Product References
G3BP1 coordinates lysophagy activity to protect against compression-induced cell ferroptosis during intervertebral disc degeneration.
Cell proliferation
Li S,Liao Z,Yin H,Liu O,Hua W,Wu X,Zhang Y,Gao Y,Yang C
Wed Mar 01 00:00:00 EST 2023
ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway.
International ophthalmology
Liu W,Chen Y,Song X,Xue Y,Zhang Y
Mon May 01 00:00:00 EDT 2023
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Science China. Life sciences
Zhang M,Zhang B,Wang X,Song J,Tong M,Dong Z,Xu J,Liu M,Jiang Y,Wang N,Wang Y,Du Z,Liu Y,Zhang R,Xu C
Sat Apr 01 00:00:00 EDT 2023
TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.
Journal of translational medicine
Zhong WJ,Zhang J,Duan JX,Zhang CY,Ma SC,Li YS,Yang NS,Yang HH,Xiong JB,Guan CX,Jiang ZX,You ZJ,Zhou Y
Mon Mar 06 00:00:00 EST 2023
A Novel Phenazine Analog, CPUL1, Suppresses Autophagic Flux and Proliferation in Hepatocellular Carcinoma: Insight from Integrated Transcriptomic and Metabolomic Analysis.
Cancers
Chen J,Feng D,Lu Y,Zhang Y,Jiang H,Yuan M,Xu Y,Zou J,Zhu Y,Zhang J,Ge C,Wang Y
Sun Mar 05 00:00:00 EST 2023
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
The Journal of nutritional biochemistry
Lin G,Qi H,Guo X,Wang W,Zhang M,Gao X
Sat Apr 01 00:00:00 EDT 2023
Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma.
Journal of natural products
Liu L,Shi D,Xia ZY,Wang BW,Wang XL,Wang XT,Wang GL,Li MJ,Zheng QS,Li D,Li BH
Fri Apr 28 00:00:00 EDT 2023
EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage.
BMC cancer
Zheng Y,Wang L,Niu X,Guo Y,Zhao J,Li L,Zhao J
Sat Jan 07 00:00:00 EST 2023
Inhibition of ATF4-mediated elevation of both autophagy and AKT/mTOR was involved in antitumorigenic activity of curcumin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Yang J,Bao S,Luo S,Jiang L,Li Q,Kong Y,Cao J
Wed Mar 01 00:00:00 EST 2023
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Translational oncology
Deng Y,Ma J,Zhao S,Yang M,Sun Y,Zhang Q
Wed Feb 01 00:00:00 EST 2023
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Journal of orthopaedic translation
Lu R,Xu H,Deng X,Wang Y,He Z,Xu S,Liang S,Huang X,You H,Guo F,Cheng P,Chen AM
Wed Mar 01 00:00:00 EST 2023
Oncogenic roles of GPR176 in breast cancer: a potential marker of aggressiveness and a potential target of gene therapy.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Yun WJ,Xue H,Yang N,Xiao LJ,Sun HZ,Zheng HC
Sun Oct 01 00:00:00 EDT 2023
S100A6 promotes the development of thyroid cancer and inhibits apoptosis of thyroid cancer cells through the PI3K/AKT/mTOR pathway.
Pathology, research and practice
Chen B,Zheng D,Liu C,Bhandari A,Hirachan S,Shen C,Mainali S,Li H,Jiang W,Xu J,Zhang X,Tang K,Zhang W
Wed Feb 01 00:00:00 EST 2023
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Endocrinology
He W,Cheng Z,Huo Z,Lin B,Wang X,Sun Y,Yu S,Cao S,Xue J,Liu R,Lv W,Li Y,Hong S,Xiao H
Mon Jan 09 00:00:00 EST 2023
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Endocrinology
He W,Cheng Z,Huo Z,Lin B,Wang X,Sun Y,Yu S,Cao S,Xue J,Liu R,Lv W,Li Y,Hong S,Xiao H
Mon Jan 09 00:00:00 EST 2023
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Endocrinology
He W,Cheng Z,Huo Z,Lin B,Wang X,Sun Y,Yu S,Cao S,Xue J,Liu R,Lv W,Li Y,Hong S,Xiao H
Mon Jan 09 00:00:00 EST 2023
STRA6 Promotes Thyroid Carcinoma Progression via Activation of the ILK/AKT/mTOR Axis in Cells and Female Nude Mice.
Endocrinology
He W,Cheng Z,Huo Z,Lin B,Wang X,Sun Y,Yu S,Cao S,Xue J,Liu R,Lv W,Li Y,Hong S,Xiao H
Mon Jan 09 00:00:00 EST 2023
The Key Role of Initiation Timing on Stroke Rehabilitation by Remote Ischemic Conditioning with Exercise (RICE).
Neurological research
Wang Q,Wehbe A,Wills M,Li F,Geng X,Ding Y
Sat Apr 01 00:00:00 EDT 2023
Promotion of colorectal cancer cell death by ezetimibe via mTOR signaling-dependent mitochondrial dysfunction.
Frontiers in pharmacology
Zheng Y,Yang W,Jia Y,Ji J,Wu L,Feng J,Li Y,Cheng Z,Zhang J,Li J,Dai W,Xu X,Wu J,Zhou Y,Guo C
Tue Feb 28 00:00:00 EST 2023
Promotion of colorectal cancer cell death by ezetimibe via mTOR signaling-dependent mitochondrial dysfunction.
Frontiers in pharmacology
Zheng Y,Yang W,Jia Y,Ji J,Wu L,Feng J,Li Y,Cheng Z,Zhang J,Li J,Dai W,Xu X,Wu J,Zhou Y,Guo C
Tue Feb 28 00:00:00 EST 2023
mTOR/ULK1 signaling axis mediated ultrashort wave regulation of autophagy to alleviate diabetic kidney disease.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University
Yan Y,Yu S,Fan Y
Wed Nov 01 00:00:00 EDT 2023
Antidepressant-like effect of CP-101,606: Evidence of mTOR pathway activation.
Molecular and cellular neurosciences
Qin Y,Guo X,Song W,Liang Z,Wang Y,Feng D,Yang Y,Li M,Gao M
Wed Mar 01 00:00:00 EST 2023
Xue-Jie-San prevents the early development of colitis-associated intestinal fibrosis by blocking Notch1 and FGL1 signaling pathways.
Journal of ethnopharmacology
Gao Y,Lu LJ,Zhang ZZ,Yang X,Du J,Wen K,Huang H,Wang XP,Sun XL
Sat Oct 28 00:00:00 EDT 2023
ZD6474 Attenuates Fibrosis and Inhibits Neovascularization in Human Pterygium by Suppressing AKT-mTOR Signaling Pathway.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Liu W,Lin T,Gong L
Wed Mar 01 00:00:00 EST 2023
CC-115 Mediates GSDME-Dependent Pyroptosis in Lung Adenocarcinoma Through the Akt/Bax Pathway.
Journal of Cancer
Zhang T,Liu MQ,Xie GS,Wu DM,Luo PW,Liu T,Deng SH,Wang YY,He S,Zhou Y,Zhou J,Xu Y
Thu Jun 08 00:00:00 EDT 2023
Chromatin remodeler BRM is a key mediator of leucine-stimulated mTOR gene transcription in mouse mammary epithelial cells.
Biochemical and biophysical research communications
Ke C,Zhao S,Wang L,Zhang M,Gao X
Sun Feb 05 00:00:00 EST 2023
Cul5 mediates taurine-stimulated mTOR mRNA expression and proliferation of mouse mammary epithelial cells.
Amino acids
Xu M,Zhou Y,Fan S,Zhang M,Gao X
Wed Feb 01 00:00:00 EST 2023
GSTP1-mediated S-glutathionylation of Pik3r1 is a redox hub that inhibits osteoclastogenesis through regulating autophagic flux.
Redox biology
Ji X,Hong J,Yang W,Yao M,Wang J,Jiang G,Wang Y,Li C,Lin J,Mou H,Li C,Li S,Chen Y,Shi M,Wang W,Lu F,Wu H,Zhao X,Qi Y,Yan S
Mon May 01 00:00:00 EDT 2023
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Journal of ethnopharmacology
Shi Y,Zhang ZW,Du MM,Wu J,Li JX
Thu Aug 10 00:00:00 EDT 2023
TREM-1 governs NLRP3 inflammasome activation of macrophages by firing up glycolysis in acute lung injury.
International journal of biological sciences
Zhong WJ,Liu T,Yang HH,Duan JX,Yang JT,Guan XX,Xiong JB,Zhang YF,Zhang CY,Zhou Y,Guan CX
Wed Jan 04 00:00:00 EST 2023
cRGD-targeted heparin nanoparticles for effective dual drug treatment of cisplatin-resistant ovarian cancer.
Journal of controlled release : official journal of the Controlled Release Society
Liang X,Yang Y,Huang C,Ye Z,Lai W,Luo J,Li X,Yi X,Fan JB,Wang Y,Wang Y
Sat Apr 01 00:00:00 EDT 2023
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
The Prostate
Chang T,Lian Z,Ma S,Liang Z,Ma X,Wen X,Wang Y,Liu R
Sat Apr 01 00:00:00 EDT 2023
LncRNA NR120519 Blocks KRT17 to Promote Cell Proliferation and Migration in Hypopharyngeal Squamous Carcinoma.
Cancers
Zhou Z,Zhang G,Li T,Ai J,Li W,Zeng S,Ye M,Liu Q,Xiao J,Li Y,Tan G,Zhang X
Wed Jan 18 00:00:00 EST 2023
Cytotoxic Steroidal Saponins Containing a Rare Fructosyl from the Rhizomes of Paris polyphylla var. latifolia.
International journal of molecular sciences
Li TY,Du Y,Wang MC,Liu K,Liu Y,Cao Y,Wang YY,Chen WW,Qian XY,Qiu PC,Tang HF,Lu YY
Wed Apr 12 00:00:00 EDT 2023
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cell death & disease
Cai J,Ye Z,Hu Y,Ye L,Gao L,Wang Y,Sun Q,Tong S,Zhang S,Wu L,Yang J,Chen Q
Sat Mar 25 00:00:00 EDT 2023
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cell death & disease
Cai J,Ye Z,Hu Y,Ye L,Gao L,Wang Y,Sun Q,Tong S,Zhang S,Wu L,Yang J,Chen Q
Sat Mar 25 00:00:00 EDT 2023
hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration.
Journal of orthopaedic translation
Chen D,Jiang X,Zou H
Wed Mar 01 00:00:00 EST 2023
Peptide encoded by lncRNA BVES-AS1 promotes cell viability, migration, and invasion in colorectal cancer cells via the SRC/mTOR signaling pathway.
PloS one
Zheng W,Guo Y,Zhang G,Bai J,Song Y,Song X,Zhu Q,Bao X,Wu G,Zhang C
Mon Jun 26 00:00:00 EDT 2023
TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway.
Biochemical pharmacology
Man J,Zhou W,Zuo S,Zhao X,Wang Q,Ma H,Li HY
Sat Jul 01 00:00:00 EDT 2023
Abamectin causes toxicity to the carp respiratory system by triggering oxidative stress, inflammation, and apoptosis and inhibiting autophagy.
Environmental science and pollution research international
Feng H,Zhou P,Liu F,Zhang W,Yang H,Li X,Dong J
Sat Apr 01 00:00:00 EDT 2023
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Journal of ethnopharmacology
Zhang PP,Zhuo BY,Duan ZW,Li X,Huang SL,Cao Q,Zhao T,Wei SL,Hu XH,Zhang Y
Thu Aug 10 00:00:00 EDT 2023
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Cancers
Jin L,Mi T,Wu X,Wang Z,Zhang Z,Liu J,Wang Z,Wang J,Li M,Ren C,Guo P,He D
Tue Mar 28 00:00:00 EDT 2023
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Deng H,Chen W,Zhang B,Zhang Y,Han L,Zhang Q,Yao S,Wang H,Shen XL
Thu Jun 01 00:00:00 EDT 2023
Trimethylamine N-oxide Promotes Atherosclerosis by Regulating Low-Density Lipoprotein-Induced Autophagy in Vascular Smooth Muscle Cells Through PI3K/AKT/mTOR Pathway.
International heart journal
Shi G,Zeng L,Shi J,Chen Y
Fri Jun 02 00:00:00 EDT 2023
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Journal of medicinal chemistry
Wang Z,Tan M,Su W,Huang W,Zhang J,Jia F,Cao G,Liu X,Song H,Ran H,Nie G,Wang H
Thu May 11 00:00:00 EDT 2023
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Oncology letters
Zhou H,Yun X,Shu Y,Xu K
Wed Mar 01 00:00:00 EST 2023
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
iScience
Lu R,Wei Z,Wang Z,Xu S,Sun K,Cheng P,Huang X,You H,Guo F,Liang S,Chen AM
Fri Feb 17 00:00:00 EST 2023
Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway.
Neural regeneration research
Sun X,Huang LY,Pan HX,Li LJ,Wang L,Pei GQ,Wang Y,Zhang Q,Cheng HX,He CQ,Wei Q
Mon May 01 00:00:00 EDT 2023
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
PeerJ
Weng M,Shi C,Han H,Zhu H,Xiao Y,Guo H,Yu Z,Wu C
Wed Jan 18 00:00:00 EST 2023
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
PeerJ
Weng M,Shi C,Han H,Zhu H,Xiao Y,Guo H,Yu Z,Wu C
Wed Jan 18 00:00:00 EST 2023
Platelet-rich plasma pretreatment protects anterior cruciate ligament fibroblasts correlated with PI3K-Akt-mTOR pathway under hypoxia condition.
Journal of orthopaedic translation
Cao Y,Li Y,Fu SC,Shen J,Zhang H,Jiang C,Shu-Hang Yung P
Sun May 01 00:00:00 EDT 2022
PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma.
FEBS open bio
Liu J,Mi J,Liu S,Chen H,Jiang L
Tue Nov 01 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
MK-2206 Alleviates Renal Fibrosis by Suppressing the Akt/mTOR Signaling Pathway In Vivo and In Vitro.
Cells
Chen M,Yu Y,Mi T,Guo Q,Xiang B,Tian X,Jin L,Long C,Shen L,Liu X,Pan J,Zhang Y,Xu T,Zhang D,Wei G
Sat Nov 05 00:00:00 EDT 2022
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
BMC medical genomics
Li B,Ge N,Pan Z,Hou C,Xie K,Wang D,Liu J,Wan J,Deng F,Li M,Luo S
Tue Sep 13 00:00:00 EDT 2022
Metformin Attenuates UVA-Induced Skin Photoaging by Suppressing Mitophagy and the PI3K/AKT/mTOR Pathway.
International journal of molecular sciences
Chen Q,Zhang H,Yang Y,Zhang S,Wang J,Zhang D,Yu H
Thu Jun 23 00:00:00 EDT 2022
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Journal of cardiovascular translational research
Wang K,Li Z,Sun Y,Liu X,Ma W,Ding Y,Hong J,Qian L,Xu D
Mon Aug 01 00:00:00 EDT 2022
3,6-dichlorobenzo[b]thiophene-2-carboxylic acid alleviates ulcerative colitis by suppressing mammalian target of rapamycin complex 1 activation and regulating intestinal microbiota.
World journal of gastroenterology
He QZ,Wei P,Zhang JZ,Liu TT,Shi KQ,Liu HH,Zhang JW,Liu SJ
Wed Dec 14 00:00:00 EST 2022
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling.
Cell death discovery
Zhao G,Li S,Wang Q,Wu W,Fu X,Zhu C,Wang W,Wang X
Mon Sep 26 00:00:00 EDT 2022
Activation of Non-Canonical Autophagic Pathway through Inhibition of Non-Integrin Laminin Receptor in Neuronal Cells.
Cells
Limone A,Veneruso I,Izzo A,Renna M,Bonavita R,Piscitelli S,Calì G,De Nicola S,Riccio P,D'Argenio V,Lavecchia A,Sarnataro D
Sat Jan 29 00:00:00 EST 2022
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Pharmaceuticals (Basel, Switzerland)
Sun Y,Li H,Liu L,Bai X,Wu L,Shan J,Sun X,Wang Q,Guo Y
Thu Dec 29 00:00:00 EST 2022
Overexpression of SFXN1 indicates poor prognosis and promotes tumor progression in lung adenocarcinoma.
Pathology, research and practice
Chen L,Kang Y,Jiang Y,You J,Huang C,Xu X,Chen F
Thu Sep 01 00:00:00 EDT 2022
LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway.
BMC cancer
Tan Y,Chen Q,Pan S,An W,Xu H,Xing Y,Zhang J
Sat Apr 30 00:00:00 EDT 2022
CD44-fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition.
Blood advances
Wang C,Wang Y,Zuo N,Fang S,Shi J
Tue Aug 09 00:00:00 EDT 2022
Oryzanol Attenuates High Fat and Cholesterol Diet-Induced Hyperlipidemia by Regulating the Gut Microbiome and Amino Acid Metabolism.
Journal of agricultural and food chemistry
Yan S,Chen J,Zhu L,Guo T,Qin D,Hu Z,Han S,Zhou Y,Akan OD,Wang J,Luo F,Lin Q
Wed Jun 01 00:00:00 EDT 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 EDT 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 EDT 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 EDT 2022
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.
Oxidative medicine and cellular longevity
Mu X,Shen Z,Lin Y,Xiao J,Xia K,Xu C,Chen B,Shi R,Zhu A,Sun X,Tao T,Song X,Xuan Q
Tue May 17 00:00:00 EDT 2022
CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.
International journal of biological sciences
Zhang Z,Xu P,Hu Z,Fu Z,Deng T,Deng X,Peng L,Xie Y,Long L,Zheng D,Shen P,Zhang M,Gong B,Zhu Z,Lin J,Chen R,Liu Z,Yang H,Li R,Fang W
Wed Jan 04 00:00:00 EST 2023
Prototheca bovis induces autophagy in bovine mammary epithelial cells via the HIF-1α and AMPKα/ULK1 pathway.
Frontiers in immunology
Zhao W,Xu M,Barkema HW,Xie X,Lin Y,Khan S,Kastelic JP,Wang D,Deng Z,Han B
Mon Sep 26 00:00:00 EDT 2022
Upregulation of Klotho Aggravates Insulin Resistance in Gestational Diabetes Mellitus Trophoblast Cells.
Genetics research
Lin L,Wang X,Zhao W,Chen Y
Mon Nov 07 00:00:00 EST 2022
Remote cyclic compression ameliorates myocardial infarction injury in rats via AMPK-dependent pathway.
Microvascular research
Xu S,Xia X,Liu Y,Chen F,Gu R,Bian X,Xu X,Jia C,Lu S,Gu Y,Bai H,Zhang H
Sun May 01 00:00:00 EDT 2022
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Cancer communications (London, England)
Dai W,Xiang W,Han L,Yuan Z,Wang R,Ma Y,Yang Y,Cai S,Xu Y,Mo S,Li Q,Cai G
Thu Sep 01 00:00:00 EDT 2022
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Frontiers in endocrinology
Lu R,He Z,Zhang W,Wang Y,Cheng P,Lv Z,Yuan X,Guo F,You H,Chen AM,Hu W
Tue Dec 20 00:00:00 EST 2022
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Materials today. Bio
Liu L,Li X,Bu W,Jin N,Meng Y,Wang Y,Wang D,Xu X,Zhou D,Sun H
Thu Dec 01 00:00:00 EST 2022
Apelin-mediated deamidation of HMGA1 promotes tumorigenesis by enhancing SREBP1 activity and lipid synthesis.
Cancer science
Zhu Y,Yang Y,Bu H,Huang H,Chen H,Ran J,Qin L,Ni Y,Yao M,Song T,Li M,Yang Y,Guo T,Chao N,Liu Z,Li W,Zhang L
Tue Nov 01 00:00:00 EDT 2022
mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.
Metabolites
Liu M,Yue Z,Zhang B,Li F,Liu L,Li F
Thu Aug 25 00:00:00 EDT 2022
Deduction of CDC42EP3 suppress development and progression of osteosarcoma.
Experimental cell research
Xu P,Li X,Tang C,Wang T,Xu J
Tue Mar 01 00:00:00 EST 2022
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Frontiers in pharmacology
Cheng Z,Luo X,Zhu Z,Huang Y,Yan X
Sat Jul 16 00:00:00 EDT 2022
Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway.
International journal of biological macromolecules
Liu Y,Li H,Zheng Z,Niu A,Liu S,Li W,Ren P,Liu Y,Inam M,Guan L,Ma H
Fri Jul 01 00:00:00 EDT 2022
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Journal of gastrointestinal oncology
Yin L,Feng S,Sun Y,Jiang Y,Tang C,Sun D
Sat Oct 01 00:00:00 EDT 2022
Overexpression of sFlt-1 represses ox-LDL-induced injury of HUVECs by activating autophagy via PI3K/AKT/mTOR pathway.
Microvascular research
Zhou YH,Tang YZ,Guo LY,Zheng LL,Zhang D,Yang CY,Wang W
Sat Jan 01 00:00:00 EST 2022
PP2A-mTOR-p70S6K/4E-BP1 axis regulates M1 polarization of pulmonary macrophages and promotes ambient particulate matter induced mouse lung injury.
Journal of hazardous materials
Chen S,Chen L,Ye L,Jiang Y,Li Q,Zhang H,Zhang R,Li H,Yu D,Zhang R,Niu Y,Zhao Q,Liu J,Ouyang G,Aschner M,Zheng Y,Zhang L,Chen W,Li D
Tue Feb 15 00:00:00 EST 2022
Morphine-induced microglial immunosuppression via activation of insufficient mitophagy regulated by NLRX1.
Journal of neuroinflammation
Peng J,Pan J,Wang H,Mo J,Lan L,Peng Y
Tue Apr 12 00:00:00 EDT 2022
Achyranthoside D (AD) improve intervertebral disc degeneration through affect the autophagy and the activation of PI3K/Akt/mTOR pathway.
Journal of orthopaedic surgery (Hong Kong)
Zhang C,Li Z,Li L,Li S,Yang L,Chen L,Zhang X,Yang S,Guo Y
Tue Nov 01 00:00:00 EDT 2022
Grass Carp Reovirus triggers autophagy enhancing virus replication via the Akt/mTOR pathway.
Fish & shellfish immunology
Zhu M,Zhang Y,Pan J,Tong X,Zhang X,Hu X,Gong C
Thu Sep 01 00:00:00 EDT 2022
Gracillin Shows Potential Efficacy Against Non-Small Cell Lung Cancer Through Inhibiting the mTOR Pathway.
Frontiers in oncology
Li Y,Liu H,Liu X,Xiao B,Zhang M,Luo Y,Li M,Yang J
Sat Apr 09 00:00:00 EDT 2022
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Drug development research
Yuan D,Guo T,Qian H,Ge H,Zhao Y,Huang A,Wang X,Cao X,Zhu D,He C,Yu H
Thu Sep 01 00:00:00 EDT 2022
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.
International journal of molecular sciences
Zhang W,Ho CT,Lu M
Tue May 17 00:00:00 EDT 2022
Dietary folic acid supplementation improves semen quality and spermatogenesis through altering autophagy and histone methylation in the testis of aged broiler breeder roosters.
Theriogenology
Ye N,Lv Z,Huang Z,Cheng Y,Wei Q,Shi F
Tue Mar 15 00:00:00 EDT 2022
Rapamycin Attenuates Anxiety and Depressive Behavior Induced by Helicobacter pylori in Association with Reduced Circulating Levels of Ghrelin.
Neural plasticity
Tian J,Wang Z,Ren Y,Jiang Y,Zhao Y,Li M,Zhang Z
Fri Jun 10 00:00:00 EDT 2022
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Ecotoxicology and environmental safety
Wu M,Cong Y,Wang K,Yu H,Zhang X,Ma M,Duan Z,Pei X
Fri Apr 01 00:00:00 EDT 2022
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Cancer cell international
Li W,Huang BS,Xiong YY,Yang LJ,Wu LX
Tue Jan 18 00:00:00 EST 2022
Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
Proceedings of the National Academy of Sciences of the United States of America
Yan W,Zheng L,Xu X,Hao Z,Zhang Y,Lu J,Sun Z,Dai J,Shi D,Guo B,Jiang Q
Tue Sep 13 00:00:00 EDT 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 EDT 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 EDT 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 EDT 2022
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Experimental dermatology
Tao T,Chen Y,Chen J,Lian C,Xu S,Zhang M,Fang C
Mon Aug 01 00:00:00 EDT 2022
Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.
Stem cell research & therapy
Zhao X,Sun W,Guo B,Cui L
Sat Aug 13 00:00:00 EDT 2022
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Frontiers in cell and developmental biology
Shen G,Wang H,Zhu N,Lu Q,Liu J,Xu Q,Huang D
Sat Jul 16 00:00:00 EDT 2022
Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway.
Journal of Cancer
Zhu N,Chen X,Zhao J,Fang L,Yao Y,Zhou F,Tao L,Xu Q
Tue Sep 20 00:00:00 EDT 2022
PEBP4 Directs the Malignant Behavior of Hepatocellular Carcinoma Cells via Regulating mTORC1 and mTORC2.
International journal of molecular sciences
Chen Q,Jin J,Guo W,Tang Z,Luo Y,Ying Y,Lin H,Luo Z
Mon Aug 08 00:00:00 EDT 2022
β-Carotene Attenuates Apoptosis and Autophagy via PI3K/AKT/mTOR Signaling Pathway in Necrotizing Enterocolitis Model Cells IEC-6.
Evidence-based complementary and alternative medicine : eCAM
Xu G,Ma T,Zhou C,Zhao F,Peng K,Li B
Sat Jul 16 00:00:00 EDT 2022
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Journal of hazardous materials
Xiaoli F,Yaqing Z,Ruhui L,Xuan L,Aijie C,Yanli Z,Chen H,Lili C,Longquan S
Sun Aug 15 00:00:00 EDT 2021
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination.
Cell & bioscience
Zhu M,Wu M,Bian S,Song Q,Xiao M,Huang H,You L,Zhang J,Zhang J,Cheng C,Ni W,Zheng W
Tue Feb 23 00:00:00 EST 2021
DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination.
Cell & bioscience
Zhu M,Wu M,Bian S,Song Q,Xiao M,Huang H,You L,Zhang J,Zhang J,Cheng C,Ni W,Zheng W
Tue Feb 23 00:00:00 EST 2021
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Cancer cell international
Liu X,Yang J,Yang C,Huang X,Han M,Kang F,Li J
Thu Nov 25 00:00:00 EST 2021
The probiotic effects of AB23A on high-fat-diet-induced non-alcoholic fatty liver disease in mice may be associated with suppressing the serum levels of lipopolysaccharides and branched-chain amino acids.
Archives of biochemistry and biophysics
Xia F,Xiang S,Chen Z,Song L,Li Y,Liao Z,Ge B,Zhou B
Wed Dec 15 00:00:00 EST 2021
The intestinal microbiota contributes to the growth and physiological state of muscle tissue in piglets.
Scientific reports
Qi R,Sun J,Qiu X,Zhang Y,Wang J,Wang Q,Huang J,Ge L,Liu Z
Thu May 27 00:00:00 EDT 2021
Shexiang Baoxin Pills Inhibited Proliferation and Migration of Human Coronary Artery Smooth Muscle Cells via PI3K/AKT/mTOR Pathway.
Frontiers in cardiovascular medicine
Hua L,Zhou Y,Hou C,Chen J,Wang Y,Zhang S,Zhou H,He S,Jia E
Tue Sep 14 00:00:00 EDT 2021
Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.
Journal of experimental & clinical cancer research : CR
Liu S,Chen L,Chen H,Xu K,Peng X,Zhang M
Fri Feb 12 00:00:00 EST 2021
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Scientific reports
Zhao Y,Liu X,Zheng Y,Liu W,Ding C
Mon Oct 18 00:00:00 EDT 2021
Increased Nuclear Transporter Importin 7 Contributes to the Tumor Growth and Correlates With CD8 T Cell Infiltration in Cervical Cancer.
Frontiers in cell and developmental biology
Chen J,Hu Y,Teng Y,Yang B
Sat Oct 16 00:00:00 EDT 2021
UPF1 impacts on mTOR signaling pathway and autophagy in endometrioid endometrial carcinoma.
Aging
Zhang M,Chen H,Qin P,Cai T,Li L,Chen R,Liu S,Chen H,Lin W,Chen H,Strickland AL,Xiong H,Jiang Q
Tue Sep 14 00:00:00 EDT 2021
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 EDT 2022
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 EDT 2022
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 EDT 2022
PPT1 Reduction Contributes to Erianin-Induced Growth Inhibition in Oral Squamous Carcinoma Cells.
Frontiers in cell and developmental biology
Luo Q,Li X,Gan G,Yang M,Chen X,Chen F
Sat Jul 16 00:00:00 EDT 2022
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Frontiers in neuroscience
Wang C,Chen H,Jiang HH,Mao BB,Yu H
Tue Dec 28 00:00:00 EST 2021
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Histology and histopathology
Ji Q,Qiao X,Liu Y,Wang D
Thu Apr 01 00:00:00 EDT 2021
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Frontiers in medicine
Yao M,Zhang J,Li Z,Bai X,Ma J,Li Y
Wed Mar 10 00:00:00 EST 2021
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
International immunopharmacology
Zhao P,Cai Z,Tian Y,Li J,Li K,Li M,Bai Y,Li J
Wed Dec 01 00:00:00 EST 2021
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
International immunopharmacology
Zhao P,Cai Z,Tian Y,Li J,Li K,Li M,Bai Y,Li J
Wed Dec 01 00:00:00 EST 2021
PRMT4 promotes hepatocellular carcinoma progression by activating AKT/mTOR signaling and indicates poor prognosis.
International journal of medical sciences
Du P,Luo K,Li G,Zhu J,Xiao Q,Li Y,Zhang X
Tue Mar 15 00:00:00 EDT 2022
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Journal of bone oncology
Guo H,Peng J,Hu J,Chang S,Liu H,Luo H,Chen X,Tang H,Chen Y
Wed Dec 01 00:00:00 EST 2021
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Journal of biochemical and molecular toxicology
Man S,Wu Z,Sun R,Guan Q,Li Z,Zuo D,Zhang W,Wu Y
Sun Aug 01 00:00:00 EDT 2021
Merazin Hydrate Produces Rapid Antidepressant Effects Depending on Activating mTOR Signaling by Upregulating Downstream Synaptic Proteins in the Hippocampus.
ACS chemical neuroscience
Lu C,Liu X,Li J,Huang Y,Huang X,Dai G,Wu L
Wed Oct 20 00:00:00 EDT 2021
Effects of Cynaroside on Cell Proliferation, Apoptosis, Migration and Invasion though the MET/AKT/mTOR Axis in Gastric Cancer.
International journal of molecular sciences
Ji J,Wang Z,Sun W,Li Z,Cai H,Zhao E,Cui H
Tue Nov 09 00:00:00 EST 2021
Combination effect of curcumin with docetaxel on the PI3K/AKT/mTOR pathway to induce autophagy and apoptosis in esophageal squamous cell carcinoma.
American journal of translational research
Deng L,Wu X,Zhu X,Yu Z,Liu Z,Wang J,Zheng Y
Wed Feb 03 00:00:00 EST 2021
UFL1 regulates milk protein and fat synthesis-related gene expression of bovine mammary epithelial cells probably via the mTOR signaling pathway.
In vitro cellular & developmental biology. Animal
Li C,Li L,Ali I,Kuang M,Wang X,Wang G
Sat May 01 00:00:00 EDT 2021
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Human & experimental toxicology
Chen M,Zhu LL,Su JL,Li GL,Wang J,Zhang YN
Sat Feb 01 00:00:00 EST 2020
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Translational cancer research
Geng F,Fan MJ,Li J,Liang SM,Li CY,Li N
Tue Oct 01 00:00:00 EDT 2019
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Oncology research
Liu X,Tan X,Liu P,Wu Y,Qian S,Zhang X
Thu Aug 23 00:00:00 EDT 2018
