Product References
PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway.
Cell death & disease
Li H,Guan B,Liu S,Liu H,Song L,Zhang G,Zhao R,Zhou C,Gao P
44-1125G was used in Western blotting following immunoprecipitation to provide a theoretical basis to better understand the occurrence and development of gastric cancer.
Fri Mar 10 00:00:00 EST 2023
Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/D-galactose Alzheimer's rat model.
Inflammopharmacology
Ibrahim WW,Kamel AS,Wahid A,Abdelkader NF
44-1125G was used in Western Blot to screen the power of DAPA centrally on LKB1/AMPK/SIRT1/mTOR signaling in the ovariectomized/D-galactose (OVX/D-Gal) rat model.
Thu Dec 01 00:00:00 EST 2022
Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell-derived retinal organoids.
Cell death discovery
Lee SH,Han JW,Yang JY,Jun HO,Bang JH,Shin H,Choi JH,Lee J,Madrakhimov SB,Chung KH,Chang HS,Lyu J,Park TK
44-1125G was used in Immunohistochemistry (PFA fixed) to identify the time-dependent role of mTORC1 in retinal development, specifically in retinal ganglion cell (RGC) differentiation and the retinal lamination process, during the early stages of retinal organoid (RO) development.
Tue Feb 08 00:00:00 EST 2022
Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.
Development (Cambridge, England)
Ma Y,Jing J,Feng J,Yuan Y,Wen Q,Han X,He J,Chen S,Ho TV,Chai Y
44-1125G was used in Western Blotting to provide novel insights into the function of Ror2-mediated non-canonical Wnt signaling in regulating tooth morphogenesis, and suggest potential avenues for dental tissue engineering.
Thu Jan 21 00:00:00 EST 2021
Ror2-mediated non-canonical Wnt signaling regulates Cdc42 and cell proliferation during tooth root development.
Development (Cambridge, England)
Ma Y,Jing J,Feng J,Yuan Y,Wen Q,Han X,He J,Chen S,Ho TV,Chai Y
44-1125G was used in Western Blotting to provide novel insights into the function of Ror2-mediated non-canonical Wnt signaling in regulating tooth morphogenesis, and suggest potential avenues for dental tissue engineering.
Thu Jan 21 00:00:00 EST 2021
ACSL4 contributes to sevoflurane-induced ferroptotic neuronal death in SH-SY5Y cells via the 5' AMP-activated protein kinase/mammalian target of rapamycin pathway.
Annals of translational medicine
Cheng L,Zhu X,Liu Y,Zhu K,Lin K,Li F
44-1125G was used in Western Blot to show that downregulation of ACSL4 restrained sev-induced ferroptotic cell death via AMPK/mTOR signaling, providing the basis for an approach to alleviate sev-induced postoperative cognitive dysfunction (POCD).
Wed Sep 01 00:00:00 EDT 2021
Implications of cell division cycle associated 4 on the Wilm's tumor cells viability via AKT/mTOR signaling pathway.
Renal failure
Li S,Qin C,Chen Y,Wei D,Tan Z,Meng J
Published figure using Phospho-mTOR (Ser2448) polyclonal antibody (Product # 44-1125G) in Western Blot
Wed Dec 01 00:00:00 EST 2021
MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer.
Cancers
Hermanowicz JM,Pawlak K,Sieklucka B,Czarnomysy R,Kwiatkowska I,Kazberuk A,Surazynski A,Mojzych M,Pawlak D
44-1125G was used in Immunocytochemistry, Western Blot to examine the pharmacodynamics of MM-129 as a novel promising drug candidate against colon cancer.
Sat Jun 26 00:00:00 EDT 2021
MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer.
Cancers
Hermanowicz JM,Pawlak K,Sieklucka B,Czarnomysy R,Kwiatkowska I,Kazberuk A,Surazynski A,Mojzych M,Pawlak D
44-1125G was used in Immunocytochemistry, Western Blot to examine the pharmacodynamics of MM-129 as a novel promising drug candidate against colon cancer.
Sat Jun 26 00:00:00 EDT 2021
MM-129 as a Novel Inhibitor Targeting PI3K/AKT/mTOR and PD-L1 in Colorectal Cancer.
Cancers
Hermanowicz JM,Pawlak K,Sieklucka B,Czarnomysy R,Kwiatkowska I,Kazberuk A,Surazynski A,Mojzych M,Pawlak D
44-1125G was used in Immunocytochemistry, Western Blot to examine the pharmacodynamics of MM-129 as a novel promising drug candidate against colon cancer.
Sat Jun 26 00:00:00 EDT 2021
Discovery of a novel potentially transforming somatic mutation in CSF2RB gene in breast cancer.
Cancer medicine
Rashid M,Ali R,Almuzzaini B,Song H,AlHallaj A,Abdulkarim AA,Mohamed Baz O,Al Zahrani H,Mustafa Sabeena M,Alharbi W,Hussein M,Boudjelal M
44-1125G was used in Western Blotting to report the discovery of a mutation in the CSF2RB gene of a breast cancer patient and the cell line KAIMRC1.
Mon Nov 01 00:00:00 EDT 2021
Isolation and Establishment of a Highly Proliferative, Cancer Stem Cell-Like, and Naturally Immortalized Triple-Negative Breast Cancer Cell Line, KAIMRC2.
Cells
Ali R,Al Zahrani H,Barhoumi T,Alhallaj A,Mashhour A,Alshammari MA,Alshawakir YA,Baz O,Alanazi AH,Khan AL,Al Nikhli H,Al Balwi MA,Al Riyees L,Boudjelal M
44-1125G was used in Western Blot to report the establishment of a naturally immortalized highly tumorigenic and triple-negative breast cancer cell line, KAIMRC2.
Mon May 24 00:00:00 EDT 2021
PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes.
Cells
Wilczek MP,Armstrong FJ,Mayberry CL,King BL,Maginnis MS
44-1125G was used in Western Blot to understand the signaling pathways activated in response to JCPyV infection, revealing and establishing the importance of the PI3K/AKT/mTOR signaling pathway in JCPyV infection in primary human astrocytes compared to transformed cell lines.
Thu Nov 18 00:00:00 EST 2021
Sinoporphyrin sodium is a promising sensitizer for photodynamic and sonodynamic therapy in glioma.
Oncology reports
An YW,Liu HQ,Zhou ZQ,Wang JC,Jiang GY,Li ZW,Wang F,Jin HT
44-1125G was used in Western Blotting to explore the antitumor effects of sinoporphyrin sodium (DVDMS)‚mediated photodynamic therapy (PDT) and sonodynamic therapy (SDT) in glioma, and to reveal the underlying mechanisms.
Thu Oct 01 00:00:00 EDT 2020
Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway.
BMC cancer
Ye T,Wei L,Shi J,Jiang K,Xu H,Hu L,Kong L,Zhang Y,Meng S,Piao H
44-1125G was used in Western Blotting to explore the activity of the Sirt1 activator SRT2183 in glioma cell lines in terms of biological response.
Thu Jul 18 00:00:00 EDT 2019
Silence of α1-Antitrypsin Inhibits Migration and Proliferation of Triple Negative Breast Cancer Cells.
Medical science monitor : international medical journal of experimental and clinical research
Zhao Z,Ma J,Mao Y,Dong L,Li S,Zhang Y
44-1125G was used in Western Blotting to explore the influence of silencing α1-antitrypsin on the abilities of migration and invasion, and study its molecular mechanism in triple negative breast cancer cells.
Thu Sep 27 00:00:00 EDT 2018
Phase II study of the oral MEK inhibitor selumetinib in advanced acute myelogenous leukemia: a University of Chicago phase II consortium trial.
Clinical cancer research : an official journal of the American Association for Cancer Research
Jain N,Curran E,Iyengar NM,Diaz-Flores E,Kunnavakkam R,Popplewell L,Kirschbaum MH,Karrison T,Erba HP,Green M,Poire X,Koval G,Shannon K,Reddy PL,Joseph L,Atallah EL,Dy P,Thomas SP,Smith SE,Doyle LA,Stadler WM,Larson RA,Stock W,Odenike O
44-1125G was used in flow cytometry to determine the clinical relevance of the RAS/RAF/MEK/ERK pathway in patients with acute myelogenous leukemia
Wed Jan 15 00:00:00 EST 2014
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase.
The Journal of biological chemistry
Holz MK,Blenis J
Fri Jul 15 00:00:00 EDT 2005