00:00 EST 2013
Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals.
Cell death & disease
Bomba M,Ciavardelli D,Silvestri E,Canzoniero LM,Lattanzio R,Chiappini P,Piantelli M,Di Ilio C,Consoli A,Sensi SL
MN1040 was used in immunohistochemistry to study the ability of a GLP-1 analog to improve cognition in PS1-KI mice but not in 3xTg-AD mice
Thu May 02 00:00:00 EDT 2013
Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
PloS one
Guo Q,Li H,Cole AL,Hur JY,Li Y,Zheng H
MN1040 was used in western blot to generate a novel humanized murine model of Alzheimer's disease that does not rely on mutant protein overexpression
Wed Dec 10 00:00:00 EST 2014
Propagation of tau pathology in a model of early Alzheimer's disease.
Neuron
de Calignon A,Polydoro M,Suárez-Calvet M,William C,Adamowicz DH,Kopeikina KJ,Pitstick R,Sahara N,Ashe KH,Carlson GA,Spires-Jones TL,Hyman BT
MN1040 was used in western blot to study the propagation of tau pathology in a model of early Alzheimer's disease
Thu Feb 23 00:00:00 EST 2012
Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Keilani S,Lun Y,Stevens AC,Williams HN,Sjoberg ER,Khanna R,Valenzano KJ,Checler F,Buxbaum JD,Yanagisawa K,Lockhart DJ,Wustman BA,Gandy S
MN1040 was used in immunohistochemistry to study the role of lysosomal dysfunction in the accumulation of ganglioside-bound amyloid-beta peptide in Sandhoff disease
Wed Apr 11 00:00:00 EDT 2012
Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wang HY,Bakshi K,Frankfurt M,Stucky A,Goberdhan M,Shah SM,Burns LH
MN1040 was used in western blot to study the ability of a small molecule that binds filamin A with high affinity to reduce beta-amyloid-associated Alzheimer's disease pathology
Wed Jul 18 00:00:00 EDT 2012
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Barten DM,Fanara P,Andorfer C,Hoque N,Wong PY,Husted KH,Cadelina GW,Decarr LB,Yang L,Liu V,Fessler C,Protassio J,Riff T,Turner H,Janus CG,Sankaranarayanan S,Polson C,Meredith JE,Gray G,Hanna A,Olson RE,Kim SH,Vite GD,Lee FY,Albright CF
MN1040 was used in immunohistochemistry to study the effects of a small molecule microtubule-stabilizer on microtubule hyperdynamics, cognitive performance and pathology in tau transgenic mice
Wed May 23 00:00:00 EDT 2012
Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
The American journal of pathology
Perez SE,Getova DP,He B,Counts SE,Geula C,Desire L,Coutadeur S,Peillon H,Ginsberg SD,Mufson EJ
MN1040 was used in immunohistochemistry to study the expression of Raclb in cholinergic nucleus basalis neurones and the correlation with tau pathology and Alzheimer's disease progression
Wed Feb 01 00:00:00 EST 2012
Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.
The American journal of pathology
Medeiros R,Kitazawa M,Chabrier MA,Cheng D,Baglietto-Vargas D,Kling A,Moeller A,Green KN,LaFerla FM
MN1040 was used in western blot to study the beneficial effects of a novel calpain inhibitor on Alzheimers's disease pathology and cognitive decline in transgenic mouse model
Wed Aug 01 00:00:00 EDT 2012
Autophagic degradation of tau in primary neurons and its enhancement by trehalose.
Neurobiology of aging
Krüger U,Wang Y,Kumar S,Mandelkow EM
MN1040 was used in western blot to investigate the effect of trehalose on tau accumulation in AD patients
Mon Oct 01 00:00:00 EDT 2012
Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats.
Neurotoxicology
Rahman A,Khan KM,Al-Khaledi G,Khan I,Al-Shemary T
MN1040 was used in western blot to study the role of hippocampal PP1 and PP2A activation in the deleterious effects of lead on learning and memory in a rat model
Fri Jun 01 00:00:00 EDT 2012
Stress hormone leads to memory deficits and altered tau phosphorylation in a model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Joshi YB,Chu J,Praticò D
MN1040 was used in western blot to study the effects of glucocorticoids on memory, tau phosphorylation and beta-amyloid levels in a murine model of Alzheimer's disease
Mon Dec 03 00:00:00 EST 2012
Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis.
Journal of Alzheimer's disease : JAD
Ho YS,Yang X,Lau JC,Hung CH,Wuwongse S,Zhang Q,Wang J,Baum L,So KF,Chang RC
MN1040 was used in immunohistochemistry to investigate the influence of endoplasmic reticulum stress on tau function and the pathogenesis of Alzheimer disease
Mon Sep 17 00:00:00 EDT 2012
Dietary supplementation with S-adenosyl methionine delayed amyloid-β and tau pathology in 3xTg-AD mice.
Journal of Alzheimer's disease : JAD
Lee S,Lemere CA,Frost JL,Shea TB
MN1040 was used in immunocytochemistry to investigate the beneficial effect of S-adenosyl methionine on the progression of Alzheimer disease neuropathology in a mouse model
Thu May 24 00:00:00 EDT 2012
Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.
Journal of molecular neuroscience : MN
Löffler T,Flunkert S,Taub N,Schofield EL,Ward MA,Windisch M,Hutter-Paier B
MN1040 was used in western blot to develop a cell line stably expressing mutant tau441 for screening Alzheimer's disease drug candidates
Tue May 01 00:00:00 EDT 2012
Early postnatal lead exposure induces tau phosphorylation in the brain of young rats.
Acta biologica Hungarica
Rahman A,Khan KM,Al-Khaledi G,Khan I,Attur S
MN1040 was used in western blot to study tau phosphorylation in response to early post-natal exposure to lead
Sat Dec 01 00:00:00 EST 2012
Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.
PLoS genetics
Iijima-Ando K,Sekiya M,Maruko-Otake A,Ohtake Y,Suzuki E,Lu B,Iijima KM
MN1040 was used in western blot to assess if and how loss of axonal mitochondria promotes tau phosphorylation and toxicity in vivo.
Fri Jan 04 00:00:00 EST 2013
Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
PloS one
Sudduth TL,Wilson JG,Everhart A,Colton CA,Wilcock DM
MN1040 was used in western blot to study the effect of lithium treatment on tau hyperphosphorylation and amyloid deposition in a model of Alzheimer's disease
Tue Jul 31 00:00:00 EDT 2012
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway.
Molecular neurodegeneration
Inoue K,Rispoli J,Kaphzan H,Klann E,Chen EI,Kim J,Komatsu M,Abeliovich A
MN1040 was used in immunohistochemistry to study the role of the phospho-Tau pathway in the mechanism by which deficient macroautophagy promotes age-related neurodegeneration
Fri Sep 21 00:00:00 EDT 2012
LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth.
PloS one
Kawakami F,Yabata T,Ohta E,Maekawa T,Shimada N,Suzuki M,Maruyama H,Ichikawa T,Obata F
MN1040 was used in western blot to investigate the important roles of LRRK2 in phosphorylation-mediated dissociation of tau from microtubules
Mon Jun 11 00:00:00 EDT 2012
Genetic knockdown of brain-derived neurotrophic factor in 3xTg-AD mice does not alter Aβ or tau pathology.
PloS one
Castello NA,Green KN,LaFerla FM
MN1040 was used in western blot to study the lack of effect of BDNF knockdown on Abeta or tau pathology in a model of Alzheimer's disease
Tue Feb 19 00:00:00 EST 2013
Interaction of endogenous tau protein with synaptic proteins is regulated by N-methyl-D-aspartate receptor-dependent tau phosphorylation.
The Journal of biological chemistry
Mondragón-Rodríguez S,Trillaud-Doppia E,Dudilot A,Bourgeois C,Lauzon M,Leclerc N,Boehm J
MN1040 was used in immunocytochemistry to study the role of NMDA receptor-dependent tau phosphorylation in modulating the interaction of endogenous tau with synaptic proteins
Fri Sep 14 00:00:00 EDT 2012
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model.
International journal of Alzheimer's disease
Lee S,Kim W,Li Z,Hall GF
MN1040 was used in immunohistochemistry to study the role of tau accumulation in distal dendrites in tauopathy
Thu Aug 23 00:00:00 EDT 2012
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.
PloS one
Schön C,Hoffmann NA,Ochs SM,Burgold S,Filser S,Steinbach S,Seeliger MW,Arzberger T,Goedert M,Kretzschmar HA,Schmidt B,Herms J
MN1040 was used in immunohistochemistry to develop an imaging system for long-term monitoring of retinal fibrillar tau in P301S tau transgenic mice and to study whether retinal tau is diagnostic in Alzheimer's disease
Mon Jun 24 00:00:00 EDT 2013
Dimethyl sulfoxide induces both direct and indirect tau hyperphosphorylation.
PloS one
Julien C,Marcouiller F,Bretteville A,El Khoury NB,Baillargeon J,Hébert SS,Planel E
MN1040 was used in western blot to study the ability of DMSO to directly and indirectly induce hyperphosphorylation of tau
Tue Nov 27 00:00:00 EST 2012
Hypothermia-induced hyperphosphorylation: a new model to study tau kinase inhibitors.
Scientific reports
Bretteville A,Marcouiller F,Julien C,El Khoury NB,Petry FR,Poitras I,Mouginot D,Lévesque G,Hébert SS,Planel E
MN1040 was used in western blot to test if hypothermia could be used to assess tau kinase inhibitors efficacy
Sun Mar 17 00:00:00 EDT 2013
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.
Proceedings of the National Academy of Sciences of the United States of America
Jin M,Shepardson N,Yang T,Chen G,Walsh D,Selkoe DJ
MN1040 was used in western blot to investigate the effect of Abeta on the regulation of tau modification and neuronal function
Tue Apr 05 00:00:00 EDT 2011
Familial prion disease with Alzheimer disease-like tau pathology and clinical phenotype.
Annals of neurology
Jayadev S,Nochlin D,Poorkaj P,Steinbart EJ,Mastrianni JA,Montine TJ,Ghetti B,Schellenberg GD,Bird TD,Leverenz JB
MN1040 was used in immunohistochemistry to study the Alzheimer disease-like clinical features and tau pathology in a familial prion disease
Fri Apr 01 00:00:00 EDT 2011
Controlled cortical impact traumatic brain injury in 3xTg-AD mice causes acute intra-axonal amyloid-β accumulation and independently accelerates the development of tau abnormalities.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tran HT,LaFerla FM,Holtzman DM,Brody DL
MN1040 was used in immunohistochemistry to investigate the effect of traumatic brain injury on the development of Alzheimer disease pathology
Wed Jun 29 00:00:00 EDT 2011
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Maeda J,Zhang MR,Okauchi T,Ji B,Ono M,Hattori S,Kumata K,Iwata N,Saido TC,Trojanowski JQ,Lee VM,Staufenbiel M,Tomiyama T,Mori H,Fukumura T,Suhara T,Higuchi M
MN1040 was used in immunohistochemistry to investigate the association of TSPO expression with pathology of Alzheimer disease
Wed Mar 23 00:00:00 EDT 2011
Environmental enrichment compensates for the effects of stress on disease progression in Tg2576 mice, an Alzheimer's disease model.
Journal of neurochemistry
Jeong YH,Kim JM,Yoo J,Lee SH,Kim HS,Suh YH
MN1040 was used in western blot to investigate the effect of environmental enrichment on disease progression caused by stress in a mouse model of Alzheimer disease
Thu Dec 01 00:00:00 EST 2011
Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model.
Journal of immunology (Baltimore, Md. : 1950)
Kitazawa M,Cheng D,Tsukamoto MR,Koike MA,Wes PD,Vasilevko V,Cribbs DH,LaFerla FM
MN1040 was used in western blot to investigate the effect of blocking IL-1 signaling in an Alzheimer disease mouse model
Thu Dec 15 00:00:00 EST 2011
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis.
Neurobiology of aging
Whitwell JL,Jack CR,Przybelski SA,Parisi JE,Senjem ML,Boeve BF,Knopman DS,Petersen RC,Dickson DW,Josephs KA
MN1040 was used in immunohistochemistry to study the temporoparietal atrophy in patients with Alzheimer disease
Thu Sep 01 00:00:00 EDT 2011
Physical exercise protects against Alzheimer's disease in 3xTg-AD mice.
Journal of Alzheimer's disease : JAD
García-Mesa Y,López-Ramos JC,Giménez-Llort L,Revilla S,Guerra R,Gruart A,Laferla FM,Cristòfol R,Delgado-García JM,Sanfeliu C
MN1040 was used in immunohistochemistry to investigate the effect of physical exercise on pathogenesis of Alzheimer disease
Mon Sep 19 00:00:00 EDT 2011
Focal expression of mutated tau in entorhinal cortex neurons of rats impairs spatial working memory.
Behavioural brain research
Ramirez JJ,Poulton WE,Knelson E,Barton C,King MA,Klein RL
MN1040 was used in immunohistochemistry to investigate the phenotypes of rats with overexpression of P301L tau in entorhinal cortex
Sat Jan 01 00:00:00 EST 2011
Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation.
Neuroscience letters
Ringman JM,Gylys KH,Medina LD,Fox M,Kepe V,Flores DL,Apostolova LG,Barrio JR,Small G,Silverman DH,Siu E,Cederbaum S,Hecimovic S,Malnar M,Chakraverty S,Goate AM,Bird TD,Leverenz JB
MN1040 was used in immunohistochemistry to characterize the effects of a novel presenilin 1 mutation in early-onset Alzheimer disease
Mon Jan 10 00:00:00 EST 2011
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia.
Neuroscience letters
Koike MA,Garcia FG,Kitazawa M,Green KN,Laferla FM
MN1040 was used in western blot to investigate the phosphorylation and aggregation of tau protein in the 3xTg-AD mice
Mon May 09 00:00:00 EDT 2011
Truncation of tau at E391 promotes early pathologic changes in transgenic mice.
Journal of neuropathology and experimental neurology
McMillan PJ,Kraemer BC,Robinson L,Leverenz JB,Raskind M,Schellenberg G
MN1040 was used in immunohistochemistry to investigate the role of a truncated tau in Alzheimer disease pathogenesis in mice
Tue Nov 01 00:00:00 EDT 2011
Accumulation of cellular prion protein within dystrophic neurites of amyloid plaques in the Alzheimer's disease brain.
Neuropathology : official journal of the Japanese Society of Neuropathology
Takahashi RH,Tobiume M,Sato Y,Sata T,Gouras GK,Takahashi H
MN1040 was used in immunocytochemistry to study the prion protein accumulation in the Alzheimer disease brain
Wed Jun 01 00:00:00 EDT 2011
Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.
PloS one
Corona C,Frazzini V,Silvestri E,Lattanzio R,La Sorda R,Piantelli M,Canzoniero LM,Ciavardelli D,Rizzarelli E,Sensi SL
MN1040 was used in immunohistochemistry to investigate the effectiveness of carnosine for the treatment of Alzheimer disease in mice model
Tue Mar 15 00:00:00 EDT 2011
Degenerating processes identified by electron microscopic immunocytochemical methods.
Methods in molecular biology (Clifton, N.J.)
Milner TA,Waters EM,Robinson DC,Pierce JP
MN1040 was used in immunocytochemistry to identify tissue degeneration through electron microscopic immunocytochemical methods
Fri Dec 30 00:00:00 EST 2011
Alzheimer's disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.
PloS one
Maarouf CL,Daugs ID,Kokjohn TA,Walker DG,Hunter JM,Kruchowsky JC,Woltjer R,Kaye J,Castaño EM,Sabbagh MN,Beach TG,Roher AE
MN1040 was used in western blot to examine the brains of non-demented high pathology controls individuals for mechanisms that protect against Alzheimer's disease
Fri May 18 00:00:00 EDT 2012
The ε3 and ε4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice.
PloS one
To AW,Ribe EM,Chuang TT,Schroeder JE,Lovestone S
MN1040 was used in western blot to study the amyloid beta and tau pathology in APOE knockout mice, carrying human APOEepsilon3 or epsilon4 transgenes, after diet-induced insulin resistance with and without pioglitazone treatment
Thu Feb 10 00:00:00 EST 2011
TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease.
Acta neuropathologica
Bigio EH,Mishra M,Hatanpaa KJ,White CL,Johnson N,Rademaker A,Weitner BB,Deng HX,Dubner SD,Weintraub S,Mesulam M
MN1040 was used in immunohistochemistry to study the pathology of TDP-43 in primary progressive aphasia and frontotemporal dementia
Thu Jul 01 00:00:00 EDT 2010
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
Molecular therapy : the journal of the American Society of Gene Therapy
Ryan DA,Mastrangelo MA,Narrow WC,Sullivan MA,Federoff HJ,Bowers WJ
MN1040 was used in immunohistochemistry to investigate the effect of a novel immunotherapeutic method on Alzheimer disease treatment
Sun Aug 01 00:00:00 EDT 2010
Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease.
Movement disorders : official journal of the Movement Disorder Society
Josephs KA,Whitwell JL,Boeve BF,Knopman DS,Petersen RC,Hu WT,Parisi JE,Dickson DW,Jack CR
MN1040 was used in immunohistochemistry to compare the gross pathology between CBS-corticobasal degeneration and CBS-Alzheimer disease
Thu Jul 15 00:00:00 EDT 2010
A novel X-linked four-repeat tauopathy with Parkinsonism and spasticity.
Movement disorders : official journal of the Movement Disorder Society
Poorkaj P,Raskind WH,Leverenz JB,Matsushita M,Zabetian CP,Samii A,Kim S,Gazi N,Nutt JG,Wolff J,Yearout D,Greenup JL,Steinbart EJ,Bird TD
MN1040 was used in immunohistochemistry to identify the locus associated with parkinsonian syndromes
Fri Jul 30 00:00:00 EDT 2010
Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy.
Brain pathology (Zurich, Switzerland)
Soontornniyomkij V,Lynch MD,Mermash S,Pomakian J,Badkoobehi H,Clare R,Vinters HV
MN1040 was used in immunohistochemistry to investigate the association of cerebral microinfarcts with severe cerebral beta-amyloid angiopathy
Mon Mar 01 00:00:00 EST 2010
Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Neurobiology of disease
Grueninger F,Bohrmann B,Czech C,Ballard TM,Frey JR,Weidensteiner C,von Kienlin M,Ozmen L
MN1040 was used in western blot to develop a transgenic mouse model for human Alzheimer disease based on Tau aggregation
Mon Feb 01 00:00:00 EST 2010
Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Peethumnongsin E,Yang L,Kallhoff-Muñoz V,Hu L,Takashima A,Pautler RG,Zheng H
MN1040 was used in western blot to investigate the interaction between presenilin- and tau-mediated pathways
Wed Oct 06 00:00:00 EDT 2010
Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Andrews-Zwilling Y,Bien-Ly N,Xu Q,Li G,Bernardo A,Yoon SY,Zwilling D,Yan TX,Chen L,Huang Y
MN1040 was used in immunohistochemistry to study the effect of apoE4 on GABAergic interneurons and its role in learning and memory deficits in mice
Wed Oct 13 00:00:00 EDT 2010
Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.
Neuropathology and applied neurobiology
Simpson JE,Ince PG,Haynes LJ,Theaker R,Gelsthorpe C,Baxter L,Forster G,Lace GL,Shaw PJ,Matthews FE,Savva GM,Brayne C,Wharton SB
MN1040 was used in immunohistochemistry to address the relationship of between astrocytic DNA damage response and Alzheimer pathology
Mon Feb 01 00:00:00 EST 2010
Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target.
The American journal of pathology
Desai MK,Mastrangelo MA,Ryan DA,Sudol KL,Narrow WC,Bowers WJ
MN1040 was used in immunohistochemistry to investigate the effect of Abeta(1-42) on the survival of mOP cells in Alzheimer disease mouse model
Wed Sep 01 00:00:00 EDT 2010
Memantine improves cognition and reduces Alzheimer's-like neuropathology in transgenic mice.
The American journal of pathology
Martinez-Coria H,Green KN,Billings LM,Kitazawa M,Albrecht M,Rammes G,Parsons CG,Gupta S,Banerjee P,LaFerla FM
MN1040 was used in western blot to investigate the effect of memantine on Alzheimer disease treatment in mice
Mon Feb 01 00:00:00 EST 2010
Oligemic hypoperfusion differentially affects tau and amyloid-{beta}.
The American journal of pathology
Koike MA,Green KN,Blurton-Jones M,Laferla FM
MN1040 was used in western blot to investigate the effect of oligemic hypoperfusion on tau and amyloid-beta in 3xTg-Alzheimer disease mice
Thu Jul 01 00:00:00 EDT 2010
A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.
Human molecular genetics
Iijima-Ando K,Zhao L,Gatt A,Shenton C,Iijima K
MN1040 was used in western blot to characterize the role of hyperphosphorylated Tau in neurodegenerative disease
Sat May 15 00:00:00 EDT 2010
3R tau expression modifies behavior in transgenic mice.
Journal of neuroscience research
Shiryaev N,Jouroukhin Y,Gozes I
MN1040 was used in western blot to assess tau-related behavior in a mouse model overexpressing the shortest human tau isoform in the brain
Wed Sep 01 00:00:00 EDT 2010
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation.
Journal of Alzheimer's disease : JAD
Parachikova A,Vasilevko V,Cribbs DH,LaFerla FM,Green KN
MN1040 was used in western blot to investigate the effect of minocycline on endogenous neuroinflammation and tau modification in Alzheimer disease mouse model
Mon Dec 20 00:00:00 EST 2010
The pattern of human tau phosphorylation is the result of priming and feedback events in primary hippocampal neurons.
Neuroscience
Bertrand J,Plouffe V,Sénéchal P,Leclerc N
MN1040 was used in western blot to study the relationship between Tau phosphorylation pattern and neurodegenerative diseases
Wed Jun 30 00:00:00 EDT 2010
Analysis of the cholinergic pathology in the P301L tau transgenic pR5 model of tauopathy.
Brain research
Köhler C,Bista P,Götz J,Schröder H
MN1040 was used in immunohistochemistry to analyze the cholinergic pathology in a tauopathy model
Fri Aug 06 00:00:00 EDT 2010
Amyloid and Tau accumulate in the brains of aged hydrocephalic rats.
Brain research
Silverberg GD,Miller MC,Machan JT,Johanson CE,Caralopoulos IN,Pascale CL,Heile A,Klinge PM
MN1040 was used in immunohistochemistry to study the accumulation of amyloid and tau in the brains of aged hydrocephalic rats
Thu Mar 04 00:00:00 EST 2010
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Journal of neuropathology and experimental neurology
Mohorko N,Repovs G,Popović M,Kovacs GG,Bresjanac M
MN1040 was used in immunohistochemistry to detect neuronal fibrillar tau inclusions in human brain
Thu Apr 01 00:00:00 EDT 2010
TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy.
Journal of neuropathology and experimental neurology
McKee AC,Gavett BE,Stern RA,Nowinski CJ,Cantu RC,Kowall NW,Perl DP,Hedley-Whyte ET,Price B,Sullivan C,Morin P,Lee HS,Kubilus CA,Daneshvar DH,Wulff M,Budson AE
MN1040 was used in immunohistochemistry to study the mechanism for amyotrophic lateral sclerosis from head injury
Wed Sep 01 00:00:00 EDT 2010
Parenchymal and vascular lesions in ageing equine brains: histological and immunohistochemical studies.
Journal of comparative pathology
Capucchio MT,Márquez M,Pregel P,Foradada L,Bravo M,Mattutino G,Torre C,Schiffer D,Catalano D,Valenza F,Guarda F,Pumarola M
MN1040 was used in immunohistochemistry to investigate the lesions of parenchyma and vasculum in ageing equine brains with histological and immunohistochemical methods
Fri Jan 01 00:00:00 EST 2010
A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation.
The Journal of biological chemistry
Zheng YL,Amin ND,Hu YF,Rudrabhatla P,Shukla V,Kanungo J,Kesavapany S,Grant P,Albers W,Pant HC
MN1040 was used in western blot to investigate the effect of a p35 fragment on Cdk5-p25 activity and tau hyperphosphorylation
Fri Oct 29 00:00:00 EDT 2010
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
Journal of neuroinflammation
Stozicka Z,Zilka N,Novak P,Kovacech B,Bugos O,Novak M
MN1040 was used in immunohistochemistry to investigate the effect of genetic background on the pathology of Alzheimer disease rat model
Tue Oct 12 00:00:00 EDT 2010
Pericellular innervation of neurons expressing abnormally hyperphosphorylated tau in the hippocampal formation of Alzheimer's disease patients.
Frontiers in neuroanatomy
Blazquez-Llorca L,Garcia-Marin V,Defelipe J
MN1040 was used in immunohistochemistry to investigate the changes of synapses around tau positive neurons in the hippocampus of Alzheimer disease patients
Thu Jul 14 00:00:00 EDT 2011
Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
PLoS genetics
Khurana V,Elson-Schwab I,Fulga TA,Sharp KA,Loewen CA,Mulkearns E,Tyynelä J,Scherzer CR,Feany MB
MN1040 was used in western blot to investigate the role of lysosomal dysfunction in tau cleavage and neurotoxicity in vivo
Thu Jul 15 00:00:00 EDT 2010
Gender-Specific Neuroimmunoendocrine Response to Treadmill Exercise in 3xTg-AD Mice.
International journal of Alzheimer's disease
Giménez-Llort L,García Y,Buccieri K,Revilla S,Suñol C,Cristofol R,Sanfeliu C
MN1040 was used in immunohistochemistry to evaluate the neuroimmunoendocrine response toward forced physical exercise in 3xTg Alzheimer disease mice
Tue Oct 12 00:00:00 EDT 2010
Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction.
Cell death & disease
Corona C,Masciopinto F,Silvestri E,Viscovo AD,Lattanzio R,Sorda RL,Ciavardelli D,Goglia F,Piantelli M,Canzoniero LM,Sensi SL
MN1040 was used in immunohistochemistry to investigate the effect of zinc for Alzheimer disease treatment
Thu Oct 28 00:00:00 EDT 2010
Therapeutic versus neuroinflammatory effects of passive immunization is dependent on Aβ/amyloid burden in a transgenic mouse model of Alzheimer's disease.
Journal of neuroinflammation
Minami SS,Sidahmed E,Aid S,Shimoji M,Niikura T,Mocchetti I,Rebeck GW,Prendergast JS,Dealwis C,Wetzel R,Bosetti F,Matsuoka Y,Hoe HS,Turner RS
MN1040 was used in western blot to investigate the benefit vs. adverse effect of passive immunization in an Alzheimer disease model
Tue Sep 28 00:00:00 EDT 2010
Changes of tau profiles in brains of the hamsters infected with scrapie strains 263 K or 139 A possibly associated with the alteration of phosphate kinases.
BMC infectious diseases
Wang GR,Shi S,Gao C,Zhang BY,Tian C,Dong CF,Zhou RM,Li XL,Chen C,Han J,Dong XP
MN1040 was used in western blot to evaluate tau expression and phophorylatin profiles in scrapie experimental animals
Thu Apr 01 00:00:00 EDT 2010
Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy.
Proceedings of the National Academy of Sciences of the United States of America
Ohmi K,Kudo LC,Ryazantsev S,Zhao HZ,Karsten SL,Neufeld EF
MN1040 was used in immunohistochemistry to investigate the dysregulation of gene expression and tau phosphorylation in MPS III B mice
Tue May 19 00:00:00 EDT 2009
Expression of Lewy body protein septin 4 in postmortem brain of Parkinson's disease and control subjects.
Movement disorders : official journal of the Movement Disorder Society
Shehadeh L,Mitsi G,Adi N,Bishopric N,Papapetropoulos S
MN1040 was used in immunohistochemistry to investigate the changes of SEPT4 production in Parkinson disease patients
Fri Jan 30 00:00:00 EST 2009
Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wilcock DM,Gharkholonarehe N,Van Nostrand WE,Davis J,Vitek MP,Colton CA
MN1040 was used in western blot to investigate the efficiency of Alzheimer disease vaccine on tau pathology and neuronal protection in mouse models
Wed Jun 24 00:00:00 EDT 2009
Ultrastructural study of florid plaques in variant Creutzfeldt-Jakob disease: a comparison with amyloid plaques in kuru, sporadic Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker disease.
Neuropathology and applied neurobiology
Sikorska B,Liberski PP,Sobów T,Budka H,Ironside JW
MN1040 was used in immunohistochemistry to investigate the florid plaques in variant Creutzfeldt-Jakob diseases
Sun Feb 01 00:00:00 EST 2009
Brain-specific deletion of extracellular signal-regulated kinase 2 mitogen-activated protein kinase leads to aberrant cortical collagen deposition.
The American journal of pathology
Heffron DS,Landreth GE,Samuels IS,Mandell JW
MN1040 was used in Immunohistochemistry to investigate neural-specific functions of extracellular signal-regulated kinase 2 in the murine brain.
Tue Dec 01 00:00:00 EST 2009
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
Neurobiology of aging
Ojala J,Alafuzoff I,Herukka SK,van Groen T,Tanila H,Pirttilä T
MN1040 was used in immunohistochemistry to examine the expression of interleukin 18 in the brains of Alzheimer disease patients
Sun Feb 01 00:00:00 EST 2009
Wnt-pathway activation during the early stage of neurodegeneration in FTDP-17 mice.
Neurobiology of aging
Wiedau-Pazos M,Wong E,Solomon E,Alarcon M,Geschwind DH
MN1040 was used in immunohistochemistry to suggest Wnt-activation occurs prior to 3 months of age in the JNPL3 mouse model of frontotemporal dementia
Thu Jan 01 00:00:00 EST 2009
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model.
Human molecular genetics
Chatterjee S,Sang TK,Lawless GM,Jackson GR
MN1040 was used in western blot to study the roles of GSK3 beta, MARK and Cdk5 in the relationship between tau toxicity and phosphorylation
Thu Jan 01 00:00:00 EST 2009
Delivery of NGF to the brain: intranasal versus ocular administration in anti-NGF transgenic mice.
Journal of Alzheimer's disease : JAD
Capsoni S,Covaceuszach S,Ugolini G,Spirito F,Vignone D,Stefanini B,Amato G,Cattaneo A
MN1040 was used in immunohistochemistry to evaluate intranasal and ocular nerve growth factor administration in mice
Wed Jun 17 00:00:00 EDT 2009
Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains.
Journal of neural transmission (Vienna, Austria : 1996)
van Eersel J,Bi M,Ke YD,Hodges JR,Xuereb JH,Gregory GC,Halliday GM,Götz J,Kril JJ,Ittner LM
MN1040 was used in western blot to study the differences in soluble tau phpsphorylation and tau kinase activity in Pick's disease as compared to Alzheimer's disease
Thu Oct 01 00:00:00 EDT 2009
PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation.
Journal of neural transmission (Vienna, Austria : 1996)
Stieler JT,Bullmann T,Kohl F,Barnes BM,Arendt T
MN1040 was used in western blot to investigate the interaction between the phosphorylation of tau and the p25-formation
Sun Mar 01 00:00:00 EST 2009
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo.
Brain research
Bitner RS,Nikkel AL,Markosyan S,Otte S,Puttfarcken P,Gopalakrishnan M
MN1040 was used in immunohistochemistry to study the effect of alpha 7 nAChR activation on GSK3 and tau phosphorylation
Fri Apr 10 00:00:00 EDT 2009
Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury.
Journal of neuropathology and experimental neurology
McKee AC,Cantu RC,Nowinski CJ,Hedley-Whyte ET,Gavett BE,Budson AE,Santini VE,Lee HS,Kubilus CA,Stern RA
MN1040 was used in immunohistochemistry to study the progressive tauopathy following repetitive head injury in athletes
Wed Jul 01 00:00:00 EDT 2009
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
PloS one
Willuweit A,Velden J,Godemann R,Manook A,Jetzek F,Tintrup H,Kauselmann G,Zevnik B,Henriksen G,Drzezga A,Pohlner J,Schoor M,Kemp JA,von der Kammer H
MN1040 was used in immunohistochemistry to evaluate the amyloid pathology in a new Alzheimer disease mouse model
Fri Nov 20 00:00:00 EST 2009
Rapidly progressive neurodegenerative dementias.
Archives of neurology
Josephs KA,Ahlskog JE,Parisi JE,Boeve BF,Crum BA,Giannini C,Petersen RC
MN1040 was used in immunohistochemistry to study the neuropathology of patients with a neurodegenerative disease and a rapidly progressive course to death
Sun Feb 01 00:00:00 EST 2009
Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease.
The Journal of biological chemistry
Ittner LM,Ke YD,Götz J
MN1040 was used in western blot to study the interaction between phosphorylated Tau and c-Jun N-terminal kinase-interacting protein 1 in Alzheimer disease
Fri Jul 31 00:00:00 EDT 2009
The excitotoxin quinolinic acid induces tau phosphorylation in human neurons.
PloS one
Rahman A,Ting K,Cullen KM,Braidy N,Brew BJ,Guillemin GJ
MN1040 was used in immunohistochemistry to study the effect of quinolinic acid on tau phosphorylation in neurons
Wed Jul 22 00:00:00 EDT 2009
Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
The Journal of clinical investigation
Lim J,Balastik M,Lee TH,Nakamura K,Liou YC,Sun A,Finn G,Pastorino L,Lee VM,Lu KP
MN1040 was used in western blot to investigate the role of Pin1 in the regulation of tau in vivo
Thu May 01 00:00:00 EDT 2008
Beta-amyloid burden is not associated with rates of brain atrophy.
Annals of neurology
Josephs KA,Whitwell JL,Ahmed Z,Shiung MM,Weigand SD,Knopman DS,Boeve BF,Parisi JE,Petersen RC,Dickson DW,Jack CR
MN1040 was used in immunohistochemistry to investigate the relation between beta-amyloid burden and brain atrophy
Fri Feb 01 00:00:00 EST 2008
Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wilcock DM,Lewis MR,Van Nostrand WE,Davis J,Previti ML,Gharkholonarehe N,Vitek MP,Colton CA
MN1040 was used in immunohistochemistry to study the amyloid pathology of Alzheimer disease
Wed Feb 13 00:00:00 EST 2008
Argyrophilic grains: a distinct disease or an additive pathology?
Neurobiology of aging
Josephs KA,Whitwell JL,Parisi JE,Knopman DS,Boeve BF,Geda YE,Jack CR,Petersen RC,Dickson DW
MN1040 was used in immunohistochemistry to investigate the association between argyrophilic grains and atrophy
Tue Apr 01 00:00:00 EDT 2008
Tau kinase inhibitors protect hippocampal synapses despite of insoluble tau accumulation.
Molecular and cellular neurosciences
Hinners I,Hill A,Otto U,Michalsky A,Mack TG,Striggow F
MN1040 was used in immunohistochemistry to study the function of tau kinase inhibitors in protecting hippocampal synapses from accumulation of insoluble tau
Sat Mar 01 00:00:00 EST 2008
Age and apoE associations with complex pathologic features in Alzheimer's disease.
Journal of the neurological sciences
Jicha GA,Parisi JE,Dickson DW,Cha RH,Johnson KA,Smith GE,Boeve BF,Petersen RC,Knopman DS
MN1040 was used in immunohistochemistry to study the role of age and apoE in Alzheimer disease pathology
Wed Oct 15 00:00:00 EDT 2008
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease.
The Journal of pharmacology and experimental therapeutics
Matsuoka Y,Jouroukhin Y,Gray AJ,Ma L,Hirata-Fukae C,Li HF,Feng L,Lecanu L,Walker BR,Planel E,Arancio O,Gozes I,Aisen PS
MN1040 was used in western blot to investigate the effect of a neuronal microtubule-interacting agent NAPVSIPQ on tau pathology and cognitive function in an Alzheimer disease mouse model
Tue Apr 01 00:00:00 EDT 2008
Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells.
Journal of neuroimmunology
Ojala JO,Sutinen EM,Salminen A,Pirttilä T
MN1040 was used in western blot to suggest that IL-18 over-expression induces hyperphosphorylation of tau and induces cell cycle activators
Mon Dec 15 00:00:00 EST 2008
Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes.
Age (Dordrecht, Netherlands)
Myung NH,Zhu X,Kruman II,Castellani RJ,Petersen RB,Siedlak SL,Perry G,Smith MA,Lee HG
MN1040 was used in immunocytochemistry to investigate the changes of gamma H2AX production in astrocytes of Alzheimer disease patients
Mon Dec 01 00:00:00 EST 2008
Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.
International journal of clinical and experimental pathology
Thakur A,Siedlak SL,James SL,Bonda DJ,Rao A,Webber KM,Camins A,Pallàs M,Casadesus G,Lee HG,Bowser R,Raina AK,Perry G,Smith MA,Zhu X
MN1040 was used in immunocytochemistry to investigate the changes of pRb phosphorylation in neurons of Alzheimer disease patients
Tue Jan 01 00:00:00 EST 2008
Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
The Journal of clinical investigation
Dias-Santagata D,Fulga TA,Duttaroy A,Feany MB
MN1040 was used in western blot to study the role of oxidative stress in tau-induced neurodegeneration in Drosophila
Mon Jan 01 00:00:00 EST 2007
Argyrophilic thorny astrocyte clusters in association with Alzheimer's disease pathology in possible primary progressive aphasia.
Acta neuropathologica
Munoz DG,Woulfe J,Kertesz A
MN1040 was used in immunohistochemistry to study argyrophilic thorny astrocyte clusters in aphasia
Mon Oct 01 00:00:00 EDT 2007
Rates of cerebral atrophy differ in different degenerative pathologies.
Brain : a journal of neurology
Whitwell JL,Jack CR,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Ferman TJ,Dickson DW,Josephs KA
MN1040 was used in immunohistochemistry to study the neuropathology of patients with different degenerative pathologies
Sun Apr 01 00:00:00 EDT 2007
A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology.
Brain : a journal of neurology
Leverenz JB,Yu CE,Montine TJ,Steinbart E,Bekris LM,Zabetian C,Kwong LK,Lee VM,Schellenberg GD,Bird TD
MN1040 was used in immunohistochemistry to characterize a new progranulin mutation and its role in tau, TDP43 and alpha-synuclein pathology
Tue May 01 00:00:00 EDT 2007
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies.
Proceedings of the National Academy of Sciences of the United States of America
Luo W,Dou F,Rodina A,Chip S,Kim J,Zhao Q,Moulick K,Aguirre J,Wu N,Greengard P,Chiosis G
MN1040 was used in western blot to study the contribution of heat-shock protein 90 towards tauopathies
Tue May 29 00:00:00 EDT 2007
Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Planel E,Tatebayashi Y,Miyasaka T,Liu L,Wang L,Herman M,Yu WH,Luchsinger JA,Wadzinski B,Duff KE,Takashima A
MN1040 was used in western blot to investigate the effect of insulin deficiency on tau hyperphosphorylation and its mechanism
Wed Dec 12 00:00:00 EST 2007
Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Green KN,Martinez-Coria H,Khashwji H,Hall EB,Yurko-Mauro KA,Ellis L,LaFerla FM
MN1040 was used in western blot to study the effect of docosahexaenoic acid and docosapentaenoic acid on amyloid beta and tau pathology
Wed Apr 18 00:00:00 EDT 2007
Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia.
The international journal of neuropsychopharmacology
Piggott MA,Ballard CG,Dickinson HO,McKeith IG,Perry RH,Perry EK
MN1040 was used in immunohistochemistry to investigate thalamic D2 density in Parkinson disease
Sun Apr 01 00:00:00 EDT 2007
Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease.
Neurobiology of aging
Grudzien A,Shaw P,Weintraub S,Bigio E,Mash DC,Mesulam MM
MN1040 was used in immunohistochemistry to investigate the pathological changes in locus coeruleus of Alzheimer disease patients
Thu Mar 01 00:00:00 EST 2007
Inflammatory changes parallel the early stages of Alzheimer disease.
Neurobiology of aging
Parachikova A,Agadjanyan MG,Cribbs DH,Blurton-Jones M,Perreau V,Rogers J,Beach TG,Cotman CW
MN1040 was used in immunohistochemistry to study the immune dysfunction in early stages of Alzheimer disease
Sat Dec 01 00:00:00 EST 2007
Neuropathologic features of frontotemporal lobar degeneration with ubiquitin-positive inclusions with progranulin gene (PGRN) mutations.
Journal of neuropathology and experimental neurology
Josephs KA,Ahmed Z,Katsuse O,Parisi JF,Boeve BF,Knopman DS,Petersen RC,Davies P,Duara R,Graff-Radford NR,Uitti RJ,Rademakers R,Adamson J,Baker M,Hutton ML,Dickson DW
MN1040 was used in immunohistochemistry to conduct neuropathologic analysis on frontotemporal lobar degeneration
Thu Feb 01 00:00:00 EST 2007
Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline.
Synapse (New York, N.Y.)
Piggott MA,Ballard CG,Rowan E,Holmes C,McKeith IG,Jaros E,Perry RH,Perry EK
MN1040 was used in immunohistochemistry to investigate the changes of D2 receptors in dementia patients
Thu Nov 01 00:00:00 EDT 2007
Bilateral striopallidodentate calcification (Fahr's syndrome) and multiple system atrophy in a patient with longstanding hypoparathyroidism.
Neuropathology : official journal of the Japanese Society of Neuropathology
Preusser M,Kitzwoegerer M,Budka H,Brugger S
MN1040 was used in immunohistochemistry to investigate the changes of brain structure in a patient with longstanding hypoparathyroidism
Mon Oct 01 00:00:00 EDT 2007
BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease.
International journal of medical sciences
Evans TA,Raina AK,Delacourte A,Aprelikova O,Lee HG,Zhu X,Perry G,Smith MA
MN1040 was used in immunohistochemistry to study the role of BRCA1 in Alzheimer disease
Sat May 12 00:00:00 EDT 2007
Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study.
Brain : a journal of neurology
Boeve BF,Baker M,Dickson DW,Parisi JE,Giannini C,Josephs KA,Hutton M,Pickering-Brown SM,Rademakers R,Tang-Wai D,Jack CR,Kantarci K,Shiung MM,Golde T,Smith GE,Geda YE,Knopman DS,Petersen RC
MN1040 was used in immunohistochemistry to investigate the relationship between frontotemporal dementia and parkinsonism and progranulin mutation
Wed Nov 01 00:00:00 EST 2006
Neuropathology in the S305S tau gene mutation.
Brain : a journal of neurology
Halliday GM,Song YJ,Creasey H,Morris JG,Brooks WS,Kril JJ
MN1040 was used in immunohistochemistry to study the neuropathology of S305S mutation in tau gene
Wed Mar 01 00:00:00 EST 2006
Memory complaints are related to Alzheimer disease pathology in older persons.
Neurology
Barnes LL,Schneider JA,Boyle PA,Bienias JL,Bennett DA
MN1040 was used in immunohistochemistry to investigate the relationship between memory complaints and Alzheimer disease pathology
Tue Nov 14 00:00:00 EST 2006
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wahle T,Thal DR,Sastre M,Rentmeister A,Bogdanovic N,Famulok M,Heneka MT,Walter J
MN1040 was used in immunohistochemistry to study the expression of GGA1 and its effect on amyloid beta peptide
Wed Dec 06 00:00:00 EST 2006
High cholesterol content in neurons increases BACE, beta-amyloid, and phosphorylated tau levels in rabbit hippocampus.
Experimental neurology
Ghribi O,Larsen B,Schrag M,Herman MM
MN1040 was used in western blot to study the effect of high cholesterol content on BACE, beta-amyloid and phosphorylated tau levels in hippocampus
Tue Aug 01 00:00:00 EDT 2006
Presence of calpain-induced proteolysis in retinal degeneration and dysfunction in a rat model of acute ocular hypertension.
Journal of neuroscience research
Oka T,Tamada Y,Nakajima E,Shearer TR,Azuma M
MN1040 was used in western blot to demonstrate the assocation of calpain-dependent proteolysis with inner retinal neuronal cell death and retinal dysfunction
Mon May 15 00:00:00 EDT 2006
Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations.
Parkinsonism & related disorders
Papapetropoulos S,McCorquodale DS,Gonzalez J,Jean-Gilles L,Mash DC
MN1040 was used in immunohistochemistry to study the Lewy body in Parkinson disease
Mon May 01 00:00:00 EDT 2006
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment.
Journal of neuropathology and experimental neurology
Jicha GA,Petersen RC,Knopman DS,Boeve BF,Smith GE,Geda YE,Johnson KA,Cha R,Delucia MW,Braak H,Dickson DW,Parisi JE
MN1040 was used in immunohistochemistry to study the argyrophilic grain disease pathology in demented subjects with amnestic mild cognitive impairment
Thu Jun 01 00:00:00 EDT 2006
Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits.
Journal of feline medicine and surgery
Gunn-Moore DA,McVee J,Bradshaw JM,Pearson GR,Head E,Gunn-Moore FJ
MN1040 was used in immunohistochemistry to study the age-dependent pathological changes in cat brains
Tue Aug 01 00:00:00 EDT 2006
The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease.
The Journal of biological chemistry
Galas MC,Dourlen P,Bégard S,Ando K,Blum D,Hamdane M,Buée L
MN1040 was used in western blot to examine the role of peptidylprolyl cis/trans-isomerase Pin1 in neuronal tau dephosphorylation
Fri Jul 14 00:00:00 EDT 2006
Cognitive impairment and celiac disease.
Archives of neurology
Hu WT,Murray JA,Greenaway MC,Parisi JE,Josephs KA
MN1040 was used in immunohistochemistry to characterize the histological features of cognitive impaired patients associated with celiac disease
Sun Oct 01 00:00:00 EDT 2006
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia.
Archives of neurology
Jicha GA,Parisi JE,Dickson DW,Johnson K,Cha R,Ivnik RJ,Tangalos EG,Boeve BF,Knopman DS,Braak H,Petersen RC
MN1040 was used in immunohistochemistry to investigate the neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
Mon May 01 00:00:00 EDT 2006
Tau interacts with Golgi membranes and mediates their association with microtubules.
Cell motility and the cytoskeleton
Farah CA,Perreault S,Liazoghli D,Desjardins M,Anton A,Lauzon M,Paiement J,Leclerc N
MN1040 was used in western blot to study the interaction between Tau and Golgi membranes and its function
Wed Nov 01 00:00:00 EST 2006
Neuropathologic features of amnestic mild cognitive impairment.
Archives of neurology
Petersen RC,Parisi JE,Dickson DW,Johnson KA,Knopman DS,Boeve BF,Jicha GA,Ivnik RJ,Smith GE,Tangalos EG,Braak H,Kokmen E
MN1040 was used in immunohistochemistry to compare the amyloid and neurofibrillary pathologic features in healthy, amnestic mild cognitive impairment, and Alzheimer disease cases
Mon May 01 00:00:00 EDT 2006
Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates.
Acta neuropathologica
Fukuda T,Shimizu J,Furuhata H,Abe T,Shimizu K,Oishi T,Ogihara M,Kubota J,Sasaki A,Sasaki K,Azuma T,Umemura S
MN1040 was used in immunohistochemistry to study HSP overexpression in nonhuman aged primate pallido-nigral axonal spheroids
Mon Aug 01 00:00:00 EDT 2005
Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology.
Acta neuropathologica
Newman J,Rissman RA,Sarsoza F,Kim RC,Dick M,Bennett DA,Cotman CW,Rohn TT,Head E
MN1040 was used in immunohistochemistry to study the accumulation of Tau fragments in neurodegenerative diseases
Mon Aug 01 00:00:00 EDT 2005
Antemortem diagnosis of frontotemporal lobar degeneration.
Annals of neurology
Knopman DS,Boeve BF,Parisi JE,Dickson DW,Smith GE,Ivnik RJ,Josephs KA,Petersen RC
MN1040 was used in immunohistochemistry to diagnose and classify frontotemporal lobar degenerations based on tau and ubiquitin immunostaining
Fri Apr 01 00:00:00 EST 2005
Tau phosphorylation increases in symptomatic mice overexpressing A30P alpha-synuclein.
Experimental neurology
Frasier M,Walzer M,McCarthy L,Magnuson D,Lee JM,Haas C,Kahle P,Wolozin B
MN1040 was used in immunohistochemistry to study the effect of A30P alpha synuclein on tau phosphorylation
Fri Apr 01 00:00:00 EST 2005
Very low levels of methylmercury induce cell death of cultured rat cerebellar neurons via calpain activation.
Toxicology
Sakaue M,Okazaki M,Hara S
MN1040 was used in western blot to investigate the mechanism of apoptosis stimulated by methylmercury in vivo
Thu Sep 15 00:00:00 EDT 2005
Tau protein aggregation in the frontal and entorhinal cortices as a function of aging.
Brain research. Developmental brain research
Yang W,Ang LC,Strong MJ
MN1040 was used in immunohistochemistry to characterize the age-dependent tau protein aggregation in frontal and entorhinal cortices
Thu May 12 00:00:00 EDT 2005
Novel presenilin 1 mutation with profound neurofibrillary pathology in an indigenous Southern African family with early-onset Alzheimer's disease.
Brain : a journal of neurology
Heckmann JM,Low WC,de Villiers C,Rutherfoord S,Vorster A,Rao H,Morris CM,Ramesar RS,Kalaria RN
MN1040 was used in immunohistochemistry to investigate the phenotypes of Southern African patients with presenilin 1 disruption
Thu Jan 01 00:00:00 EST 2004
Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules.
The Journal of biological chemistry
Li G,Yin H,Kuret J
MN1040 was used in western blot to study the tau phosphorylation by Cki delta and its effect on microtubule binding
Fri Apr 16 00:00:00 EDT 2004
Coexistent Lewy body disease in a case of "visual variant of Alzheimer's disease".
Journal of neurology, neurosurgery, and psychiatry
Tang-Wai DF,Josephs KA,Boeve BF,Petersen RC,Parisi JE,Dickson DW
MN1040 was used in immunohistochemistry to study a clinical case with both Lewy body and Alzheimer diseases
Sat Mar 01 00:00:00 EST 2003
Distribution, levels, and activation of MEK1 in Alzheimer's disease.
Journal of neurochemistry
Zhu X,Sun Z,Lee HG,Siedlak SL,Perry G,Smith MA
MN1040 was used in immunocytochemistry to characterize the MEK1 protein in Alzheimer disease
Tue Jul 01 00:00:00 EDT 2003
Neuropathology of cognitively normal elderly.
Journal of neuropathology and experimental neurology
Knopman DS,Parisi JE,Salviati A,Floriach-Robert M,Boeve BF,Ivnik RJ,Smith GE,Dickson DW,Johnson KA,Petersen LE,McDonald WC,Braak H,Petersen RC
MN1040 was used in immunohistochemistry to investigate the neuropathology of cognitively normal elderly
Sat Nov 01 00:00:00 EST 2003
Molecular cloning and functional characterization of chicken brain tau: isoforms with up to five tandem repeats.
Biochemistry
Yoshida H,Goedert M
MN1040 was used in western blot to investigate the function of chicken brain tau
Tue Dec 24 00:00:00 EST 2002
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Ko J,Humbert S,Bronson RT,Takahashi S,Kulkarni AB,Li E,Tsai LH
MN1040 was used in western blot to investigate the role of p35 and p39 in the regulation of cyclin-dependent kinase 5 activity during neurodevelopment
Sat Sep 01 00:00:00 EDT 2001
Structural analysis of Pick's disease-derived and in vitro-assembled tau filaments.
The American journal of pathology
King ME,Ghoshal N,Wall JS,Binder LI,Ksiezak-Reding H
MN1040 was used in western blot to investigate the differences between the structure of tau filaments from variant sources
Sun Apr 01 00:00:00 EST 2001
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis.
Mechanisms of ageing and development
Zhu X,Castellani RJ,Takeda A,Nunomura A,Atwood CS,Perry G,Smith MA
MN1040 was used in immunocytochemistry to investigate the regulation of MAPK pathways during the progression of Alzheimer disease
Sat Dec 01 00:00:00 EST 2001
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads.
Acta neuropathologica
Braak E,Braak H,Mandelkow EM
MN1040 was used in immunocytochemistry to investigate the correlation between the changes in the cytoskeleton and the formation of neurofibrillary tangles and neuropil threads
Mon Oct 17 00:00:00 EDT 1994
